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WO2007096740A3 - Novel cephalosporins - Google Patents

Novel cephalosporins Download PDF

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Publication number
WO2007096740A3
WO2007096740A3 PCT/IB2007/000403 IB2007000403W WO2007096740A3 WO 2007096740 A3 WO2007096740 A3 WO 2007096740A3 IB 2007000403 W IB2007000403 W IB 2007000403W WO 2007096740 A3 WO2007096740 A3 WO 2007096740A3
Authority
WO
WIPO (PCT)
Prior art keywords
general formula
present
formula
novel cephalosporins
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/000403
Other languages
French (fr)
Other versions
WO2007096740A2 (en
Inventor
Uma Ramachandran
Gaddam Om Reddy
Ravikumar Tadiparthi
Prabhakar Theratipally
Jakkala Venkateshwarlu
Santhosh Subramanian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchid Research Laboratories Ltd
Original Assignee
Orchid Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Research Laboratories Ltd filed Critical Orchid Research Laboratories Ltd
Publication of WO2007096740A2 publication Critical patent/WO2007096740A2/en
Publication of WO2007096740A3 publication Critical patent/WO2007096740A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

The present invention relates to novel compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel cephalosporin antibiotics of the general formula (I). Also included is a method for treatment of infectious diseases in a mammal comprising administering an effective amount of a compound of formula (I) as described above.
PCT/IB2007/000403 2006-02-20 2007-02-20 Novel cephalosporins Ceased WO2007096740A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN266CH2006 2006-02-20
IN266/CHE/2006 2006-02-20

Publications (2)

Publication Number Publication Date
WO2007096740A2 WO2007096740A2 (en) 2007-08-30
WO2007096740A3 true WO2007096740A3 (en) 2007-10-18

Family

ID=38437742

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/000403 Ceased WO2007096740A2 (en) 2006-02-20 2007-02-20 Novel cephalosporins

Country Status (1)

Country Link
WO (1) WO2007096740A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009049086A1 (en) 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
LT2960244T (en) 2008-10-31 2016-11-25 Shionogi & Co., Ltd. Cephalosporin having catechol group
KR20130018845A (en) 2010-04-05 2013-02-25 시오노기세야쿠 가부시키가이샤 Cephem compound having catechol group
JP5852559B2 (en) 2010-04-05 2016-02-03 塩野義製薬株式会社 Cephem compounds having pseudo-catechol groups
JP5852562B2 (en) 2010-04-28 2016-02-03 塩野義製薬株式会社 Novel cephem derivatives
EP2703406A4 (en) * 2011-04-28 2015-08-05 Shionogi & Co Novel cephem compound having catechol or pseudo-catechol structure
US9242999B2 (en) 2011-06-27 2016-01-26 Shionogi & Co., Ltd. Cephem compound having pyridinium group
CN103958527A (en) 2011-10-04 2014-07-30 盐野义制药株式会社 Cephem derivative having catechol group
WO2014069649A1 (en) 2012-10-29 2014-05-08 Shionogi & Co., Ltd. Processes for production of intermediates for 2-alkyl cephem compounds
CN106967093B (en) * 2017-03-31 2019-05-17 成都大学 A kind of cephalosporin compound and its preparation method and application

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137440A2 (en) * 1983-10-08 1985-04-17 Hoechst Aktiengesellschaft Cephalasporin derivatives and process for their preparation
JPS6230788A (en) * 1985-08-02 1987-02-09 Banyu Pharmaceut Co Ltd Novel cephalosporin derivative
JPH01279893A (en) * 1988-04-28 1989-11-10 Fujisawa Pharmaceut Co Ltd Cephem compound
WO1992018508A1 (en) * 1991-04-15 1992-10-29 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds
US5571909A (en) * 1993-06-09 1996-11-05 Korea Institute Of Science And Technology Cephalosporin compounds and processes for preparing thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137440A2 (en) * 1983-10-08 1985-04-17 Hoechst Aktiengesellschaft Cephalasporin derivatives and process for their preparation
DE3409431A1 (en) * 1983-10-08 1985-04-18 Hoechst Ag, 6230 Frankfurt CEPHALOSPORINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION
JPS6230788A (en) * 1985-08-02 1987-02-09 Banyu Pharmaceut Co Ltd Novel cephalosporin derivative
JPH01279893A (en) * 1988-04-28 1989-11-10 Fujisawa Pharmaceut Co Ltd Cephem compound
WO1992018508A1 (en) * 1991-04-15 1992-10-29 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds
US5571909A (en) * 1993-06-09 1996-11-05 Korea Institute Of Science And Technology Cephalosporin compounds and processes for preparing thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] accession no. STN Database accession no. (103:160295) *
DATABASE CAPLUS [online] accession no. STN Database accession no. (103:215071) *
DATABASE CAPLUS [online] accession no. STN Database accession no. (107:115433) *
DATABASE CAPLUS [online] accession no. STN Database accession no. (112:216552) *
DATABASE CAPLUS [online] accession no. STN Database accession no. (126:59805) *
DATABASE CAPLUS [online] WATANABE K. AND KATSU K.: "Affinity of E1077, a new cephalosporin, for penicillin-binding proteins of Staphylococcus aureus and its antistaphylococcal activity", accession no. STN Database accession no. (121:4889) *
JOURNAL OF ANTIBIOTICS, vol. 46, no. 11, 1993, pages 1707 - 1715 *

Also Published As

Publication number Publication date
WO2007096740A2 (en) 2007-08-30

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