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WO2007091881A3 - Procedes et dispositifs destines a detecter une infection induite par le mycobacterium leprae - Google Patents

Procedes et dispositifs destines a detecter une infection induite par le mycobacterium leprae Download PDF

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Publication number
WO2007091881A3
WO2007091881A3 PCT/NL2006/050105 NL2006050105W WO2007091881A3 WO 2007091881 A3 WO2007091881 A3 WO 2007091881A3 NL 2006050105 W NL2006050105 W NL 2006050105W WO 2007091881 A3 WO2007091881 A3 WO 2007091881A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
infections
detection
leprae
mycobacterium leprae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NL2006/050105
Other languages
English (en)
Other versions
WO2007091881A2 (fr
Inventor
Tom Henricus Maria Ottenhof
Annemieke Geluk
Sampaio Elizabeth Pereira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leids Universitair Medisch Centrum LUMC
Original Assignee
Leids Universitair Medisch Centrum LUMC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leids Universitair Medisch Centrum LUMC filed Critical Leids Universitair Medisch Centrum LUMC
Publication of WO2007091881A2 publication Critical patent/WO2007091881A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007091881A3 publication Critical patent/WO2007091881A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne de nouveaux antigènes du Mycobacterium leprae à utiliser dans des procédés et des dispositifs destinés à détecter et diagnostiquer des infections induites par le M. leprae chez des individus, en particulier au premier stade de l'infection et dans les infections paucibacillaires, que les procédés de diagnostic classiques ne détectent pas. Les antigènes de l'invention sont spécifiques au M. leprae et le procédé de diagnostic permet d'éviter de 'faux résultats positifs' chez les sujets ayant une réponse immunitaire contre d'autres espèces mycobacteriennes, telles que le M. tuberculosis, le M. bovis, le M. paratuberculosis, le M. avium, le M. smegmatis, le M. ulcerans, le M. microtii et le M. marinum, ou les individus vaccinés par le BCG.
PCT/NL2006/050105 2005-04-29 2006-04-28 Procedes et dispositifs destines a detecter une infection induite par le mycobacterium leprae Ceased WO2007091881A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05103576 2005-04-29
EP05103576.4 2005-04-29

Publications (2)

Publication Number Publication Date
WO2007091881A2 WO2007091881A2 (fr) 2007-08-16
WO2007091881A3 true WO2007091881A3 (fr) 2007-11-29

Family

ID=34939609

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2006/050105 Ceased WO2007091881A2 (fr) 2005-04-29 2006-04-28 Procedes et dispositifs destines a detecter une infection induite par le mycobacterium leprae

Country Status (1)

Country Link
WO (1) WO2007091881A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2384795B2 (es) * 2010-12-13 2013-01-29 Medlumics, S.L. Píldora electrónica gastrointestinal.
CN117821625B (zh) * 2023-12-29 2024-07-26 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) 引物探针、试剂盒、检测方法及应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051725A2 (fr) * 1998-04-02 1999-10-14 Yeda Research And Development Co. Ltd. Methode de diagnostic de la schizophrenie basee sur un peptide nouveau
WO2001023402A1 (fr) * 1999-09-27 2001-04-05 Human Genome Sciences, Inc. 43 proteines secretees humaines
WO2001042276A1 (fr) * 1999-12-13 2001-06-14 Proteom Limited Ligands de peptides complementaires generes a partir de sequences de genomes d'eucaryotes superieurs
WO2002074903A2 (fr) * 2001-02-22 2002-09-26 Institut Pasteur Analyse comparative des genomes de mycobacteries en vue de l'identification de cibles a des fins de diagnostic, de prophylaxie ou de traitement de mycobacterioses
EP1443116A1 (fr) * 2003-01-31 2004-08-04 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Procédé amélioré pour la détection des enzymes protéolitiques
WO2005007758A2 (fr) * 2003-07-03 2005-01-27 C Steven Mcdaniel Peintures et revetements antifongiques

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051725A2 (fr) * 1998-04-02 1999-10-14 Yeda Research And Development Co. Ltd. Methode de diagnostic de la schizophrenie basee sur un peptide nouveau
WO2001023402A1 (fr) * 1999-09-27 2001-04-05 Human Genome Sciences, Inc. 43 proteines secretees humaines
WO2001042276A1 (fr) * 1999-12-13 2001-06-14 Proteom Limited Ligands de peptides complementaires generes a partir de sequences de genomes d'eucaryotes superieurs
WO2002074903A2 (fr) * 2001-02-22 2002-09-26 Institut Pasteur Analyse comparative des genomes de mycobacteries en vue de l'identification de cibles a des fins de diagnostic, de prophylaxie ou de traitement de mycobacterioses
EP1443116A1 (fr) * 2003-01-31 2004-08-04 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Procédé amélioré pour la détection des enzymes protéolitiques
WO2005007758A2 (fr) * 2003-07-03 2005-01-27 C Steven Mcdaniel Peintures et revetements antifongiques

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
CHUA-INTRA BOOSBUN ET AL: "T-cell recognition of peptides from the Mycobacterium leprae 35 kDa protein in Thai leprosy patients, healthy contacts, and non-contacts.", IMMUNOLOGY LETTERS. 3 JUL 2003, vol. 88, no. 1, 3 July 2003 (2003-07-03), pages 71 - 76, XP002343189, ISSN: 0165-2478 *
COLE S T ET AL, NATURE, 22 February 2001 (2001-02-22), pages 1 - 1, XP002451029, Retrieved from the Internet <URL:http://www.nature.com/nature/journal/v409/n6823/extref/4091007a0_S2.pdf> [retrieved on 20070914] *
COLE S T ET AL, NATURE, 22 February 2001 (2001-02-22), pages 1 - 3, XP002451030 *
COLE S T ET AL, NATURE, 22 February 2001 (2001-02-22), pages 1 - 46, XP002451028, Retrieved from the Internet <URL:http://www.nature.com/nature/journal/v409/n6823/extref/4091007a0_S3.htm> [retrieved on 20070914] *
COLE S T ET AL: "Massive gene decay in the leprosy bacillus.", NATURE, vol. 409, no. 6823, 22 February 2001 (2001-02-22), pages 1007 - 1011, XP001026092, ISSN: 0028-0836 *
DATABASE EMBL [online] 1 June 2001 (2001-06-01), COLE S T ET AL: "Putative integral membrane protein", XP002451036, Database accession no. Q9CBG6 *
DATABASE EMBL [online] 1 June 2001 (2001-06-01), COLE S T ET AL: "Putative uncharacterized protein ML1989", XP002451035, Database accession no. Q9CBG7 *
DATABASE EMBL [online] 1 June 2001 (2001-06-01), COLE S T ET AL: "Putative uncharacterized protein ML2283", XP002451037, Database accession no. Q9CBA2 *
DATABASE EMBL [online] 1 June 2001 (2001-06-01), COLE S T ET AL: "Putative uncharacterized protein ML2567", XP002451038, Database accession no. Q9CD21 *
DATABASE EMBL [online] 1 November 1996 (1996-11-01), COLE S T E T AL: "B1496_C1_130 (Hypothetical protein ML0576).", XP002344009, Database accession no. Q49681 *
SPENCER JOHN S ET AL: "Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6.", INFECTION AND IMMUNITY. FEB 2002, vol. 70, no. 2, February 2002 (2002-02-01), pages 1010 - 1013, XP002343188, ISSN: 0019-9567 *
SPENCER JOHN S ET AL: "Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10.", INFECTION AND IMMUNITY. JUN 2004, vol. 72, no. 6, June 2004 (2004-06-01), pages 3161 - 3170, XP002343190, ISSN: 0019-9567 *
WILLIAMS D L ET AL: "PCR-based diagnosis of leprosy in the United States", CLINICAL MICROBIOLOGY NEWSLETTER 15 APR 2003 UNITED STATES, vol. 25, no. 8, 15 April 2003 (2003-04-15), pages 57 - 61, XP002343191, ISSN: 0196-4399 *

Also Published As

Publication number Publication date
WO2007091881A2 (fr) 2007-08-16

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