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WO2007090822A3 - Pharmazeutische formulierung für aerosole mit zwei oder mehr wirkstoffen und mindestens einer oberflächenaktiven substanz - Google Patents

Pharmazeutische formulierung für aerosole mit zwei oder mehr wirkstoffen und mindestens einer oberflächenaktiven substanz Download PDF

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Publication number
WO2007090822A3
WO2007090822A3 PCT/EP2007/051095 EP2007051095W WO2007090822A3 WO 2007090822 A3 WO2007090822 A3 WO 2007090822A3 EP 2007051095 W EP2007051095 W EP 2007051095W WO 2007090822 A3 WO2007090822 A3 WO 2007090822A3
Authority
WO
WIPO (PCT)
Prior art keywords
surfactant
aerosols
active agents
pharmaceutical formulation
active agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/051095
Other languages
English (en)
French (fr)
Other versions
WO2007090822A2 (de
Inventor
Erhard Berkel
Hubert Hoelz
Friedrich Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38266105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007090822(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2007213819A priority Critical patent/AU2007213819B2/en
Priority to NZ571016A priority patent/NZ571016A/en
Priority to EA200801767A priority patent/EA014776B1/ru
Priority to CA002641883A priority patent/CA2641883A1/en
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to EP07704378A priority patent/EP1988874A2/de
Priority to BRPI0707594-4A priority patent/BRPI0707594A2/pt
Priority to JP2008553744A priority patent/JP2009526012A/ja
Publication of WO2007090822A2 publication Critical patent/WO2007090822A2/de
Publication of WO2007090822A3 publication Critical patent/WO2007090822A3/de
Priority to NO20083375A priority patent/NO20083375L/no
Priority to IL193274A priority patent/IL193274A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die vorliegende Erfindung betrifft neue pharmazeutische Formulierungen für Aerosole mit mindestens zwei oder mehr Wirkstoffen zusammen mit mindestens einer oberflächenaktiven Substanz für die inhalative oder nasale Anwendung. Im Einzelnen betrifft die Erfindung pharmazeutische Zubereitungen für treibmittelbetriebene Dosieraerosole mit einem Fluorkohlenwasserstoff (HFA) als Treibmittel, die eine Wirkstoffkombination aus zwei oder mehr Wirkstoffen enthalten, wobei mindestens ein Wirkstoff in gelöster Form neben mindestens einem weiteren Wirkstoff in Form suspendierter Teilchen zusammen mit mindestens einer oberflächenaktiven Substanz vorliegt.
PCT/EP2007/051095 2006-02-09 2007-02-06 Pharmazeutische formulierung für aerosole mit zwei oder mehr wirkstoffen und mindestens einer oberflächenaktiven substanz Ceased WO2007090822A2 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BRPI0707594-4A BRPI0707594A2 (pt) 2006-02-09 2007-02-06 composÇço farmacÊutica para aerossàis com duas ou mais substÂncias ativas e pelo menos um tensoativo
JP2008553744A JP2009526012A (ja) 2006-02-09 2007-02-06 ２以上の活性物質及び少なくとも一つの界面活性剤を有するエアロゾル用の医薬組成物
NZ571016A NZ571016A (en) 2006-02-09 2007-02-06 Pharmaceutical formulation for aerosols, comprising two or more active agents and at least one surfactant
EA200801767A EA014776B1 (ru) 2006-02-09 2007-02-06 Фармацевтическая композиция для аэрозольного распыления с двумя действующими веществами и по меньшей мере одним поверхностно-активным веществом
CA002641883A CA2641883A1 (en) 2006-02-09 2007-02-06 Pharmaceutical formulation for aerosols, comprising two or more active agents and at least one surfactant
AU2007213819A AU2007213819B2 (en) 2006-02-09 2007-02-06 Pharmaceutical formulation for aerosols, comprising two or more active agents and at least one surfactant
EP07704378A EP1988874A2 (de) 2006-02-09 2007-02-06 Pharmazeutische formulierung für aerosole mit zwei oder mehr wirkstoffen und mindestens einer oberflächenaktiven substanz
NO20083375A NO20083375L (no) 2006-02-09 2008-08-04 Farmasoytisk formulering for aerosoler, omfattende to eller aktive midler og minst et overflate aktivt middel
IL193274A IL193274A0 (en) 2006-02-09 2008-08-06 Pharmaceutical formulation for aerosols, comprising two or more active agents and at least one surfactant

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102006006207 2006-02-09
DE102006006207.8 2006-02-09
DE102006053374A DE102006053374A1 (de) 2006-02-09 2006-11-10 Pharmazeutische Formulierung für Aerosole mit zwei oder mehr Wirkstoffen und mindestens einer oberflächenaktiven Substanz
DE102006053374.7 2006-11-10

Publications (2)

Publication Number Publication Date
WO2007090822A2 WO2007090822A2 (de) 2007-08-16
WO2007090822A3 true WO2007090822A3 (de) 2007-11-08

Family

ID=38266105

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/051095 Ceased WO2007090822A2 (de) 2006-02-09 2007-02-06 Pharmazeutische formulierung für aerosole mit zwei oder mehr wirkstoffen und mindestens einer oberflächenaktiven substanz

Country Status (19)

Country Link
US (1) US20070183982A1 (de)
EP (1) EP1988874A2 (de)
JP (1) JP2009526012A (de)
KR (1) KR20080098656A (de)
CN (1) CN102861339A (de)
AR (1) AR059350A1 (de)
AU (1) AU2007213819B2 (de)
BR (1) BRPI0707594A2 (de)
CA (1) CA2641883A1 (de)
DE (1) DE102006053374A1 (de)
EA (1) EA014776B1 (de)
EC (1) ECSP088653A (de)
IL (1) IL193274A0 (de)
NO (1) NO20083375L (de)
NZ (1) NZ571016A (de)
PE (2) PE20070951A1 (de)
TW (1) TW200800294A (de)
UY (1) UY30139A1 (de)
WO (1) WO2007090822A2 (de)

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AU2005259523B2 (en) * 2004-07-02 2011-06-09 Boehringer Ingelheim International Gmbh Aerosol suspension formulations containing TG 227 ea or TG 134 a as a propellant
DE102006017320A1 (de) * 2006-04-11 2007-10-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel
GB0712454D0 (en) 2007-06-27 2007-08-08 Generics Uk Ltd Pharmaceutical compositions
EP2077132A1 (de) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Abgabevorrichtung, Aufbewahrungsvorrichtung und Verfahren zur Abgabe einer Formulierung
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
JP5763053B2 (ja) 2009-05-18 2015-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アダプタ、吸入器具及びアトマイザ
EP2504051B1 (de) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Zerstäuber
AP3141A (en) 2009-11-25 2015-02-28 Boehringer Ingelheim Int Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
JP5874724B2 (ja) 2010-06-24 2016-03-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
WO2012087094A1 (es) * 2010-12-21 2012-06-28 Techsphere S.A. De C.V. Composición farmacéutica inhalable para el tratamiento del asma por administración vía aérea mediante un succionador de emulación de aerosol
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
GB201306984D0 (en) * 2013-04-17 2013-05-29 Mexichem Amanco Holding Sa Composition
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
RU2536253C1 (ru) * 2013-10-09 2014-12-20 Шолекс Девелопмент Гмбх Комбинированный аэрозольный препарат для лечения болезней органов дыхания
CN106255554B (zh) 2014-05-07 2021-05-04 勃林格殷格翰国际有限公司 容器、喷雾器及用途
PE20210959A1 (es) 2014-05-07 2021-05-25 Boehringer Ingelheim Int Nebulizador, dispositivo indicador y recipiente
ES2874029T3 (es) 2014-05-07 2021-11-04 Boehringer Ingelheim Int Nebulizador
EP2985019B1 (de) 2014-08-16 2021-10-20 Church & Dwight Co., Inc. Nasale Zusammensetzung mit antiviralen Eigenschaften
EP3280393A1 (de) * 2015-04-10 2018-02-14 3M Innovative Properties Company Formulierung und aerosoldosen, inhalatoren und dergleichen mit der formulierung
GB2573297A (en) * 2018-04-30 2019-11-06 Mexichem Fluor Sa De Cv Pharmaceutical composition
CN110876723A (zh) * 2018-09-06 2020-03-13 天津金耀集团有限公司 一种含有表面活性剂的异丙托溴铵喷雾剂

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WO1992022286A1 (en) * 1991-06-12 1992-12-23 Minnesota Mining And Manufacturing Company Albuterol sulfate suspension aerosol formulations
GB2332372A (en) * 1997-12-08 1999-06-23 Minnesota Mining & Mfg Pharmaceutical aerosol compositions containing a plurality of active ingredients
WO1999065464A1 (en) * 1998-06-18 1999-12-23 Boehringer Ingelheim Pharmaceuticals, Inc. Pharmaceutical formulations for aerosols with two or more active substances
WO2004019985A1 (en) * 2002-08-29 2004-03-11 Cipla Ltd Pharmaceutical products and compositions comprising specific anticholinergic agents, beta-2 agonists and corticosteroids

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Publication number Priority date Publication date Assignee Title
WO1992022286A1 (en) * 1991-06-12 1992-12-23 Minnesota Mining And Manufacturing Company Albuterol sulfate suspension aerosol formulations
GB2332372A (en) * 1997-12-08 1999-06-23 Minnesota Mining & Mfg Pharmaceutical aerosol compositions containing a plurality of active ingredients
WO1999065464A1 (en) * 1998-06-18 1999-12-23 Boehringer Ingelheim Pharmaceuticals, Inc. Pharmaceutical formulations for aerosols with two or more active substances
WO2004019985A1 (en) * 2002-08-29 2004-03-11 Cipla Ltd Pharmaceutical products and compositions comprising specific anticholinergic agents, beta-2 agonists and corticosteroids

Also Published As

Publication number Publication date
EA014776B1 (ru) 2011-02-28
PE20070951A1 (es) 2007-09-24
IL193274A0 (en) 2009-08-03
AU2007213819A1 (en) 2007-08-16
CN102861339A (zh) 2013-01-09
NO20083375L (no) 2008-10-30
EP1988874A2 (de) 2008-11-12
PE20120023A1 (es) 2012-02-13
NZ571016A (en) 2012-01-12
US20070183982A1 (en) 2007-08-09
AU2007213819B2 (en) 2012-11-15
BRPI0707594A2 (pt) 2011-05-10
UY30139A1 (es) 2007-09-28
KR20080098656A (ko) 2008-11-11
WO2007090822A2 (de) 2007-08-16
CA2641883A1 (en) 2007-08-16
TW200800294A (en) 2008-01-01
DE102006053374A1 (de) 2007-08-16
EA200801767A1 (ru) 2009-02-27
JP2009526012A (ja) 2009-07-16
ECSP088653A (es) 2008-10-31
AR059350A1 (es) 2008-03-26

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