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WO2007090162A3 - OXYLIPINS FROM STEARIDONIC ACID AND γ-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME - Google Patents

OXYLIPINS FROM STEARIDONIC ACID AND γ-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME Download PDF

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Publication number
WO2007090162A3
WO2007090162A3 PCT/US2007/061397 US2007061397W WO2007090162A3 WO 2007090162 A3 WO2007090162 A3 WO 2007090162A3 US 2007061397 W US2007061397 W US 2007061397W WO 2007090162 A3 WO2007090162 A3 WO 2007090162A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxylipins
acid
making
methods
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/061397
Other languages
French (fr)
Other versions
WO2007090162A2 (en
Inventor
Linda Mary Arterburn
William Barclay
Bindi Dangi
James Flatt
Jung Lee
Dutt Vinjamoori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Martek Biosciences Corp
Original Assignee
Martek Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martek Biosciences Corp filed Critical Martek Biosciences Corp
Priority to EP07762723A priority Critical patent/EP1983977A4/en
Priority to US12/162,945 priority patent/US20090320148A1/en
Publication of WO2007090162A2 publication Critical patent/WO2007090162A2/en
Anticipated expiration legal-status Critical
Publication of WO2007090162A3 publication Critical patent/WO2007090162A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)

Abstract

Disclosed are novel oxylipins that are derived from γ-linolenic acid (GLA; 18:3n-6) and stearidonic acid (STA or SDA; 18:4n-3), and methods of making and using such oxylipins. Also disclosed is the use of such oxylipins in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. Also disclosed are The invention novel ways of producing long chain polyunsaturated acid (LCPUF A)-rich oils and compositions that contain enhanced and effective amounts of SDA- and/or GLA-derived oxylipins.
PCT/US2007/061397 2006-01-31 2007-01-31 OXYLIPINS FROM STEARIDONIC ACID AND γ-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME Ceased WO2007090162A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07762723A EP1983977A4 (en) 2006-01-31 2007-01-31 Oxylipins from stearidonic acid and gamma-linolenic acid and methods of making and using the same
US12/162,945 US20090320148A1 (en) 2006-01-31 2007-01-31 Oxylipins from stearidonic acid and gamma-linolenic acid and methods of making and using the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76396406P 2006-01-31 2006-01-31
US60/763,964 2006-01-31

Publications (2)

Publication Number Publication Date
WO2007090162A2 WO2007090162A2 (en) 2007-08-09
WO2007090162A3 true WO2007090162A3 (en) 2008-08-21

Family

ID=38328150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/061397 Ceased WO2007090162A2 (en) 2006-01-31 2007-01-31 OXYLIPINS FROM STEARIDONIC ACID AND γ-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME

Country Status (3)

Country Link
US (1) US20090320148A1 (en)
EP (1) EP1983977A4 (en)
WO (1) WO2007090162A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893106B2 (en) * 2004-11-19 2011-02-22 Martek Biosciences, Corporation Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same
US8343753B2 (en) 2007-11-01 2013-01-01 Wake Forest University School Of Medicine Compositions, methods, and kits for polyunsaturated fatty acids from microalgae
US20110027841A1 (en) * 2007-12-21 2011-02-03 Martek Biosciences Corporation Method for preparation of oxylipins
PL2887923T3 (en) 2012-08-24 2023-08-14 Sun Pharmaceutical Industries Limited Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and treatment of ocular conditions
CN106456586A (en) 2014-01-24 2017-02-22 国立大学法人京都大学 Metabolism-improving agent comprising rare fatty acid
CN106163511A (en) * 2014-01-24 2016-11-23 国立大学法人京都大学 Anti-inflammatory agent containing rare fatty acids
JP2018532809A (en) 2015-11-10 2018-11-08 サン ファーマ グローバル エフジーイー Topical formulations and uses thereof
EP4468884A4 (en) * 2022-01-26 2025-12-10 Amarin Pharmaceuticals Ie Ltd LYMPH-RELEASING COMPOSITIONS OF FAT ACIDS AND USES THERE FOR LYMPHATIC INCORPORATION AND SYSTEMIC DISEASE TREATMENT
EP4437858A1 (en) * 2023-03-31 2024-10-02 Fundación Para la Investigación del Hospital Universitario y Politécnico La Fe de la Comunidad Valenciana Composition comprising oxylipins present in human milk derived small extracellular vesicles and its use in the prevention and treatment of intestinal diseases
FR3148365A1 (en) * 2023-05-04 2024-11-08 Pierre Fabre Dermo-Cosmetique Oxylipins in the treatment of seborrhea and/or acne

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955496A (en) * 1996-08-13 1999-09-21 The Regents Of The University Of California Dihydroxy-oxy-eicosadienoates
US20040014817A1 (en) * 2000-09-19 2004-01-22 Joerg Rosenberg Stable dosage forms containing ubiquinones
US20040048927A1 (en) * 1996-10-11 2004-03-11 Scotia Holdings Plc Pharmaceutical preparation comprising eicosapentaenoic acid and/or stearidonic acid
US20040088752A1 (en) * 2000-10-06 2004-05-06 Howe Gregg A. Divinyl ether synthase gene, and protein and uses thereof
US20040166130A1 (en) * 2002-12-23 2004-08-26 L'oreal Lanolin-free cosmetic composition comprising a hydroxylated fatty acid aromatic ester
US20060241088A1 (en) * 2004-11-19 2006-10-26 Martek Biosciences Corporation Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US486046A (en) * 1892-11-08 Spring chair-bottom
US5102670A (en) * 1990-09-14 1992-04-07 Abraham Nader G Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels
US20050027004A1 (en) * 1993-06-09 2005-02-03 Martek Biosciences Corporation Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions
US6887901B1 (en) * 1993-06-15 2005-05-03 Brigham & Women's Hospital, Inc. Lipoxin compounds and their use in treating cell proliferative disorders
GB9403857D0 (en) * 1994-03-01 1994-04-20 Scotia Holdings Plc Fatty acid derivatives
US6174695B1 (en) * 1997-08-12 2001-01-16 The Regents Of The University Of California Epoxide hydrolase inhibitor methods
DE19757414A1 (en) * 1997-12-23 1999-07-01 Nutricia Nv Fat blend
ES2286999T5 (en) * 1999-03-04 2016-11-17 Suntory Holdings Limited Use of a material containing docosapentaenoic acid
EP1197560A4 (en) * 1999-07-07 2005-08-03 Kyowa Hakko Kogyo Kk PROCESS FOR THE PRODUCTION OF HYDROXYL FATTY ACID AND DELTA-LACTONE
IL151299A0 (en) * 2000-02-16 2003-04-10 Brigham & Womens Hospital Aspirin-triggered lipid mediators
US7527935B2 (en) * 2002-03-19 2009-05-05 Mitsubishi Tanabe Pharma Corporation G-protein coupled receptor having eicosanoid as ligand and gene thereof
SI2022775T1 (en) * 2002-04-01 2015-03-31 University Of Southern California Trihydroxy polyunsaturated eicosanoids
US7582785B2 (en) * 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
FR2843124B1 (en) * 2002-08-02 2004-10-15 Goemar Lab Sa PROCESS FOR THE PREPARATION OF FREE POLYUNSATURATED FATTY ACIDS AND THEIR OXIDATION METABOLITES
DK2216318T3 (en) * 2002-08-12 2018-12-10 Brigham & Womens Hospital Resolvins: Bio templates for therapeutic interventions
US7893106B2 (en) * 2004-11-19 2011-02-22 Martek Biosciences, Corporation Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955496A (en) * 1996-08-13 1999-09-21 The Regents Of The University Of California Dihydroxy-oxy-eicosadienoates
US20040048927A1 (en) * 1996-10-11 2004-03-11 Scotia Holdings Plc Pharmaceutical preparation comprising eicosapentaenoic acid and/or stearidonic acid
US20040014817A1 (en) * 2000-09-19 2004-01-22 Joerg Rosenberg Stable dosage forms containing ubiquinones
US20040088752A1 (en) * 2000-10-06 2004-05-06 Howe Gregg A. Divinyl ether synthase gene, and protein and uses thereof
US20040166130A1 (en) * 2002-12-23 2004-08-26 L'oreal Lanolin-free cosmetic composition comprising a hydroxylated fatty acid aromatic ester
US20060241088A1 (en) * 2004-11-19 2006-10-26 Martek Biosciences Corporation Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BOUARAB ET AL.: "The Innate Immunity of a Marine Red Alga Involves Oxylipins from Both the Eicosanoid and Octadecanoid Pathways", PLANT PHYSIOLOGY, vol. 135, July 2004 (2004-07-01), pages 838 - 1848, XP008131744 *

Also Published As

Publication number Publication date
EP1983977A2 (en) 2008-10-29
WO2007090162A2 (en) 2007-08-09
US20090320148A1 (en) 2009-12-24
EP1983977A4 (en) 2011-11-30

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