[go: up one dir, main page]

WO2007089583A3 - Systèmes et procédés pour l'analyse statistique et l'évaluation à base d'adn génomique - Google Patents

Systèmes et procédés pour l'analyse statistique et l'évaluation à base d'adn génomique Download PDF

Info

Publication number
WO2007089583A3
WO2007089583A3 PCT/US2007/002167 US2007002167W WO2007089583A3 WO 2007089583 A3 WO2007089583 A3 WO 2007089583A3 US 2007002167 W US2007002167 W US 2007002167W WO 2007089583 A3 WO2007089583 A3 WO 2007089583A3
Authority
WO
WIPO (PCT)
Prior art keywords
face
disposed
front sealing
statistical
evaluation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/002167
Other languages
English (en)
Other versions
WO2007089583A2 (fr
WO2007089583A9 (fr
Inventor
Shreeram Akilesh
Kevin D Mills
Derry Charles Roopenian
Daniel J Shaffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jackson Laboratory
Original Assignee
Jackson Laboratory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jackson Laboratory filed Critical Jackson Laboratory
Publication of WO2007089583A2 publication Critical patent/WO2007089583A2/fr
Publication of WO2007089583A3 publication Critical patent/WO2007089583A3/fr
Publication of WO2007089583A9 publication Critical patent/WO2007089583A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La présente invention concerne des procédés permettant l'analyse rapide d'ADN génomique d'échantillons, tels que des échantillons témoins et d'échantillons expérimentaux. Dans un aspect, le système utilise une donnée d'entrée d'ADN génomique, plutôt qu'une donnée d'entrée d'expression génétique telle qu'un ARNm et/ou un ARNc associé à un ARNm. Les systèmes et les procédés effectuent des analyses statistiques sur des données générées à partir d'échantillons afin de déterminer quelles séquences d'ADN dans un ensemble identifié de séquences d'ADN ont une base de variation dans un échantillon expérimental lorsqu'il est comparé à un échantillon témoin, et fournissent en outre une mesure quantitative de cette variation. La mesure quantitative peut être basée sur une métrique telle qu'un nombre de copies et/ou un taux de modifications. Les systèmes et les procédés utilisent ce cadre statistique dans des paramètres d'évaluation à base d'ADN, comprenant l'évaluation/le diagnostic d'une condition pathologique telle que le cancer ou l'analyse de plantes et d'animaux transgéniques. Les systèmes et procédés fournissent également un moyen pour la sélection et l'affinement de la sélection de séquences d'ADN, telles que des gènes, connus pour une modification de copie pour une condition pathologique particulière. Cela entraîne la création d'ensembles de gènes de réserve destinés à des domaines d'application individuels et/ou d'utilisations cliniques, qui peuvent être utilisés avec les systèmes et procédés selon l'invention afin de produire, par exemple, une trousse clinique pour une évaluation rapide à base d'ADN.
PCT/US2007/002167 2006-01-27 2007-01-26 Systèmes et procédés pour l'analyse statistique et l'évaluation à base d'adn génomique Ceased WO2007089583A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/341,699 US7881873B2 (en) 2003-04-29 2006-01-27 Systems and methods for statistical genomic DNA based analysis and evaluation
US11/341,699 2006-01-27

Publications (3)

Publication Number Publication Date
WO2007089583A2 WO2007089583A2 (fr) 2007-08-09
WO2007089583A3 true WO2007089583A3 (fr) 2007-10-25
WO2007089583A9 WO2007089583A9 (fr) 2008-04-24

Family

ID=38349472

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/002167 Ceased WO2007089583A2 (fr) 2006-01-27 2007-01-26 Systèmes et procédés pour l'analyse statistique et l'évaluation à base d'adn génomique

Country Status (2)

Country Link
US (1) US7881873B2 (fr)
WO (1) WO2007089583A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7822556B2 (en) * 2003-04-29 2010-10-26 The Jackson Laboratory Expression data analysis systems and methods
US20060009916A1 (en) * 2004-07-06 2006-01-12 Xitong Li Quantitative PCR data analysis system (QDAS)
EP2041574B1 (fr) 2006-07-14 2016-11-16 The Regents of The University of California Biomarqueurs du cancer et méthodes d'utilisation
CN101932723B (zh) * 2007-09-17 2014-09-10 肿瘤甲基化科学公司 改进的对mage-a表达的检测
KR101413659B1 (ko) * 2007-12-06 2014-07-01 삼성전자주식회사 실시간 핵산 증폭 데이터로부터 시료 중의 표적 핵산의초기 농도를 결정하는 방법
US8538733B2 (en) * 2008-01-25 2013-09-17 Life Technologies Corporation Methods for the analysis of dissociation melt curve data
CN102066578B (zh) * 2008-04-16 2016-07-06 哈森阿尔法生物技术研究院 用于评价和比较免疫组库的方法
US20120185177A1 (en) * 2009-02-20 2012-07-19 Hannon Gregory J Harnessing high throughput sequencing for multiplexed specimen analysis
US20120220478A1 (en) 2009-07-20 2012-08-30 Bar Harbor Biotechnology, Inc. Methods for assessing disease risk
EP2564200B8 (fr) 2010-04-27 2019-10-02 The Regents of The University of California Biomarqueurs de cancer et leurs procédés d'utilisation
US9268903B2 (en) 2010-07-06 2016-02-23 Life Technologies Corporation Systems and methods for sequence data alignment quality assessment
EP3227687A4 (fr) 2014-12-05 2018-10-24 Prelude, Inc. Récurrence de carcinome canalaire in situ (dcis) et cancer du sein invasif
US10294518B2 (en) 2016-09-16 2019-05-21 Fluxion Biosciences, Inc. Methods and systems for ultra-sensitive detection of genomic alterations
CN109477140B (zh) * 2016-09-22 2022-05-31 华为技术有限公司 一种数据处理方法、装置及计算节点
CN108959182B (zh) * 2018-05-21 2021-09-17 北京理工大学 基于高斯过程回归的小天体引力场建模方法
WO2020056338A1 (fr) 2018-09-14 2020-03-19 Prelude Corporation Méthode de sélection pour le traitement d'individus présentant un risque de cancer du sein invasif
DE102020212036A1 (de) * 2020-09-24 2022-03-24 Siemens Healthcare Gmbh Verfahren zur Aufnahme diffusionsgewichteter Messdaten mittels einer Magnetresonanzanlage
CN115341049A (zh) * 2022-09-23 2022-11-15 大连海关技术中心 基于蒙特卡洛法的转基因作物成分检测方法及装置
CN117236797A (zh) * 2023-11-13 2023-12-15 长威信息科技发展股份有限公司 一种食品通用的感官性质客观评价方法及装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180349B1 (en) * 1999-05-18 2001-01-30 The Regents Of The University Of California Quantitative PCR method to enumerate DNA copy number

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002512046A (ja) 1998-04-23 2002-04-23 ジェネンテック・インコーポレーテッド 遺伝子発現の定量的分析
US6263287B1 (en) * 1998-11-12 2001-07-17 Scios Inc. Systems for the analysis of gene expression data
US20020115070A1 (en) 1999-03-15 2002-08-22 Pablo Tamayo Methods and apparatus for analyzing gene expression data
US6691041B2 (en) 2000-03-31 2004-02-10 Roche Molecular Systems, Inc. Method for the efficiency-corrected real-time quantification of nucleic acids
MXPA03000575A (es) 2000-07-21 2004-12-13 Global Genomics Ab Metodos para analisis e identificacion de genes transcritos e impresion dactilar.
US7197400B2 (en) * 2000-12-12 2007-03-27 Affymetrix, Inc. System and computer software products for comparative gene expression analysis
US20030190689A1 (en) * 2002-04-05 2003-10-09 Cell Signaling Technology,Inc. Molecular profiling of disease and therapeutic response using phospho-specific antibodies

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180349B1 (en) * 1999-05-18 2001-01-30 The Regents Of The University Of California Quantitative PCR method to enumerate DNA copy number

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AKILESH S ET AL: "CUSTOMIZED MOLECULAR PHENOTYPING BY QUANTITATIVE GENE EXPRESSION AND PATTERN RECOGNITION ANALYSIS", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, WOODBURY, NY, US, vol. 13, no. 7, July 2003 (2003-07-01), pages 1719 - 1727, XP001167928, ISSN: 1088-9051 *
GINZINGER D G: "Gene Quantification using real-time quantitative PCR: An emerging technology hits the mainstream", EXPERIMENTAL HEMATOLOGY, NEW YORK, NY, US, vol. 30, 2002, pages 503 - 512, XP003005557, ISSN: 0301-472X *
SUZUKI SEIJI ET AL: "Comparative study between DNA copy number aberrations determined by quantitative microsatellite analysis and clinical outcome in patients with stomach cancer.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 1 MAY 2004, vol. 10, no. 9, 1 May 2004 (2004-05-01), pages 3013 - 3019, XP002471065, ISSN: 1078-0432 *
VANDESOMPELE JO ET AL: "Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes", GENOME BIOLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 3, no. 7, 18 June 2002 (2002-06-18), pages 1 - 12, XP021021149, ISSN: 1465-6906 *

Also Published As

Publication number Publication date
WO2007089583A2 (fr) 2007-08-09
US20060129331A1 (en) 2006-06-15
US7881873B2 (en) 2011-02-01
WO2007089583A9 (fr) 2008-04-24

Similar Documents

Publication Publication Date Title
WO2007089583A3 (fr) Systèmes et procédés pour l'analyse statistique et l'évaluation à base d'adn génomique
WO2007044427A3 (fr) Détection d’acides nucléiques provenant de sang total
WO2006110613A3 (fr) Cellule d'electrolyse photovoltaique integree
WO2007100500A3 (fr) Traitement d'échantillon
WO2006069328A3 (fr) Cartouche pour essais diagnostiques
WO2007008294A8 (fr) Élément d’étanchéite destiné à un orifice d'entrée
WO2007002006A3 (fr) Detection multiplex d’acides nucleiques
WO2007015134A3 (fr) Detecteur de l'angle postural d'un corps mobile
WO2009086519A3 (fr) Interpolymères contenant des motifs monomères isobutylène et diène
WO2008064046A3 (fr) Systèmes de distribution et de stockage intégrés pour des compositions nutritionnelles
WO2006107758A3 (fr) Dispositif adaptateur allume-cigare assurant une interface avec un dispositif externe au moyen d'une interface de port
WO2008022735A8 (fr) Dispositif pour amener des fermetures sur une machine de fermeture
WO2009026339A3 (fr) Entraînement d'actionneur de gouttelettes modulaire
WO2006089091A3 (fr) Procedes pour la detection de maladie residuelle minimale
WO2007137745A8 (fr) Écouvillon avec effet d'étanchéité amélioré
WO2007081640A3 (fr) Vanne de commande pour cartouche de joint
EP1905592A3 (fr) Tête à jet d'encre
EP2253722A3 (fr) Réactifs et methodes pour la détection du coronavirus du syndrome respiratoire aigu
WO2008127370A3 (fr) Composition d'amorceur et articles incorporant l'amorceur
WO2007121987A3 (fr) Gant ventilé
WO2006113580A3 (fr) Evaluation de correspondance lineaire
AU2003900277A0 (en) Particle detection by electron multiplication
WO2007005860A3 (fr) Clapet de systeme de refroidissement
MX2010005515A (es) Recipiente y membrana para el mismo.
WO2006116698A3 (fr) Composant d'etancheite definissant un premier, un second et un troisieme joints

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07762671

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 07762671

Country of ref document: EP

Kind code of ref document: A2