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WO2007088367A1 - inhalateur - Google Patents

inhalateur Download PDF

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Publication number
WO2007088367A1
WO2007088367A1 PCT/GB2007/000345 GB2007000345W WO2007088367A1 WO 2007088367 A1 WO2007088367 A1 WO 2007088367A1 GB 2007000345 W GB2007000345 W GB 2007000345W WO 2007088367 A1 WO2007088367 A1 WO 2007088367A1
Authority
WO
WIPO (PCT)
Prior art keywords
canister
inhaler
assembly according
attachment
relative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/000345
Other languages
English (en)
Inventor
Naseem Bari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trumeter Co Ltd
Original Assignee
Trumeter Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trumeter Co Ltd filed Critical Trumeter Co Ltd
Publication of WO2007088367A1 publication Critical patent/WO2007088367A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008—Electronic counters

Definitions

  • the present invention relates to an inhaler canister assembly, and in particular to a PMDI (pressurised measured-dose inhaler) .
  • PMDI pressurised measured-dose inhaler
  • Inhalers are commonly used to administer medication such as bronchodilators, corticosteroids and anti- allergenics to the pulmonary tracts of humans and other animals, and in particular to treat nasal and bronchial complaints such as asthma.
  • a typical inhaler includes a canister, having a nozzle, containing the drug or medicine, and a detachable casing for attachment to the canister.
  • the canister contains the drug in powder or liquid form, and the dispensing action forces out a regulated dose of the drug in aerosol form.
  • the aerosol may be created using a propellant e.g. CFC or HFA forced through the drug by the dispensing motion, or more preferably in PMDIs (pressurised measured-does inhaler) by creation of a significant overpressure inside the canister.
  • a propellant e.g. CFC or HFA forced through the drug by the dispensing motion
  • PMDIs pressurised measured-does inhaler
  • the dispensing action consists of moving the canister relative to the casing, the action of the casing on the nozzle of the canister causing the predetermined dose to be released when the nozzle has been depressed a set distance.
  • WO 2005/007226, WO 03/103759 and EP 1163922 each disclose such a PMDI.
  • Existing inhalers therefore include a detachable casing having a seat member that is engaged with the canister nozzle when the canister is removably inserted to the casing.
  • the seat member includes a gripping portion for gripping the nozzle, so that the canister is held in the casting, but only held so that the canister can be easily withdrawn from the casing by simply pulling the canister and casing in opposite directions.
  • the device in WO 03/103759 has an additional attachment attached to an aerosol container with an aperture through which the nozzle of a container can pass so the dispensing action of the container is not impeded by the attachment.
  • the device relies upon a seat in an additional removable external body to activate a nozzle of the container to dispense medicament.
  • the seat member of existing inhaler casings is usually formed to put the nozzle of the canister into fluid communication with a mouthpiece portion of the casing.
  • the canister is prone to unwanted detachment from the casing, possibly resulting in loss of the casing. Therefore, a user may find it very difficult, if not impossible, to actuate the canister, to deliver a dose, in a suitable manner to ensure that the drug is delivered e.g. to the user's airway, or other appropriate bodily region. Therefore, there is a need for an inhaler canister that can be relatively easily actuated when it is separated from its casing.
  • typical PMDI canisters for use in PMDIs contain between 60 and 200 doses, and may be administered on a regular (e.g. daily) basis, or only occasionally to relieve particular symptoms. In either case, the patient is unlikely to keep a record of the number of doses administered, so will not be aware when the canister no longer contains any drug. The patient will not necessarily be immediately aware that the drug is no longer being dispensed as the pressure of the canister, or the dispensing motion, may appear unaltered. In an extreme situation, this could result in a patient needing a dose in an emergency but finding that the drug in their inhaler had been exhausted in an earlier use.
  • EP 1163922 discloses a device with a counter.
  • the mechanism of the counter is located in a body that is attached to an aerosol container.
  • a pin connected to an outer removable casing cooperates with switch contacts of the counter mechanism in the body in order to advance the counter on actuation of the device, i.e. the counter is operable in response to movement of the outer removable casing relative to the body.
  • a nozzle of the container is actuatable without the container being located in the outer casing, and thus independently of the count mechanism. Therefore, this device suffers from the problem that, if the aerosol container is removed from the outer casing and the nozzle is actuated, the counter is not progressed, resulting in an inaccurate reading of the number of doses of medicament output from, or remaining in, the container.
  • the device in WO 03/103759 has a counter triggered by movement of a switch mounted on the aforementioned attachment relative to the external body that is removable from the container and attachment.
  • the nozzle of the container is actuatable without the external body and therefore independently of the counter.
  • this device too may output an inaccurate count value of the amount of medicament remaining in a container.
  • WO 01/28887 shows a device with a housing movably attached to an aerosol canister. Movement of the housing relative to the canister actuates the nozzle of the canister to dispense medicament. A counter mechanism is held in the housing, which mechanism is triggered in response to movement of the housing relative to a post of a further external housing that is removable from the canister and housing. In other words, a movement of the attached housing relative to the canister to output a dose of medicament would not be recorded when these components are not located in the external housing. Moreover, the external housing is movable relative to the housing containing the counter to progress the counter without delivery of a dose of medicament. Thus, an output reading from the counter of this device may also be inaccurate.
  • WO 2005/007226 shows a further inhaler apparatus which has a smooth aerosol canister located in a container holder.
  • a further outer casing of the apparatus there is both a seat for cooperation with a nozzle of the canister, and a counter adjacent the opposite end of the canister from the nozzle for recording the number of actuations of the canister.
  • the counter is triggered by movement of a sleeve surrounding the non-dispensing end of the canister relative to the outer casing.
  • Another known device does not include a counter for recording the number of individual actuations of a canister as such, but has count means for measuring how many refill units have been used in a particular refillable device, in the interests of device efficiency and hygiene.
  • the count means are shown as being tab portions detachable from the refill units .
  • a counter mounted on the "top" end of the canister (the opposite end from the dispensing nozzle and normally the part which the user presses to use the inhaler) , and includes a pressure-activated switch which increments the counter.
  • the present invention may provide an inhaler canister assembly including: a canister which has a canister body for containing a substance, for example, a drug or medicine and a suitable propellant, and which canister has a nozzle, by which nozzle the substance may be delivered from the canister body, the canister being actuatable to deliver the substance by displacement of the nozzle relative to the canister body; and, the assembly further including a collar (attachment) having a seat member (body) for engagement with the nozzle, the seat member being movable relative to the canister body to actuate the canister; wherein the collar is permanently attached to the canister body, preferably so that the collar is not re- attachably separable from the canister body, wherein the collar includes count means for registering an actuation of the canister in response to switch means of the count means detecting the actuation, and wherein the switch means is triggerable in response to movement of the seat member relative to the canister body. Therefore, an inhaler canister assembly including: a canister
  • the switch means is arranged to be triggered, i.e. arranged to detect an actuation of the canister.
  • the switch means is arranged to detect a movement of the seat member (body) relative to the canister body, e.g. when the movement is sufficiently great.
  • a sufficiently great movement, i.e. the relative movement required to trigger the switch means may be less than 15mm, or less than 10mm, or less than 5mm, or less than 3mm.
  • Movement of the seat member relative to the canister body to actuate the canister may be movement of the seat member towards or away from the canister body in the direction of the longitudinal axis of the canister body. Additionally or alternatively, the relative movement may be rotational movement, e.g. about the longitudinal axis of the canister, to actuate the canister body. The relative movement may have a direction with a component in both the longitudinal and circumferential directions of the canister body.
  • the seat member may be moveable with the rest of the collar relative to the canister body to actuate the canister, i.e. the whole collar may move relative to the canister body.
  • the seat member may move relative to the rest of the collar and relative to the canister body on actuation of the canister.
  • a collar according to the present invention may be adapted to include directing means so that the nozzle may be put in fluid communication with the environment outside the space bound by the collar.
  • the seat member preferably defines a conduit or passage through which the substance delivered from the actuated canister can be passed.
  • a user requiring a dose of the substance is able to direct the delivered dose to the appropriate region of his/her body without the need for the inhaler casing.
  • the collar seat member is shaped to cooperate with the exhaust end of the canister nozzle, thereby forming a seal.
  • the seal may be reformably breakable so the seat member and nozzle can be sealably coupled and decoupled.
  • the collar seat member may include a relay portion shaped to engage with a seat member included in an inhaler casing of the standard type.
  • the collar seat member may act as an actuating conduit for the passage of the delivered substance from the nozzle to a passageway defined by a seat member of an inhaler casing.
  • the passageway usually guides the delivered substance to a mouthpiece of the inhaler casing .
  • a canister assembly according to the present invention can be inserted to a standard inhaler casing.
  • a collar according to the present invention projects beyond the outermost radial periphery of the canister 5 mm or so, preferably by 1 mm or less, more preferably by 0.5 mm or less, yet more preferably by 0.3 mm or less, or even not at all. It is also envisaged that the collar may extend along only half, or less, of the length of the canister body; more preferably along only one quarter, or less, of the length of the canister body, or even only one eighth, or less, of the length of the canister body.
  • a collar according to the present invention is permanently attached to the canister body, and many means and ways to achieve this are envisaged.
  • a preferred permanent attachment means is an adhesive applied between an attachment arm of the collar and a portion of the canister body, the adhesive being of sufficient adhesive strength, so that the collar and canister cannot be separated, preferably, without damage to one or other or both of the component parts of the assembly.
  • the collar and canister body are not readily couplable and decouplable: the assembly is not intended to provide a canister with a detachable collar. Therefore, it is preferred that the means of attaching the collar to the canister body is such that the collar cannot simply be detached from the canister body to be re-attached thereto. In other words, the collar is not detachable from the canister body by a user, at least not without the use of tools such as specially adapted tools for the job.
  • permanently attached it is not intended to mean that parts of the collar are necessarily permanently fixed in position relative to the canister body.
  • the collar may be, for example, permanently attached to the canister body but may be, e.g.
  • the seat member (with or without the rest of the collar) is moveable towards and away from the canister body in the direction of the longitudinal axis of the canister body. More preferably this movement is only within predetermined limits.
  • the switch means is arranged such that it is operable/triggerable by movement in an axis parallel to the axis of movement of the seat member relative to the canister body. The switch means may be triggerable when the seat member (with or without the rest of the collar) moves towards the canister body (i.e. on depression of the nozzle into the canister) or when the seat member (with or without the rest of the collar) moves away from the canister body.
  • the- seat member (with or without the rest of the collar) may be rotatable relative to the canister, e.g. about the longitudinal axis of the canister, in order to actuate the canister.
  • Such rotation is preferably only within predetermined limits, e.g. 90°, less than 90°, less than 45°, less than 30° or less than 20°.
  • the switch means may be arranged such that it is operable by movement in a rotational direction, preferably rotational movement about the longitudinal axis of the canister.
  • Such rotational movement of the switch means is preferably in the same rotational direction as the rotational direction of movement of the seat member or the whole collar relative to the canister body on actuation of the canister.
  • the switch means may be operable by its rotational movement in the opposite rotational .direction. That is to say in the same rotational direction as the rotational direction of movement of the seat member or the whole collar relative to the canister body from a canister-actuation position to a settled (non-actuation) position.
  • Alternative means of permanent attachment of the collar to the canister body include ultrasonic welding or heat staking the collar around the canister, shrink fitting the collar to canister or a snap fit around the collar. In other words, there may be an interlock or fit between the collar and the canister.
  • the combination of the collar and the canister is effectively an integral unit that allows relative movement between the seat member (or the whole collar) and the canister.
  • the collar and canister are preferably easily removable from e.g. known inhaler housings without separation of the collar from the canister.
  • the assembly includes a collar having count means which is actuated when the nozzle of the inhaler canister has been depressed to the extent necessary to dispense a dose.
  • the count means may be actuated when the nozzle is moved from a rest position to a depressed position relative to the canister body, or when the nozzle is moved from a depressed position to a rest position.
  • the present invention provides a counting device which maintains an accurate record of the number of doses delivered from a canister, and which is retained with that canister when the canister is removed from the inhaler.
  • an inhaler canister assembly in which the collar includes: a counter, display means connected to the counter and a switch wherein, in use, the switch triggers the counter when the canister has travelled far enough to dispense a dose of the drug contained in the canister.
  • the counter may be mechanical, but is preferably electronic, forming part of an electrical circuit with the switch, the display means and/or a battery.
  • the counter may be contained in an integrated circuit.
  • the collar may radially protrude beyond the side wall of the canister.
  • the collar does not protrude more than 5 mm beyond the side wall. Most preferably, it does not radially protrude beyond the side wall of the canister at all. Having a small, or no protrusion, beyond the side wall of the canister means that the attachment of the invention can also be mounted in known inhaler housings, as in known inhaler housing modified to lack a seat member for engagement with the nozzle of the canister.
  • the collar includes at least one arm for engaging a groove (i.e. ridge or slot) in the side of the canister.
  • a groove i.e. ridge or slot
  • the groove (s) may lie in the longitudinal or circumferential direction of the canister, or may have a direction with a component in both the longitudinal and circumferential directions.
  • the at least one arm may be moveable relative to the canister body or fixed to the canister body. The arrangement may be such that, when attached to the canister, the at least one arm does not radially protrude more than lmm beyond the side wall of the canister. Preferably, it does not protrude more than 0.5mm beyond the side wall. Most preferably, it does not radially protrude beyond the side wall of the canister at all.
  • sectional area of the canister Preferably, it is never
  • electronic components in the collar are all located in a region having an area less than the cross-sectional area of the canister.
  • the electronic components do not radially protrude from the side wall of the canister, (i.e. the region is located directly below the nozzle end of the canister) .
  • the electronic components are all located in a region of the collar having a longitudinal length of less than 15mm.
  • the length is less than 12mm. Most preferably it is less than 10.5mm.
  • the collar When attached to the canister, the collar preferably extends less than 15mm below the bottom of the canister. Preferably, it extends less than 12mm. Most preferably it extends less than 10.5mm.
  • the maximum diameter of the collar is no more than 32mm. More preferably, it is no more than 23mm.
  • the maximum longitudinal length of the collar is 50mm. More preferably, it is no more than 30mm. Most preferably, it is no more than 20mm.
  • the counter may be arranged to count upwards or downwards, and may have respectively a fixed upper limit or a fixed starting number.
  • the attachment may allow the upper limit or the starting number to be set for an appropriate canister.
  • the display means provides at least a warning when a number of doses equal to the upper limit or the starting number have been dispensed.
  • Alternative warning means may also (or alternatively) be used, however.
  • the display means are a mechanical display, a clock, and/or a liquid crystal display (LCD) (any, or all, of which may display the number of doses dispensed and/or remaining, and may display other information as well, and/or light emitting diodes (LEDs) , which may, according to the patterns displayed, indicate one or more states of the canister (e.g. full, in use, nearly empty and/or empty) .
  • LCD liquid crystal display
  • LEDs light emitting diodes
  • a first LED is lit permanently or flashes in a first predetermined pattern, and when the counter reaches the first predetermined level, that first LED flashes in a second predetermined pattern. Then, when the counter reaches a second predetermined level, a second LED is lit or flashes in a predetermined pattern.
  • the display means may include a green LED as the first LED and a red LED as the second LED. Thus, in normal use, the green LED may be lit permanently. When the number of doses remaining in the canister reaches a first level (for example 10 doses remaining), the green LED may flash continuously. When there are no more doses remaining in the canister, the green LED is no longer lit and the red LED may be lit permanently. In this way, the user can be given some warning that the canister is about to run out, and so be able to obtain a replacement canister assembly before it becomes necessary.
  • the display means may include at least two and preferably three LEDs .
  • the display means includes control means for operating one or more of the LEDs for a predetermined time interval, at a predetermined point in the operation of the device.
  • the LED(s) may activate for a predetermined time, e.g. 10, 15 or 20 seconds, immediately after the canister has been activated or a dose has been dispensed.
  • a green LED would flash when the canister was operating normally, an amber LED would instead operate or flash when a set level is reached (e.g. the canister is becoming nearly empty) and a red LED would operate or flash when the canister is empty.
  • the operation of the LEDs for a suitable time after a dose is dispensed from the canister has the advantages of conserving battery life and also serving as an indication that a dose has been dispensed.
  • all of the components of the counter, switch and display means are sealed within a body of the collar, and preferably that body is waterproof. This allows the canister assembly to be removed from an inhaler casing (if provided) and cleaned without any risk of damaging the components with water or damp.
  • the body of the collar is made from silicone rubber.
  • the electronics are mounted on a printed circuit board, and more preferably that circuit board is made from a flexible substrate which allows that circuit board to be fitted into the best location in the collar.
  • the electronic components are mounted on one or more metal frames. These frames may also form part of the switch, such as one of the contacts of the switch. The or each frame may connect one or more of the electronic components to each other, or to the power source (e.g. a battery).
  • the switch may be mounted on the collar so that when the collar has been displaced relative to the canister sufficiently for the canister to be actuated by the collar seat member, the switch is triggered thereby indicating a dose is delivered from the canister.
  • the switch may be mounted on the seat member or on the rest of the collar so that it is triggerable on displacement of the seat member relative to the rest of the collar, this latter displacement being equivalent to displacement of the seat member relative to the canister body.
  • the switch may interact with a portion of the canister main body, for example the end face of the canister from which the canister nozzle projects.
  • the switch may be configured so that when the collar seat member is engaged with the canister nozzle and the collar seat member is positioned relative to the canister body so that the canister is actuated, the switch is triggered, indicating an actuation of the canister.
  • the switch may be mounted on one or other of the seat member or the rest of the collar (the collar casing or attachment casing) such that it may interact with the other of the seat member or the collar casing.
  • the switch may be configured such that, when the collar casing is fixed to the canister body leaving the seat member free to move relative to the canister body, relative movement of the seat member to the collar casing is equivalent to relative movement of the seat member to the canister body, and such relative movement triggers the switch.
  • the switch is moulded at the same time as the body is formed.
  • the switch includes two electrical contacts and a substantially circular button with a head portion, the button being connected to the body of the collar by a skirt, wherein both the head portion and the skirt are made from resilient material, and the button has a projection extending radially inwards from the head portion, wherein the face of the projection opposite the head portion is made from, or has on it, conducting material, such that when the button is subjected to a longitudinal force on the head portion, the button deforms urging the conducting face of the projection into contact with both of the contacts, thereby completing an electrical circuit.
  • the canister and casing may be any of the usual types used in these devices.
  • a casing according to the present invention includes a casing body portion, and that casing body portion is adapted so as to allow the display means, included in some embodiments according to the present invention, to be visible at least some of the time.
  • Figure 1 shows an inhaler canister and an attachment according to the present invention
  • Figure 2 shows the inhaler canister and attachment according to the present invention mounted in an inhaler casing
  • Figure 3 is an exploded view of the attachment of Figure 1;
  • Figures 4 to 6 show an alternative embodiment in which the attachment includes a mouthpiece
  • Figures 7 to 9 show a further embodiment in which the mouthpiece section is removable from the attachment;
  • Figures 10 to 11 show a further embodiment with a different attachment.
  • an attachment (collar) 20 is shown about to be attached to an inhaler canister 10.
  • the attachment includes a body (seat member) 26, from which arms 24 extend. The arms 24 will engage with the ridges 16 on the body of the inhaler canister.
  • the attachment has an aperture 32 through which the nozzle 14 of the canister 10 can pass, so the dispensing action of the canister is not impeded by the attachment.
  • a switch 22 is mounted on the inside of body 26, a switch 22 is mounted.
  • the attachment and canister assembly may then be located inside the casing 12, which includes mouthpiece 14. When the canister 10 is forced into body 26, nozzle 14 is forced into the canister.
  • a dose of the drug contained in canister 10 is dispensed in aerosol form.
  • the body of casing 12 may include a mouthpiece to facilitate administration of the drug concerned.
  • mouthpiece can be used since its function is simply to act as a passage for delivery of the drug to the exterior of the assembly.
  • body 26 The part of the assembly which cooperates with the nozzle 14 of the canister 10, and which thus inherently has design restrictions, is body 26.
  • Switch 22 is located such that when canister 10 has travelled far enough to dispense a dose, as detailed above, it is engaged by the canister 10. This causes switch 22 to be depressed, which motion causes the counter to either increment (in the case of a counter initially set to zero which is counting the number of doses dispensed from the inhaler canister) or decrement (in the case of a counter initially set to the number of doses in the canister and recording the number remaining at any time) .
  • the casing 12 of the inhaler shown in Figure 1 also has viewing means (see Figure 2), e.g. a window 56, which may be cut out from the body, or be an integral part of the body which is translucent.
  • viewing means e.g. a window 56, which may be cut out from the body, or be an integral part of the body which is translucent.
  • display 30 in this case a counter, but it could be other means e.g. one or more LEDs
  • Figure 3 shows a cut-away view of the inside of a first embodiment of attachment 20, showing the switch 22 and hole 32 through which the nozzle 14 passes when the attachment is attached to a canister. Also inside the attachment are the circuit board 28 on which the circuitry for the electronic counter is mounted, powered by a power source 36. Mounted in the body 26 of the attachment is the display (in this case LEDs) which displays the current status of the counter.
  • the display in this case LEDs
  • Figures 4-6 show an alternative embodiment wherein the attachment 70 includes a mouthpiece 80, removing the need for any casing.
  • display 30 is shown as an LCD.
  • the second embodiment of the attachment also shows that when using LEDs as the display means, the attachment can be made much smaller, since there is no need to incorporate the display.
  • the attachment may have both LEDs and an LCD.
  • the LEDs may be visible to the patient/user when the canister is in the inhaler body, and give general indication as to the state of the canister, whilst removing the canister from the inhaler body allows the LCD to be viewed which gives more detailed information, for example about the exact number of doses used from or remaining in the canister.
  • the display means may be mounted on a printed circuit board made from flexible substrate, which allows the circuit board to be fitted into a smaller space.
  • Figures 7-9 show a further embodiment similar to Figures 4-6, but in which the mouthpiece section 85 is removable from the attachment 90.
  • Figures 10-11 show a further embodiment, similar to Figures 7-9, but which includes additional arms 24, which substantially surround canister 10, to provide a more secure connection.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention a pour objet un ensemble cartouche d'inhalateur comprenant une cartouche (10) à embouchure (14), la cartouche (10) pouvant être actionnée pour délivrer une substance contenue dans son corps par déplacement relatif de l'embouchure (14) et du corps de cartouche, et une attache (20) fixée en permanence au corps de cartouche. L'attache (20) présente un corps (26) à introduire dans l'embouchure (14) afin de se déplacer par rapport au corps de cartouche lorsque la cartouche (10) est actionnée. L'attache (20) comporte également des moyens de comptage conçus pour enregistrer les actionnements de la cartouche (10) suite à l'actionnement d'un commutateur (22) par le mouvement du corps (26) de l'attache (20) par rapport au corps de cartouche. L'ensemble de l'attache (20) peut être mobile par rapport au corps de cartouche et le commutateur (22) peut interagir avec une partie du corps de cartouche.
PCT/GB2007/000345 2006-02-01 2007-02-01 inhalateur Ceased WO2007088367A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0602049.9 2006-02-01
GBGB0602049.9A GB0602049D0 (en) 2006-02-01 2006-02-01 Inhaler

Publications (1)

Publication Number Publication Date
WO2007088367A1 true WO2007088367A1 (fr) 2007-08-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/000345 Ceased WO2007088367A1 (fr) 2006-02-01 2007-02-01 inhalateur

Country Status (2)

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GB (2) GB0602049D0 (fr)
WO (1) WO2007088367A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102553041A (zh) * 2010-10-05 2012-07-11 艾里希普费弗工程师有限公司 药物排出装置
CN108187202A (zh) * 2018-02-09 2018-06-22 上海华瑞气雾剂有限公司 一种智能驱动器
EP3300753B1 (fr) 2016-09-30 2018-12-12 Presspart Gmbh & Co. Kg Inhalateur de dose mesuree destine a administrer des doses d'aerosols
US12415048B2 (en) 2019-12-10 2025-09-16 Trudell Medical International Inc. Integrated dose counter

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8181591B1 (en) 2008-05-23 2012-05-22 Trudell Medical International Domed actuator for indicating device
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757395B2 (en) * 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
WO2018138749A1 (fr) 2017-01-24 2018-08-02 日本たばこ産業株式会社 Dispositif d'inhalation et procédé et programme pour son fonctionnement
EA037296B1 (ru) * 2017-01-24 2021-03-05 Джапан Тобакко Инк. Ингаляторное устройство, а также способ и программа для его работы
GB2636071A (en) * 2023-11-21 2025-06-11 Haughton Design Ltd Inhaler and nozzle unit for an inhaler

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1163922A2 (fr) * 1997-06-10 2001-12-19 Glaxo Group Limited Dispenseur à compteur de doses
EP1216720A1 (fr) * 2000-12-23 2002-06-26 Ing. Erich Pfeiffer Gmbh Moyen pour enregistrer l'actionnement d'un inhalateur et inhalateur avec ce moyen
WO2002100469A2 (fr) * 2001-06-11 2002-12-19 Glaxo Group Limited Distributeur de medicaments
WO2003103759A1 (fr) * 2002-06-05 2003-12-18 Trumeter Company Ltd Compteur
WO2004001664A1 (fr) * 2002-06-21 2003-12-31 Glaxo Group Limited Indicateur d'actionnement pour dispositif distributeur
WO2006054083A1 (fr) * 2004-11-19 2006-05-26 Clinical Designs Limited Distributeur de substance

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001028887A1 (fr) * 1999-10-16 2001-04-26 Glaxo Group Limited Dispositif de logement pour contenant d'aerosol
US20040255936A1 (en) * 2003-04-30 2004-12-23 David Urbanus Disposable metered dose inhaler with integrated electronic counter

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1163922A2 (fr) * 1997-06-10 2001-12-19 Glaxo Group Limited Dispenseur à compteur de doses
EP1216720A1 (fr) * 2000-12-23 2002-06-26 Ing. Erich Pfeiffer Gmbh Moyen pour enregistrer l'actionnement d'un inhalateur et inhalateur avec ce moyen
WO2002100469A2 (fr) * 2001-06-11 2002-12-19 Glaxo Group Limited Distributeur de medicaments
WO2003103759A1 (fr) * 2002-06-05 2003-12-18 Trumeter Company Ltd Compteur
WO2004001664A1 (fr) * 2002-06-21 2003-12-31 Glaxo Group Limited Indicateur d'actionnement pour dispositif distributeur
WO2006054083A1 (fr) * 2004-11-19 2006-05-26 Clinical Designs Limited Distributeur de substance

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102553041A (zh) * 2010-10-05 2012-07-11 艾里希普费弗工程师有限公司 药物排出装置
EP3300753B1 (fr) 2016-09-30 2018-12-12 Presspart Gmbh & Co. Kg Inhalateur de dose mesuree destine a administrer des doses d'aerosols
US10729861B2 (en) 2016-09-30 2020-08-04 Presspart Gmbh & Co. Kg Metered dose inhaler
EP3300753B2 (fr) † 2016-09-30 2025-02-12 Presspart Gmbh & Co. Kg Inhalateur de dose mesuree destine a administrer des doses d'aerosols
CN108187202A (zh) * 2018-02-09 2018-06-22 上海华瑞气雾剂有限公司 一种智能驱动器
US12415048B2 (en) 2019-12-10 2025-09-16 Trudell Medical International Inc. Integrated dose counter

Also Published As

Publication number Publication date
GB2434754B (en) 2008-08-27
GB0602049D0 (en) 2006-03-15
GB2434754A (en) 2007-08-08
GB0701946D0 (en) 2007-03-14

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