[go: up one dir, main page]

WO2007081583A3 - Anti-pneumococcal preparations and methods of use - Google Patents

Anti-pneumococcal preparations and methods of use Download PDF

Info

Publication number
WO2007081583A3
WO2007081583A3 PCT/US2006/049632 US2006049632W WO2007081583A3 WO 2007081583 A3 WO2007081583 A3 WO 2007081583A3 US 2006049632 W US2006049632 W US 2006049632W WO 2007081583 A3 WO2007081583 A3 WO 2007081583A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cwps
pneumococci
pneumococcal
preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/049632
Other languages
French (fr)
Other versions
WO2007081583A8 (en
WO2007081583A2 (en
Inventor
Richard Malley
Porter Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
University of Rochester
Original Assignee
Boston Childrens Hospital
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Childrens Hospital, University of Rochester filed Critical Boston Childrens Hospital
Publication of WO2007081583A2 publication Critical patent/WO2007081583A2/en
Publication of WO2007081583A3 publication Critical patent/WO2007081583A3/en
Publication of WO2007081583A8 publication Critical patent/WO2007081583A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Disclosed are methods for treating, reducing or preventing diseases and infections caused by pneumococci. The methods rely on the use of a cell wall polysaccharide- (CWPS-) containing composition (e.g., a CWPS teichoic acid polymer preparation) of pneumococcus and an adjuvant, which may be chemically conjugated or simply admixed. The methods are particularly useful against nasopharyngeal colonization and invasive disease due to encapsulated pneumococci.
PCT/US2006/049632 2006-01-04 2006-12-29 Anti-pneumococcal preparations and methods of use Ceased WO2007081583A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75598406P 2006-01-04 2006-01-04
US60/755,984 2006-01-04

Publications (3)

Publication Number Publication Date
WO2007081583A2 WO2007081583A2 (en) 2007-07-19
WO2007081583A3 true WO2007081583A3 (en) 2007-11-08
WO2007081583A8 WO2007081583A8 (en) 2008-05-08

Family

ID=38256815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/049632 Ceased WO2007081583A2 (en) 2006-01-04 2006-12-29 Anti-pneumococcal preparations and methods of use

Country Status (1)

Country Link
WO (1) WO2007081583A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009094730A1 (en) * 2008-02-01 2009-08-06 Newcastle Innovation Limited Vaccine compositions
EP2108656A1 (en) 2008-03-19 2009-10-14 Beninati, Concetta Antigenic protein fragments of streptococcus pneumoniae
US9125863B2 (en) 2008-05-22 2015-09-08 Children's Medical Center Corporation Synergistic immunogenic fusion protein-polysaccharide conjugate
US8598342B2 (en) 2008-06-12 2013-12-03 President And Fellows Of Harvard College Methods and compounds for antimicrobial intervention
ES2864764T3 (en) 2011-05-11 2021-10-14 Childrens Medical Center Immunogenic composition presenting multiple antigens, and its methods and uses
EP2589387A1 (en) * 2011-11-04 2013-05-08 Lunamed AG Use of a teichoic acid for the treatment of malignant liquor cerebrospinalis in the brain
WO2014124228A1 (en) 2013-02-07 2014-08-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
CN110730670A (en) 2017-03-28 2020-01-24 儿童医疗中心有限公司 Multi-antigen presentation system (MAPS) -based staphylococcus aureus vaccines, immunogenic compositions, and uses thereof
JP2020525540A (en) 2017-06-23 2020-08-27 ノソコミアル ヴァクスィーン コーポレイション Immunogenic composition
JP2021535921A (en) 2018-09-12 2021-12-23 アフィニバックス、インコーポレイテッド Multivalent pneumococcal vaccine
JP7535791B2 (en) 2018-09-12 2024-08-19 ザ チルドレンズ メディカル センター コーポレーション Pneumococcal fusion protein vaccine
WO2023039223A1 (en) 2021-09-09 2023-03-16 Affinivax, Inc. Multivalent pneumococcal vaccines

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BRILES ET AL.: "Pneumococcal Diversity: Considerations for New Vaccine Strategies with Emphasis on Pneumococcal Surface Protein A (PspA)", CLINICAL MICROBIOLOGY REVIEWS, vol. 11, no. 4, October 1998 (1998-10-01), pages 645 - 657 *
KALIN: "Pneumococcal serotypes and their clinical relevance", THORAX, vol. 53, March 1998 (1998-03-01), pages 159 - 162 *
KHAN ET AL.: "Both Innate Immunity and Type 1 Humoral Immunity to Streptococcus pneumoniae Are Mediated by MyD88 but Differ in Their Relative Levels of Dependence on Toll-like Receptor 2", INFECTION AND IMMUNITY, vol. 73, no. 1, January 2005 (2005-01-01), pages 298 - 307 *
MALLEY ET AL.: "CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization", PROC. NATL. ACAD. SCI. U.S.A., vol. 102, no. 13, 19 March 2005 (2005-03-19), pages 4848 - 4853 *
SZU ET AL.: "Protection against pneumococcal infection in mice conferred by phosphocholine-binding antibodies: specificity of the phosphocholine binding and relation to several types", INFECT. IMMUN., vol. 39, no. 2, February 1983 (1983-02-01), pages 993 - 999 *

Also Published As

Publication number Publication date
WO2007081583A8 (en) 2008-05-08
WO2007081583A2 (en) 2007-07-19

Similar Documents

Publication Publication Date Title
WO2005016273A3 (en) Infection prophylaxis using immune response modifier compounds
WO2007081583A8 (en) Anti-pneumococcal preparations and methods of use
WO2009072007A3 (en) Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
WO2009026166A3 (en) Antiinfective flavonol compounds and methods of use thereof
WO2009156462A3 (en) Organic compounds
WO2008005651A3 (en) Cyclic carboxylic acid rhodanine derivatives for the treatment and prevention of tuberculosis
WO2010030598A3 (en) Pharmaceutical formulations comprising pemetrexed
WO2008066784A3 (en) Expression of foxp3 by cancer cells
WO2007109105A3 (en) Flavivirus inhibition by sultams and related compounds
WO2012050949A3 (en) Living hinge
WO2009126301A3 (en) Controlled release of active agents from oleosomes
WO2008108830A8 (en) Immunogenic and therapeutic compositions for streptococcus pyogenes
WO2010041242A3 (en) Oxidized thiophospholipid compounds and uses thereof
WO2005089733A3 (en) Anti-adhesive compounds to prevent and treat bacterial infections
WO2008062436A3 (en) Antimicrobial derivatives of anacardic acid and process for preparing the same
WO2009011305A1 (en) Amide compound and method for controlling plant disease using the same
WO2008073863A3 (en) Preparation and utility of substituted allylamines
WO2008071961A8 (en) 2-quinolinone and 2-quinoxalinone- derivatives and their use as antibacterial agents
WO2005089447A3 (en) Streptococcus agalactiae vaccine
WO2009103813A3 (en) Fungicidal compositions comprising 3'-bromine-2,3,4,6'-tetramethoxy-2'-6-dimethylbenzophenone
WO2009047634A3 (en) Aqueous formulations of acetaminophen for injection
WO2007046890A8 (en) Lozenge for treatment of dry mouth and related conditions
WO2009075250A1 (en) Plant disease control agent
WO2008146883A1 (en) Sleep-improving agent
WO2008029351A3 (en) A modified release formulation comprising amoxicillin and clavulanate

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06848372

Country of ref document: EP

Kind code of ref document: A2