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WO2007076864A1 - Adhésif contenant du blanc d'œuf - Google Patents

Adhésif contenant du blanc d'œuf Download PDF

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Publication number
WO2007076864A1
WO2007076864A1 PCT/DK2006/000727 DK2006000727W WO2007076864A1 WO 2007076864 A1 WO2007076864 A1 WO 2007076864A1 DK 2006000727 W DK2006000727 W DK 2006000727W WO 2007076864 A1 WO2007076864 A1 WO 2007076864A1
Authority
WO
WIPO (PCT)
Prior art keywords
adhesive
egg white
recipe
egg
adhesives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2006/000727
Other languages
English (en)
Inventor
Esben Stroebech
Danuta Ciok
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coloplast AS
Original Assignee
Coloplast AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coloplast AS filed Critical Coloplast AS
Publication of WO2007076864A1 publication Critical patent/WO2007076864A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/225—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts

Definitions

  • the present invention relates to an adhesive for application to human skin, the adhesive comprising egg white.
  • egg white is used as a preparation before applying an adhesive to the skin.
  • the sensation is good adhesion and low trauma of the skin upon removal (skin-protein peel). It is also assumed that proteins will have a good effect on the healing of the skin.
  • the egg white preparation is obtained by evaporation of the water in the egg white.
  • WO02/074325 describes a pressure-sensitive adhesive layer with at least one immunologically-active protein applied to the adhesive or incorporated in the pressure- sensitive adhesive.
  • the pressure-sensitive adhesives are acrylic adhesives or silicone adhesives.
  • water-absorptive polymers polyols and mucopolysaccharides such as hyaluronic acid, chitin, and carboxy- methylcellulose can be incorporated. It is proposed to use albumin as a stabilizer.
  • the present invention relies on the discovery that mixing of egg white with a hydrocolloid containing non-polar adhesive provides an adhesive with an excellent balance between gel strength and water absorption.
  • the prevent invention relates to a non-polar adhesive comprising hydrocolloids and egg white.
  • non-polar adhesives are adhesives wherein the predominant elastomer is non-polar; i.e. 50% or more of total elastomer content .
  • adhesives are Styrene Block Copolymers, for example Styrene-lsoprene-Styrene triblockcopolymer (SIS), and PolylsoButylene (PIB) based adhesives.
  • SIS Styrene-lsoprene-Styrene triblockcopolymer
  • PIB PolylsoButylene
  • Skin friendly adhesives needs to hit the right balance between sufficient initial tack that the adhesive will ( 'stick" to the skin when applied, and, on the other hand, it must be possible to remove the adhesive after use without causing too much pain. Another balance is that the adhesive must be able to absorb water and remain cohesive during use.
  • the adhesive according to the invention incorporate protein (egg-white) into the Pressure Sensitive Adhesive (PSA). This avoids the extra operation step of applying it to the skin before applying the adhesive. Furthermore, the egg white will cover the skin and go into cavities and give a better seal to the skin i.e. provide increased initial tack. On removal the protein film will lower the trauma of removal. In addition the egg white containing different proteins will give a skin friendly barrier as well as an improved healing, leakage frequency will decrease and aggressive output will not irritate the skin.
  • protein egg-white
  • PSA Pressure Sensitive Adhesive
  • the adhesive is selected from the group consisting of a PIB based adhesive matrix and a SIS based adhesive matrix.
  • the non-polar adhesive matrix is polyisobutylene (PIB).
  • PIB polyisobutylene
  • Examples of such adhesives are disclosed in US6451883.
  • Such an adhesive typically comprises from 25 to 50% (w/w) polyisobutylene, from 0 to 20% (w/w) butyl rubber, from 0 to 15% (w/w) tackifying resin and from 25 to 55% (w/w) of hydrocolloid.
  • the non-polar adhesive matrix is a blockcopolymer comprising styrene and one or more olefins and/or dienes, e.g., olefins or dienes having 4-6 carbon atoms, preferably having 4 carbon atoms, such as 1-butene, isoprene or butadiene.
  • the block copolymer may, e.g., be a styrene-isoprene copolymer (SIS) or a styrene-butadiene-styrene copolymer.
  • such an adhesive comprises from 5 to 30% (w/w) styrene-isoprene-styrene block copolymer, from 15 to 50% (w/w) tackifying resin and from 25 to 55% (w/w) of hydrocolloid, and from 0 to 25% (w/w) of plasticizer.
  • a plasticizer may be any conventional plasticizer for use together with the copolymer e.g., be a phthalate such as dioctyl phthalate or an adipate such as dioctyl adipate or an oil such as liquid paraffin.
  • the hydrocolloids contained in the second material are suitably water soluble or water swellable hydrocolloids.
  • Such hydrocolloids are naturally occurring hydrocolloids such as guar gum, locust bean gum, pectin, alginates, gelatine, xanthan or karaya gum, semisynthetic hydrocolloids such as cellulose derivatives, e.g. salts of carboxymethylcellulose, methylcellulose and hydroxypropylmethylcellulose, sodium starch glycollate and synthetic hydrocolloids such as polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol or certain polyacrylates.
  • the hydrocolloid particles are microcolloids such as described in VVO 02/066087.
  • Egg white is the colorless proteinaceous fluid (albumin) surrounding the egg yolk of bird eggs.
  • Egg white is approximately 85% water and 12% protein with small amounts of fat, carbohydrates and salts.
  • the distribution of major amino acids is: glutamic acid (13.9%), aspartic acid (10.5%), leucine (10.3%), lysine (8.0%), valine (8.3%), arginine (6.8%), alanine (6.3%), isoleucine (6.2%) and serine (5.8%) with no measurable amounts of hydroxyproline (Mills and White 1994).
  • This proteinaceous mixture is chemically known as albumin but has been commercially spelled as albumen when used in food and as a binder for photographic emulsions.
  • Albumin forms an amorphous solid when dried that is soluble in water.
  • egg white is heat sensitive and forms an insoluble irreversible mass when heated to temperatures above 60°C.
  • the adhesives of this invention the albumin is not denatured and have not coagulated.
  • albumin is the prime component of egg white.
  • the non-polar adhesive contains albumin.
  • One way to prepare the adhesive according to the invention is to apply the egg white in dry form to the melted adhesive.
  • the adhesive to be tested was pressed into a plate with a thickness of 1 mm.
  • a sample of 25*25 mm was then punched out and adhered on an object glass.
  • the object glass with the sample was weighed and placed in a beaker with 0.9% isotonic saline at 37°C. After 2 hours, the object glass with the sample was removed form the beaker, dried on the surface, and weighed again. The increase of weight was recorded as the water absorption.
  • Leaching out of adhesives was tested using a dynamic method as described in WO01/05340. Leaching took place for 24 hours in 0.9% saline solution. The result is given as the size in mm of the leached zone measured from the center of the adhesive. The size of the washed-out zone was measured as well.
  • the adhesive to be tested was pressed into a plate with a thickness of 1 mm.
  • a sample with an diameter of 50 mm was punched out and adhered on a 0 80 mm Petri dish.
  • 0.9% isotonic saline was poured into the Petri dish until the sample is totally covered.
  • a lid was put on. After 18 hours, the sample were evaluated for their gel strength according to a scale from 5 (highest) to 1 (lowest).
  • recipe A is without egg-white
  • recipe B is with egg-white.
  • Recipe A Recipe B
  • Figure 1 shows the water absorption on the y-axis (g H 2 O/cm 2 ) as a function of time in minutes on the x-axis of recipe A ( ⁇ ) and recipe B (A).
  • An adhesive having high water absorption (above 0.2 g H 2 O/cm 2 after 2 h) is well suited for use as an ostomy adhesive.
  • Recipes C and D retain high cohesive (gel) strengths after 18 h in saline solution.
  • Recipe E comprises hydrocolloids and is able to absorb water efficiently, but with an accompanying loss in coherence after 18 h in saline solution (lower gel-strength). It is clear from this example that a suitable trade-off between gel strength and water absorption can be obtained by a formulation comprising egg white and hydrocolloid.
  • Recipes B and C are examples of such adhesives.
  • Figure 2 shows the water absorption on the y-axis (g H 2 O/cm 2 ) as a function of time in minutes on the x-axis of recipe C ( ⁇ ), D (•) and E (A).
  • Figure 1 shows the water absorption on the y-axis (g H 2 O/cm 2 ) as a function of time in minutes on the x-axis of recipe A ( ⁇ ) and recipe B (A).
  • Figure 2 shows the water absorption on the y-axis (g H 2 O/cm 2 ) as a function of time in minutes on the x-axis of recipe C ( ⁇ ), D (•) and E (A).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Surgery (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne un adhésif non polaire comprenant des hydrocolloïdes et du blanc d'œuf.
PCT/DK2006/000727 2006-01-05 2006-12-19 Adhésif contenant du blanc d'œuf Ceased WO2007076864A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200600024 2006-01-05
DKPA200600024 2006-01-05

Publications (1)

Publication Number Publication Date
WO2007076864A1 true WO2007076864A1 (fr) 2007-07-12

Family

ID=36809017

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2006/000727 Ceased WO2007076864A1 (fr) 2006-01-05 2006-12-19 Adhésif contenant du blanc d'œuf

Country Status (1)

Country Link
WO (1) WO2007076864A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9050387B2 (en) 2013-02-07 2015-06-09 Hollister Incorporated Sound absorbing ostomy pouch
US9931239B2 (en) 2013-02-07 2018-04-03 Hollister Incorporated Asymmetric multilayer film for ostomy application

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2930728A (en) * 1954-02-26 1960-03-29 Armstrong Cork Co Butadiene-styrene-albumin adhesive composition and method of joining members therewith
SU1438802A1 (ru) * 1986-10-28 1988-11-23 Киевский Медицинский Институт Им.Акад.А.А.Богомольца Состав дл моделировани и склеивани костных фрагментов на скелетах
WO1999011302A1 (fr) * 1997-08-29 1999-03-11 Coloplast A/S Composition adhesive autocollante
WO2002058735A1 (fr) * 2001-01-25 2002-08-01 Gainful Plan Limited Procede de preparation de materiaux biologiques et produits resultants

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2930728A (en) * 1954-02-26 1960-03-29 Armstrong Cork Co Butadiene-styrene-albumin adhesive composition and method of joining members therewith
SU1438802A1 (ru) * 1986-10-28 1988-11-23 Киевский Медицинский Институт Им.Акад.А.А.Богомольца Состав дл моделировани и склеивани костных фрагментов на скелетах
WO1999011302A1 (fr) * 1997-08-29 1999-03-11 Coloplast A/S Composition adhesive autocollante
WO2002058735A1 (fr) * 2001-01-25 2002-08-01 Gainful Plan Limited Procede de preparation de materiaux biologiques et produits resultants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 198931, Derwent World Patents Index; Class L02, AN 1989-226414, XP002395730 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9050387B2 (en) 2013-02-07 2015-06-09 Hollister Incorporated Sound absorbing ostomy pouch
US9931239B2 (en) 2013-02-07 2018-04-03 Hollister Incorporated Asymmetric multilayer film for ostomy application
US10980662B2 (en) 2013-02-07 2021-04-20 Hollister Incorporated Asymmetric multilayer film for ostomy application

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