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WO2007075931A3 - Reactive heterocyclic derivatives and methods for their synthesis and use - Google Patents

Reactive heterocyclic derivatives and methods for their synthesis and use Download PDF

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Publication number
WO2007075931A3
WO2007075931A3 PCT/US2006/048864 US2006048864W WO2007075931A3 WO 2007075931 A3 WO2007075931 A3 WO 2007075931A3 US 2006048864 W US2006048864 W US 2006048864W WO 2007075931 A3 WO2007075931 A3 WO 2007075931A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
methods
heterocyclic derivatives
reactive heterocyclic
reactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/048864
Other languages
French (fr)
Other versions
WO2007075931A2 (en
Inventor
Joseph Barry Noar
Mariusz G Banaszczyk
Violeta Millan
Gunars Valkirs
Kenneth F Buechler
Brian Noland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alere San Diego Inc
Original Assignee
Biosite Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosite Inc filed Critical Biosite Inc
Publication of WO2007075931A2 publication Critical patent/WO2007075931A2/en
Publication of WO2007075931A3 publication Critical patent/WO2007075931A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention describes molecules having a core structure that is an indole or an indolene that is modified to provide a functional moiety, and methods for their synthesis and use. Such functionalized heterocyclic derivatives may be used in a variety of assay formats.
PCT/US2006/048864 2005-12-22 2006-12-22 Reactive heterocyclic derivatives and methods for their synthesis and use Ceased WO2007075931A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81362105P 2005-12-22 2005-12-22
US60/813,621 2005-12-22

Publications (2)

Publication Number Publication Date
WO2007075931A2 WO2007075931A2 (en) 2007-07-05
WO2007075931A3 true WO2007075931A3 (en) 2007-11-08

Family

ID=38218634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/048864 Ceased WO2007075931A2 (en) 2005-12-22 2006-12-22 Reactive heterocyclic derivatives and methods for their synthesis and use

Country Status (1)

Country Link
WO (1) WO2007075931A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2990076B1 (en) 2012-04-27 2015-08-21 Labinal CURRENT RETURN LINK HARNESS, AND METHOD OF MOUNTING ON A COMPOSITE FUSELAGE FRAME
CN107257805A (en) * 2014-11-19 2017-10-17 雀巢产品技术援助有限公司 Antibody of antiserotonin, tryptophan and kynurenine metabolites and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US6503907B2 (en) * 2000-11-28 2003-01-07 Hoffmann-La Roche Inc. Indole and dihydroindole derivatives
US20030054356A1 (en) * 2000-09-21 2003-03-20 Jacobson James W. Multiple reporter read-out for bioassays

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US20030054356A1 (en) * 2000-09-21 2003-03-20 Jacobson James W. Multiple reporter read-out for bioassays
US6503907B2 (en) * 2000-11-28 2003-01-07 Hoffmann-La Roche Inc. Indole and dihydroindole derivatives

Also Published As

Publication number Publication date
WO2007075931A2 (en) 2007-07-05

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