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WO2007075798A3 - Methods and systems for the delivery of corticosteroids having an increased lung deposition - Google Patents

Methods and systems for the delivery of corticosteroids having an increased lung deposition Download PDF

Info

Publication number
WO2007075798A3
WO2007075798A3 PCT/US2006/048628 US2006048628W WO2007075798A3 WO 2007075798 A3 WO2007075798 A3 WO 2007075798A3 US 2006048628 W US2006048628 W US 2006048628W WO 2007075798 A3 WO2007075798 A3 WO 2007075798A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
systems
methods
corticosteroids
corticosteroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/048628
Other languages
French (fr)
Other versions
WO2007075798A9 (en
WO2007075798A2 (en
Inventor
Malcolm R Hill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tika Lakemedel AB
Original Assignee
Tika Lakemedel AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tika Lakemedel AB filed Critical Tika Lakemedel AB
Priority to JP2008547495A priority Critical patent/JP2009520821A/en
Priority to EP06848786A priority patent/EP1971349A2/en
Publication of WO2007075798A2 publication Critical patent/WO2007075798A2/en
Publication of WO2007075798A9 publication Critical patent/WO2007075798A9/en
Anticipated expiration legal-status Critical
Publication of WO2007075798A3 publication Critical patent/WO2007075798A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to methods and systems for the delivery of a corticosteroid comprising (1) an inhalable aqueous mixture comprising a corticosteroid and a solubility enhancer and (2) an inhalable nebulizer, wherein the delivery of the aqueous mixture comprising the corticosteroid by the nebulizer results in an enhanced pharmacokinetic profile of the corticosteroid as compared to conventional inhalable therapies.
PCT/US2006/048628 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an increased lung deposition Ceased WO2007075798A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008547495A JP2009520821A (en) 2005-12-20 2006-12-19 Methods and systems for delivering corticosteroids with increased intrapulmonary deposition
EP06848786A EP1971349A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an increased lung deposition

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US75273505P 2005-12-20 2005-12-20
US75233205P 2005-12-20 2005-12-20
US75276505P 2005-12-20 2005-12-20
US60/752,332 2005-12-20
US60/752,765 2005-12-20
US60/752,735 2005-12-20
US77399806P 2006-02-15 2006-02-15
US77399906P 2006-02-15 2006-02-15
US60/773,999 2006-02-15
US60/773,998 2006-02-15
US82009606P 2006-07-21 2006-07-21
US82009206P 2006-07-21 2006-07-21
US82009406P 2006-07-21 2006-07-21
US60/820,096 2006-07-21
US60/820,094 2006-07-21
US60/820,092 2006-07-21

Publications (3)

Publication Number Publication Date
WO2007075798A2 WO2007075798A2 (en) 2007-07-05
WO2007075798A9 WO2007075798A9 (en) 2007-08-23
WO2007075798A3 true WO2007075798A3 (en) 2008-11-20

Family

ID=38218568

Family Applications (6)

Application Number Title Priority Date Filing Date
PCT/US2006/048629 Ceased WO2007075799A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048735 Ceased WO2007075859A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids having an increased lung deposition
PCT/US2006/048628 Ceased WO2007075798A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an increased lung deposition
PCT/US2006/048631 Ceased WO2007075801A2 (en) 2005-12-20 2006-12-19 Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048927 Ceased WO2007075963A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids
PCT/US2006/048630 Ceased WO2007075800A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2006/048629 Ceased WO2007075799A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048735 Ceased WO2007075859A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids having an increased lung deposition

Family Applications After (3)

Application Number Title Priority Date Filing Date
PCT/US2006/048631 Ceased WO2007075801A2 (en) 2005-12-20 2006-12-19 Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048927 Ceased WO2007075963A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids
PCT/US2006/048630 Ceased WO2007075800A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids

Country Status (5)

Country Link
EP (6) EP1971346A2 (en)
JP (6) JP2009520827A (en)
BR (1) BRPI0620225A2 (en)
CA (2) CA2634413A1 (en)
WO (6) WO2007075799A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US12370352B2 (en) 2007-06-28 2025-07-29 Cydex Pharmaceuticals, Inc. Nasal and ophthalmic delivery of aqueous corticosteroid solutions
EP2220629B1 (en) * 2007-11-16 2020-04-22 Particle Measuring Systems, Inc. System and method for calibration verification of an optical particle counter
AR073796A1 (en) * 2008-10-10 2010-12-01 Schering Corp CORTICOSTEROID FORMULATIONS AND THEIR TREATMENT METHODS
EP3094355A1 (en) * 2014-01-17 2016-11-23 Nephron Pharmaceuticals Corporation Budesonide cyclodextrin formulation
EP2923702A1 (en) * 2014-03-28 2015-09-30 Universite De Liege Composition of cyclodextrin with budesonide derivatives for treatment and prevention of pulmonary inflammatory disease
DK3151836T3 (en) * 2014-03-28 2023-04-03 Univ Liege COMPOSITION COMPRISING CYCLODEXTRIN AND BUDESONIDE DERIVATIVES FOR USE IN THE TREATMENT AND PROPHYLAXIS OF PULMONARY INFLAMMATIONS
WO2019217286A1 (en) 2018-05-07 2019-11-14 Prana Biosciences Inc Metaxalone formulations
CN113490691A (en) 2019-01-03 2021-10-08 劣势者药物有限公司 Cyclodextrin dimers, compositions thereof, and uses thereof
CN113491677B (en) * 2020-03-18 2023-09-26 南京知和医药科技有限公司 Novel medicinal antiviral drug inhalant preparation and preparation method thereof
US20240189244A1 (en) * 2021-04-09 2024-06-13 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for delivering pharmaceutical agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
US20050009795A1 (en) * 2000-12-04 2005-01-13 Bernard Cuenoud Mixtures or organic compounds for the treatment of airway diseases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
US5874418A (en) * 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
US6598603B1 (en) * 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
HUP0302891A2 (en) * 2001-01-31 2003-12-29 Pfizer Products Inc. Ether derivatives useful as inhibitors of pde4 isozymes, their use and pharmaceutical compositions containing them
US20030055023A1 (en) * 2001-03-20 2003-03-20 Rajewski Roger A. Formulations containing etomidate and a sulfoalkyl ether cyclodextrin
US20030055026A1 (en) * 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US7244742B2 (en) * 2002-08-17 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co Kg Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
SI1585548T1 (en) * 2002-12-09 2018-11-30 Abraxis Bioscience, Llc Compositions and methods of delivery of pharmacological agents
US20050065141A1 (en) * 2003-07-31 2005-03-24 Odink Debra A. Carbapenems useful in treating and preventing pulmonary infections, pharmaceutical compositions thereof and modes of administration thereof
DE602004031356D1 (en) * 2003-11-21 2011-03-24 Zalicus Inc METHOD AND REAGENTS FOR THE TREATMENT OF INFLAMMATORY DISEASES
DK1732512T3 (en) * 2003-12-31 2017-07-10 Cydex Pharmaceuticals Inc INHALABLE FORMULATION CONTAINING SULPHALKYLETHERCYCLODEXTRIN AND CORTIC COSTEROID

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
US20050009795A1 (en) * 2000-12-04 2005-01-13 Bernard Cuenoud Mixtures or organic compounds for the treatment of airway diseases

Also Published As

Publication number Publication date
WO2007075801A2 (en) 2007-07-05
EP1973550A2 (en) 2008-10-01
WO2007075963A3 (en) 2008-11-27
WO2007075800A3 (en) 2008-11-20
BRPI0620225A2 (en) 2011-11-01
WO2007075801A3 (en) 2008-12-31
JP2009520828A (en) 2009-05-28
WO2007075963A2 (en) 2007-07-05
WO2007075800A2 (en) 2007-07-05
JP2009520827A (en) 2009-05-28
WO2007075799A2 (en) 2007-07-05
WO2007075799A3 (en) 2009-01-15
JP2009520823A (en) 2009-05-28
WO2007075859A3 (en) 2008-12-11
CA2634413A1 (en) 2007-07-05
JP2009520822A (en) 2009-05-28
EP1971346A2 (en) 2008-09-24
JP2009520821A (en) 2009-05-28
JP2009524590A (en) 2009-07-02
WO2007075859A2 (en) 2007-07-05
WO2007075798A9 (en) 2007-08-23
EP1971347A2 (en) 2008-09-24
EP1971348A2 (en) 2008-09-24
WO2007075798A2 (en) 2007-07-05
EP1971349A2 (en) 2008-09-24
EP1971345A2 (en) 2008-09-24
CA2634398A1 (en) 2007-07-05

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