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WO2007070679A3 - Compositions and methods for dermally treating pain - Google Patents

Compositions and methods for dermally treating pain Download PDF

Info

Publication number
WO2007070679A3
WO2007070679A3 PCT/US2006/047926 US2006047926W WO2007070679A3 WO 2007070679 A3 WO2007070679 A3 WO 2007070679A3 US 2006047926 W US2006047926 W US 2006047926W WO 2007070679 A3 WO2007070679 A3 WO 2007070679A3
Authority
WO
WIPO (PCT)
Prior art keywords
volatile solvent
drug
pain
treating pain
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/047926
Other languages
French (fr)
Other versions
WO2007070679A2 (en
Inventor
Jie Zhang
Kevin S Warner
Sanjay Sharma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zars Inc
Original Assignee
Zars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zars Inc filed Critical Zars Inc
Priority to EP06848632A priority Critical patent/EP1959931A4/en
Priority to CA2633515A priority patent/CA2633515C/en
Priority to JP2008545844A priority patent/JP2009524586A/en
Priority to AU2006326018A priority patent/AU2006326018B2/en
Priority to CN200680051992.4A priority patent/CN101494976B/en
Publication of WO2007070679A2 publication Critical patent/WO2007070679A2/en
Anticipated expiration legal-status Critical
Publication of WO2007070679A3 publication Critical patent/WO2007070679A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention is drawn to solidifying formulations for dermal delivery of a drug for treating pain, such as musculoskeletal pain, inflammation, joint pain, or neuropathic pain. The formulation can include a drug selected from certain drug classes, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein the evaporation of at least some of the volatile solvent converts the formulation on the skin into a solidified layer and the non-volatile solvent system is capable of facilitating the topical delivery of the drug(s) at therapeutically effective rates over a sustained period of time.
PCT/US2006/047926 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain Ceased WO2007070679A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP06848632A EP1959931A4 (en) 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain
CA2633515A CA2633515C (en) 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain
JP2008545844A JP2009524586A (en) 2005-12-14 2006-12-14 Compositions and methods for skin treatment of pain
AU2006326018A AU2006326018B2 (en) 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain
CN200680051992.4A CN101494976B (en) 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US75051905P 2005-12-14 2005-12-14
US75068305P 2005-12-14 2005-12-14
US75063705P 2005-12-14 2005-12-14
US60/750,683 2005-12-14
US60/750,637 2005-12-14
US60/750,519 2005-12-14

Publications (2)

Publication Number Publication Date
WO2007070679A2 WO2007070679A2 (en) 2007-06-21
WO2007070679A3 true WO2007070679A3 (en) 2009-01-08

Family

ID=38163542

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/047926 Ceased WO2007070679A2 (en) 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain

Country Status (5)

Country Link
EP (1) EP1959931A4 (en)
JP (1) JP2009524586A (en)
AU (1) AU2006326018B2 (en)
CA (1) CA2633515C (en)
WO (1) WO2007070679A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865727B2 (en) 2008-02-29 2014-10-21 Vm Therapeutics Llc Method for treating pain syndrome and other disorders

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8741333B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for treating dermatitis or psoriasis
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
US8741332B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
US9283177B2 (en) 2007-01-16 2016-03-15 Juventio, Llc Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic
US8759391B2 (en) 2007-01-16 2014-06-24 Juventio, Llc Topical anesthetic for rapid local anesthesia
US9050293B2 (en) 2008-07-16 2015-06-09 Juventio, Llc Small molecule solubilization system
US9012477B2 (en) * 2009-01-06 2015-04-21 Nuvo Research Inc. Method of treating neuropathic pain
US20110086913A1 (en) * 2009-04-01 2011-04-14 Jie Zhang Methods for treating myofascial, muscle, and/or back pain
EP2427160A4 (en) 2009-05-04 2012-12-19 Zars Pharma Inc Methods of treating pains associated with neuroma, nerve entrapment, and other conditions
US9186334B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Heat assisted lidocaine and tetracaine for transdermal analgesia
EP2523660A4 (en) 2010-01-14 2013-07-10 Nuvo Res Inc FORMULATIONS FOR LOCAL ANESTHESIA SOLIDIFYING FOR THE MANAGEMENT OF PAIN
US20130324502A1 (en) 2011-02-10 2013-12-05 Moberg Pharma Ab Novel formulations for dermal, transdermal and mucosal use 1
BR112013028802B1 (en) 2011-05-10 2021-10-26 Itochu Chemical Frontier Corporation NON-AQUEOUS ADHESIVE DRESSING
US11786455B2 (en) 2011-05-10 2023-10-17 Itochu Chemical Frontier Corporation Non-aqueous patch
ES3034911T3 (en) 2011-05-10 2025-08-26 Itochu Chemical Frontier Corp Non-aqueous patch
JP2014515365A (en) * 2011-05-26 2014-06-30 ノバルティス アーゲー Composition for transdermal administration of physiologically active agents
CN102302418B (en) * 2011-09-21 2013-01-23 韩褆 Water-saving type multifunctional hand-washing disinfectant
TR201810942T4 (en) 2011-09-27 2018-09-21 Itochu Chemical Frontier Corp Waterless tape.
CN103142458B (en) * 2013-01-22 2015-09-09 莱普德制药有限公司 Without prescription and the preparation method of additive analgesia sustained release drug delivery systems
GB201317718D0 (en) * 2013-10-07 2013-11-20 Buzzz Pharmaceuticals Ltd Novel formulation
JP6209749B2 (en) * 2015-12-10 2017-10-11 伊藤忠ケミカルフロンティア株式会社 Non-aqueous patch
JP7116434B2 (en) * 2017-04-11 2022-08-10 株式会社 メドレックス Transdermal solution containing memantine
CA3082286A1 (en) 2017-12-04 2019-06-13 Johnson & Johnson Consumer Inc. Topical emulsion composition containing nonsteroidal anti-inflammatory drug
KR20240001117A (en) * 2021-02-02 2024-01-03 듀폰 뉴트리션 유에스에이 인코포레이티드 Aqueous gel composition containing ethylcellulose

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037890A1 (en) * 1999-11-23 2001-05-31 Ever Power Holding Inc A propellant free spray-on skin patch composition for improving wound healing and for drug administration
US6432415B1 (en) * 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US20040018241A1 (en) * 1997-09-26 2004-01-29 Noven Pharmaceuticals, Inc. Bioadhesive compositions and methods for topical administration of active agents
WO1999015210A2 (en) * 1997-09-26 1999-04-01 Noven Pharmaceuticals, Inc. Bioadhesive compositions and methods for topical administration of active agents
US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037890A1 (en) * 1999-11-23 2001-05-31 Ever Power Holding Inc A propellant free spray-on skin patch composition for improving wound healing and for drug administration
US6432415B1 (en) * 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FARBER ET AL.: "Serotonergic Agents That Activate 5HT2A Receptors Prevent NMDA Antagonist Neurotoxicity", NEUROPSYCHOPHARMACOLOGY, vol. 18, no. 1, 1998, pages 57 - 62, XP002396767 *
PADILLA ET AL.: "TOPICAL MEDICATIONS FOR OROFACIAL NEUROPATHIC PAIN: A REVIEW", J. AM. DENT. ASSOC., vol. 131, no. 2, 2000, pages 184 - 195, XP008131443 *
See also references of EP1959931A4 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865727B2 (en) 2008-02-29 2014-10-21 Vm Therapeutics Llc Method for treating pain syndrome and other disorders
US8980900B2 (en) 2008-02-29 2015-03-17 VM Therapeutics, LLC. Method for treating pain syndrome and other disorders
US9402848B2 (en) 2008-02-29 2016-08-02 Vm Therapeutics Llc Method for treating pain syndrome and other disorders
US9834555B2 (en) 2008-02-29 2017-12-05 VM Therapeutics LLC. Method for treating pain syndrome and other disorders

Also Published As

Publication number Publication date
CA2633515C (en) 2011-10-18
CA2633515A1 (en) 2007-06-21
AU2006326018B2 (en) 2013-04-18
WO2007070679A2 (en) 2007-06-21
EP1959931A2 (en) 2008-08-27
AU2006326018A1 (en) 2007-06-21
EP1959931A4 (en) 2012-08-22
JP2009524586A (en) 2009-07-02

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