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WO2007069033A3 - Pharmaceutical compositions comprising dexibuprofen, an opiate analgesic and paracetamol - Google Patents

Pharmaceutical compositions comprising dexibuprofen, an opiate analgesic and paracetamol Download PDF

Info

Publication number
WO2007069033A3
WO2007069033A3 PCT/IB2006/003567 IB2006003567W WO2007069033A3 WO 2007069033 A3 WO2007069033 A3 WO 2007069033A3 IB 2006003567 W IB2006003567 W IB 2006003567W WO 2007069033 A3 WO2007069033 A3 WO 2007069033A3
Authority
WO
WIPO (PCT)
Prior art keywords
dexibuprofen
paracetamol
pharmaceutically acceptable
opiate
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/003567
Other languages
French (fr)
Other versions
WO2007069033A2 (en
Inventor
Bradley Ryan Parsons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adcock Ingram Ltd
Original Assignee
Adcock Ingram Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adcock Ingram Ltd filed Critical Adcock Ingram Ltd
Publication of WO2007069033A2 publication Critical patent/WO2007069033A2/en
Publication of WO2007069033A3 publication Critical patent/WO2007069033A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A pharmaceutical composition including a combination of a sub-therapeutic amount of the S isomer of ibuprofen, also referred to as dexibuprofen, or a pharmaceutically acceptable salt or derivative thereof, an opiate or a pharmaceutically acceptable salt or derivative thereof, and a centrally-acting cyclo-oxygenase inhibitor, as active ingredients, and a pharmaceutically acceptable carrier. A typical combination includes paracetamol, dexibuprofen and codeine, with the dexibuprofen being provided in an amount to give a daily dose of 100 mg or less. A method of treatment using a combination of a sub-therapeutic amount of dexibuprofen, an opiate and a centrally-acting cyclo-oxygenase inhibitor is also described.
PCT/IB2006/003567 2005-12-12 2006-12-12 Pharmaceutical compositions comprising dexibuprofen, an opiate analgesic and paracetamol Ceased WO2007069033A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA2005/10091 2005-12-12
ZA200510091 2005-12-12

Publications (2)

Publication Number Publication Date
WO2007069033A2 WO2007069033A2 (en) 2007-06-21
WO2007069033A3 true WO2007069033A3 (en) 2007-10-04

Family

ID=38055508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003567 Ceased WO2007069033A2 (en) 2005-12-12 2006-12-12 Pharmaceutical compositions comprising dexibuprofen, an opiate analgesic and paracetamol

Country Status (2)

Country Link
WO (1) WO2007069033A2 (en)
ZA (1) ZA200803566B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010007358A (en) * 2008-01-03 2011-05-25 Wockhardt Research Center ORAL PHARMACEUTICAL SUSPENSION INCLUDING PARACETAMOL AND IBUPROFEN.
GB201811858D0 (en) * 2018-07-20 2018-09-05 Wockhardt Uk Ltd Liquid pharmaceutical composition for oral administration comprising paracetamol and codeine

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU605538B2 (en) * 1988-01-19 1991-01-17 Adcock Ingram Limited Pharmaceutical unit
US5164398A (en) * 1991-04-01 1992-11-17 Merck & Co., Inc. Ibuprofen-antitussive combinations
WO1996005834A1 (en) * 1994-08-23 1996-02-29 Smithkline Beecham Plc Improved pharmaceutical formulations containing ibuprofen and codeine
WO2006004449A2 (en) * 2004-07-07 2006-01-12 Aft Pharmaceuticals Limited A combination composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU605538B2 (en) * 1988-01-19 1991-01-17 Adcock Ingram Limited Pharmaceutical unit
US5164398A (en) * 1991-04-01 1992-11-17 Merck & Co., Inc. Ibuprofen-antitussive combinations
WO1996005834A1 (en) * 1994-08-23 1996-02-29 Smithkline Beecham Plc Improved pharmaceutical formulations containing ibuprofen and codeine
WO2006004449A2 (en) * 2004-07-07 2006-01-12 Aft Pharmaceuticals Limited A combination composition

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BEUBLER E: "Clinical pharmacology of analgesics: outlook and risks", DER INTERNIST ; ORGAN DES BERUFSVERBANDES DEUTSCHER INTERNISTEN ORGAN DER DEUTSCHEN GESELLSCHAFT FÜR INNERE MEDIZIN, SPRINGER-VERLAG, BE, vol. 46, no. 10, 1 October 2005 (2005-10-01), pages 1076 - 1086, XP019320006, ISSN: 1432-1289 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 17 October 1987 (1987-10-17), VLOK G J ET AL: "Comparison of a standard ibuprofen treatment regimen with a new ibuprofen/paracetamol/codeine combination in chronic osteo-arthritis.", XP002440673, Database accession no. NLM3313757 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 1992 (1992-09-01), LOWNIE J F ET AL: "Comparison of the safety and efficacy of a combination analgesic Myprodol and Ponstan in the treatment of dental pain.", XP002440674, Database accession no. NLM9511622 *
SOUTH AFRICAN MEDICAL JOURNAL = SUID-AFRIKAANSE TYDSKRIF VIR GENEESKUNDE 17 OCT 1987, vol. Suppl, 17 October 1987 (1987-10-17), pages 1 , 4 - 6, ISSN: 0256-9574 *
THE JOURNAL OF THE DENTAL ASSOCIATION OF SOUTH AFRICA = DIE TYDSKRIF VAN DIE TANDHEELKUNDIGE VERENIGING VAN SUID-AFRIKA SEP 1992, vol. 47, no. 9, September 1992 (1992-09-01), pages 403 - 406, ISSN: 0011-8516 *
WARD ET AL: "Paracetamol revisited: A review of the pharmacokinetics and pharmacodynamics", ACUTE PAIN, ELSEVIER, vol. 2, no. 3, September 1999 (1999-09-01), pages 139 - 149, XP005162523, ISSN: 1366-0071 *

Also Published As

Publication number Publication date
WO2007069033A2 (en) 2007-06-21
ZA200803566B (en) 2009-10-28

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