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WO2007067619A3 - Certain chemical entities, compositions, and methods for modulating trpv1 - Google Patents

Certain chemical entities, compositions, and methods for modulating trpv1 Download PDF

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Publication number
WO2007067619A3
WO2007067619A3 PCT/US2006/046549 US2006046549W WO2007067619A3 WO 2007067619 A3 WO2007067619 A3 WO 2007067619A3 US 2006046549 W US2006046549 W US 2006046549W WO 2007067619 A3 WO2007067619 A3 WO 2007067619A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemical entities
compositions
methods
certain chemical
trpv1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/046549
Other languages
French (fr)
Other versions
WO2007067619A2 (en
Inventor
Jose S Mendoza
Carl Nicholas Hodge
John K Dickson Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amphora Discovery Corp
Original Assignee
Amphora Discovery Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amphora Discovery Corp filed Critical Amphora Discovery Corp
Publication of WO2007067619A2 publication Critical patent/WO2007067619A2/en
Publication of WO2007067619A3 publication Critical patent/WO2007067619A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Provided are chemical entities chosen from compounds of Formula I and pharmaceutically or cosmetically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof. The chemical entities modulate TRPV1and are useful in the treatment of at least one disease or disorder modulated by TRPV1activity.
PCT/US2006/046549 2005-12-08 2006-12-05 Certain chemical entities, compositions, and methods for modulating trpv1 Ceased WO2007067619A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74887805P 2005-12-08 2005-12-08
US60/748,878 2005-12-08

Publications (2)

Publication Number Publication Date
WO2007067619A2 WO2007067619A2 (en) 2007-06-14
WO2007067619A3 true WO2007067619A3 (en) 2007-12-13

Family

ID=38123453

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/046549 Ceased WO2007067619A2 (en) 2005-12-08 2006-12-05 Certain chemical entities, compositions, and methods for modulating trpv1

Country Status (1)

Country Link
WO (1) WO2007067619A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101925575B (en) 2008-01-28 2014-06-18 株式会社爱茉莉太平洋 Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanillic acid receptor antagonist
EP2264031B1 (en) 2008-04-18 2015-04-15 Daewoong Pharmaceutical Co., Ltd. A novel benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof
CN102137851B (en) 2008-07-02 2014-08-27 株式会社爱茉莉太平洋 Compounds as vanilloid receptor antagonists, isomers thereof or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them
KR101293384B1 (en) 2010-10-13 2013-08-05 주식회사 대웅제약 Novel pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050096358A1 (en) * 2002-03-28 2005-05-05 Yang Gao Substituted biaryl amides as C5A receptor modulators
US20050159394A1 (en) * 2003-12-31 2005-07-21 Wei Edward T. Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050096358A1 (en) * 2002-03-28 2005-05-05 Yang Gao Substituted biaryl amides as C5A receptor modulators
US20050159394A1 (en) * 2003-12-31 2005-07-21 Wei Edward T. Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets

Also Published As

Publication number Publication date
WO2007067619A2 (en) 2007-06-14

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