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WO2007066200A3 - Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications - Google Patents

Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications Download PDF

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Publication number
WO2007066200A3
WO2007066200A3 PCT/IB2006/003475 IB2006003475W WO2007066200A3 WO 2007066200 A3 WO2007066200 A3 WO 2007066200A3 IB 2006003475 W IB2006003475 W IB 2006003475W WO 2007066200 A3 WO2007066200 A3 WO 2007066200A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
pharmaceutical compositions
therapeutic applications
cysteine proteases
proteases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/003475
Other languages
French (fr)
Other versions
WO2007066200A2 (en
Inventor
Philippe Guedat
Guillaume Boissy
Catherine Borg-Capra
Frederic Colland
Laurent Daviet
Etienne Formstecher
Xavier Jacq
Jean-Christophe Rain
Remi Delansorne
Ilaria Peretto
Stefano Vignando
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aton SA
Original Assignee
Hybrigenics SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/296,564 external-priority patent/US7462615B2/en
Priority claimed from EP05292612A external-priority patent/EP1798232A1/en
Priority to MX2008007195A priority Critical patent/MX2008007195A/en
Priority to ES06831646.2T priority patent/ES2439456T3/en
Priority to JP2008543932A priority patent/JP5173829B2/en
Priority to UAA200807680A priority patent/UA95930C2/en
Priority to NZ568805A priority patent/NZ568805A/en
Priority to CN200680052498XA priority patent/CN101365702B/en
Application filed by Hybrigenics SA filed Critical Hybrigenics SA
Priority to US12/096,273 priority patent/US20090181972A1/en
Priority to EP06831646.2A priority patent/EP1963328B1/en
Priority to AU2006322958A priority patent/AU2006322958B2/en
Priority to CA2632635A priority patent/CA2632635C/en
Publication of WO2007066200A2 publication Critical patent/WO2007066200A2/en
Publication of WO2007066200A3 publication Critical patent/WO2007066200A3/en
Priority to IL191992A priority patent/IL191992A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)

Abstract

The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.
PCT/IB2006/003475 2005-12-08 2006-12-05 Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications Ceased WO2007066200A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU2006322958A AU2006322958B2 (en) 2005-12-08 2006-12-05 Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
CA2632635A CA2632635C (en) 2005-12-08 2006-12-05 Novel inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
US12/096,273 US20090181972A1 (en) 2005-12-08 2006-12-05 Novel Inhibitors of Cysteine Proteases, the Pharmaceutical Compositions Thereof and their Therapeutic Applications
JP2008543932A JP5173829B2 (en) 2005-12-08 2006-12-05 Novel cysteine protease inhibitors, their pharmaceutical compositions and their use for therapy
UAA200807680A UA95930C2 (en) 2005-12-08 2006-12-05 Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
NZ568805A NZ568805A (en) 2005-12-08 2006-12-05 pentaaza-cyclopenta[b]fluoren-9-one inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
CN200680052498XA CN101365702B (en) 2005-12-08 2006-12-05 Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
MX2008007195A MX2008007195A (en) 2005-12-08 2006-12-05 Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications.
ES06831646.2T ES2439456T3 (en) 2005-12-08 2006-12-05 Cysteine protease inhibitors, their pharmaceutical compositions and their therapeutic applications
EP06831646.2A EP1963328B1 (en) 2005-12-08 2006-12-05 Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
IL191992A IL191992A (en) 2005-12-08 2008-06-05 Fused cyclic compounds, pharmaceutical compositions comprising them, processes for their manufacture and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/296,564 US7462615B2 (en) 2005-12-08 2005-12-08 Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
US11/296,564 2005-12-08
EP05292612.8 2005-12-08
EP05292612A EP1798232A1 (en) 2005-12-08 2005-12-08 Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications

Publications (2)

Publication Number Publication Date
WO2007066200A2 WO2007066200A2 (en) 2007-06-14
WO2007066200A3 true WO2007066200A3 (en) 2007-09-07

Family

ID=38006777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003475 Ceased WO2007066200A2 (en) 2005-12-08 2006-12-05 Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications

Country Status (10)

Country Link
EP (1) EP1963328B1 (en)
JP (1) JP5173829B2 (en)
AU (1) AU2006322958B2 (en)
CA (1) CA2632635C (en)
ES (1) ES2439456T3 (en)
IL (1) IL191992A (en)
MX (1) MX2008007195A (en)
NZ (1) NZ568805A (en)
RU (1) RU2440351C2 (en)
WO (1) WO2007066200A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2633095T3 (en) * 2006-10-30 2017-09-19 Hybrigenics S.A. Tetracyclic cysteine protease inhibitors, their pharmaceutical compositions and their therapeutic applications
EP2208725A1 (en) * 2009-01-13 2010-07-21 Hybrigenics S.A. Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications
WO2011069149A2 (en) 2009-12-04 2011-06-09 Dcb-Usa Llc Cathepsin s inhibitors
AU2021385572A1 (en) 2020-11-25 2023-06-22 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids, and related methods of use
WO2023230587A2 (en) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405619A (en) * 1981-09-02 1983-09-20 Diamond Shamrock Corporation Antiinflammatory substituted-1,2,4-triazolo[4,3-b]-1,2,4-triazines
US5726175A (en) * 1994-07-20 1998-03-10 Rhone-Poulenc Rorer S.A. Imidazo 1,2-A!indeno 1,2-E!pyrazine-2-carboxylic acid derivatives, preparation thereof and drugs containing same
WO2000054772A1 (en) * 1999-03-12 2000-09-21 Aventis Pharma S.A. Amyotropic lateral sclerosis treatment with a combination of riluzole and an ampa receptor antagonist
WO2001079209A2 (en) * 2000-04-13 2001-10-25 Millennium Pharmaceuticals, Inc. Diazafluorenone il-8 antagonists
WO2002002562A2 (en) * 2000-07-06 2002-01-10 Kinetek Pharmaceuticals, Inc. Heteropolycyclic inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405619A (en) * 1981-09-02 1983-09-20 Diamond Shamrock Corporation Antiinflammatory substituted-1,2,4-triazolo[4,3-b]-1,2,4-triazines
US5726175A (en) * 1994-07-20 1998-03-10 Rhone-Poulenc Rorer S.A. Imidazo 1,2-A!indeno 1,2-E!pyrazine-2-carboxylic acid derivatives, preparation thereof and drugs containing same
WO2000054772A1 (en) * 1999-03-12 2000-09-21 Aventis Pharma S.A. Amyotropic lateral sclerosis treatment with a combination of riluzole and an ampa receptor antagonist
WO2001079209A2 (en) * 2000-04-13 2001-10-25 Millennium Pharmaceuticals, Inc. Diazafluorenone il-8 antagonists
WO2002002562A2 (en) * 2000-07-06 2002-01-10 Kinetek Pharmaceuticals, Inc. Heteropolycyclic inhibitors

Non-Patent Citations (20)

* Cited by examiner, † Cited by third party
Title
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1993, XP002380979 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1993, XP002380987 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1975, FISCHER-COLBRIE, H. ET AL: "Syntheses with nitriles. XXXIX. Dyes obtained from 2-(dicyanomethylene)-1,3-indandione by amine-hydrogen cyanide exchange. II", XP002380983, retrieved from STN Database accession no. 1975:516907 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1979, PROSTAKOV, N. S. ET AL: "Substituted indolizines and indenoindolizines", XP002380984, retrieved from STN Database accession no. 1979:523620 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1983, PROSTAKOV, N. S. ET AL: "Reduction of quaternary salts of 3-azafluorene and 3-azafluorenone and their conversions into indenoindolizines", XP002380986, retrieved from STN Database accession no. 1983:215441 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1987, METWALLY, MOHAMED ABBAS ET AL: "Heterocyclic compounds with bridgehead nitrogen. The synthesis of indeno[1,2:4,5]pyrimido[1,2-a]benzimidazole-13-ones, indeno[1,2-b]pyrazolo[4,3-e]pyridine-3,5-dione and related compounds", XP002380980, retrieved from STN Database accession no. 1987:102209 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1989, ALI, MOHAMED I. ET AL: "Synthesis and reactions of 2,3-dihydro-5-aryl-5H,6H-thiazolo[3,2-b]- 2,4-diazafluorene-3,6-diones of potential biological activities", XP002380981, retrieved from STN Database accession no. 1989:423468 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1990, KRAUSE, A. ET AL: "Synthesis and properties of hydrogenated 2-(alkylthio)-5-oxo-3- cyanoindeno[1,2-b]pyridines", XP002380985, retrieved from STN Database accession no. 1990:423640 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2000, ABD EL BASAT HASSANEIN, ABU ZEID: "Synthesis and reaction of some indenopyridine and thieno[2,3-b]indeno[2,1-e]pyridine derivatives", XP002380978, retrieved from STN Database accession no. 2000:712354 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2003, HASSANEEN, HAMDI M. ET AL: "Polyfunctional fused heterocyclic compounds via indene-1,3-diones", XP002380982, retrieved from STN Database accession no. 2003:736852 *
HASSAN, A. A. ET AL: "A novel synthesis of heterocycles from thiocarbohydrazides", MONATSHEFTE FUER CHEMIE , 128(1), 61-70 CODEN: MOCMB7; ISSN: 0026-9247, 1997, XP002380967 *
HETEROATOM CHEMISTRY , 14(6), 491-497 CODEN: HETCE8; ISSN: 1042-7163, 2003 *
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII , (1), 115-19 CODEN: KGSSAQ; ISSN: 0453-8234, 1990 *
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII , (2), 252-5 CODEN: KGSSAQ; ISSN: 0453-8234, 1983 *
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII , (6), 794-8 CODEN: KGSSAQ; ISSN: 0453-8234, 1979 *
MONATSHEFTE FUER CHEMIE , 106(3), 743-53 CODEN: MOCMB7; ISSN: 0026-9247, 1975 *
PHOSPHORUS AND SULFUR AND THE RELATED ELEMENTS , 39(3-4), 211-16 CODEN: PREEDF; ISSN: 0308-664X, 1988 *
STUTZMANN J M ET AL: "Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 7 MAY 2001, vol. 11, no. 9, 7 May 2001 (2001-05-07), pages 1205 - 1210, XP002380966, ISSN: 0960-894X *
SYNTHETIC COMMUNICATIONS , 30(21), 3883-3895 CODEN: SYNCAV; ISSN: 0039-7911, 2000 *
ZEITSCHRIFT FUER NATURFORSCHUNG, TEIL B: ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE , 41B(4), 486-8 CODEN: ZNBAD2; ISSN: 0340-5087, 1986 *

Also Published As

Publication number Publication date
IL191992A0 (en) 2008-12-29
JP2009518383A (en) 2009-05-07
IL191992A (en) 2016-09-29
EP1963328A2 (en) 2008-09-03
AU2006322958B2 (en) 2012-06-07
RU2008127502A (en) 2010-01-20
ES2439456T3 (en) 2014-01-23
CA2632635A1 (en) 2007-06-14
JP5173829B2 (en) 2013-04-03
NZ568805A (en) 2011-06-30
AU2006322958A1 (en) 2007-06-14
CA2632635C (en) 2014-04-29
RU2440351C2 (en) 2012-01-20
MX2008007195A (en) 2008-09-10
WO2007066200A2 (en) 2007-06-14
EP1963328B1 (en) 2013-10-30

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