WO2007065359A1 - A material with blood compatibility and preparation method thereof - Google Patents

Abstract

A method of preparing a material with blood compatibility comprises dissolving polymer into an organic solvent to form a polymer solution; dissolving an anticoagulant in an inorganic solvent to form an emulsion, slurry or fluid-like mixture; then producing the material with blood compatibility by one of the following means:1) mixing the polymer solution and the emulsion, slurry or fluid-like mixture containing the anticoagulant to make the material with blood compatibility; 2) mixing the polymer solution, a pore forming agent and the emulsion, slurry or fluid-like mixture containing the anticoagulant to make the material with blood compatibility; 3) mixing the polymer solution, a filler and the emulsion, slurry or fluid-like mixture containing the anticoagulant to make the material with blood compatibility. And a material with blood compatibility is prepared by said method. The material has good anticoagulant property, and can meet the requirements of various properties as tissue and organ repair material used in vitro or implanted in vivo such as good anticoagulant property, biocompatibility, high mechanical strength, toughness and the like.

Description

 Compatible materials and methods for making them

 This presentation clearly refers to blood-compatible materials and their preparation methods.

Background wood

 At present, there are biological materials in the blood pipe system, dialysis system, artificial and artificial support systems that cause coagulation and thrombosis. The general solution is to use the surface to enhance its anticoagulant performance. Once the surface of the material is divided into and etc., its anticoagulant properties will drop or disappear. The material is in contact with the blood and maintains the anticoagulant performance of the phase. The use is generally only small to

On the same day.

 There are multiple organ systems, stenosis and other reasons that require or maintain function. Blood vessels Blood vessels cannot work properly due to pulse sclerosis, blood vessel aging or damage, etc. Blood vessel transplantation is required. Due to the strong reaction of organs, few sources, etc., the research of artificial blood vessels has been paid more and more attention. As early as in the last 1940s, some people studied the transplantation of biological blood vessels. Only plastic tubes can be used instead of blood vessels to be implanted in biological blood vessels. Due to heavy coagulation, no case has been successful. 952 oo hees accidentally implanted in the biological rest

 It is covered with an endothelial cell. He assumes that the same phenomenon as nickel implanted in the body can avoid the direct connection of blood and implants to prevent coagulation. At present, the most used raw material for artificial blood vessels is ethylene vinyl. Artificial blood vessels with an inward greater than or equal to are generally. Maintain the tightness and make the surroundings attached to the outside of the blood vessel and inwardly covered the endothelial cells. The 6-meter-long straight straight artificial blood vessel is generally made of ethylene, which is a biologically inert material that does not need to cover endothelial cells to prevent blood clotting. Artificial blood vessels with diameters under 6 m are not available on the bed.

In the past twenty years, people have been exploring the synthesis of blood vessels, especially those that are smaller than 5 m, h noka h noka T h T a P ea. Ea on OV ab e Pu mo ayaey au og ash ough ssue eng nee ng. J ho ac ad ovasc ug 998; 15 36 545 Po yg an P. The mixed cell components obtained from the sheep head or the external vein include endothelial cells E s, almost cell-cell sheep replacement methods and result in the formation of new blood vessels with higher content. But P support 5 is weaker and stiff to withstand higher rest. hu et hum T ock UH kachJ ea. T ssue eg ee g O au o gou s ao aus ng aeb odeg adab e Po yne. n Tho ac ug

 1999; 68 2293 2305 polymer Po y hyd oxya ka oa e PH is a poly scaffold material of 0 octanoic acid. The inner has a porous P scaffold. It works on the PH of the outer pore of the cell. The thickness of the sheep is 1.5. k ason et al. N k aso LE aoJ bo ea. Fu coaae es gon V o. ce ce

 1999 284 489 493 P-stent and E s perfusion system were used to cultivate small-sized engineering vessels that could withstand a certain force. e be g and Be e be g5 B Be E. b ood Vesse ode Cons uc ed o C u ed

 vascu a Ce s. c e ce, 98; 3 97 400 The blood vessels were engineered with the original protein material E s and the whole biochemical group of adult cells. Due to the special requirements of anti-coagulation and strength of blood vessels, the above-mentioned engineering blood vessels all have certain limitations. The materials themselves have no anti-coagulant properties in the absence of endothelial cells.

 Po y e hane or U is a poly-material containing amino groups, each with good stitchability, and good molding processing has been

. Butyric acid and 3 copolymerized Po (3 hyd oxybu yae co 3 hyd oxyhexa oa e), or PHBHHx, is an internal bacterium 5 synthesized by bacteria in the form of granular inclusions. PHBHHx is a promising new type of bio-composite material, which has similar plasticity performance and biodegradability of plastics obtained from petrochemical raw materials. Currently PHBHHx has been used as a scaffold material for cells, cells, chondrocytes, etc. ang hao K hen. E ec O Su ace ea en On he b oco pa by O0 c ob a Po yhyd oxya kanoa es. B oaeas 2002 3 391 1397 hao K eg he J he. Po yhyd oxya kanoa e (PH) Sca o ds W h good echa ca P ope es and

B oco pa b y. B o a e a s 200 4 04 045, its mechanical strength and biocompatibility are better than other PLL PL, PHB, etc. but the rate is very high. At present, there is no material that can be used as the material for the large and small straight pipelines and the pipeline system in the organ, especially the pipeline system for the force vessel or organ. Group rate matches the multi-faceted performance material.

 Liter

 The purpose of this book is to provide blood compatible materials and their preparation methods.

 The method of each blood-compatible material provided in this book is to convert the polymer material with a force of 00 force to a percentage of the force of 0%. A high score of 20 is in the solution. Dissolve the anticoagulant material to form a milky, slurry, or still. Follow the method described below or 2 or 3 to obtain a blood compatible material

 Extra-organic materials mixed with polymers and anticoagulant materials in milky, pasty, or interstitial materials

 2 Remove the blood-compatible material that is high in the solution, the anti-coagulant material milky, paste-like, or mixed with the rest material or the implanted organ material.

 3 Fill the polymer solution, the milky, pasty or anti-coagulant material and the mixed extra-rest material or the organ material implanted within the rest, that is, the blood-compatible material is 20% of the amount of the polymer material Or 20 to 2 or 3 anticoagulant material is the original amount of polymer material 0.00 0

Civil polymer material strength, all copolymerization, inner copolymerization also polymer, ethylene carbonic acid, carbonic acid, propylene, aromatic, 3 butyric acid and 3 copolymerization, Lactic acid, internal lactic acid copolymer, butyric acid, ethoxyl, ethylene oxide, ethylene vinyl acetate copolymer, ethene, polyvinyl chloride, polypropylene, propylene, carbonic acid, ethene, ethene acetate, ethene acetate, ethene, polyvinyl chloride, Dimethicone copolymerization, copolymerization of living and polymerization, ethylene, one or a mixture of ethylene, anticoagulant biomaterials, anticoagulant, epinephrine, thiophene, anti-inflammatory, anti-inflammatory, it, basified sulfate, Water, inhibitory or oxygen-inhibiting sucrose, d-rotation, Na NHH, (NH 0, Na NH, or Na (NH) 0 mixture as described in the filling force apatite calcium phosphate. There are 4 dioxins,,, dioxins

 , Hydrogen, dimethyl, or dimethyl or a mixture of or more.

 Forced water, physiological water, phosphoric acid, solution or water. The mixture is made of thin films,,,,, or blood-soluble extracorporeal materials or organ materials implanted within the rest of the time by the rapid prototyping or method of making the material uniform or.

 Remove with water or aqueous solution.

 Anticoagulant material: Dissolve the anticoagulant material with the following method, add the anti-coagulant material to the dissolved anticoagulant material solution by the amount of 0.0.

 The N N carbon carbon

 2 N sulfonic acid system,, poly, or gini.

The inner or outer surface of the shape-like or arhat-like blood-compatible material is composed of cells, thousands of cells, cells, cells, islet cells or cardiomyocytes, or cells and self-coagulated blood are mixed, and the syringe is injected into the organ materials formed by the pipeline system . Inject or inject the cells on the surface or inside of the material, cytophobia factor or serum. The blood-compatible biomaterials prepared by the above methods are also covered by this book.

 The best way

 The percentage content in the following is as the percentage of the special uniform force.

 The method in the following is a special uniform force method.

 This is a blood-compatible biomaterial. The material is composed of materials and anticoagulant biomaterials that are dissolved and mixed into or filled with,,,, rapid prototyping or Zhufa made of thin films, hollow hollow,, shape or Axius for external use of blood-compatible biomaterials or implantation The organ material of the group, wherein the percentage of anticoagulant biomaterial polymer material is 0.000 or the percentage of filling is higher than the material percentage 0 20. The polymer material

 Po yu e hane, internal copolymerization L LPE namely PU, 3 butyric acid and 3 copolymerization (PHBHHx), ethylene carbonate, lactic acid (PLL), internal (PL), lactic acid copolymerization (PL), butyric acid (PHB)

 (PHB),, some copolymers,, ethylene oxide, ethylene, vinyl acetate copolymer,,, polyvinyl chloride, ethylene, polypropylene, propylene, carbonic acid,,,, or their derivatives acetic acid, polyvinyl chloride,

 (Po ye e e ha e ea) (Po y e a e ea) Possession and polymerization copolymerization, ethylene, living and polymerization copolymerization, po yd e hy s oxane

(po ye he e ha eu ea) one or a mixture of copolymers of anticoagulant biomaterials, anticoagulant, epinephrine,,,,, a, anti-inflammatory sulfation, water, inhibition or oxygen inhibition . The said mixture of sucrose, dextrose, Na NHH (NH) Na NHH or Na (NH4) The filled apatite, calcium phosphate

 Feast of blood compatibility

 , Each with different blood compatibility

The P LPE with an average molecular weight of 0 is U According to the article, the method of P LPE PU material research in 2003 is to prepare 0 L of 4 dioxins to form 9 P LPE solutions. 0 in the beaker. Add nL to dissolve the solution in water. The upper P LPE solution was mixed according to the ratio of Huby 000, fully and evenly divided into the mixture.

 High scores on a multi-media support to the mixed Pioneer media quickly to form a consistent consistency will be 0. In the aqueous solution, there are many unformed surfaces.

 Blood incompatibility

 Each step can be used as a biological material for dialysis, plasma and bio-intracellular support. It can also be used as an endothelial cell, cell or cell on the upper and lower surfaces of the organ, which can be used as a blood vessel, etc. Below is the effect of blood vessels

 Anesthetize 0 ordinary dogs with Barbie anesthetize the abdominal cavity, keep the vein all the way to a gap of 3 m, and follow the steps of 8 m in diameter.

 6 0 Stitch the outer side of the gap so as not to sew the skin. Mu injected the powder of 40 in L chloride injection into the abdomen. The endothelial cells of 10 dogs, etc. are full of gaps and you gradually become venous blood vessels completely.

 2 The effects and effects of blood compatibility tubes

 , Each of blood compatibility tubes

 Divide 29 evenly-weighted poly Jinan Materials Co., Ltd. in a 10 L 4 oxygen cup with a 29 m poly solution. In the beaker, add L. acetic acid to dissolve the solution at a ratio of 0.00, then add 0. 0 by weight. N N Erlin carbon by carbon

 E, and NH 2 N sulfonic acid E was mixed according to the ratio of 4 2 and then the solution was fully uniform and highly divided into the mixed solution.

Mixing a polymer solution on one to form a tube will result in a large percentage content of 0. Soak in water Million removal system, blood compatibility.

 2. Compatibility tube

 Step 1 The compatibility of each can be used for each of them. It can also be combined with endothelial cells, cells and functions on its upper and lower surfaces.

 , Blood vessels, etc. Below of

 Its effect

 0 rabbits were anaesthetized by Barbie anesthesia from the inside of the thigh. The 1.2 C gap will be straightened to the step 2 to make each blood compatible tube. The two ends of the gap are sutured and the outer skin is sutured. Mu injects the powder of the 40-force parking space into the chlorinated injection, and then injects it into the thigh muscles. 0 rabbits damaged

 The gap material is gradually completed in half a year.

 3 Blood compatibility materials and their effects

 , Each of the blood-compatible materials

 9 Average molecular weight 0 3 Copolymerization of butyric acid and 3 acids (PHBHHx) a ou L any B o ech o pany a gdo gha according to literature Z yang P u he. E abo ceg ee go P od co O Copo yes es Co ssg O 3 hyd oxyb yaead 3 hyd oxyhexa oa e by eco b nan ae o aonas

hyd oph aha bo g phb a d phbB ge es. ac o o B osc

The method in 2004 4 255 26 was prepared by refluxing in 00 mL at 6 C. Then, the PHBHHx solution with an average molecular weight of 0 was 500 g 2 n to remove insoluble particles. Add PHBHHx of 93 to it. The PHBHHx is evenly divided into a poly- 9 of 0 to a force of 8 in a polymer solution of 9 m in chloroform. Then, 0 L of polymer solution, 5 L of 9 aqueous solution of blood compatible polymers are mixed. Pour the solution onto the plate 3 of material.

 Blood compatibility

As a result, the various materials can be used in the cardiovascular system. Can also be used for blood vessels Anastomotic or vascular stent. The following is based on the effect of the atrium on the safety of 0 rabbits in New West University, respectively.

 Suture the skin. Mu injected 40 units of powder into L chloride and injected it into the abdomen. It shows that the atrium of 0 rabbits is completely material.

 4 Each and effect of blood-compatible film materials

 , Each of the blood-compatible film materials

 According to the literature, the research on P LPE PU materials is based on the copolymerization (P LPE) with an average molecular weight of 20 and 29 forces.

The method described in 2003 prepared 0.29 lactic acid copolymer (PL Biotechnology Co., Ltd.), which was evenly divided into 0. The weight of Na and the weight of 20 are the high scores used in the materials P LPE and PL. The weight is 0.5 L. The solution is added to the weight of P LPE PL 0. The aqueous solution of Yi 3 was poured on the upper film of ethylene.

 Soak the obtained film in the aqueous solution to remove and transfer the film material.

 2. Blood compatible film materials

 Step The nickel thin film material is used for atrium.

0 New Zealand white rabbits were Barbie anesthetized and her skin was removed. Or, the bone marrow cells in the bone marrow are divided into a large number of the above-mentioned blood-compatible materials. The rabbits were anesthetized with a barium anesthesia with a diameter of one atrium, and the material with a diameter of 4 that was combined with the self-resting bone marrow cells was sutured with 80 ° to the rabbit at the atrial gap so as not to suture the outer skin. Mu injected the powder of 40 into the abdomen during L chloride injection. 12 10 rabbits on the complete material. 2 step

of .

 0 rabbits of New Zealand University were anesthetized with Barbie anesthetized abdominal cavity, the gap of the central nerve 3 was cut, and the single-sided copper-nickel thin film material of bone marrow cells was sutured with 80 sutures and the outer skin was sutured outside the gap. Mu injected the powder of 40 sheep in mL of chlorinated injection and then injected it into the abdomen. The central god of 0 rabbits is completely garden material.

 5 Hemocompatibility scores high for each stent material and effects Hemocompatibility scores high for each stent material

 Polylactic acid (PLL Biotechnology Co., Ltd.) with an average molecular weight of 20 force and polylactic acid (PLL Biotechnology Co., Ltd.) with an average molecular weight of 30 force and a force of 30 force is added to the material and The PLL weight is 0 in L. The neutralization in water is the polymer material used and the PLL weight 0 in Na is fully stirred to remove the high score in the material mixing. Mix high scores with materials and rest on ethylene. Hemocompatibility is high on films. Ten thousand principles through rapid prototyping on the high scores on the film. Each high score for the stent material.

 Blood compatibility A high score for stent material

On the scaffold material, the rabbit cardiomyocytes were combined with 0 neo-Xinda rabbits from the skin, and the outer skin of each rabbit was anesthetized to remove the fat and suture. A large amount of nickel fat cells in the fat group will convert cardiomyocytes. 0. L-digested cardiomyocytes are dissolved in L PB solution and then on the blood-compatible polymer film. The above 0 rabbits were anesthetized under Barbie anesthesia, respectively, and the one with myocardial cells was inserted in the atrium opening. Mu injected 20 powder into the abdomen in L sodium chloride injection. Wood 2 0 rabbits in the atrium good material 2 0 rabbits were anesthetized in New Zealand University Place the atrium all the way to the notch. The above method straight to 4 m is combined with the high score of cardiomyocytes in the membrane 80.

 Suture the skin. Mu will inject 40 units of powder into L sodium chloride injection and then abdomen into the stomach. Sixty October 0 rabbit's atrium completely

 Materials.

 6 Materials and effects of blood compatible stent system

 1. The materials of the blood compatible stent system

 Polyethylene carbonate, which is evenly divided into the quantity 0, and Sanan Chemical Co., Ltd. is equally divided into the quantity 10, the strength of the polyethylene PET Chemical Co., Ltd., the ratio of ethylene carbonate to ethylene, and the ratio of 2 to 4 dioxins. Ethylene carbonate and ethene weight adrenaline phosphate dissolve and the high molecular weight ethene carbonate and ethene weight 0 NHH in the mixed solution. The rapid prototyping principle is based on the principle of 10,000, and it will be highly divided into the multi-branch piping and support system inside the mixed solution at low temperature. Use in the following method to inject the big one to get an artificial break. Inject into the cell wall to leave a large polymer solution under vacuum.

 2. Material of blood compatible stent system

 Wu'an will be 0 big each

 She took out part of her skin. The solution method is to divide the bone marrow cells in the bone marrow into a large amount, and then recombine the cells in each of the above to obtain artificial anterior breaks. Anesthetize 0 pieces of Barbie under one piece, and close the gap of each suture phase so as not to suture the outer skin. Mu put 40 units of the powder in L sodium chloride injection, and then inject it into the abdomen. There are 120 large, medium and small materials.

 Blood compatibility characteristics or stent materials and their effects

 , Blood compatibility or stent material

The Polyvinyl Chloride Products Co., Ltd., which is evenly divided into Measure 0, and the Polyvinyl Chloride, which is evenly divided into Measure 0, mix with the polymer of polyvinyl chloride 59 in oxygen at a ratio of 59 to 10 in the Jiangxi Institute of Chemical Industry in the above solutions. Is added to the polymer used (NH) 0 of 10 by weight of the material polyvinyl chloride, and a polymer mixed solution containing an aqueous solution and an aqueous solution which are high in the weight of the material polyvinyl chloride. Each material of polymer mixed solution with a thickness of 0.3 on a glass rod.

 2. Blood compatibility or stent material

 The above tube materials can be used for the cardiovascular system or. It is also possible to make an internal stent rounded to the anastomosis or blood vessel on the wall of the stent. Below

 Its effect

 0 rabbits were anaesthetized on the inner thighs of the New Zealand University from Barbie. A 2 cm gap is used to sew the tube material straight to 2 m with sutures and sew the ends to the west side of the tube. Mu took the powder of 40 in L chloride injection, and then injected it into the thigh muscle. One year, 0 rabbits, god, notch, material

 Completely.

 8 Each and every effect of blood compatibility

 , Each of blood compatibility

 The polymer solution of polypropylene divided evenly by the ratio of 1: 1 to the polypropylene in MF. Polypropylene is added to the polymer solution

 M is dissolved in water and mixed with NHH particles which are polypropylene 1 with high content. The high score will be the blood compatibility at 60C under the flow of ethylene first.

 Blood compatibility

 Respectively inside and outside of the above blood compatibility or inside the tube, outer endothelial cells, smooth cells, cells enhance anticoagulation and strength in the blood tube, its effect is better than blood compatibility.

 Barbie anesthetizes her skin and removes the fat from it. The fat in the solution is tens of thousands of fat, and the fat in the cell will be in the outermost and smooth.

In the same, the blood of the innermost cell is compatible Material. 0 large gaps of Barbie anesthetized atrium were directly sutured to the upper-conjunct large endothelial cells, cells, and polymer membranes of 4 to the large atrium gap to prevent the outer skin from being sutured. Mu injected the powder of the 40-force parking space into the stomach with mL sodium chloride injection.

 10 large atria with complete blood compatibility materials.

 9 Blood compatibility and effects

 1. Blood compatibility

 Will be evenly divided into 10 Polypropylene Plastics Co., Ltd.

 City Trading Co., Ltd. 1 in chloroform, 29 Qingdao Biological Engineering Co., Ltd. in a mixed solution of chloroethyl and chloroethyl chloride and chloroethyl ratio of 3.6 6.5, respectively, a polymer solution and then the solution was mixed and added A mixed aqueous solution with a percent content of force has a high score for mixing. The high score is the blood compatibility obtained by mixing 5 first on ethylene or on the periphery of the plastic etc. on the outside and then on the solution.

 Blood compatibility

 The blood compatibility of the above can be used as a hemostatic material or material. Below with its effect

0 Will be 0 big 5D separately 20 anesthetize scrape the back blade to form 3X3. Put the blood compatibility of step 1 together. Mu inject 20% of the powder in mL of sodium chloride injection and then inject it into the back. 60 large materials.

 0 Blood compatibility materials and their effects

 1. Blood compatibility materials

 The poly Shanghai Kehua Chemical Co., Ltd. and Beijing Yongtai Welfare Chemicals Co., Ltd. with an average molecular weight of 30 and 99 are all used in a weight ratio of 1 to 14 in a dioxin cup and mixed. The polymer material used and the amount of 0

0 The polymer materials and materials used by South Co., Ltd. The amount of gn apatite, the high-weight pre-material used and the reverse amount of gn carbon ED 2 acetic acid solution are added to the

 And mixed solution.

 Pour the solution into the container with 2 C to obtain 3 m of material. A large number of blisters to obtain blood-compatible materials.

 2. Blood compatibility, regenerative absorbability. 0. Form the protein BMP 2 in the acetic acid solution. Place the blood compatibility materials in the step in the solution and soak for 6 hours. Adsorb the protein forming PHBHHx 4 dioxin solution in room 1 to obtain the material. Among them PHBHHx 0. m. The soft-connected material is dense and has good cell function or connects more than a stumbling cell. Below is the material and its effect

 0 rabbits from New West University will be anesthetized separately from Barbie. 2 Cm, move 1 straight towards the 3 mm phase

 Material implantation Suture the skin. Mu injected the powder of 40 into the leg with L injection and then injected it into the rest. Wood 2 Newly generated materials for 10 rabbits.

 11 Compatibility of materials and their effects

 , Each of the blood-compatible materials

 Add Poly Nanjing Engineering Plastics Co., Ltd. and Thousand Tianjin with the average molecular weight of 98.2 purity to the chemical industry 2 and add it to the mixed solution with dimethyl n-neutralizer. Then add it to 0 and 0.

 d azo e stir well to mix the solution pour the solution into glassware

 Under 4C, blood compatible materials are obtained. The materials thus obtained can be directly used for manual labor and support systems.

 2. Blood compatibility materials

To effect 0 large babies were separately anesthetized in the abdominal cavity to produce local ten thousand cells. Connect the blood-compatible materials of step 1 to the extracellular support system and the non-endovascular support system to increase the support system 5.

 2 Blood compatibility materials and their effects

 , Compatible materials

 The average molecular weight is 20 force, and the average molecular weight is 8 force.

Medium to high score in solution. Polymer materials, You and You

 The copolymerization of the same amount of apatite and acetic acid is a polymer material with an amount of 0.

 Put the formed mixture in a container and pour the mixture on it, not the material at 2 C to the bottom. Put the material into the content of 0.5. Formed from the BMP 7 physiological monitoring water to form a protein and then unite 0 The solution is to obtain blood compatible materials.

 2. Blood compatibility materials

 The materials on the above can be directly on the materials or on the regenerative absorbability. Next, the effect of tooth regeneration

 Pull out one of the 0 big barbie anesthesias, and implant the materials around the muscles in the step. Wood 6

 0 large blood-compatible materials are not, and 0 large ones form new ones.

 3 Blood compatibility and its effects

 , Each of the blood compatibility stents

 A new product with an average molecular weight of 00, Acetic Acid Materials Trading Co., Ltd. 209, was given a higher score than 0 to 0 in the mixed solution.

Add polymer materials and acetic acid to the above solutions 0 Na N The mixture of the two is stronger than the particles (towards less than pm). It is higher in the material and acetic acid.

0. The sulfation of the base is stirred and mixed evenly.

 Mix the upper part for rapid prototyping 0. Tube material. Holes, cuts, etc. are made on the wall of the material.

 Soak the obtained tube holder in water 2 to remove the blood-compatible holder.

 2. Blood compatibility

 The above tube materials can be directly connected to the esophagus system, tube system, urinary tract system, tract system, fallopian tube system and neurological system. The following is the effect of the esophagus system

 Bare anesthesia to expose 0 esophagus, cut 2c and close the upper material. Wooden 80 new large esophagus materials, summer intact materials are not.

 14 Blood compatibility and its effects

 , Each of the blood compatibility stents

 Polycarbonate with an average molecular weight of 0 is from Sanan Chemical Co., Ltd. (PL from Yixi Jinfeng Chemical Co., Ltd.) 9 Weight ratio 0 1 is added to the middle of the dimethyl and then added is higher in the material carbon and internal content Water stirring. The solution is supported by 0 copper to form a bracket. Put the above brackets into the mold

 Since Beijing Kang Biological Engineering [solution Yu 0. M carbon

 E aqueous solution then withdraws the support to obtain a blood compatible organ stent.

 2. Blood compatibility

The materials obtained from the above blood-compatible scaffolds are mixed with epidermal growth factor and endothelial cell protein coagulation on the inner surface of the scaffolds, and can be used for organs such as,, and. The following is based on the effect of organs 0 big Barbie anesthetized her skin to remove the fat and suture it. A large number of fat cells in fat divided into endothelial cells. 0. 0.1 L in 0.1 mL digestion. The endothelial cells were born in EF ga 5 U pB solution and 10 protein gma U mixed evenly or placed in 5 L 00 UL coagulation PB solution to solidify on the inner surface of the stent. 0 large barbie anesthesias were used to connect endothelial cells, endothelial cell growth factor and protein-containing scaffolds to small blood vessels and the outer skin was closed. Mu injected 20 of the powder in mL of sodium chloride injection and then injected it into the abdomen. 80 large blood vessels formed

 Proofreading materials.

 5 Compatibility of liver anterior break and its effect

 , Blood compatible liver

 Ethylene Vinyl Acetate Copolymer, which is divided equally in the capital of 20, is propelled by Sanyou Co., Ltd., Beijing Baicao Technology Muyou Co., Ltd. 9 to 9%, and is mixed with ethylene vinyl acetate copolymer propylene. Add the high content of the material used in the solution ethylene vinyl acetate copolymer propylene 0 NH 0 force, and the high content of the material ethylene vinyl acetate copolymer propylene 0.00

20 Restricted to 0. L.1 phosphoric acid.

 Form a bracket and put it into the corresponding mold. Pour the upper solution to get one or three racks.

0 New Zealand white rabbits were Barbie anesthetized her skin, and the fat was taken out and sutured. A large number of ~ 5 cells in the fat group of fat will endothelial cells. 0. L-digested endothelial cells were dissolved in mL PB solution and then placed in the stent. The upper 0 rabbits were respectively anesthetized with Babi anesthetized, and the stents incorporating their endothelial cells were connected to small blood vessels, and the skin was sutured. Mu injects 20 units of powder into L-sodium chloride injection and then into the abdomen. None of the 10 12 rabbits had vascular forming materials. 2. The blood compatibility of the liver

 Barbie anesthetize her skin, remove the fat and sew it. A large number of fat cells in the fat group will endothelial cells. 0. Million endothelial cells L 0. Endothelial cells produced in E F g a U PB solution and L 0 protein g a U are mixed evenly, or they can be solidified in 5 L 00 U L coagulation PB solution on the inner surface of the stent. Anesthetize 0 large barbie anesthesia. Connect the endothelial cells, endothelial cell production and protein-mediated scaffolds to the small blood vessels to join the outer skin. Mu inject 20% of the powder in mL of sodium chloride injection and then abdomen into the stomach. There are no materials for the 20 large blood vessel forming cells.

 6 Hemocompatibility A stent material and its effect, blood compatibility Stent material

 Add a polymer material that is evenly divided into the 20 strengths of Ethylene Surface Wood Co., Ltd. 29 5 1 to chloroform

 A mixed solution of vinyl. Adding NHH with a high content of 0 in the amount of ethylene used in the solution is more than 4 in the amount of ethylene in the material and the oxygen content of the polymer material 1 is evenly mixed. Polymer mixing.

 Divide the above high scores into the dense and dense Yuan Yuan 2c X2cm of the mixed wood, put it into a cylindrical mold, add the solution of each above 2 C, and soak in water to obtain the Yuan Yuan stent material.

 2. Hemocompatibility of thousands of scaffold materials

Barbie anesthetizes her skin with 0 big D, removes the fat and sews it. A large number of fat cells in fat cells will be divided into cells. Digest 0 L into 10,000. The solution of the epidermal growth factor EF ga U PB of L 0 is mixed evenly, or on the inner surface of the stent. 0 big Barbie anesthetized the scaffold material with metablasts and epidermal cells on the back of his body. Mu injected 20 powders into the abdomen during L chloride injection. None of the 60 large skin materials of wood.

 7 Each of blood compatibility and its effect

 1. Compatibility

 The polybutyric acid (PHB), which is evenly distributed to the metropolis 20, is composed of copolymers, copolymers, and poly products. South Products Co., Ltd. 29 The ratio of 2 to 1 is higher than 1 for the mixing of materials. Adding in the solution is a high score in the material PHB and by, living and polymerization

 The copolymerized anticoagulant is NH 0 which is higher than the material 0, and the force added is 0% of PHB. The Gini ge p aqueous solution is added in the form of a well-mixed blood-compatible polymer mixed solution. Each of the above-mentioned blood-compatible polymer mixed solutions was prepared by Zhufa method, and each element material was immersed in water.

 2. Each of the blood compatibility

 Anesthetize 0 animals, 20, anesthetize her skin, remove the fat, and sew it. Fat cells in fat are divided into a large number of cells. 0. L digests 10,000 adult cells. The epidermal cells of L 0.1 are produced in E F gma U PB solution and mixed evenly, or on the inner surface of the stent. Anesthetize the upper and the lower 20 respectively on its back and suture the Yuan-A scaffold material with epithelial cells and epidermal cells. Mu inject 20% of the powder in mL of chlorinated injection and then inject it into the abdomen. Wood 2

 10 large skin materials.

 8 Blood compatibility materials and their effects, blood compatibility materials

Will 9 PHB) (according to the text osh e N ao noue. Cuaaso O aea C ys asna so o phous Copo ye Po y (3 hyd oxyb yae co 3 hyd oxyva eae). ac oo ecu es. 200 26) 953 8960 made in the method) in the 9 L PHB solution and then add 2 aqueous solutions to mix. One portion is added with an amount of 0 for the right-handed molecular weight of 4000 and the other portion is not right-handed. A polymer solution that is right-handed on a piece of glass and then does not contain a right-handed polymer solution with a high score of right-handedness outside the solution forms a material that holds the material 0.1

 This material can be used as a substitute for nickel, and can also be used on the upper and lower surfaces of endothelial cells, vascular cells, and adult cells. Below is the physiotherapy effect of esophagus

 Anesthetize her 0 skins and 20 skins, remove the fat and sew it. A large number of thousands of cells in the fat group will be divided into endothelial cells, almost cells and thousands of cells. 0. The endothelial cells, smooth cells and thousands of cells of L-digestion are mixed in the L pB solution or on the inner surface of the material. Anesthetize each of the above 20, cut the esophagus 6 and sew each tube material to the top. Wood Inject powder of 20 knives in L sodium chloride and inject it into the container. Wooden 24 large esophagus material. This use

The obvious method of dissolving and dissolving polymer materials with high mechanical properties and anticoagulant materials can uniformly fix the anticoagulant materials in the high score in the material. Conventional methods are used for external use or implantation The organ material overcomes the shortcomings that the effect of the wood is only absorbed on the surface, or the anticoagulant effect of grafting is unclear or very short. The proven blood-compatible materials do not have good anticoagulant properties and delay the anticoagulant orders. They also have good anticoagulant and biological properties to meet the needs of tissue materials for external or internal implant Compatibility, high strength and toughness, and many other performance requirements. The material safety method and the materials used showed that within a short period of time, such as within 3 m 2 3c of rabbits and veins. Internal discomforts that cause inflammation, thousands of packages, thrombosis, hemangioma, calcification and other undesirable effects are promising and multifunctional biomaterials.

Claims

Requirements 1. The method of each blood-compatible material is to convert the polymer material with a molecular weight of 0 to a percentage of 0. gn's high score is  Dissolve the anticoagulant material to form a milky, syrupy, or still. Follow steps 1 or 2 or 3 to obtain a blood-compatible material  Extracorporeal materials mixed with polymer solutions and anticoagulant materials in milky, pasty, or interstitial groups  2 Removal of high-resolution materials, milky, syrupy or anti-coagulant materials and mixed extra-orthopedic materials or implanted organ materials to obtain blood compatible materials is 9 or 20 the following  3 Highly categorize the anti-coagulant solution milky, syrupy or rest materials and fill the mixed rest materials or the tissue materials implanted inside the rest, that is, the blood compatible materials. The filling is the amount of polymer materials or 9 following  001 0% The anticoagulant material described in 1 or 2 or 3 is a polymer material  2 The method of requirement 1 is characterized by a high score in material strength, some copolymerization, internal copolymerization, ethylene carbonate, carbonic acid, propylene, aromatic, 4 butyric acid and _ copolymerization, lactic acid, internal, lactic acid copolymerization, 3 butyric acid, ,,, Ethylene oxide, vinyl acetate copolymerization,,, polyvinyl chloride, polypropylene, propylene, carbonic acid,,, or their derivatives acetic acid,, polyvinyl chloride, dimethyl copolymerization, copolymerization, and copolymerization, One or a mixture of ethylene, the anticoagulant biomaterial, coagulation, epinephrine,,,,, , It, basified sulfation, water, inhibition or oxygen inhibition of sucrose, dextrose, Na NHH, H), N NL or Na (NH) 0 mixture of filling apatite, calcium phosphate.  The method required by R is characterized by the presence of 4 dioxins, blazes, dioxins, hydrogen, chloroform, dimethyl or dimethyl and a combination of the above.  4. The required method is characterized by the physiologic monitoring water, phosphoric acid, solution or water. 1 R. The required method is characterized in that the mixture is made of a thin film, a hollow, a, or a blood-compatible restorative material or an organ material implanted within the rest of the material by using the method, the method, the rapid method, or the method.  6 The required method is characterized in that it is removed by immersion in water or an aqueous solution.  7. The required method is characterized in that the anticoagulant material is as follows: she will dissolve the anticoagulant material in the dissolved anticoagulant material and add the amount of anticoagulant material. N gn means carbon, carbon 2 N sulfonic acid system,, poly or gin.  8. The method of claim 5 is characterized by a liquid or liquid compatible material whose inner and outer surfaces are combined with endothelial cells, cells, cells, cells, islets or cardiomyocytes or the cells, thousands  Coagulation and mixing syringes are injected into the piping system to form materials in various organs.  9. The method according to claim 8, which is characterized in that the cell is injected with or on the surface of or inside the material, or the serum is combined.  1 Requires any of the methods in any of the nine methods to make blood-compatible biomaterials.