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WO2007063384A3 - Pyrimidine derivatives for the treatment of abnormal cell growth - Google Patents

Pyrimidine derivatives for the treatment of abnormal cell growth Download PDF

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Publication number
WO2007063384A3
WO2007063384A3 PCT/IB2006/003349 IB2006003349W WO2007063384A3 WO 2007063384 A3 WO2007063384 A3 WO 2007063384A3 IB 2006003349 W IB2006003349 W IB 2006003349W WO 2007063384 A3 WO2007063384 A3 WO 2007063384A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell growth
abnormal cell
treatment
pyrimidine derivatives
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/003349
Other languages
French (fr)
Other versions
WO2007063384A2 (en
Inventor
John Charles Kath
Michael Joseph Luzzio
Susan Deborah Lagreca
Nandini Chaturbhai Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Priority to CA2632149A priority Critical patent/CA2632149C/en
Priority to US12/095,716 priority patent/US8722884B2/en
Priority to EP06809250A priority patent/EP1966192B1/en
Publication of WO2007063384A2 publication Critical patent/WO2007063384A2/en
Publication of WO2007063384A3 publication Critical patent/WO2007063384A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to salts, solvates and substoichiometric solvates of N- [3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4- pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide. The invention also provides pharmaceutical compositions comprising such complexes, as well as methods of treating abnormal cell growth by administering the complexes of the invention.
PCT/IB2006/003349 2005-12-01 2006-11-20 Pyrimidine derivatives for the treatment of abnormal cell growth Ceased WO2007063384A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA2632149A CA2632149C (en) 2005-12-01 2006-11-20 Pyrimidine derivatives for the treatment of abnormal cell growth
US12/095,716 US8722884B2 (en) 2005-12-01 2006-11-20 Pyrimidine derivatives for the treatment of abnormal cell growth
EP06809250A EP1966192B1 (en) 2005-12-01 2006-11-20 Pyrimidine derivatives for the treatment of abnormal cell growth

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74125205P 2005-12-01 2005-12-01
US60/741,252 2005-12-01

Publications (2)

Publication Number Publication Date
WO2007063384A2 WO2007063384A2 (en) 2007-06-07
WO2007063384A3 true WO2007063384A3 (en) 2007-10-04

Family

ID=38092618

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003349 Ceased WO2007063384A2 (en) 2005-12-01 2006-11-20 Pyrimidine derivatives for the treatment of abnormal cell growth

Country Status (7)

Country Link
US (1) US8722884B2 (en)
EP (1) EP1966192B1 (en)
JP (2) JP5134234B2 (en)
AR (1) AR057202A1 (en)
CA (1) CA2632149C (en)
TW (1) TWI374880B (en)
WO (1) WO2007063384A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2684447C (en) 2007-04-18 2012-01-24 Pfizer Products Inc. Sulfonyl amide derivatives for the treatment of abnormal cell growth
US8569298B2 (en) * 2008-06-17 2013-10-29 Astrazeneca Ab Pyridine compounds
EP2464633A1 (en) 2009-08-14 2012-06-20 Boehringer Ingelheim International GmbH Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
US20120244141A1 (en) 2010-09-28 2012-09-27 Boehringer Ingelheim International Gmbh Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
CN103534240B (en) 2011-02-17 2015-12-09 癌症疗法Crc私人有限公司 Selectivity Fak inhibitor
ES2691673T3 (en) 2011-02-17 2018-11-28 Cancer Therapeutics Crc Pty Limited Fak inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056807A1 (en) * 2002-12-20 2004-07-08 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
US20050256145A1 (en) * 2002-12-20 2005-11-17 Pfizer Inc Pyrimidine derivatives for the treatment of abnormal cell growth
US20050256125A1 (en) * 2004-05-14 2005-11-17 Pfizer Inc. Pyrimidine derivatives for the treatment of abnormal cell growth

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5924990B2 (en) * 1979-11-21 1984-06-13 協和醗酵工業株式会社 Novel piperidine derivatives
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
DK0999838T3 (en) * 1997-07-29 2002-07-08 Upjohn Co Self-emulsifying formulation for lipophilic compounds
CH689805A8 (en) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Paroxetine methanesulfonate, process for its preparation and pharmaceutical compositions containing it.
JP2001261654A (en) * 2000-03-21 2001-09-26 Mitsui Chemicals Inc Quinoline derivative and intranuclear receptor agonist containing the same as active ingredient
EP1441733A1 (en) * 2001-11-02 2004-08-04 Shire Biochem Inc. Pharmaceutical compositions for the treatment of leukemia comprising dioxolane nucleosides analogs
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
EP1758887A1 (en) 2004-05-14 2007-03-07 Pfizer Products Incorporated Pyrimidine derivatives for the treatment of abnormal cell growth
MXPA06011658A (en) 2004-05-14 2006-12-14 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056807A1 (en) * 2002-12-20 2004-07-08 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
US20050256145A1 (en) * 2002-12-20 2005-11-17 Pfizer Inc Pyrimidine derivatives for the treatment of abnormal cell growth
US20050256125A1 (en) * 2004-05-14 2005-11-17 Pfizer Inc. Pyrimidine derivatives for the treatment of abnormal cell growth

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BASTIN R J ET AL: "Salt Selection and Optimisation for Pharmaceutical New Chemical Entities", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, CAMBRIDGE, GB, vol. 4, no. 5, 2000, pages 427 - 435, XP002228592 *
DESROSIERS P ET AL: "High-throughput screening techniques for pre-formulation: SAlt selection and polymorh studies", ACTA CRYSTALLOGRAPHICA, MUNKSGAARD, COPENHAGEN, DK, vol. A58 (SUPPLEMENT), C9, 2002, pages 1, XP002978369, ISSN: 0365-110X *

Also Published As

Publication number Publication date
EP1966192B1 (en) 2012-10-17
JP5134234B2 (en) 2013-01-30
JP2012255038A (en) 2012-12-27
US8722884B2 (en) 2014-05-13
AR057202A1 (en) 2007-11-21
US20110033441A1 (en) 2011-02-10
EP1966192A2 (en) 2008-09-10
CA2632149C (en) 2011-11-15
WO2007063384A2 (en) 2007-06-07
CA2632149A1 (en) 2007-06-07
JP2007153892A (en) 2007-06-21
TW200730507A (en) 2007-08-16
TWI374880B (en) 2012-10-21

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