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WO2007061554A3 - Dosage de derives de 4-aminopyridine pour le traitement des lesions du systeme nerveux central - Google Patents

Dosage de derives de 4-aminopyridine pour le traitement des lesions du systeme nerveux central Download PDF

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Publication number
WO2007061554A3
WO2007061554A3 PCT/US2006/041302 US2006041302W WO2007061554A3 WO 2007061554 A3 WO2007061554 A3 WO 2007061554A3 US 2006041302 W US2006041302 W US 2006041302W WO 2007061554 A3 WO2007061554 A3 WO 2007061554A3
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WO
WIPO (PCT)
Prior art keywords
compounds
treatment
nerve tissue
compositions
dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/041302
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English (en)
Other versions
WO2007061554A2 (fr
Inventor
Ryi Shi
Richard B Borgens
Daniel T Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
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Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of WO2007061554A2 publication Critical patent/WO2007061554A2/fr
Publication of WO2007061554A3 publication Critical patent/WO2007061554A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouvelles pyridines, des compositions pharmaceutiques comprenant ces pyridines et l'utilisation de ces compositions dans le traitement des lésions du tissu nerveux mammifère, y compris mais non de façon limitative, une lésion de la moelle épinière. Dans un mode de réalisation, les composés, les compositions et les méthodes selon l'invention traitent une lésion du tissu nerveux mammifère en rétablissant le potentiel d'action ou la conduction nerveuse à travers une lésion du tissu nerveux. De manière significative, l'application in vivo de composés selon l'invention établit, sur la base d'un test de potentiel évoqué somesthésique, que les composés produisent à de faibles concentrations des effets plus durables qu'un traitement comparable à l'aide de l'agent 4-aminopyridine (4 AP) connu.
PCT/US2006/041302 2005-10-21 2006-10-23 Dosage de derives de 4-aminopyridine pour le traitement des lesions du systeme nerveux central Ceased WO2007061554A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72896005P 2005-10-21 2005-10-21
US60/728,960 2005-10-21

Publications (2)

Publication Number Publication Date
WO2007061554A2 WO2007061554A2 (fr) 2007-05-31
WO2007061554A3 true WO2007061554A3 (fr) 2007-10-11

Family

ID=38067700

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/041302 Ceased WO2007061554A2 (fr) 2005-10-21 2006-10-23 Dosage de derives de 4-aminopyridine pour le traitement des lesions du systeme nerveux central

Country Status (1)

Country Link
WO (1) WO2007061554A2 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9533984B2 (en) 2013-04-19 2017-01-03 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
US9533954B2 (en) 2010-12-22 2017-01-03 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA125503C2 (uk) 2012-06-13 2022-04-13 Інсайт Холдинґс Корпорейшн Заміщені трициклічні сполуки як інгібітори fgfr
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
UA121669C2 (uk) 2015-02-20 2020-07-10 Інсайт Корпорейшн Біциклічні гетероцикли як інгібітори fgfr
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CN112566912A (zh) 2018-05-04 2021-03-26 因赛特公司 Fgfr抑制剂的盐
SI3788047T1 (sl) 2018-05-04 2024-11-29 Incyte Corporation Trdne oblike inhibitorja fgfr in postopki priprave le-teh
WO2020185532A1 (fr) 2019-03-08 2020-09-17 Incyte Corporation Méthodes de traitement du cancer au moyen d'un inhibiteur de fgfr
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP4045151A1 (fr) 2019-10-14 2022-08-24 Incyte Corporation Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr
CA3163875A1 (fr) 2019-12-04 2021-06-10 Incyte Corporation Heterocycles tricycliques en tant qu'inhibiteurs de fgfr
EP4069695A1 (fr) 2019-12-04 2022-10-12 Incyte Corporation Dérivés d'un inhibiteur de fgfr
WO2021146424A1 (fr) 2020-01-15 2021-07-22 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
US20240024216A1 (en) * 2021-01-06 2024-01-25 The Penn State Research Foundation Methods and materials for treating hair loss
US12065494B2 (en) 2021-04-12 2024-08-20 Incyte Corporation Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent
WO2022261160A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr
CA3220155A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Heterocycles tricycliques utiles en tant qu'inhibiteurs de fgfr

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242468B1 (en) * 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
US20040171587A1 (en) * 2002-12-06 2004-09-02 Borgens Richard B. Pyridines for treating injured mammalian nerve tissue

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242468B1 (en) * 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
US20040171587A1 (en) * 2002-12-06 2004-09-02 Borgens Richard B. Pyridines for treating injured mammalian nerve tissue

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SMITH D.T. ET AL.: "Development of novel 4-aminopyridine derivatives as potential treatments for neurological injury and disease", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, 1 August 2005 (2005-08-01), pages 908 - 917 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9533954B2 (en) 2010-12-22 2017-01-03 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9533984B2 (en) 2013-04-19 2017-01-03 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors

Also Published As

Publication number Publication date
WO2007061554A2 (fr) 2007-05-31

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