[go: up one dir, main page]

WO2007060421A3 - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

Info

Publication number
WO2007060421A3
WO2007060421A3 PCT/GB2006/004362 GB2006004362W WO2007060421A3 WO 2007060421 A3 WO2007060421 A3 WO 2007060421A3 GB 2006004362 W GB2006004362 W GB 2006004362W WO 2007060421 A3 WO2007060421 A3 WO 2007060421A3
Authority
WO
WIPO (PCT)
Prior art keywords
fragmentation
mass spectra
ions
parent
ion mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2006/004362
Other languages
French (fr)
Other versions
WO2007060421A2 (en
Inventor
Robert Harold Bateman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/286,141 external-priority patent/US20060151689A1/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Priority to JP2008541816A priority Critical patent/JP4959712B2/en
Priority to EP06808640A priority patent/EP1952422A2/en
Priority to CA2628924A priority patent/CA2628924C/en
Publication of WO2007060421A2 publication Critical patent/WO2007060421A2/en
Publication of WO2007060421A3 publication Critical patent/WO2007060421A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0068—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with a surface, e.g. surface induced dissociation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

A method of mass spectrometry is disclosed wherein an Electron Capture Dissociation, Electron Transfer Dissociation or Surface Induced Dissociation fragmentation device is repeatedly switched between a high fragmentation or reaction mode and a low fragmentation or reaction mode. Parent ions from a first sample are passed through the device and parent ion mass spectra and fragmentation ion mass spectra are obtained. Parent ions from a second sample are then passed through the device and a second set of parent ion mass spectra and fragmentation ion mass spectra are obtained. The mass spectra are then compared and if either certain parent ions or certain fragmentation ions in the two samples are expressed differently then further analysis is performed to seek to identify the ions which are expressed differently in the two different samples.
PCT/GB2006/004362 2005-11-23 2006-11-23 Mass spectrometer Ceased WO2007060421A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008541816A JP4959712B2 (en) 2005-11-23 2006-11-23 Mass spectrometer
EP06808640A EP1952422A2 (en) 2005-11-23 2006-11-23 Mass spectrometer
CA2628924A CA2628924C (en) 2005-11-23 2006-11-23 Mass spectrometer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/286,141 2005-11-23
GBGB0523806.8A GB0523806D0 (en) 2005-11-23 2005-11-23 Mass spectrometer
GB0523806.8 2005-11-23
US11/286,141 US20060151689A1 (en) 2002-07-24 2005-11-23 Mass spectrometer

Publications (2)

Publication Number Publication Date
WO2007060421A2 WO2007060421A2 (en) 2007-05-31
WO2007060421A3 true WO2007060421A3 (en) 2008-05-08

Family

ID=35601028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/004362 Ceased WO2007060421A2 (en) 2005-11-23 2006-11-23 Mass spectrometer

Country Status (5)

Country Link
EP (1) EP1952422A2 (en)
JP (1) JP4959712B2 (en)
CA (2) CA2628924C (en)
GB (4) GB0523806D0 (en)
WO (1) WO2007060421A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201122178D0 (en) 2011-12-22 2012-02-01 Thermo Fisher Scient Bremen Method of tandem mass spectrometry
EP2924425B1 (en) * 2012-11-22 2019-09-11 Shimadzu Corporation Tandem quadrupole mass spectrometer
US9352020B2 (en) 2013-03-15 2016-05-31 Mead Johnson Nutrition Company Reducing proinflammatory response
US9289461B2 (en) 2013-03-15 2016-03-22 Mead Johnson Nutrition Company Reducing the risk of autoimmune disease
US9138455B2 (en) 2013-03-15 2015-09-22 Mead Johnson Nutrition Company Activating adiponectin by casein hydrolysate
US8889633B2 (en) 2013-03-15 2014-11-18 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof
CN104345107B (en) * 2013-07-24 2016-08-17 上海科倍斯生物科技有限公司 Lac Bovis seu Bubali serum albumin immue quantitative detection reagent box in a kind of breast or milk product
GB201407123D0 (en) * 2014-04-23 2014-06-04 Micromass Ltd Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences
US9991103B2 (en) 2014-04-23 2018-06-05 Micromass Uk Limited Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences
EP3775929B1 (en) * 2018-04-10 2025-08-13 DH Technologies Development Pte. Ltd. Top-down analysis of antibodies in mass spectrometry
WO2020248757A1 (en) 2019-06-14 2020-12-17 Shanghai Polaris Biology Co., Ltd. Systems and methods for single particle analysis
US20220390421A1 (en) * 2019-10-10 2022-12-08 Janssen Biotech, Inc. Materials and methods for mass spectrometric protein analysis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040155180A1 (en) * 2001-03-22 2004-08-12 Roman Zubarev Mass spectrometry methods using electron capture by ions
US20040188603A1 (en) * 2002-07-24 2004-09-30 Bateman Robert Harold Method of mass spectrometry and a mass spectrometer
US20050199804A1 (en) * 2004-03-12 2005-09-15 Hunt Donald F. Electron transfer dissociation for biopolymer sequence analysis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3300602B2 (en) * 1996-06-20 2002-07-08 株式会社日立製作所 Atmospheric pressure ionization ion trap mass spectrometry method and apparatus
JP2000241390A (en) * 1999-02-17 2000-09-08 Japan Atom Energy Res Inst Charge inversion mass spectrometry using neutral species dissociation
US6545268B1 (en) * 2000-04-10 2003-04-08 Perseptive Biosystems Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
US6744040B2 (en) * 2001-06-13 2004-06-01 Bruker Daltonics, Inc. Means and method for a quadrupole surface induced dissociation quadrupole time-of-flight mass spectrometer
GB0121172D0 (en) * 2001-08-31 2001-10-24 Shimadzu Res Lab Europe Ltd A method for dissociating ions using a quadrupole ion trap device
JP4161125B2 (en) * 2002-04-24 2008-10-08 滋雄 早川 Mass spectrometry and mass spectrometer
CA2643534C (en) * 2002-05-31 2011-08-02 Analytica Of Branford, Inc. Fragmentation methods for mass spectrometry
GB2390935A (en) * 2002-07-16 2004-01-21 Anatoli Nicolai Verentchikov Time-nested mass analysis using a TOF-TOF tandem mass spectrometer
AU2002952747A0 (en) * 2002-11-18 2002-12-05 Ludwig Institute For Cancer Research Method for analysing peptides
GB2402260B (en) * 2003-05-30 2006-05-24 Thermo Finnigan Llc All mass MS/MS method and apparatus
JP4275545B2 (en) * 2004-02-17 2009-06-10 株式会社日立ハイテクノロジーズ Mass spectrometer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040155180A1 (en) * 2001-03-22 2004-08-12 Roman Zubarev Mass spectrometry methods using electron capture by ions
US20040188603A1 (en) * 2002-07-24 2004-09-30 Bateman Robert Harold Method of mass spectrometry and a mass spectrometer
US20050199804A1 (en) * 2004-03-12 2005-09-15 Hunt Donald F. Electron transfer dissociation for biopolymer sequence analysis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DE HOFFMANN E: "Tandem mass spectrometry: A primer", JOURNAL OF MASS SPECTROMETRY, WILEY, CHICHESTER, GB, vol. 31, no. 2, 1996, pages 129 - 137, XP007903162, ISSN: 1076-5174 *

Also Published As

Publication number Publication date
GB2435713A (en) 2007-09-05
GB0816195D0 (en) 2008-10-15
GB0623376D0 (en) 2007-01-03
GB0801093D0 (en) 2008-02-27
WO2007060421A2 (en) 2007-05-31
GB2435713B (en) 2010-06-16
JP2009516842A (en) 2009-04-23
GB0523806D0 (en) 2006-01-04
EP1952422A2 (en) 2008-08-06
CA2835314A1 (en) 2007-05-31
GB2451962A (en) 2009-02-18
CA2628924A1 (en) 2007-05-31
GB2443571A (en) 2008-05-07
JP4959712B2 (en) 2012-06-27
CA2628924C (en) 2017-09-05
GB2451962B (en) 2010-02-17
GB2443571B (en) 2010-05-12

Similar Documents

Publication Publication Date Title
Fuchs et al. An update of MALDI-TOF mass spectrometry in lipid research
WO2008142579A3 (en) Method of mass analysis of target molecules in complex mixtures
WO2006129083A3 (en) Multiple ion injection in mass spectrometry
WO2006110644A3 (en) Improved methods and devices for concentration and fractionation of analytes for chemical analysis including matrix-assisted laser desorption/ionization (maldi) mass spectrometry (ms)
WO2006130474A3 (en) Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection
WO2007067759A3 (en) Methods and devices for concentration and fractionation of analytes for chemical analysis
IN2012DN02538A (en)
EP3570315A3 (en) Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of biopsy samples
WO2005036132A3 (en) Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (maldi) mass spectrometry (ms)
TW200729274A (en) Electrospray-assisted laser desorption ionization devices, mass spectrometers, and methods for mass spectrometry
WO2007103124A3 (en) Methods for distinguishing isomers using mass spectrometry
WO2007060427A3 (en) Mass spectrometer
EP1376651A3 (en) Mass spectrometric data processing method and apparatus
GB2363249B (en) Methods and apparatus for mass spectrometry
WO2007112234A3 (en) Means and method for analyzing samples by mass spectrometry
ATE479895T1 (en) ELECTRON TRANSFER DISSOCIATION FOR BIOPOLYMER SEQUENCE ANALYSIS
WO2011041416A3 (en) Analyte ionization by charge exchange for sample analysis under ambient conditions
EP2086000A3 (en) Methods and Apparatus for Reducing Noise in Mass Spectrometry
WO2005065307A3 (en) Maldi-im-ortho-tof mass spectrometry with simultaneaous positive and negative mode detection
WO2004102180A3 (en) Mass spectrometry
WO2013093114A3 (en) Method of tandem mass spectrometry
GB2423187B (en) Laser system for the ionization of a sample by matrix-assisted laser desorption in mass spectrometric analysis
WO2008154523A3 (en) Improved methods and devices for concentration and fractionation of analytes for chemical analysis including matrix-assisted laser desorption/ionization (maldi) mass spectrometry (ms)
WO2006064280A3 (en) Mass spectrometer
WO2007060421A3 (en) Mass spectrometer

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2006808640

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2628924

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2008541816

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWP Wipo information: published in national office

Ref document number: 2006808640

Country of ref document: EP