[go: up one dir, main page]

WO2007060156A1 - Système d'appareils d'injection de formes différentes - Google Patents

Système d'appareils d'injection de formes différentes Download PDF

Info

Publication number
WO2007060156A1
WO2007060156A1 PCT/EP2006/068705 EP2006068705W WO2007060156A1 WO 2007060156 A1 WO2007060156 A1 WO 2007060156A1 EP 2006068705 W EP2006068705 W EP 2006068705W WO 2007060156 A1 WO2007060156 A1 WO 2007060156A1
Authority
WO
WIPO (PCT)
Prior art keywords
injection
insulin
injection device
cartridge
injection devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/068705
Other languages
English (en)
Inventor
Thomas Dedenroth Miller
Michael Ejstrup Hansen
Jakob Oest Wielandt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of WO2007060156A1 publication Critical patent/WO2007060156A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A61M5/003—Kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button

Definitions

  • the invention relates to a system of injection devices for subcutaneous injections.
  • the system preferably comprises at least two injection devices containing insulin primarily for self- treatment of people suffering from diabetes.
  • a prior art system is known from WO 2004/069314.
  • This application discloses a system of substantially identical injection devices, each individual injection device comprising a housing accommodating an ampoule containing medicine sufficient for a number of injections and a dose setting mechanism by which a predetermined dose size can be set, and wherein each of the plurality of injection devices has a different predetermined dose size.
  • the difference in the predetermined dose sizes can in one embodiment be based on the drug in the devices having different strength.
  • People suffering from diabetes are often treated with multiple daily injections in a regimen comprising one or two daily injections of a long acting insulin to cover the basal requirement supplemented by bolus injections of a short or rapid acting insulin to cover requirements related to meals.
  • a user will therefore often require two different injection devices, one containing the long act- ing insulin and another containing the short or rapid acting insulin.
  • these injection devices have different colour indications to inform the user of the kind of insulin contained in the injection device. Orange or yellow is usually the colour used for short or rapid acting insulin whereas green is often used to indicate the long acting insulin types.
  • these injection devices can be provided with tactile means such as a mechanical coding informing the user of the kind of insulin contained in the injection device.
  • the first type being injection devices with a replaceable cartridge containing the insulin to be injected. Often such cartridges contain 3 ml of insulin, and when this amount has been in- jected a new cartridge is inserted in the same injection device which therefore often is in use for several years. Such injections devices are usually referred to durable injection devices.
  • the other type being injection devices containing a predetermined and non-replaceable amount of insulin, also often 3 ml. The insulin is often contained in a cartridge embedded in the injection device. When the predetermined amount has been injected which in average takes anywhere from a few days to a month, the entire injection device is discarded and a new injection device is used for subsequent injections.
  • Such injection devices are often referred to as disposable of prefilled injection pens.
  • U 201 10 689 discloses a pen-shaped injection device having a cap with a clip for holding the injection device e.g. in a pocket of a shirt.
  • the injection device is contained in a cut-out in a box. Since persons suffering from diabetes often require two injection devices with different types of insulin, the physical shape of the injection device is according to this patent designed such that the right injection device fits into the right box. This is according to the prior art done by having devices with different of length of the clip and boxes with a similar shaped cut-out.
  • insulin itself is known to be used to distinguish between insulin types. Some long- acting insulins are cloudy due to the insulin crystals and thus easy distinguishable from fast- acting insulin that are normally clear. However, new types of long-acting insulin analogues are clear and thus this method to distinguish between insulin types is no longer applicable. This may potentially lead to increased uncertainty about insulin type.
  • the only indicia differentiating two otherwise identical injection pens is a colour indication
  • a user must learn which colour indicates what type of insulin.
  • the colour indica- tion is only located on a minor part of the injection pen such as the injection button.
  • the user must be able to distinct the colours used also when taking the injections in poorly lighted rooms such as public restaurants, restrooms or the like, which can be difficult.
  • Injection devices usually also carries labels with a text spelling out which type of insulin is contained in the injection device.
  • the label is usually located on the replaceable cartridge itself.
  • the indicia are tactile they are usually restricted to a very little, Braille-like indication on the injection button. This requires fine motor skills and dexterity in the finger tips, which is often not the case for persons suffering from late stage diabetes complications
  • the indicia are coupled to the length of the injection device a user can easily distinct the two injection device from each other. The user is thereby able to instantly distinct two injection devices from each other both by vision and by touching the injection de- vice.
  • the longest injection device contains the long acting insulin i.e. the basal insulin and the shortest injection device contains the short (rapid) acting insulin i.e. the bolus or meal time insulin then the user only has to memorize the sentence "long pen for long acting - short pen for short acting" which is highly self explanatory.
  • the ampoules or cartridges contain insulin with different strength, the same number of International Units (IU) can be contained in different volumes. If e.g. 300 IU is wanted in one cartridge and the cartridge is filled with insulin having a strength of 100 IU per millilitre of insulin the total volume of the cartridge will be 3 millilitre. If instead the cartridge is filled with insulin having a strength on 200 IU per millilitre then only half the volume i.e. 1 ,5 millilitre is required.
  • IU International Units
  • a compact cartridge containing insulin with a strength of 200 IU per millilitre is disclosed in EP 1.424.984.
  • a compact cartridge according to this patent usually has a total length ap- proximately between 44 to 52 millimetres, whereas a 3 ml cartridge as the ones sold by leading insulin producers has a total length of approximately 65 to 70 millimetres i.e. approximately 20 millimetres longer.
  • a system according to the present invention could in an exemplary embodiment comprise two injection devices which are based on identical or almost identical technologies i.e. injection devices having the same or slightly modified interior dose setting and injection mechanism. It could e.g. be two prefilled injection devices like the Flexpen® from the company Novo Nordisk A/S.
  • the same system could further comprise a second injection device containing short acting insulin in a concentration of 200 IU per millilitres. Such injection device would also contain 300 IU of insulin. If the two injection devices were based on the same mechanical dose setting and injec- tion mechanism, the only difference would be the cartridge used.
  • the injection device with the long acting insulin would have the longest cartridge and be the longest injection device whereas the injection device containing short acting insulin would have a shorter cartridge and be significantly shorter.
  • the length differentiation could be obtained through a differentiation of the dose setting and injection mechanics.
  • Most dose setting and injection mechanics has a threaded piston rod co-operating with a nut where the nut and the piston rod may be rotated relatively to each other.
  • the dose setting may be obtained by screwing the nut away from a stop to which it is returned during injection by pressing the piston rod forward until the nut member abuts the stop.
  • one of the elements, the nut or the piston rod is kept inro- tatable and the other is allowed to rotate a set angle depending on the set dose, whereby the piston rod is screwed forward a distance through the nut member.
  • the cartridge When injecting insulin the piston rod is moved forward inside the cartridge.
  • the cartridge is provided with a plunger that, when moved forward by the piston rod expels a volume.
  • the volume expelled is the area of the plunger multiplied with the distance the plunger and the piston rod is moved forward. This distance is a result of the rotations of the mechanical sys- tern and the pitch of the thread of the piston rod. If the pitch is little, the piston rod is moved forward at a slower pace than if the pitch is large. Therefore a little pitch is suitable for compact cartridges containing insulin with a strength of 200 IU per ml, since a smaller volume must be expelled in order to expel the same amount of International Units.
  • the difference could also be a difference in diameter since the diameter of the cartridge is also a parameter decisive for the volume expelled.
  • the shorter diameter cartridge could contain short or rapid acting insulin in a strength of 200 IU per millilitre and the cartridge having the largest diameter could contain long acting insulin in a strength of 100 IU per millilitre.
  • the diameter of the cartridge would also influence the diameter of the injection pen thereby informing the user of the type of insulin contained in the injection pen.
  • a system of injection devices can include any number of injection devices preceding one. In an exemplary use of the system it would involve two injection devices e.g. prefilled injection devices filled with two different types of insulin. These two injection devices could be used separately in either basal or bolus treatment or combined in a basal/bolus treatment.
  • an "injection pen” is typically an injection apparatus having an oblong or elongated shape somewhat like a pen for writing. Although such pens usually have a tubular cross-section, they could easily have a different cross-section such as triangular, rectangular or square or any variation around these geometries.
  • drug is meant to encompass any drug-containing flowable medicine capable of being passed through a delivery means such as a hollow needle in a controlled manner, such as a liquid, solution, gel or fine suspension.
  • Representative drugs includes pharmaceuticals such as peptides, proteins (e.g. insulin, insulin analogues and C- peptide), and hormones, biologically derived or active agents, hormonal and gene based agents, nutritional formulas and other substances in both solid (dispensed) or liquid form.
  • subcutaneous injection is meant to encompass any method of transcutaneous delivery to a subject.
  • injection needle defines a piercing member adapted to penetrate the skin of a subject for the purpose of delivering or removing a liquid.
  • outer shape or “outer form” is throughout the present application used to indi- cate the outer appearance of the injection device such as the length or the cross-section.
  • active area of a cartridge is meant to refer to the area of a cartridge within which the plunger or piston can move.
  • a cartridge usually has a narrow area at the distal end into which area the plunger can not move due to the narrow diameter of that section.
  • Cartridge is the term used to describe the container containing the insulin. Cartridges are usually made from glass but could also moulded from any suitable polymer.
  • a cartridge or ampoule is preferably sealed at one end by a pierceable membrane which can be pierced e.g. by an injection needle. The opposite end is closed by a plunger or piston made from rubber or a suitable polymer. The plunger or piston can be slidable moved inside the cartridge. The space between the pierceable membrane and the movable plunger holds the insulin which is pressed out as the plunger decreased the volume of the space holding the insulin.
  • Technology platform is meant to mean the basic structure upon which the injection devices in the system are based.
  • the injection devices of the system must work by the same mechanical principles i.e. the individual constructional components of each injection device must be the same and interact in the same way. The only difference is the physical appearance and especially the physical size of the various mechanical components.
  • Technology platform products share underlying structures or basic architectures that are common across a group of products or that will be the basis of a series of products commercialized over a number of years. Several products may be derived from a common technol- ogy platform. Members of a product family normally have many common parts and assemblies.
  • Figure 1 Shows a system comprising to injection pens having a difference in length.
  • Figure 2 Shows the interior of one of the injection pens in the system.
  • distal end in the appended figures is meant to refer to the end of the injection device carrying the injection needle whereas the term “proximal end” is meant to refer to the opposite end pointing away from the injection needle.
  • Figure 1 discloses a number of injection pens.
  • the injection pen disclosed in figure 1A comprises a standard cartridge 1 containing 3,0 ml of insulin with a strength of 100 IU per mil IiIi- tre, thus containing a total of 300 IU.
  • the injection pen disclosed in figure 1 B comprises a more compact cartridge 100 but contains the same dose setting and injection mechanics as in figure 1 A.
  • the injection pen disclosed in figure 1 B contains 1 ,5 ml of insulin with a strength of 200 IU per millilitre, thus also containing a total of 300 IU.
  • the cartridge 1 is at its proximal end provided with a rubber piston 10 which is acted upon by a piston rod 20.
  • the piston rod 20 has an external thread 21 which mates the internal thread 31 of the nut member 30.
  • the nut member 30 is secured to the cartridge holder which is part of the housing 40.
  • the piston rod 20 further has a keyed surface 22 mating the internal keyed surface 52 of the piston rod guide 50 such that the piston rod 20 is rotated when the piston rod guide 50 is rotated.
  • the outer shape of the piston rod guide 50 fits with the internal shape of the connector tube 60.
  • the connector tube 60 can be coupled to the dose dial 70 by engagement of the teeth 61 on the connector tube 60 with corresponding slits 71 on the dose dial 70.
  • the connector tube 60 is coupled to the dose dial 70 when a user exerts pressure on the injection button 80.
  • the user rotates the dose dial 70 which screws out from the housing 40 in the thread connection 42, 72 provided between the dose dial 70 and the housing 40.
  • the size of the dose can be viewed in the window 41.
  • the connector tube 60 follows the axial movement of the combined rotational/axial movement of the dose dial 70.
  • the connector tube 60 is prevented from rotating by the engagement with the piston rod guide 50 which is connected to the housing through a one-way coupling 33, 53 comprising a ratchet 53 and a toothed ring 33.
  • the user When the correct dose is set, the user expels the set dose by pushing back the injection button 80. This movement makes the dose dial 70 rotate down in the thread connection 42, 72 between the dose dial 70 and the housing 40. Since the connector tube 60 is now locked to the dose dial 70 through the engagement between the teeth 61 and the corresponding slits 71 and is free to rotate in the one-way coupling 33, 53, the connector tube 60 rotates with the dose dial 70. This rotation is transformed to the piston rod guide 50 and on to the piston rod 20 which is screwed forward in the internal thread 31 of the nut member 30.
  • injection pen could further be equipped with an End-of-Content ring 90 as detailed described in EP 1.250.167
  • FIG. 1 B and 2B illustrates the same kind of injection pen, however in order to make the injection pen shorter, the cartridge 100 has been shortened. Since the total volume of a cartridge 1 , 100, 200 is determined by the formula:
  • V ⁇ x R 2 x L
  • the length (L) only needs to be half the length of the before mentioned standard cartridge 1 when the volume (V) is decreased from 3,0 ml to 1 ,5 ml and the radius (R) are kept constant.
  • the pitch between the threaded piston rod 20 and the interior thread 31 of the nut member 30 is decisive for the distance the piston rod 20 travels when rotated.
  • the forward travel of the piston rod 20 multiplied with the area of the plunger 10 determines the volume to be expelled.
  • the pitch is approximately 1 :3 whereas the pitch of the injection pen shown in figure 1 B and 2B is around 1 :1 ,5. All other mechanical components of the dose setting and injection mechanism are the same.
  • the active area, i.e. the area through which the rubber piston 10 can move, of the more compact cartridge 100 has only half the length of the active area of the standard cartridge 1.
  • the standard cartridge 1 is filled with long acting insulin in a concentration of 100 IU per mil- lilitre and the compact cartridge 100 is filled with short acting insulin in a concentration of 200 IU per millilitre then the longest injection pen is filled with long acting insulin and the shortest injection pen is filled with short acting insulin.
  • FIG. 1 C and 2C An even shorter injection pen is disclosed in figure 1 C and 2C.
  • the length of the dose dial has been shortened and the distance the dose dial 270 can be screwed out from the housing 240 has been decreased.
  • the maximum number of IU a user can set is fewer than in the injection pens disclosed in the figures 1 A, 2A and 1 B, 2B.
  • the shorter dose setting and injection mechanism combined with the compact cartridge 100, 200 results in a very short and compact injection pen.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L’invention concerne un système d'appareils d’injection pour injecter de l'insuline liquide, qui consiste en un premier appareil d'injection (IA) contenant un premier type d'insuline liquide et un deuxième appareil d'injection (IB) contenant un deuxième type d'insuline liquide. Les deux appareils d’injection ont des formes extérieures différentes. Dans un mode de réalisation, le premier appareil d'injection est plus long que le deuxième appareil d'injection et le plus long des deux contient l’insuline active le plus longtemps.
PCT/EP2006/068705 2005-11-22 2006-11-21 Système d'appareils d'injection de formes différentes Ceased WO2007060156A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05111066.6 2005-11-22
EP05111066 2005-11-22

Publications (1)

Publication Number Publication Date
WO2007060156A1 true WO2007060156A1 (fr) 2007-05-31

Family

ID=35892337

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/068705 Ceased WO2007060156A1 (fr) 2005-11-22 2006-11-21 Système d'appareils d'injection de formes différentes

Country Status (1)

Country Link
WO (1) WO2007060156A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010112565A1 (fr) * 2009-03-31 2010-10-07 Sanofi-Aventis Deutschland Gmbh Bouton doseur pour dispositif d'administration de médicament et procédé de fabrication d'un bouton doseur
WO2011138316A1 (fr) * 2010-05-04 2011-11-10 Sanofi-Aventis Deutschland Gmbh Identification tactile de cartouche remplie de médicament
US20120101445A1 (en) * 2009-01-23 2012-04-26 Sanofi-Aventis Deutschland Gmbh Medicament Identification System for Multi-Dose Injection Devices
JP2013523231A (ja) * 2010-03-31 2013-06-17 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 触覚又は視覚向上を備えた薬物送達デバイスのセット
CN103431921A (zh) * 2013-08-28 2013-12-11 史其新 用于小型动物经门静脉肝内胰岛移植的手术器械
CN106983931A (zh) * 2017-05-08 2017-07-28 甘肃成纪生物药业有限公司 一种注射笔
WO2018205409A1 (fr) * 2017-05-08 2018-11-15 甘肃成纪生物药业有限公司 Stylo d'injection
US10166338B2 (en) 2009-09-21 2019-01-01 Novo Nordisk A/S Drug delivery system and device with cap function
EP3446733A4 (fr) * 2016-04-21 2019-05-22 Beijing Gangan Technology Co., Ltd. Stylo injecteur pré-rempli
US11565053B2 (en) 2013-08-02 2023-01-31 Becton, Dickinson And Company Injection pen

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004297A (en) * 1998-01-30 1999-12-21 Novo Nordisk A/S Injection syringe
DE20110689U1 (de) * 2001-06-27 2002-01-03 Spyra, Heinrich, 91056 Erlangen Aufbewahrungsschachtel für Injektionshilfen mit Verwechslungsschutz und mit weiteren Erkennungsmerkmalen
WO2002011664A1 (fr) * 2000-08-03 2002-02-14 Novo Nordisk A/S Codage d'un dispositif medical
WO2003086511A1 (fr) * 2002-04-16 2003-10-23 Pfizer Health Ab Procede et systeme de modification d'un dispositif et dispositif approprie a cette modification
WO2004030729A1 (fr) * 2002-09-30 2004-04-15 Bausch & Lomb Incorporated Seringue a double cylindre pour chirurgies ophtalmiques
DE202004002676U1 (de) * 2004-02-20 2004-05-27 Svechnikov, Vadym Außer-Haus-Box für Diabetiker

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004297A (en) * 1998-01-30 1999-12-21 Novo Nordisk A/S Injection syringe
WO2002011664A1 (fr) * 2000-08-03 2002-02-14 Novo Nordisk A/S Codage d'un dispositif medical
DE20110689U1 (de) * 2001-06-27 2002-01-03 Spyra, Heinrich, 91056 Erlangen Aufbewahrungsschachtel für Injektionshilfen mit Verwechslungsschutz und mit weiteren Erkennungsmerkmalen
WO2003086511A1 (fr) * 2002-04-16 2003-10-23 Pfizer Health Ab Procede et systeme de modification d'un dispositif et dispositif approprie a cette modification
WO2004030729A1 (fr) * 2002-09-30 2004-04-15 Bausch & Lomb Incorporated Seringue a double cylindre pour chirurgies ophtalmiques
DE202004002676U1 (de) * 2004-02-20 2004-05-27 Svechnikov, Vadym Außer-Haus-Box für Diabetiker

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "FlexPen - Product benefits", NOVO NORDISK A/S, 5 June 2004 (2004-06-05), XP002370570, Retrieved from the Internet <URL:http://web.archive.org/web/20040605145704/http://www.novonordisk.com/diabetes/public/insulinpens/flexpen/benefits.asp> [retrieved on 20060303] *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120101445A1 (en) * 2009-01-23 2012-04-26 Sanofi-Aventis Deutschland Gmbh Medicament Identification System for Multi-Dose Injection Devices
JP2012515585A (ja) * 2009-01-23 2012-07-12 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 反復投与注入デバイス用の医薬品識別システム
WO2010112565A1 (fr) * 2009-03-31 2010-10-07 Sanofi-Aventis Deutschland Gmbh Bouton doseur pour dispositif d'administration de médicament et procédé de fabrication d'un bouton doseur
US10286150B2 (en) 2009-03-31 2019-05-14 Michael Harms Dose button for a drug delivery device and method for manufacturing a dose button
JP2012521836A (ja) * 2009-03-31 2012-09-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイス用の投与ボタン及び投与ボタンの製造方法
US10166338B2 (en) 2009-09-21 2019-01-01 Novo Nordisk A/S Drug delivery system and device with cap function
JP2013523231A (ja) * 2010-03-31 2013-06-17 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 触覚又は視覚向上を備えた薬物送達デバイスのセット
WO2011138316A1 (fr) * 2010-05-04 2011-11-10 Sanofi-Aventis Deutschland Gmbh Identification tactile de cartouche remplie de médicament
US11565053B2 (en) 2013-08-02 2023-01-31 Becton, Dickinson And Company Injection pen
US11911599B2 (en) 2013-08-02 2024-02-27 Becton, Dickinson And Company Injection pen
CN103431921A (zh) * 2013-08-28 2013-12-11 史其新 用于小型动物经门静脉肝内胰岛移植的手术器械
EP3446733A4 (fr) * 2016-04-21 2019-05-22 Beijing Gangan Technology Co., Ltd. Stylo injecteur pré-rempli
US11052197B2 (en) 2016-04-21 2021-07-06 Beijing Gangan Technology Co., Ltd. Prefilled injection pen
CN106983931A (zh) * 2017-05-08 2017-07-28 甘肃成纪生物药业有限公司 一种注射笔
WO2018205409A1 (fr) * 2017-05-08 2018-11-15 甘肃成纪生物药业有限公司 Stylo d'injection

Similar Documents

Publication Publication Date Title
EP2806925B1 (fr) Dispositif d&#39;injection avec une échelle mobile
US9227015B2 (en) Spring driven injection device with twin cartridges
EP2040780B1 (fr) Couplage pour dispositif d&#39;injection
US8257318B2 (en) Injection device having a rotatable scale drum
US9114211B2 (en) Injection device with visual end-of-content indication
JP4906730B2 (ja) 注入デバイス
EP3160551B1 (fr) Dispositif d&#39;injection entraîné par un ressort de torsion en forme de crayon
CN107847688B (zh) 扭力弹簧驱动注射装置
EP2817045B1 (fr) Extrémité d&#39;indicateur de dose
US8915887B2 (en) Medical injection device with large, mechanical cipher dose display
WO2007060156A1 (fr) Système d&#39;appareils d&#39;injection de formes différentes
EP3077024B1 (fr) Boîtier pour dispositif d&#39;injection médicale
US11383041B2 (en) Prefilled injection device with cleaning chamber
WO2009150028A1 (fr) Dispositif amélioré d&#39;injection
WO2018002044A1 (fr) Distributeur de médicaments avec chargement par l&#39;avant.
WO2025196054A1 (fr) Dispositif d&#39;injection pour délivrer une pluralité de doses fixes prédéfinies

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06830054

Country of ref document: EP

Kind code of ref document: A1