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WO2007056068A3 - Macrocyclic formulations for transmembrane drug delivery - Google Patents

Macrocyclic formulations for transmembrane drug delivery Download PDF

Info

Publication number
WO2007056068A3
WO2007056068A3 PCT/US2006/042827 US2006042827W WO2007056068A3 WO 2007056068 A3 WO2007056068 A3 WO 2007056068A3 US 2006042827 W US2006042827 W US 2006042827W WO 2007056068 A3 WO2007056068 A3 WO 2007056068A3
Authority
WO
WIPO (PCT)
Prior art keywords
active ingredient
formulations
topically applied
delivery
effective amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/042827
Other languages
French (fr)
Other versions
WO2007056068A2 (en
Inventor
Robert J Gyurik
Carl Reppucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bentley Pharmaceuticals Inc
Original Assignee
Bentley Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bentley Pharmaceuticals Inc filed Critical Bentley Pharmaceuticals Inc
Priority to EP06827385A priority Critical patent/EP1947938A4/en
Publication of WO2007056068A2 publication Critical patent/WO2007056068A2/en
Publication of WO2007056068A3 publication Critical patent/WO2007056068A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Topically applied pharmaceutical products comprising (a) an active ingredient, (b) an organogel, and (c) a non-irritating permeation enhancer, are disclosed, along with and methods of use and formulations thereof. The topically applied products and methods are intended to be used to enhance any of the transdermal, subdermal, transmembrane, musculoskeletal, transungual, transonychial, and / or peronychial deliveries of a therapeutically effective amount of an active ingredient to a patient. The invention is particularly directed to topically applied pharmaceutical products for enhancing the delivery of a therapeutically effective amount of an active ingredient to a diseased or infected nail bed, nail matrix, and / or nail plate in the toenails or fingernails of a patient suffering from onychomycosis. The invention is also directed to delivery of an anti-inflammatory agent, preferably of the Cox-2 enzyme inhibitory class, topically to a site of soft tissue injury or discomfort.
PCT/US2006/042827 2005-11-02 2006-11-02 Macrocyclic formulations for transmembrane drug delivery Ceased WO2007056068A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06827385A EP1947938A4 (en) 2005-11-02 2006-11-02 Macrocyclic formulations for transmembrane drug delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26571105A 2005-11-02 2005-11-02
US11/265,711 2005-11-02

Publications (2)

Publication Number Publication Date
WO2007056068A2 WO2007056068A2 (en) 2007-05-18
WO2007056068A3 true WO2007056068A3 (en) 2007-09-27

Family

ID=38023806

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/042827 Ceased WO2007056068A2 (en) 2005-11-02 2006-11-02 Macrocyclic formulations for transmembrane drug delivery

Country Status (2)

Country Link
EP (1) EP1947938A4 (en)
WO (1) WO2007056068A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012033349A2 (en) * 2010-06-28 2016-10-11 Adetherapeutics keloid treatment
WO2017031075A1 (en) * 2015-08-17 2017-02-23 Arno Therapeutics, Inc. Methods and compositions for enhanced transungual delivery of ar-12

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837289A (en) * 1996-07-23 1998-11-17 Grasela; John C. Transdermal delivery of medications using a combination of penetration enhancers
US5945409A (en) * 1995-03-10 1999-08-31 Wilson T. Crandall Topical moisturizing composition and method
US20050123592A1 (en) * 2003-12-08 2005-06-09 Gyurik Robert J. Pharmaceutical compositions and methods for insulin treatment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510391A (en) * 1993-10-22 1996-04-23 Mayapple Holdings, Llc Method of treating blood vessel disorders of the skin using vitamin K
US5560910A (en) * 1994-08-26 1996-10-01 Crandall; Wilson T. Topical anti-inflammatory composition and method
WO1999011208A1 (en) * 1997-08-28 1999-03-11 Williams C Donald Method and composition for transdermal administration of pharmacologic agents
US5817699A (en) * 1997-05-30 1998-10-06 Flores; John A. Process for the preparation of ketamine ointment
KR20080049148A (en) * 2000-02-16 2008-06-03 벤트레이 파마슈티칼스, 인코포레이티드 Pharmaceutical composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945409A (en) * 1995-03-10 1999-08-31 Wilson T. Crandall Topical moisturizing composition and method
US5837289A (en) * 1996-07-23 1998-11-17 Grasela; John C. Transdermal delivery of medications using a combination of penetration enhancers
US20050123592A1 (en) * 2003-12-08 2005-06-09 Gyurik Robert J. Pharmaceutical compositions and methods for insulin treatment

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1947938A4 *

Also Published As

Publication number Publication date
EP1947938A4 (en) 2009-07-01
WO2007056068A2 (en) 2007-05-18
EP1947938A2 (en) 2008-07-30

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