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WO2007053915A3 - Derives de naringenine presentant une selectivite sur des ers - Google Patents

Derives de naringenine presentant une selectivite sur des ers Download PDF

Info

Publication number
WO2007053915A3
WO2007053915A3 PCT/BE2006/000121 BE2006000121W WO2007053915A3 WO 2007053915 A3 WO2007053915 A3 WO 2007053915A3 BE 2006000121 W BE2006000121 W BE 2006000121W WO 2007053915 A3 WO2007053915 A3 WO 2007053915A3
Authority
WO
WIPO (PCT)
Prior art keywords
ers
selectivity
naringenin derivatives
diseases
naringenin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BE2006/000121
Other languages
English (en)
Other versions
WO2007053915A2 (fr
Inventor
Keukeleire Denis De
Frederik Roelens
Willem Dhooge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universiteit Gent
Original Assignee
Universiteit Gent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Gent filed Critical Universiteit Gent
Publication of WO2007053915A2 publication Critical patent/WO2007053915A2/fr
Publication of WO2007053915A3 publication Critical patent/WO2007053915A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des dérivés de naringénine à activité anti-oestrogène sélective, et leur utilisation dans le traitement de maladies ou de troubles liés à des déficiences en oestrogène, de maladies à production excessive en oestrogène, ou d'états résultant d'une production d'oestrogène modulée.
PCT/BE2006/000121 2005-11-09 2006-11-09 Derives de naringenine presentant une selectivite sur des ers Ceased WO2007053915A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05447250 2005-11-09
EP05447250.1 2005-11-09

Publications (2)

Publication Number Publication Date
WO2007053915A2 WO2007053915A2 (fr) 2007-05-18
WO2007053915A3 true WO2007053915A3 (fr) 2007-08-02

Family

ID=37989813

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE2006/000121 Ceased WO2007053915A2 (fr) 2005-11-09 2006-11-09 Derives de naringenine presentant une selectivite sur des ers

Country Status (1)

Country Link
WO (1) WO2007053915A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100898330B1 (ko) 2007-09-12 2009-05-20 건국대학교 산학협력단 항암성을 갖는 새로운 플라보노이드 유도체 7-ｏ-(3-벤질옥시프로필)-5,4' -ｏ-디메틸-아피제닌, 그 제법 및 그것을 포함하는 항암 조성물
US11090313B2 (en) 2010-05-20 2021-08-17 University Of Iowa Research Foundation Methods for inhibiting muscle atrophy
CN103037692B (zh) 2010-05-20 2015-02-25 爱荷华大学研究基金会 用于抑制肌萎缩的方法
US9295664B2 (en) 2011-06-06 2016-03-29 University Of Iowa Research Foundation Methods for lowering blood glucose
CN103012348B (zh) * 2012-12-19 2015-04-08 苏薇薇 一种6,8位取代柚皮素衍生物及其应用
CN113321637A (zh) * 2021-06-15 2021-08-31 西南大学 一种抗氧化活性良好的柚皮素酰腙类衍生物及其制作方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08165238A (ja) * 1994-12-12 1996-06-25 Sankyo Co Ltd エストロゲン作用剤
JPH09301915A (ja) * 1996-05-08 1997-11-25 Sankyo Co Ltd フラボン及びナフタレン誘導体
WO2004080474A1 (fr) * 2003-03-06 2004-09-23 The Medical Research And Education Trust Compositions d'extraits vegetaux ayant une action anti-cancereuse ou phytoestrogenique contenant des flavonoides de prenyle
EP1543834A1 (fr) * 2003-12-16 2005-06-22 Biodynamics Production de d'extraits de houblon ayant une bioactivité oestrogénique et anti-proliférative

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08165238A (ja) * 1994-12-12 1996-06-25 Sankyo Co Ltd エストロゲン作用剤
JPH09301915A (ja) * 1996-05-08 1997-11-25 Sankyo Co Ltd フラボン及びナフタレン誘導体
WO2004080474A1 (fr) * 2003-03-06 2004-09-23 The Medical Research And Education Trust Compositions d'extraits vegetaux ayant une action anti-cancereuse ou phytoestrogenique contenant des flavonoides de prenyle
EP1543834A1 (fr) * 2003-12-16 2005-06-22 Biodynamics Production de d'extraits de houblon ayant une bioactivité oestrogénique et anti-proliférative

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DASKIEWICZ JEAN-BAPTISTE ET AL: "Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: An SAR study", April 2005, JOURNAL OF MEDICINAL CHEMISTRY, VOL. 48, NR. 8, PAGE(S) 2790-2804, ISSN: 0022-2623, XP002433018 *
GOMEZ-GARIBAY F ET AL: "FLAVANONES FROM TEPHROSIA-LEIOCARPA", PHYTOCHEMISTRY (OXFORD), vol. 30, no. 11, 1991, pages 3832 - 3834, XP002432825, ISSN: 0031-9422 *
MILLIGAN S ET AL: "OESTROGENIC ACTIVITY OF THE HOP PHYTO-OESTROGEN, 8-PRENYLNARINGENIN", February 2002, REPRODUCTION, PORTLAND PRESS,, AU, PAGE(S) 235-242, ISSN: 1470-1626, XP009038592 *
POSSEMIERS S ET AL: "Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 53, no. 16, 16 July 2005 (2005-07-16), pages 6281 - 6288, XP002393639, ISSN: 0021-8561 *

Also Published As

Publication number Publication date
WO2007053915A2 (fr) 2007-05-18

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