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WO2007053800A3 - Compositions antimicrobiennes a base de lisozymes de charge modifiee, tensio-actifs et procedes de lutte contre les infections et la fibrose cystique - Google Patents

Compositions antimicrobiennes a base de lisozymes de charge modifiee, tensio-actifs et procedes de lutte contre les infections et la fibrose cystique Download PDF

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Publication number
WO2007053800A3
WO2007053800A3 PCT/US2006/060100 US2006060100W WO2007053800A3 WO 2007053800 A3 WO2007053800 A3 WO 2007053800A3 US 2006060100 W US2006060100 W US 2006060100W WO 2007053800 A3 WO2007053800 A3 WO 2007053800A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
infections
cystic fibrosis
charge
surfactants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/060100
Other languages
English (en)
Other versions
WO2007053800A2 (fr
Inventor
Gerard C L Wong
Wujing Xian
Lori K Sanders
Kirstin R Purdy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois at Urbana Champaign
University of Illinois System
Original Assignee
University of Illinois at Urbana Champaign
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois at Urbana Champaign, University of Illinois System filed Critical University of Illinois at Urbana Champaign
Publication of WO2007053800A2 publication Critical patent/WO2007053800A2/fr
Publication of WO2007053800A3 publication Critical patent/WO2007053800A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur des antimicrobiens de charge modifiée, comprenant des lysozymes de charge modifiée, et sur des compositions et des procédés qui permettent de potentialiser l'activité antimicrobienne en modifiant un niveau de charge net de l'antimicrobien. L'invention concerne également un procédé destiné à traiter les infections microbiennes, y compris les infections associées à la fibrose cystique, lequel procédé consiste à administrer ou à coadministrer un composé de l'invention. L'invention se rapporte à des compositions et procédés permettant de potentialiser un traitement antibiotique en administrant une composition tensio-active au moins partiellement cationique ou positivement chargée. L'invention concerne enfin des compositions lipidiques comprenant des formulations de DOTAP/DOPE.
PCT/US2006/060100 2005-10-21 2006-10-20 Compositions antimicrobiennes a base de lisozymes de charge modifiee, tensio-actifs et procedes de lutte contre les infections et la fibrose cystique Ceased WO2007053800A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72937605P 2005-10-21 2005-10-21
US60/729,376 2005-10-21

Publications (2)

Publication Number Publication Date
WO2007053800A2 WO2007053800A2 (fr) 2007-05-10
WO2007053800A3 true WO2007053800A3 (fr) 2008-03-06

Family

ID=38006536

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/060100 Ceased WO2007053800A2 (fr) 2005-10-21 2006-10-20 Compositions antimicrobiennes a base de lisozymes de charge modifiee, tensio-actifs et procedes de lutte contre les infections et la fibrose cystique

Country Status (2)

Country Link
US (1) US20080118489A1 (fr)
WO (1) WO2007053800A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010083504A2 (fr) * 2009-01-16 2010-07-22 Karl Edwin Griswold Variants de lysozyme thérapeutiques à charge génétiquement modifiée et procédés d'utilisation correspondants pour le traitement d'infections
CN102133404B (zh) * 2011-03-23 2013-01-16 成都诺恩生物科技有限公司 一种肿瘤靶向治疗药物载体、其制备方法及其应用
WO2013086243A2 (fr) * 2011-12-07 2013-06-13 Omega Protein Corporation Compositions de phospholipides enrichies pour les acides palmitoléique, myristoléique ou lauroléique, leur préparation et leur utilisation dans le traitement de maladie métabolique et cardiovasculaire
EP4204553A1 (fr) * 2020-08-27 2023-07-05 Danisco US Inc. Enzymes et compositions d'enzymes pour le nettoyage

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442133A (en) * 1982-02-22 1984-04-10 Greco Ralph S Antibiotic bonding of vascular prostheses and other implants
US4879135A (en) * 1984-07-23 1989-11-07 University Of Medicine And Dentistry Of New Jersey Drug bonded prosthesis and process for producing same
US20010036443A1 (en) * 2000-04-10 2001-11-01 Jerome Owen Cantor Intratracheal administration of lysozyme
US20030074700A1 (en) * 2000-05-02 2003-04-17 Ning Huang Expression of human milk proteins in transgenic plants

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358523B1 (en) * 1996-12-06 2002-03-19 The Regents Of The University Of California Macromolecule-lipid complexes and methods for making and regulating
CA2399944A1 (fr) * 2000-02-11 2001-08-16 Altana Pharma Ag Nouvelle utilisation d'un surfactant pulmonaire dans la prophylaxie et le traitement des maladies pulmonaires chroniques
AU2003225689B2 (en) * 2002-03-05 2009-03-26 Transave, Inc. Methods for entrapment of bioactive agent in a liposome or lipid complex
EP2823820B1 (fr) * 2002-10-29 2018-06-06 Insmed Incorporated Liposomes contenant un aminoglycoside pour le traitement d'infections pulmonaires

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442133A (en) * 1982-02-22 1984-04-10 Greco Ralph S Antibiotic bonding of vascular prostheses and other implants
US4879135A (en) * 1984-07-23 1989-11-07 University Of Medicine And Dentistry Of New Jersey Drug bonded prosthesis and process for producing same
US20010036443A1 (en) * 2000-04-10 2001-11-01 Jerome Owen Cantor Intratracheal administration of lysozyme
US20030074700A1 (en) * 2000-05-02 2003-04-17 Ning Huang Expression of human milk proteins in transgenic plants

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DONG ET AL.: "Electrostatic contributions to T4 lysozyme stability: solvent-exposed charges versus semi-buried salt bridges", BIOPHYS., vol. 83, no. 3, September 2002 (2002-09-01), pages 1341 - 1347 *
TANG ET AL.: "Anionic poly(amino acid)s dissolve F-actin and DNA bundles, enhance DNase activity, and reduce the viscosity of cystic fibrosis sputum", AM. J. PHYSIOL. LUNG CELL MOL. PHYSIOL., vol. 289, no. 4, 17 June 2005 (2005-06-17), pages L599 - L605 *

Also Published As

Publication number Publication date
WO2007053800A2 (fr) 2007-05-10
US20080118489A1 (en) 2008-05-22

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