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WO2007051071A3 - Two-step method of functionalizing carbon allotropes and pegylated carbon allotropes made by such methods - Google Patents

Two-step method of functionalizing carbon allotropes and pegylated carbon allotropes made by such methods Download PDF

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Publication number
WO2007051071A3
WO2007051071A3 PCT/US2006/042589 US2006042589W WO2007051071A3 WO 2007051071 A3 WO2007051071 A3 WO 2007051071A3 US 2006042589 W US2006042589 W US 2006042589W WO 2007051071 A3 WO2007051071 A3 WO 2007051071A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbon allotropes
conjugate
methods
functionalizing
peg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/042589
Other languages
French (fr)
Other versions
WO2007051071A2 (en
Inventor
W Edward Billups
Anil Sadana
Jayanta Chattopadhyay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William Marsh Rice University
Original Assignee
William Marsh Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Marsh Rice University filed Critical William Marsh Rice University
Publication of WO2007051071A2 publication Critical patent/WO2007051071A2/en
Publication of WO2007051071A3 publication Critical patent/WO2007051071A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B32/00—Carbon; Compounds thereof
    • C01B32/15—Nano-sized carbon materials
    • C01B32/158—Carbon nanotubes
    • C01B32/168—After-treatment
    • C01B32/174—Derivatisation; Solubilisation; Dispersion in solvents
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B32/00—Carbon; Compounds thereof
    • C01B32/20—Graphite
    • C01B32/21—After-treatment
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B2202/00—Structure or properties of carbon nanotubes
    • C01B2202/02—Single-walled nanotubes
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B2202/00—Structure or properties of carbon nanotubes
    • C01B2202/04—Nanotubes with a specific amount of walls
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B2202/00—Structure or properties of carbon nanotubes
    • C01B2202/06—Multi-walled nanotubes
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B2202/00—Structure or properties of carbon nanotubes
    • C01B2202/20—Nanotubes characterized by their properties
    • C01B2202/28—Solid content in solvents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Geology (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Composite Materials (AREA)
  • Epidemiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)
  • Carbon And Carbon Compounds (AREA)

Abstract

A method of functionalizing a carbon allotrope includes reacting a carbon allotrope with an alkali metal and an organohalide species to yield a first reaction product. The first reaction product reacts with a reactive species to yield a PEG-carbon allotrope conjugate. Water soluble CNTs and graphite are provided by this methods. A conjugate used in drug delivery includes at least one of a drug, an antibody, and a fluorescent tag. The conjugate further includes at least one of a PEG-CNT conjugate and a PEG-graphite conjugate.
PCT/US2006/042589 2005-10-28 2006-10-30 Two-step method of functionalizing carbon allotropes and pegylated carbon allotropes made by such methods Ceased WO2007051071A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73118805P 2005-10-28 2005-10-28
US60/731,188 2005-10-28

Publications (2)

Publication Number Publication Date
WO2007051071A2 WO2007051071A2 (en) 2007-05-03
WO2007051071A3 true WO2007051071A3 (en) 2007-06-14

Family

ID=37872182

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/042589 Ceased WO2007051071A2 (en) 2005-10-28 2006-10-30 Two-step method of functionalizing carbon allotropes and pegylated carbon allotropes made by such methods

Country Status (1)

Country Link
WO (1) WO2007051071A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008097343A2 (en) * 2006-08-08 2008-08-14 William Marsh Rice University Functionalized graphene materials and method of production thereof
CN100590070C (en) * 2008-04-23 2010-02-17 郑州大学 A method for modifying carbon nanotubes with polyethylene glycol
PH12013502278A1 (en) * 2011-05-18 2019-07-03 Basf Se Method for producing carbon fillers having covalently bonded amino groups
US8921600B2 (en) 2011-05-18 2014-12-30 Basf Se Process for producing carbon fillers having covalently bonded amino groups
CN106913886A (en) * 2015-12-28 2017-07-04 上海交通大学医学院附属新华医院 A kind of CNT photoacoustic contrast agent of cancer target and preparation method thereof
CN110980693A (en) * 2019-12-09 2020-04-10 宁波中乌新材料产业技术研究院有限公司 Carbon composite material and method for producing same
CN114518453B (en) * 2022-01-26 2023-05-16 东北农业大学 Multi-wall carbon nano tube compound and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090233A2 (en) * 2004-03-12 2005-09-29 William Marsh Rice University Reductive functionalization of carbon nanotubes
US20060191842A1 (en) * 2005-02-25 2006-08-31 Fred Wudl Hydrogen cyano fullerene containing proton conducting membranes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090233A2 (en) * 2004-03-12 2005-09-29 William Marsh Rice University Reductive functionalization of carbon nanotubes
US20060191842A1 (en) * 2005-02-25 2006-08-31 Fred Wudl Hydrogen cyano fullerene containing proton conducting membranes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIN ZHAO, HUI HU, AIPING YU,: "Synthesis and characterization of water soluble single-walled carbon nanotube graft copolymers", J. AM. CHEM. SOC., vol. 127, 5 December 2005 (2005-12-05), pages 8197 - 8203, XP002426704 *
BORONDICS F ET AL: "Reductive functionalization of carbon nanotubes", FULLERENES, NANOTUBES, AND CARBON NANOSTRUCTURES MARCEL DEKKER USA, vol. 13, 2005, pages 375 - 382, XP002426703, ISSN: 1536-383X *
DAE-HWAN JUNG, YOUNG KOAN KO, HEE-TAE JUNG: "Aggregation behavior of chemically attached poly(ethylene glycol) to single-walled carbon nanotubes (SWNTs) ropes", MATERIALS SCIENCE AND ENGINEERING, vol. 24, 2004, pages 117 - 121, XP002426702 *
E-MRS SPRING MEETING, SYMPOSIUM I "ADVANCED MULTIFUNCTIONAL NANOCARBON MATERIALS AND NANOSYSTEMS" 24-28 MAY 2004 STRASBOURG, FRANCE, 2004, ISSN: 1536-383X *
TABATA Y ET AL: "ANTITUMOR EFFECT OP POLY(ETHYLENE GLYCOL)- MODIFIED FULLERENE", FULLERENCE SCIENCE AND TECHNOLOGY, MARCEL DEKKER INC., NEW YORK, NY, US, vol. 5, no. 5, 1997, pages 989 - 1007, XP001007193, ISSN: 1064-122X *

Also Published As

Publication number Publication date
WO2007051071A2 (en) 2007-05-03

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