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WO2007050789A3 - Glycosyl-oligonucleotide conjugates and methods - Google Patents

Glycosyl-oligonucleotide conjugates and methods Download PDF

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Publication number
WO2007050789A3
WO2007050789A3 PCT/US2006/041837 US2006041837W WO2007050789A3 WO 2007050789 A3 WO2007050789 A3 WO 2007050789A3 US 2006041837 W US2006041837 W US 2006041837W WO 2007050789 A3 WO2007050789 A3 WO 2007050789A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycosyl
methods
oligonucleotide
oligonucleotide conjugates
sugar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/041837
Other languages
French (fr)
Other versions
WO2007050789A2 (en
Inventor
Mario H Genero
Andres P Montefeltro
Gabriel G Alvarado
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NEDKEN Corp
Original Assignee
NEDKEN Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NEDKEN Corp filed Critical NEDKEN Corp
Publication of WO2007050789A2 publication Critical patent/WO2007050789A2/en
Publication of WO2007050789A3 publication Critical patent/WO2007050789A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A glycosyl-oligonucleotide conjugate comprising a sugar or oligosaccharide moiety linked to an oligonucleotide by an oligonucleotide linkage between the 5' hydroxyl group of the oligonucleotide and a primary hydroxyl group of the sugar or oligosaccharide, and methods of making and using the conjugate are disclosed.
PCT/US2006/041837 2005-10-25 2006-10-25 Glycosyl-oligonucleotide conjugates and methods Ceased WO2007050789A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73049805P 2005-10-25 2005-10-25
US60/730,498 2005-10-25

Publications (2)

Publication Number Publication Date
WO2007050789A2 WO2007050789A2 (en) 2007-05-03
WO2007050789A3 true WO2007050789A3 (en) 2007-06-28

Family

ID=37890360

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/041837 Ceased WO2007050789A2 (en) 2005-10-25 2006-10-25 Glycosyl-oligonucleotide conjugates and methods

Country Status (1)

Country Link
WO (1) WO2007050789A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2560687B1 (en) * 2010-04-19 2017-05-24 Nlife Therapeutics S.L. Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
HK1214179A1 (en) * 2012-10-26 2016-07-22 恩莱弗医疗有限公司 Compositions and methods for the treatment of parkinson disease by the selective delivery of oligonucleotide molecules to specific neuron types
CN111148519A (en) * 2017-07-28 2020-05-12 细胞基因公司 Methods of preparing oligonucleotide compounds
CN114717224B (en) * 2022-04-08 2024-01-30 苏州大学 A method based on solid phase enrichment and identification of glycosylated ribonucleic acid glycoRNA
AU2023279271A1 (en) * 2022-05-30 2024-11-28 Nurexone Biologic Ltd. Compositions and methods for loading extracellular vesicles

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ADINOLFI M ET AL: "Solid Phase Glycosidation of Oligonucleotides", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 40, no. 13, 26 March 1999 (1999-03-26), pages 2607 - 2610, XP004158097, ISSN: 0040-4039 *
ADINOLFI M ET AL: "Solid-phase synthesis of glyco-oligonucleotide conjugates", SYNLETT 2001 GERMANY, no. 6, 2001, pages 745 - 748, XP002428046, ISSN: 0936-5214 *
KATAJISTO JOHANNA ET AL: "Solid-phase synthesis of oligonucleotide glycoconjugates bearing three different glycosyl groups: orthogonally protected bis(hydroxymethyl)-N,N'-bis(3-hydroxypropyl)malondiamide phosphoramidite as key building block.", THE JOURNAL OF ORGANIC CHEMISTRY 29 OCT 2004, vol. 69, no. 22, 29 October 2004 (2004-10-29), pages 7609 - 7615, XP002428045, ISSN: 0022-3263 *
MATSUURA K ET AL: "Construction of glyco-clusters by self-organization of site-specifically glycosylated oligonucleotides and their cooperative amplification of lectin-recognition", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 123, no. 2, 2001, pages 357 - 358, XP002968426, ISSN: 0002-7863 *
ZATSEPIN TIMOFEI S ET AL: "Synthesis and applications of oligonucleotide-carbohydrate conjugates.", CHEMISTRY & BIODIVERSITY OCT 2004, vol. 1, no. 10, October 2004 (2004-10-01), pages 1401 - 1417, XP002428047, ISSN: 1612-1880 *

Also Published As

Publication number Publication date
WO2007050789A2 (en) 2007-05-03

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