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WO2007049278A3 - Methode de preparation de liposomes et utilisations - Google Patents

Methode de preparation de liposomes et utilisations Download PDF

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Publication number
WO2007049278A3
WO2007049278A3 PCT/IL2006/001229 IL2006001229W WO2007049278A3 WO 2007049278 A3 WO2007049278 A3 WO 2007049278A3 IL 2006001229 W IL2006001229 W IL 2006001229W WO 2007049278 A3 WO2007049278 A3 WO 2007049278A3
Authority
WO
WIPO (PCT)
Prior art keywords
liposome
liposomes
lipid
forming lipid
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2006/001229
Other languages
English (en)
Other versions
WO2007049278A2 (fr
Inventor
Yechezkel Barenholz
Olga Garbuzenko
Keren Barhum
Gilbert Grant
Boris Piskoun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
New York University NYU
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem, New York University NYU filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Priority to AU2006307460A priority Critical patent/AU2006307460A1/en
Priority to JP2008537312A priority patent/JP2009513621A/ja
Priority to CA002627657A priority patent/CA2627657A1/fr
Priority to EP06809790A priority patent/EP1954243A2/fr
Publication of WO2007049278A2 publication Critical patent/WO2007049278A2/fr
Publication of WO2007049278A3 publication Critical patent/WO2007049278A3/fr
Anticipated expiration legal-status Critical
Priority to IL191074A priority patent/IL191074A0/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

La présente invention concerne une méthode simplifiée et rentable de préparation de liposomes, ladite méthode consistant à utiliser un lipide sec de formation de liposomes ou un mélange sec comprenant un lipide de formation de liposomes, à dissoudre le lipide de formation de liposomes ou ledit mélange comprenant un lipide de formation de liposomes de l'étape (a) avec un solvant organique protique pour obtenir une solution ou une dispersion dudit lipide; et à ajouter la solution ou dispersion de l'étape (b) dans une solution aqueuse contenant des ions pour former une suspension de liposomes, les liposomes pouvant encapsuler un agent avec un rapport supérieur à 1,0 entre l'agent et le lipide de formation des liposomes. Le procédé de l'invention se caractérise en ce qu'il n'est pas nécessaire de sécher la solution ou la dispersion pour former un film lipidique sec, et/ou réduire la dimension des liposomes dans ladite suspension de liposomes pour former de petites vésicules unilaméllaires (SUV). Les liposomes ainsi formés peuvent alors être utilisés pour recevoir un agent actif, par exemple des médicaments amphipatiques à base d'acide faible.
PCT/IL2006/001229 2005-10-26 2006-10-26 Methode de preparation de liposomes et utilisations Ceased WO2007049278A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2006307460A AU2006307460A1 (en) 2005-10-26 2006-10-26 A method for preparing liposomes and uses thereof
JP2008537312A JP2009513621A (ja) 2005-10-26 2006-10-26 リポソームを調製する方法及びその使用
CA002627657A CA2627657A1 (fr) 2005-10-26 2006-10-26 Methode de preparation de liposomes et utilisations
EP06809790A EP1954243A2 (fr) 2005-10-26 2006-10-26 Methode de preparation de liposomes et utilisations
IL191074A IL191074A0 (en) 2005-10-26 2008-04-27 A method for preparing liposomes and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73004505P 2005-10-26 2005-10-26
US60/730,045 2005-10-26

Publications (2)

Publication Number Publication Date
WO2007049278A2 WO2007049278A2 (fr) 2007-05-03
WO2007049278A3 true WO2007049278A3 (fr) 2007-09-13

Family

ID=37968217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/001229 Ceased WO2007049278A2 (fr) 2005-10-26 2006-10-26 Methode de preparation de liposomes et utilisations

Country Status (5)

Country Link
EP (1) EP1954243A2 (fr)
JP (1) JP2009513621A (fr)
AU (1) AU2006307460A1 (fr)
CA (1) CA2627657A1 (fr)
WO (1) WO2007049278A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2523413A1 (fr) 2003-04-25 2004-11-11 The Penn State Research Foundation Methode et systeme de liberation systemique de composes bioactifs derives de lipides, d'arret de croissance
CN102137713A (zh) * 2008-12-24 2011-07-27 生物制药开发股份有限公司 脂质体的制备方法及胆固醇溶解方法
WO2011092708A2 (fr) * 2010-02-01 2011-08-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Liposomes comprenant des médicaments amphipathiques et procédé pour leur préparation
JP6194248B2 (ja) 2010-10-28 2017-09-06 パシラ ファーマシューティカルズ インコーポレーテッド 非ステロイド性抗炎症薬の徐放性処方物
JP5889279B2 (ja) * 2011-03-25 2016-03-22 テルモ株式会社 持続徐放性リポソーム組成物およびその製造方法
WO2014046191A1 (fr) * 2012-09-21 2014-03-27 テルモ株式会社 Préparation d'un liposome à libération prolongée à longue durée anesthésique locale
NZ711500A (en) * 2013-03-15 2020-05-29 Taiwan Liposome Co Ltd Engineering a control drug release profile via liposome compositions in both aqueous and non-aqueous compartments
US10220095B2 (en) 2013-03-15 2019-03-05 Taiwan Liposome Company, Ltd Controlled drug release liposome compositions and methods thereof
CN104906586A (zh) * 2014-03-10 2015-09-16 中国科学院上海药物研究所 一种盐酸伊立替康复合磷脂组合物、制备方法及其应用
JP6866060B2 (ja) * 2014-10-27 2021-04-28 花王株式会社 精製茶抽出物の製造方法
DK3302435T3 (da) * 2015-05-26 2023-06-06 Plumb Pharmaceuticals Inc Liposomladning
CN106619516B (zh) * 2016-10-10 2020-07-03 常州金远药业制造有限公司 一种小分子靶向药物脂质体制剂的制备方法
WO2018094253A1 (fr) 2016-11-18 2018-05-24 Pacira Pharmaceuticals, Inc. Formulations de liposomes multivésiculaires à microparticules de complexe de méloxicam de zinc et leurs procédés de fabrication
JP6974670B2 (ja) * 2017-07-24 2021-12-01 ファルモサ バイオファーマ インコーポレイテッド 弱酸性薬物を含むリポソーム組成物およびその使用
JP7140418B2 (ja) * 2018-05-07 2022-09-21 ファルモサ バイオファーマ インコーポレイテッド トレプロスチニルの制御放出のための医薬組成物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3335701A1 (de) * 1982-10-04 1984-04-05 Lipoderm Pharmaceuticals Ltd., Halifax, Nova Scotia Verfahren zur herstellung grosser multilamellarer lipidblaeschen
FR2550706A1 (fr) * 1983-08-17 1985-02-22 Sterwin Ag
EP0260241A1 (fr) * 1986-09-12 1988-03-16 Aktiebolaget Draco Système pour l'administration de liposomes aux mammifères
US5169637A (en) * 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
WO1996010393A1 (fr) * 1994-09-30 1996-04-11 Bracco Research S.A. Liposomes a capacite de piegage amelioree, procede et utilisation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3335701A1 (de) * 1982-10-04 1984-04-05 Lipoderm Pharmaceuticals Ltd., Halifax, Nova Scotia Verfahren zur herstellung grosser multilamellarer lipidblaeschen
US5169637A (en) * 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
FR2550706A1 (fr) * 1983-08-17 1985-02-22 Sterwin Ag
EP0260241A1 (fr) * 1986-09-12 1988-03-16 Aktiebolaget Draco Système pour l'administration de liposomes aux mammifères
WO1996010393A1 (fr) * 1994-09-30 1996-04-11 Bracco Research S.A. Liposomes a capacite de piegage amelioree, procede et utilisation

Also Published As

Publication number Publication date
JP2009513621A (ja) 2009-04-02
AU2006307460A1 (en) 2007-05-03
WO2007049278A2 (fr) 2007-05-03
EP1954243A2 (fr) 2008-08-13
CA2627657A1 (fr) 2007-05-03

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