[go: up one dir, main page]

WO2007045663A3 - Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure - Google Patents

Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure Download PDF

Info

Publication number
WO2007045663A3
WO2007045663A3 PCT/EP2006/067523 EP2006067523W WO2007045663A3 WO 2007045663 A3 WO2007045663 A3 WO 2007045663A3 EP 2006067523 W EP2006067523 W EP 2006067523W WO 2007045663 A3 WO2007045663 A3 WO 2007045663A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetic
hypertension
disease
renal
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/067523
Other languages
French (fr)
Other versions
WO2007045663A2 (en
Inventor
John Glasspool
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of WO2007045663A2 publication Critical patent/WO2007045663A2/en
Publication of WO2007045663A3 publication Critical patent/WO2007045663A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates a pharmaceutical composition comprising a combination of (i) an AT1 receptor antagonist selected from the group selected from the group consisting of candesartan, eprosartan, irbesartan, losartan, saprisartan, tasosartan, telmisartan, or, in each case, a pharmaceutically acceptable salt thereof and (ii) a NEP inhibitor or a pharmaceutically acceptable salt thereof and optionally a pharmaceutically acceptable carrier and to a method for the treatment or prevention of a condition or disease selected from the group consisting of hypertension, heart failure such as (acute and chronic) congestive heart failure, left ventricular dysfunction and hypertrophic cardiomyopathy, diabetic cardiac myopathy, supraventricular and ventricular arrhythmias, atrial fibrillation, atrial flutter, detrimental vascular remodeling, myocardial infarction and its sequelae, atherosclerosis, angina (whether unstable or stable), renal insufficiency (diabetic and non- diabetic), heart failure, angina pectoris, diabetes, secondary aldosteronism, primary and secondary pulmonary hypertension, renal failure conditions, such as diabetic nephropathy, glomerulonephritis, scleroderma, glomerular sclerosis, proteinuria of primary renal disease, and also renal vascular hypertension, diabetic retinopathy, the management of other vascular disorders, such as migraine, peripheral vascular disease, Raynaud's disease, luminal hyperplasia, cognitive dysfunction (such as Alzheimer's), glaucoma and stroke, comprising administering a therapeutically effective amount of the pharmaceutical composition to a mammal in need thereof.
PCT/EP2006/067523 2005-10-19 2006-10-17 Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure Ceased WO2007045663A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72837505P 2005-10-19 2005-10-19
US60/728,375 2005-10-19

Publications (2)

Publication Number Publication Date
WO2007045663A2 WO2007045663A2 (en) 2007-04-26
WO2007045663A3 true WO2007045663A3 (en) 2008-03-27

Family

ID=37876130

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/067523 Ceased WO2007045663A2 (en) 2005-10-19 2006-10-17 Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure

Country Status (1)

Country Link
WO (1) WO2007045663A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200838501A (en) 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
TWI448284B (en) 2007-04-24 2014-08-11 Theravance Inc Dual-acting antihypertensive agents
TWI406850B (en) 2007-06-05 2013-09-01 Theravance Inc Dual-acting benzoimidazole antihypertensive agents
EP2200975A1 (en) 2007-09-07 2010-06-30 Theravance, Inc. Dual-acting antihypertensive agents
JP2011506459A (en) 2007-12-11 2011-03-03 セラヴァンス， インコーポレーテッド Dual acting benzimidazole derivatives and their use as antihypertensive agents
EP2297113A1 (en) 2008-04-29 2011-03-23 Theravance, Inc. Dual-acting antihypertensive agents
US7863309B2 (en) 2008-07-24 2011-01-04 Theravance, Inc. Dual-acting antihypertensive agents
ES2523734T3 (en) 2009-05-28 2014-12-01 Novartis Ag Aminopropionic derivatives substituted as neprilysin inhibitors
JP5466759B2 (en) 2009-05-28 2014-04-09 ノバルティス アーゲー Substituted aminobutyric acid derivatives as neprilysin inhibitors
WO2011005674A1 (en) 2009-07-07 2011-01-13 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
US8372984B2 (en) 2009-07-22 2013-02-12 Theravance, Inc. Dual-acting oxazole antihypertensive agents
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
JP2013517295A (en) 2010-01-19 2013-05-16 セラヴァンス， インコーポレーテッド Dual acting thiophene, pyrrole, thiazole and furan antihypertensive drugs
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
JP6301371B2 (en) 2013-02-14 2018-04-11 ノバルティス アーゲー Substituted bisphenylbutanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
MX367525B (en) 2013-02-14 2019-08-26 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors.
CN104230865B (en) * 2013-06-13 2018-01-09 上海翰森生物医药科技有限公司 4 amino butyric acid derivatives of biaryl substituted and its production and use
JP2016530282A (en) * 2013-08-26 2016-09-29 ノバルティス アーゲー New use
CN106795099B (en) * 2014-04-10 2019-11-26 南京奥昭生物科技有限公司 prodrugs and compositions for the treatment of hypertension and cardiovascular disease
US10285992B2 (en) * 2014-08-07 2019-05-14 Intra-Cellular Therapies, Inc. Combinations of PDE1 inhibitors and NEP inhibitors and associated methods
US20180311241A1 (en) * 2015-10-29 2018-11-01 Cadila Healthcare Limited Pharmaceutical synergistic combination
CN105348209B (en) 2015-12-09 2017-12-26 浙江天宇药业股份有限公司 A kind of anti-heart failure medicine LCZ696 preparation method
MX2018007129A (en) 2015-12-11 2018-11-09 Zentiva Ks Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)a mino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method.
US11096928B2 (en) * 2016-10-08 2021-08-24 Wuhan Ll Science And Technology Development Co., Ltd. Pharmaceutical composition
CN108892624B (en) * 2018-06-20 2020-12-15 重庆威鹏药业有限公司 Sacubitril nitroxide derivative and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
EP0726072A2 (en) * 1995-02-08 1996-08-14 Bristol-Myers Squibb Company Composition for the treatment of hypertension and congestive heart failure, containing an angiotensin II antagonist and an endopeptidase inhibitor
WO2001074348A2 (en) * 2000-04-03 2001-10-11 Bristol-Myers Squibb Co. Vasopeptidase inhibitors to treat isolated systolic hypertension
WO2002006253A1 (en) * 2000-07-19 2002-01-24 Novartis Ag Valsartan salts
WO2003059345A1 (en) * 2002-01-17 2003-07-24 Novartis Ag Pharmaceutical compositions comprising valsartan and nep inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
EP0726072A2 (en) * 1995-02-08 1996-08-14 Bristol-Myers Squibb Company Composition for the treatment of hypertension and congestive heart failure, containing an angiotensin II antagonist and an endopeptidase inhibitor
WO2001074348A2 (en) * 2000-04-03 2001-10-11 Bristol-Myers Squibb Co. Vasopeptidase inhibitors to treat isolated systolic hypertension
WO2002006253A1 (en) * 2000-07-19 2002-01-24 Novartis Ag Valsartan salts
WO2003059345A1 (en) * 2002-01-17 2003-07-24 Novartis Ag Pharmaceutical compositions comprising valsartan and nep inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TRIPPODO N C ET AL: "Repression of angiotensin II and potentiation of bradykinin contribute to the synergistic effects of dual metalloprotease inhibition in heart failure.", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS FEB 1995, vol. 272, no. 2, February 1995 (1995-02-01), pages 619 - 627, XP002460938, ISSN: 0022-3565 *

Also Published As

Publication number Publication date
WO2007045663A2 (en) 2007-04-26

Similar Documents

Publication Publication Date Title
WO2007045663A3 (en) Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure
WO2007106708A3 (en) Combinations of the angiotensin ii antagonist valsartan and the nep inhibitor daglutril
NO2016009I1 (en) Sakubitrile / valsartan, including pharmaceutically acceptable salts thereof
LU92000I2 (en) A combination comprising aliskiren or a pharmaceutically acceptable salt thereof and amlodipine or a pharmaceutically acceptable salt thereof and hydrochlorothiazide or a pharmaceutically acceptable salt thereof
EP1870098A3 (en) Combined use of valsartan and calcium channel blockers for therapeutic purposes
JP2010280708A5 (en)
AR040017A1 (en) COMBINATION OF ORGANIC COMPOUNDS
CA2486144A1 (en) Compositions comprising an angiotensin receptor blocker, a calcium channel blocker and a diuretic
BR0317384A (en) Combinations of valsartan with cox-2 inhibitors
RU2014145827A (en) COMPOSITION, INCLUDING AMLODIPINE AND LOZARTAN, HAVING IMPROVED STABILITY

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06819089

Country of ref document: EP

Kind code of ref document: A2