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WO2007045475A1 - Dispositif de comptage de doses - Google Patents

Dispositif de comptage de doses Download PDF

Info

Publication number
WO2007045475A1
WO2007045475A1 PCT/EP2006/010095 EP2006010095W WO2007045475A1 WO 2007045475 A1 WO2007045475 A1 WO 2007045475A1 EP 2006010095 W EP2006010095 W EP 2006010095W WO 2007045475 A1 WO2007045475 A1 WO 2007045475A1
Authority
WO
WIPO (PCT)
Prior art keywords
counting device
canister
dose
dose counting
actuator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/010095
Other languages
English (en)
Inventor
Richard Pavkov
Dominik Ziegler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH Austria
Novartis AG
Original Assignee
Novartis Pharma GmbH Austria
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma GmbH Austria, Novartis AG filed Critical Novartis Pharma GmbH Austria
Publication of WO2007045475A1 publication Critical patent/WO2007045475A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0075—Mechanical counters having a display or indicator on a disc
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0076—Mechanical counters having a display or indicator on a drum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans

Definitions

  • the present invention relates to a dose counting device for a pressurised metered dose inhaler.
  • Inhalers are commonly used to administer medicaments to the pulmonary tracts of humans or animals to treat respiratory diseases such as asthma, chronic obstructive pulmonary disease and allergies.
  • a well-known type of inhaler comprises a medicament canister and an actuator.
  • the medicament is formulated as a liquid and stored under pressure in the canister.
  • the canister is located in the actuator and includes a valve stem that engages a support block within the actuator.
  • the canister can be depressed relative to the actuator so as to dispense a metered dose of medicament in aerosol form through a mouthpiece that extends from the actuator.
  • the valve stem which is typically spring-loaded, biases the canister away from the support block so that after the dose has been dispensed the canister will move back again relative to the actuator. In this way a metered dose of medicament is administered by each cycle of linear reciprocal movement of the canister relative to the actuator.
  • Pressurised metered dose inhalers often include some means for counting the number of doses dispensed from or remaining in the canister so that the user can monitor the frequency of doses taken and be aware when the canister is almost empty.
  • a variety of dose counting devices for pressurised metered dose inhalers are known in the field but they are not entirely satisfactory to use or manufacture and thus can be improved.
  • the present invention provides a dose counting device for a pressurised metered dose inhaler that overcomes certain problems associated with known dose counting devices for those inhalers or at least provides a useful alternative to such dose counting devices.
  • the invention in broad terms relates to a dose counting device suitable for indicating the number of doses of a medicament that have been dispensed from or remain in a canister located within the actuator of a pressurised metered dose inhaler, wherein the dose counting device comprises
  • a cylindrical body that is attachable to the base of the canister; a counting mechanism that is contained in the body;
  • display means that displays the number of doses of a medicament that have been dispensed from or remain in the canister
  • the trigger is formed to engage with the actuator of the inhaler when the dose counting device is displaced relative to the actuator thereby actuating the counting mechanism.
  • the dose counting device is constructed to minimise stack-up tolerances on a canister-by- canister basis and/or a dose-by-dose basis.
  • the trigger converts the linear translational movement created by displacing the dose counting device with respect to the actuator to a radial translation movement that actuates the counting mechanism.
  • the trigger is one of a plurality of radially extending fingers of a count wheel.
  • the count wheel, or at least the fingers thereof, is preferably composed of a flexible plastics material to avoid or at least minimise problems arising from tolerance issues associated with the manufacture and assembly of the inhaler.
  • the dose counting device is permanently fixed to the base of the canister, for example by an adhesive, especially a UV-activated adhesive.
  • the body of the dose counting device has a floor that is shaped to receive and accommodate the base of the canister.
  • a truncated cone extends from the body that is adapted to receive and accommodate the base of the canister.
  • Figure 1 shows a cutaway perspective side view of a pressurised metered dose inhaler with a dose counting device of the present invention attached to the base of a medicament canister that is located in the actuator of the inhaler.
  • FIG 2 shows the dose counting device shown in Figure 1 without the inhaler.
  • Figure 3 shows a cut-a-way side view of the dose counting device of Figure 1 attached to the base of the medicament canister of inhaler.
  • Figure 4 shows a cut-a-way side view of an alternative embodiment of the dose counting device of the present invention attached to the base of a medicament canister that is located in the actuator of a pressurised metered dose inhaler.
  • Figure 5 shows a cut-a-way side view of another alternative embodiment of the dose counting device of the present invention attached to the base of a medicament canister that is located in the actuator of a pressurised metered dose inhaler.
  • Figure 6 shows a cut-a-way side view of a further alternative embodiment of the dose counting device of the present invention that is attached to the base of a medicament canister in the same way as the embodiment shown in Figure 5.
  • the trigger takes the form of a toggle that activates a count wheel that is shown in the drawing.
  • the dose counting device of the present invention is a device that is attached to the base of the medicament canister of a pressurised metered dose inhaler. It records every time a user uses the inhaler to administer medication stored in the canister of the inhaler.
  • Figure 1 shows the dose counting device 1 attached to the base of a medicament canister 5 of a standard pressurised metered dose inhaler 10.
  • the canister contains a pressurised liquid formulation of a medicament that is suitable for the treatment of a respiratory disease by pulmonary inhalation, for example asthma or chronic obstructive pulmonary disease.
  • the inhaler has an actuator 15 that is substantially tubular in shape.
  • the canister 5 is loaded into one end of the actuator i.e. the canister-loading end 18.
  • the other end of the actuator 15 forms a mouthpiece 20 that can be closed by attaching a removable cap 25.
  • the aerosol canister 5 has a spring-biased valve stem 30 that rests in a support block 35 formed on the internal surface of the actuator 15 adjacent the mouthpiece 20.
  • the support block 35 has a passage 40 that connects the end of the valve stem 30, when resting on the support block 35, and an outlet 45 that is directed towards the mouthpiece.
  • the inhaler is constructed so that in use the user removes the removable cap 25, places his lips on the mouthpiece and depresses the canister 5 relative to the valve stem 30, whilst holding the actuator 15. This causes the valve to open and discharge a predetermined dose of the medicament from the canister through the passage 40 of the support block 35 and out of the outlet 45. The user inhales the medicament into his lungs through the mouthpiece 20.
  • the valve stem is spring-loaded and biases the canister away from the support block so that after the dose has been dispensed the canister will move back again relative to the actuator. These steps are repeated to administer any further doses.
  • the dose counting device is shown in more detail in Figure 2. It has a substantially cylindrical body 50, which has a top 55, side 60 and floor (not shown). A dose counting display 70 is formed in the top 55 of the body 50. This displays the number of doses that have dispensed, or more preferably the number of doses that remain.
  • the body 50 contains a trigger mechanism that is activated when the dose counting device is displaced linearly with respect to the actuator. Preferably the trigger mechanism converts this linear translational movement to a radial translation movement within the counting device.
  • the trigger mechanism comprises a count wheel that has a plurality of radially extending fingers and which is geared to a count mechanism (not shown). One of these fingers 75 of that count wheel is shown protruding from an aperture 80 that is formed in the side of 60 of the device.
  • the floor of the dose counting device is fixed to the base of the canister, preferably permanently, to avoid or at least minimise tolerances associated with the manufacture and assembly of the inhaler and dose counting device stacking in a manner that might prejudice accurate actuation and counting.
  • the device is fixed to the base of the canister using an adhesive.
  • the adhesive is activated by UV radiation. Suitable UV- activated adhesives include LOCTITETM 3301 and LOCTITETM 3311 light cure acrylic adhesives (ex Henkel Loctite Corporation).
  • the floor of the dose counting device shown in Figure 1 is formed as a recess in the lower part of the body 50 of the dose counting device shown. This floor is seen in Figure 3.
  • the recess is shaped to receive and accommodate the base of the canister snugly however there may be a gap or buffer space to minimise the impact of any of the aforementioned tolerances, especially on a canister-by-canister basis.
  • the dose counting device is preferably fixed to the base of the canister by an adhesive. This adhesive is preferably applied to the inner surface of the lower part of the body during manufacture i.e. where the base of the canister contacts the dose counting device and/or, more preferably, on the inner surface of the annular part of the body.
  • the user depresses the top 55 of the body 50 of the dose counting device to depress the canister 5 of the inhaler relative to the actuator of the inhaler.
  • the fingers 75 are formed to engage with the actuator of the inhaler and cause the count wheel to a rotate forward one notch or position when the dose counting device is displaced relative to the actuator. This action draws the exposed finger 75 into the aperture 80.
  • the fingers are formed to engage the lip of the canister-loading end 18 of the actuator.
  • the fingers might alternatively be formed to engage with some other part of the actuator, which might for example be formed specifically to receive the fingers 75.
  • the count wheel indexes a count mechanism (not shown) that displays the count in the dose counting display 70.
  • the count wheel or at least the fingers thereof, is preferably composed of a material that enables the fingers 75 to be flexible but resilient, for example a flexible plastics material such as polypropylene. This permits the count wheel mechanism to avoid or at least minimise problems arising from tolerance issues associated with the manufacture and assembly of the inhaler and the dose counting device, especially on a dose-by-dose basis.
  • the user removes downwards pressure on the dose counting device and the spring-biased valve stem returns the dose counting device and canister to their original position. In doing so another finger 75 will emerge from the aperture 80 of the body 50. This cycle is repeated to administer multiple doses.
  • FIG. 4 An alternative preferred embodiment of the dose counting device of the present invention is shown in Figure 4.
  • a truncated cone depends from the body 50 which is adapted to receive and accommodate the base of the canister snugly.
  • the diameter of the cylindrical body 50 of the dose counting device is substantially the same as the diameter of the canister 5 of the inhaler.
  • the diameter of the cylindrical body 50 of the dose counting device is also substantially the same as the diameter of the canister 5 of the inhaler.
  • the trigger mechanism takes the form of a toggle or ratchet 85 that is hinged at pivot point 90 and activates a count mechanism 95 when the dose counting device is displaced linearly with respect to the actuator. The number of doses that remain in the medicament canister 5 is visible through the dose counting display 70.
  • the dose counting device of the present invention can be made of any suitable material, for example a tough plastics material such as acrylonitrile-butadiene-styrene (ABS) or polypropylene.
  • ABS acrylonitrile-butadiene-styrene
  • polypropylene polypropylene

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Dispositif de comptage de doses destiné à indiquer le nombre de doses d'un médicament qui ont été distribuées depuis, ou qui restent dans, une cartouche située à l'intérieur de l'actionneur d'un inhalateur doseur pressurisé. Le dispositif de comptage de doses comporte un corps cylindrique qui peut être fixé à la base de la cartouche, un mécanisme de comptage contenu dans le corps, une détente qui dépasse du corps cylindrique pour activer le mécanisme de comptage et un moyen d'affichage qui affiche le nombre de doses d'un médicament qui ont été distribuées depuis, ou qui restent dans, la cartouche. La détente est formée de façon à engrener avec l'actionneur de l'inhalateur lorsque le dispositif de comptage de doses est déplacé par rapport à l'actionneur, actionnant ainsi le mécanisme de comptage.
PCT/EP2006/010095 2005-10-21 2006-10-19 Dispositif de comptage de doses Ceased WO2007045475A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0521510.8A GB0521510D0 (en) 2005-10-21 2005-10-21 Organic compounds
GB0521510.8 2005-10-21

Publications (1)

Publication Number Publication Date
WO2007045475A1 true WO2007045475A1 (fr) 2007-04-26

Family

ID=35458485

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/010095 Ceased WO2007045475A1 (fr) 2005-10-21 2006-10-19 Dispositif de comptage de doses

Country Status (2)

Country Link
GB (1) GB0521510D0 (fr)
WO (1) WO2007045475A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8807131B1 (en) 2013-06-18 2014-08-19 Isonea Limited Compliance monitoring for asthma inhalers
CN106255554A (zh) * 2014-05-07 2016-12-21 勃林格殷格翰国际有限公司 容器、喷雾器及用途
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
EP3928818A1 (fr) * 2014-05-07 2021-12-29 Boehringer Ingelheim International GmbH Nébuliseur et récipient

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002275A1 (fr) * 1984-10-09 1986-04-24 Aktiebolaget Draco Dispositif vaporisateur medical
US5871007A (en) * 1997-06-09 1999-02-16 Chase Marketing International L.L.C. Throat spray counting mechanism
GB2372542A (en) * 2001-02-23 2002-08-28 Bespak Plc Dosage counting device
WO2006004498A1 (fr) * 2004-07-05 2006-01-12 Astrazeneca Ab Inhalateur reduisant le risque d'erreur de calcul des doses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002275A1 (fr) * 1984-10-09 1986-04-24 Aktiebolaget Draco Dispositif vaporisateur medical
US5871007A (en) * 1997-06-09 1999-02-16 Chase Marketing International L.L.C. Throat spray counting mechanism
GB2372542A (en) * 2001-02-23 2002-08-28 Bespak Plc Dosage counting device
WO2006004498A1 (fr) * 2004-07-05 2006-01-12 Astrazeneca Ab Inhalateur reduisant le risque d'erreur de calcul des doses

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8807131B1 (en) 2013-06-18 2014-08-19 Isonea Limited Compliance monitoring for asthma inhalers
US10716905B2 (en) 2014-02-23 2020-07-21 Boehringer Lngelheim International Gmbh Container, nebulizer and use
CN106255554A (zh) * 2014-05-07 2016-12-21 勃林格殷格翰国际有限公司 容器、喷雾器及用途
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
CN106255554B (zh) * 2014-05-07 2021-05-04 勃林格殷格翰国际有限公司 容器、喷雾器及用途
EP3928818A1 (fr) * 2014-05-07 2021-12-29 Boehringer Ingelheim International GmbH Nébuliseur et récipient
EP3139979B1 (fr) * 2014-05-07 2023-07-05 Boehringer Ingelheim International GmbH Unité, nébuliseur et procédé

Also Published As

Publication number Publication date
GB0521510D0 (en) 2005-11-30

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