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WO2006138324A3 - Treponema pallidum antigens for vaccine development and diagnostic tests - Google Patents

Treponema pallidum antigens for vaccine development and diagnostic tests Download PDF

Info

Publication number
WO2006138324A3
WO2006138324A3 PCT/US2006/023040 US2006023040W WO2006138324A3 WO 2006138324 A3 WO2006138324 A3 WO 2006138324A3 US 2006023040 W US2006023040 W US 2006023040W WO 2006138324 A3 WO2006138324 A3 WO 2006138324A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnostic tests
vaccine development
treponema pallidum
pallidum antigens
antigens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/023040
Other languages
French (fr)
Other versions
WO2006138324A2 (en
Inventor
Matthew Mckevitt
Timothy Palzkill
Steven J Norris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Publication of WO2006138324A2 publication Critical patent/WO2006138324A2/en
Anticipated expiration legal-status Critical
Publication of WO2006138324A3 publication Critical patent/WO2006138324A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/571—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses for venereal disease, e.g. syphilis, gonorrhoea
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to T. pallidum antigens. More particularly, the present invention relates to immunogenic compositions comprised of T. pallidum antigens, methods of inducing an immune response in a subject agains T, pallidum antigens, and methods to detect anti-T. pallidum antibodies in a sample.
PCT/US2006/023040 2005-06-14 2006-06-14 Treponema pallidum antigens for vaccine development and diagnostic tests Ceased WO2006138324A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69048105P 2005-06-14 2005-06-14
US60/690,481 2005-06-14

Publications (2)

Publication Number Publication Date
WO2006138324A2 WO2006138324A2 (en) 2006-12-28
WO2006138324A3 true WO2006138324A3 (en) 2008-10-16

Family

ID=37571080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/023040 Ceased WO2006138324A2 (en) 2005-06-14 2006-06-14 Treponema pallidum antigens for vaccine development and diagnostic tests

Country Status (1)

Country Link
WO (1) WO2006138324A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010031127A1 (en) * 2008-09-17 2010-03-25 Oral Health Australia Pty Ltd Detection of treponema infection
AU2010259360B2 (en) * 2009-06-12 2015-01-22 Kode Biotech Limited Assays for serological detection of syphilis
CA2824758C (en) * 2011-01-13 2019-06-04 Ortho-Clinical Diagnostics, Inc. Treponema pallidum triplet antigen
US20140186861A1 (en) * 2011-07-11 2014-07-03 Uvic Industry Partnerships Inc. Soluble treponema pallidum protein tp0453, tp0453-tp0326 fusion protein, and use in syphilis diagnosis
WO2015004604A1 (en) * 2013-07-12 2015-01-15 Uvic Industry Partnerships, Inc. Immunogenic tp0751 fragments
CN115141266A (en) * 2022-08-02 2022-10-04 英科新创(厦门)科技股份有限公司 Chemical modification method of TP17 protein and application of product thereof
CN116042678A (en) * 2023-02-08 2023-05-02 南方医科大学皮肤病医院（广东省皮肤病医院、广东省皮肤性病防治中心、中国麻风防治研究中心） Fusion protein for detecting nerve syphilis and kit thereof
CN117849340A (en) * 2023-10-16 2024-04-09 首都医科大学附属北京地坛医院 Application of soluble factor cluster in early-stage neurosyphilis detection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FRASER C.M. ET AL.: "Complete Genome Sequence of Treponema pallidum", THE SYPHILLIS SPIROCHETE SCIENCE, vol. 281, no. 5375, 17 July 1998 (1998-07-17), pages 375 - 388, XP000910239 *

Also Published As

Publication number Publication date
WO2006138324A2 (en) 2006-12-28

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