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WO2006131512A3 - Anti-thrombotic agents - Google Patents

Anti-thrombotic agents Download PDF

Info

Publication number
WO2006131512A3
WO2006131512A3 PCT/EP2006/062908 EP2006062908W WO2006131512A3 WO 2006131512 A3 WO2006131512 A3 WO 2006131512A3 EP 2006062908 W EP2006062908 W EP 2006062908W WO 2006131512 A3 WO2006131512 A3 WO 2006131512A3
Authority
WO
WIPO (PCT)
Prior art keywords
agents
bind
epitopes
relates
gpvi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/062908
Other languages
French (fr)
Other versions
WO2006131512A2 (en
Inventor
Goetz Muench
Andreas Bueltmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trigen GmbH
Original Assignee
Trigen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trigen GmbH filed Critical Trigen GmbH
Priority to EP06763512A priority Critical patent/EP1943277A2/en
Publication of WO2006131512A2 publication Critical patent/WO2006131512A2/en
Publication of WO2006131512A3 publication Critical patent/WO2006131512A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present disclosure relates to agents which bind to glycoprotein VI (GPVI) protein or sequences thereof. More particularly, though without limitation, the invention concerns agents which bind one or more epitopes of human GPVI. The invention also relates to certain epitopes of human GPVI, methods of identifying or screening agents which bind to the epitopes. The invention also relates to the use of agents for treatment or prevention of diseases arising from processes of blood platelet aggregation, as well as other subject matter.
PCT/EP2006/062908 2005-06-07 2006-06-05 Anti-thrombotic agents Ceased WO2006131512A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06763512A EP1943277A2 (en) 2005-06-07 2006-06-05 Anti-thrombotic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0511590.2 2005-06-07
GB0511590A GB0511590D0 (en) 2005-06-07 2005-06-07 Anti-thrombotic agents

Publications (2)

Publication Number Publication Date
WO2006131512A2 WO2006131512A2 (en) 2006-12-14
WO2006131512A3 true WO2006131512A3 (en) 2007-05-10

Family

ID=34835268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/062908 Ceased WO2006131512A2 (en) 2005-06-07 2006-06-05 Anti-thrombotic agents

Country Status (3)

Country Link
EP (1) EP1943277A2 (en)
GB (1) GB0511590D0 (en)
WO (1) WO2006131512A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2000802A4 (en) 2006-03-31 2009-04-15 Mochida Pharm Co Ltd Novel platelet activation marker and method for determination thereof
EP2336188A1 (en) * 2009-12-18 2011-06-22 Sanofi-Aventis Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
EP2397495A1 (en) * 2010-06-21 2011-12-21 Sanofi Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
MA33930B1 (en) * 2009-12-18 2013-01-02 Sanofi Sa New antibody counter GPVI and commuting Fab and uses the latter
AU2016301969B2 (en) * 2015-08-05 2022-10-06 Acticor Biotech Novel anti-human GPVI antibodies and uses thereof
SG11201906530TA (en) * 2017-02-03 2019-08-27 Acticor Biotech Inhibition of platelet aggregation using anti-human gpvi antibodies
EP4355352A1 (en) * 2021-06-18 2024-04-24 advanceCOR GmbH Use of a pharmaceutical composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000810A1 (en) * 1999-06-30 2001-01-04 Millennium Pharmaceuticals, Inc. Glycoprotein vi and uses thereof
WO2001016321A1 (en) * 1999-09-01 2001-03-08 Otsuka Pharmaceutical Co., Ltd. Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof
EP1369128A1 (en) * 2002-06-07 2003-12-10 Procorde GmbH Inhibitors of glycoprotein VI and their therapeutic use
EP1538165A1 (en) * 2003-12-03 2005-06-08 Procorde GmbH Inhibitors of glycoprotein VI based on monoclonal antibody hgp 5c4

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000810A1 (en) * 1999-06-30 2001-01-04 Millennium Pharmaceuticals, Inc. Glycoprotein vi and uses thereof
WO2001016321A1 (en) * 1999-09-01 2001-03-08 Otsuka Pharmaceutical Co., Ltd. Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof
EP1369128A1 (en) * 2002-06-07 2003-12-10 Procorde GmbH Inhibitors of glycoprotein VI and their therapeutic use
EP1538165A1 (en) * 2003-12-03 2005-06-08 Procorde GmbH Inhibitors of glycoprotein VI based on monoclonal antibody hgp 5c4

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LECUT C ET AL.: "Identification of Residues with Human Glycoprotein VI Involved in the Binding to Collagen", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 50, 10 December 2004 (2004-12-10), pages 52293 - 52299, XP002399837, ISSN: 0021-9258 *
SMETHURST P A ET AL: "Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 103, no. 3, 1 February 2004 (2004-02-01), pages 903 - 911, XP002383117, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
GB0511590D0 (en) 2005-07-13
EP1943277A2 (en) 2008-07-16
WO2006131512A2 (en) 2006-12-14

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