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WO2006129110A3 - Assay - Google Patents

Assay Download PDF

Info

Publication number
WO2006129110A3
WO2006129110A3 PCT/GB2006/002030 GB2006002030W WO2006129110A3 WO 2006129110 A3 WO2006129110 A3 WO 2006129110A3 GB 2006002030 W GB2006002030 W GB 2006002030W WO 2006129110 A3 WO2006129110 A3 WO 2006129110A3
Authority
WO
WIPO (PCT)
Prior art keywords
ace2
fragment
assay
eclampsia
angiotensin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2006/002030
Other languages
French (fr)
Other versions
WO2006129110A2 (en
Inventor
Manu Vatish
David Charles Pritlove
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Warwick
Original Assignee
University of Warwick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Warwick filed Critical University of Warwick
Publication of WO2006129110A2 publication Critical patent/WO2006129110A2/en
Publication of WO2006129110A3 publication Critical patent/WO2006129110A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a method for screening for pre-eclampsia in a mammal, such as a human, by determining the amount of ACE2 (Angiotensin-converting Enzyme 2), variant, or fragment of ACE2, or mRNA encoding the ACE2. Additionally a new fragment of ACE2 has been identified and isolated. Reagents and kits for carrying out the method are also provided.
PCT/GB2006/002030 2005-06-02 2006-06-02 Assay Ceased WO2006129110A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0511279.2 2005-06-02
GB0511279A GB0511279D0 (en) 2005-06-02 2005-06-02 Assay

Publications (2)

Publication Number Publication Date
WO2006129110A2 WO2006129110A2 (en) 2006-12-07
WO2006129110A3 true WO2006129110A3 (en) 2007-02-15

Family

ID=34835037

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/002030 Ceased WO2006129110A2 (en) 2005-06-02 2006-06-02 Assay

Country Status (2)

Country Link
GB (1) GB0511279D0 (en)
WO (1) WO2006129110A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102033100B (en) 2009-09-25 2013-03-13 同方威视技术股份有限公司 Detecting system of ion migration spectrometer (IMS) using doping agent and detecting method thereof
WO2022012688A1 (en) * 2020-07-17 2022-01-20 Shenzhen Bay Laboratory Ace2-ig fusion variants

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004000367A1 (en) * 2002-06-19 2003-12-31 University Health Network Ace2 activation for treatment of heart, lung and kidney disease and hypertension

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004000367A1 (en) * 2002-06-19 2003-12-31 University Health Network Ace2 activation for treatment of heart, lung and kidney disease and hypertension

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BROSNIHAN K BRIDGET ET AL: "Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy.", HYPERTENSION (BALTIMORE), vol. 42, no. 4 Part 2, October 2003 (2003-10-01), pages 749 - 753, XP002405387, ISSN: 0194-911X *
DANILCZYK U ET AL: "Physiological roles of angiotensin-converting enzyme 2", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 61, no. 21, November 2004 (2004-11-01), pages 2714 - 2719, XP002405388, ISSN: 1420-682X *
PRITLOVE D C ET AL: "EMERGING TECHNOLOGIES FOR THE IDENTIFICATION OF THERAPEUTIC TARGETS FOR THE MANAGEMENT OF PRE-ECLAMPSIA", EXPERT OPINION ON THERAPEUTIC TARGETS, ASHLEY PUBLICATIONS, LONDON, GB, vol. 8, no. 6, 2004, pages 507 - 514, XP008061230, ISSN: 1472-8222 *
VALDES G ET AL: "Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies", PLACENTA, vol. 27, no. 2-3, March 2006 (2006-03-01), pages 200 - 207, XP005199238, ISSN: 0143-4004 *
VALDES GLORIA ET AL: "Distribution of angiotensin-(1-7) and ACE2 in human placenta of early and term normotensive pregnancy and preeclampsia.", JOURNAL OF HYPERTENSION, vol. 22, no. Suppl. 1, February 2004 (2004-02-01), & 20TH SCIENTIFIC MEETING OF THE INTERNATIONAL-SOCIETY-OF-HYPERTENSION; SAO PAULO, BRAZIL; FEBRUARY 15 -19, 2004, pages S65, XP009074076, ISSN: 0263-6352 *

Also Published As

Publication number Publication date
WO2006129110A2 (en) 2006-12-07
GB0511279D0 (en) 2005-07-13

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