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WO2006129149A2 - Nouveaux complements destines aux volailles et au betail - Google Patents

Nouveaux complements destines aux volailles et au betail Download PDF

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Publication number
WO2006129149A2
WO2006129149A2 PCT/IB2006/001285 IB2006001285W WO2006129149A2 WO 2006129149 A2 WO2006129149 A2 WO 2006129149A2 IB 2006001285 W IB2006001285 W IB 2006001285W WO 2006129149 A2 WO2006129149 A2 WO 2006129149A2
Authority
WO
WIPO (PCT)
Prior art keywords
poultry
livestock
vitamin
antibiotics
supplements
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/001285
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English (en)
Other versions
WO2006129149A3 (fr
Inventor
Anselm De Souza
Asim Banerjee
Adala Balakrishna Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wockhardt Ltd
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Priority to EP06744714A priority Critical patent/EP1906754A4/fr
Publication of WO2006129149A2 publication Critical patent/WO2006129149A2/fr
Publication of WO2006129149A3 publication Critical patent/WO2006129149A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis

Definitions

  • the subject matter of the present invention relates to novel poultry and livestock supplements that can replace the use of antibiotics, and at the same time provide nutritive value that can enhance the growth and productivity of poultry and livestock.
  • the present invention is directed to novel supplements for poultry and livestock.
  • the supplement formulation comprises of synergistic combinations of probiotics, methylsulfonylmethane, saccharides, vitamins, carotenoids, xanthophylls, minerals and electrolytes.
  • the supplements can effectively replace the use of antibiotics in poultry and livestock and at the same time serve as a source of pronutrients that enhance growth, weight gain and overall health of the same.
  • Antibiotics are widely used in poultry and livestock feeds and water. Apart from their direct medicinal value in treating and preventing infections, antibiotics have also been used as "pronutrients" to increase the efficiency of feed utilization, stimulate growth in intensive poultry and livestock farming and reduce bird and animal morbidity mortality.
  • poultry and livestock achieve rapid growth and body weight gain so that they may be shipped earliest for markets. Activities such as general handling, debeaking, tagging, medications, vaccinations, transportation, any kind of nutritional inadequacy, water shortage etc. result in a great deal of stress in birds and livestock.
  • feeding and rearing of poultry and livestock are often carried out in intensive farming, often under such conditions of great stress for the birds and animals; a consequence of which is that the birds and animals may become greatly susceptible to contracting and transmitting infections.
  • rapid spread of infections amongst the birds and livestock in the feeding facility can be caused by feed contamination by fecal droppings.
  • Clostridium perfringens, Escherichia coli and Salmonella species that colonize the gastrointestinal tract of chickens and livestocks are food borne pathogens that are not only responsible for major epidemics, but are also associated with processed poultry and animal products and may cause severe illness, and even death, hi human beings (Ref: Poultry: Feeds and Nutrition, 2 nd Ed, Authors Patrick, H and Schaible P.J, AVI Publishing Company INC and Microbes Infect. 1999 Jul;l(8):639-44.).
  • antibiotics are routinely included in the feeds of poultry and livestock to inhibit the growth of microbial pathogens, as well as to prevent their spread in feeding facilities.
  • antibiotics Apart from their direct role in treating and preventing infections, antibiotics, often in subtherapeutic doses, also act as growth promoters and pronutrients in poultry and livestock (Ref: Poultry: Feeds and Nutrition, 2 nd Ed, Authors Patrick, H and Schaible PJ, AVI Publishing Company INC and Drugs. 1999 Oct;58(4):589-607.).
  • Antibiotics increase the rate of growth in poultry and livestock and facilitate more efficient utilization of feed. They are also known to enhance the utilization of calcium, phosphorus and manganese, possibly because of increased acidity of the small intestine and ceca (Ref: and Drugs.
  • antibiotic effects could be related to destruction of harmful microorganisms that otherwise sequester or destroy nutrients, while at the same time either sparing the ones which have no such effects on nutrients, or actually stimulating those organisms that may synthesize some growth promoting factors.
  • the modes of pronutrient action may differ amongst various antibiotics, but in general they are believed to be one or more of the following:
  • antibiotics have been used extensively as poultry and livestock supplements, in therapeutic as well as sub-therapeutic doses, for its anti- pathogenic and pronutrient, progrowth effects.
  • Commonly used antibiotics include penicillin, oxytetracycline, chlortetracycline, flavomycin, virginiamycin and bacitracin.
  • the present invention describes novel supplements that replace the use of antibiotics in poultry and livestock feeds.
  • the supplement compositions are a source of nutrients, that can enhance the growth and productivity of poultry and livestock, as well as anti-microbial factors that effectively inhibit, if not completely eliminate, pathogenic microorganisms.
  • the present supplement formulations can replace antibiotics in chick and livestock feeds when supplemented through drinking water.
  • the supplements according to the present invention comprise of combinations of probiotics and methylsulfonylmethane that effectively replace antibiotics in feed supplements.
  • the supplements, according to the present invention further comprise saccharides, vitamins, carotenoids, xanthophylls, minerals and electrolytes.
  • the components of the supplements, according to the present invention function synergistically to effectively replace antibiotics in poultry and livestock feeds.
  • US patent US5928686 and the PCT application WO96/39862 describes a process for enhancing the health, livability and cumulative weight gain of poultry by making available for consumption a high moisture solid containing 30% to 90% by weight water and 10 to 70 % dry matter, and wherein the dry matter contains at least 10 % carbohydrate, and between 15 to 50% by weight of an amino acid source.
  • US patent US4914135 describes the use of methylsulfonylmethane to treat parasitic infections.
  • Patent application WO9736603A1 describes biocontrol agents for use in the treatment of opportunistic infection.
  • MSM The Definitive Guide, Authors Jacob, S. W and Appleton, J, Freedom Press is a review of the science of methylsulfonylmethane.
  • Poultry Science, 2004 M; 83(7): 1148-54 is an article that describes the effects of mannan oligosaccharide, bacitracin methylene disalicylate on the live performance and intestinal microbiology of turkeys.
  • J Nutrition 2004 Jun; 134 (6): 1487-92 is a paper that describes the role of dietary antibiotics in enhancing the bioavailability of alpha-tocopheryl acetate in broilers.
  • the present invention relates to novel poultry and livestock supplements that comprise of probiotics and methylsulfonylmethane.
  • the supplements further comprise saccharides, vitamins, carotenoids, xanthophylls, minerals and electrolytes.
  • the components of the supplements described in the present invention function synergistically as nutrients sources, that enhance the growth and productivity of poultry and livestock, as well as anti-microbial factors that effectively inhibit, if not completely eliminate, pathogenic microorganisms.
  • the supplements of the present invention can thus effectively replace antibiotics hi poultry and livestock feeds.
  • antibiotics have been widely used as poultry and livestock feed supplements, in therapeutic and sub-therapeutic doses. They have been used for their therapeutic value - for the treatment as well as prevention of infections, as well as for their "pronutrient" value in poultry and livestock.
  • the pronutrient-growth promoting effects of antibiotics are manifested as increase in the rate of growth of poultry and livestock and greater utilization of feeds. They are also known to enhance the utilization of calcium, phosphorus and manganese, possibly because of favourable pH of the small intestine and ceca.
  • the present invention describes novel supplements that replace the use of antibiotics in poultry and livestock feeds.
  • the supplement compositions are a source of nutrients, that can enhance the growth and productivity of poultry and livestock as well as anti-microbial factors that effectively inhibit, if not completely eliminate, pathogenic microorganisms.
  • the supplement compositions of the present invention comprise of probiotics and methylsulfonylmethane.
  • Probiotics is the term used to describe microbes that have beneficial effects in the health of animals, including humans. They include some of normal flora of the intestines of animals and are known to be responsible for the healthy function and development of the gastro-intestinal tract.
  • Methylsulfonylmethane is a compound that is used in animal nutrition.
  • the supplement compositions of the present inventions comprise of combinations probiotics and methylsulfonylmethane. Rather than inhibiting the probiotic microorganisms, methylsulfonylmethane functions synergistically with the probiotics to improve the feed composition of poultry and livestock.
  • compositions further comprise saccharides, vitamins, carotenoids, xanthophylls, minerals and electrolytes.
  • the components of the supplements described in the present invention function synergistically as nutrient/pronutrient sources, that enhance the growth and productivity of poultry and livestock; as well as anti-microbial factors that effectively inhibit, if not completely eliminate, pathogenic microorganisms.
  • the supplement compositions of the present invention offer an excellent alternative to antibiotics in poultry and livestock feed.
  • Probiotics are live microbial feed supplements that beneficially affect the host animal by improving its intestinal microbial balance.
  • the rumen in ruminant animals and the colon in monogastric animals or birds can be perceived as a metabolic chamber rich in microorganisms.
  • the fermentative conditions in the rumen and colon are optimal for the development of a rich microbial flora.
  • the rumen and colon are strictly anaerobic environments.
  • Its bacterial ecosystem is composed of about 400 to 500 different types of bacteria most of which are "commensals" that participate in the fermentation of non- digestible food compounds, hi addition, the colonic flora also contains pathogenic bacteria such as Clostridium perfringens, certain types of Escherichia coli, Salmonella etc. Li imbalanced intestinal conditions these pathogens can develop and produce toxins, which can cause acute or chronic illness that could lead to severe gastro-intestinal disorders in the host.
  • Bifidobacteria has been suggested to protect against gastroenteritis associated with enteropathogenic bacteria (in particular the toxins produced by the same), as well as inhibit the growth of Salmonella
  • enteropathogenic bacteria in particular the toxins produced by the same
  • probiotic microbes or “friendly microbes” help in the absorption and metabolism of carbohydrates, lipids, proteins and amino acids, as well as salvage energy and vitamins from such components that have escaped digestion and absorption in' the stomach and small intestine. They may also carry out detoxification and subsequent excretion of toxic factors that are either produced and/or released into the gastro-intestinal tract, provide additional uncharacterized factors, such as anti-microbial factors, and have anti- tumor/anti-carcinogenic effects.
  • proper maintenance of the gut flora is essential for the normal growth and development of an animal.
  • compositions that comprise probiotics as one of the components of poultry and livestock supplements. These probiotics eliminate the need for antibiotics. Also since newborn chicks and newborn animals are germ-free, feed supplements comprising probiotics competitively inhibit colonization by pathogenic microorganisms, and help establish a healthy gut microflora. Examples of probiotics used in the formulation include Lactobacillus acidophilus and Saccharomyces bouldardii.
  • Lactobacillus acidophilus is used to inhibit the growth of enteropathogens like E.coli, Salmonella and Clostridium perfringens. Saccharomyces bouldardii is included as a source of cell wall mannanooligosaccharides. Methylsulfonylmethane
  • Methylsulfonylmethane is a sulfur compound that is the primary oxidized metabolite of dimethyl sulfoxide. It belongs to a family of compounds present abundantly in the food chains of terrestrial and ocean life that provides bioavailable sulfur to as many as 85% of all living organisms. They are among the primary sources for sulfur. Biological effects of methylsulfonylmethane include its effects on connective tissue where, as a sulfur donor, it contributes to normal cross-linking or proteoglycans, a key component of connective tissue. Methylsulfonylmethane has also been shown to have antiinflammatory effects when administered orally, topically or intravenously.
  • methylsulfonylmethane has been shown to have several clinical uses including in the treatment of osteoarthritis, scleroderma, interstitial cystitis etc. It has also been shown to have beneficial effects in the treatment of poor hoof health in horses, sulfur deficiency, chronic obstructive pulmonary disease in horses, canine arthritis, fibrous pleurisy in foals, as well as reduction in stress related deaths etc. Thus methylsulfonylmethane has general beneficial effects in the health of animals.
  • compositions of the present invention include methylsulfonylmethane. It has good anti-stress action in poultry that increases its livability and productivity. It also acts as a critical methyl group donor, as well as a sulfur source, for which poultry and livestock have a very high requirement. In addition it acts as a water retention factor that prevents the loss of water from the body, thereby preventing weight loss in poultry and livestock. Despite its known anti-microbial effects, including bacteriostatic and bactericidal effects, most unexpectedly methylsulfonylmethane appears to have no effects on the viability of the probiotics used in the supplements of the present invention.
  • probiotics and methylsulfonyhnethane function synergistically as a source of growth-promoters, anti-stress agents and anti-pathogenic microbial factors, thus effectively replacing antibiotics in poultry and livestock supplements.
  • the combination of probiotics and methylsulfonylmethane thus improves the overall health and performance of poultry and livestock. Saccharides
  • Saccharides are carbohydrates and include to mono, di, oligo and polysaccharides.
  • Monosaccharides are molecules that have the general formula C n H 2n O n where n is an integer equal to 6 in case of dominant food monosaccharides. Examples of monosaccharides include glucose, fructose, galactose etc.
  • Disaccharides are molecules that are composed of two monosaccharides units linked together by a "glycosidic" bond. Examples of disaccharides include sucrose, lactose, maltose etc.
  • Oligosaccharides and Polysaccharides are saccharides that have more than three monosaccharide units.
  • oligo/polysaccharides examples include maltotrioses, dextrans, mannans, starch etc.
  • Saccharides are the major source of energy for organisms. Di and oligosaccharide are first broken down to their individual monosaccharides in the gastro-intestinal tract by the action of specific enzymes. The monosaccharides are then metabolized in cells of tissues, and the energy released used to drive the metabolic processes required for the growth and maintenance of cells and tissues. Hence feed compositions require saccharides as a source of metabolic energy.
  • saccharides In additional to its nutritional function, saccharides, especially non-digestible ones such as fructo-oligosaccharides, also function as factors that encourage the development and multiplication of probiotics in the gut (hence called "prebiotics) and inhibit the growth of pathogens such as Salmonella.
  • prebiotics probiotics
  • saccrahrides adsorb pathogenic bacteria containing type 1 fimbriae thus inactivating them, promote mineral absorption, greatly improve lipid metabolism, improve gut and intestinal function (by increasing villi height, uniformity and integrity) and acts as immunomodulator that stimulates gut associated and systemic immunity by acting as a non-pathogenic microbial antigen giving an adjuvant like effect.
  • the supplements of the present invention include saccharides, such as dextran-oligosaccharides.
  • the supplement compositions of the present invention preferably include one or more vitamins, xanthophylls, carotenoids and minerals.
  • the vitamins in the present invention include niacinamide, dl- ⁇ -tocopheryl acetate, dl- ⁇ -tocopherol (vitamin E), pyridoxine HCl, ⁇ -carotene (precursor of Vitamin A), riboflavin (vitamin B2), cyanocobalmin (vitamin B12), vitamin A, folic acid, thiamin HCl (vitamin Bl), menadione (vitamin K) and ergocalciferol (vitamin D2 and D3), Ascrobic acid (Vitamin C). Ascorbic acid in particular acts as an anti-oxidant and also enhances the absorption of methylsulfonylmethane.
  • Carotenoids and Xanthophylls include niacinamide, dl- ⁇ -tocopheryl acetate,
  • Carotenoids and Xanthophylls are also included in the compositions of the present invention. They are precursors of vitamins. Carothenoids are known to protect tissues from free radical damage. Both carotenoids and xanthophylls are free radical scavengers and have been shown to function as antioxidants in vitro, as well as reduce cancer cell formation. Marigold Oleoresin contains carotenoids and xanthophylls and can be used in the supplement as the source for the same. Minerals and Electrolytes
  • the supplement compositions of the present invention also comprises of Sodium, Potassium, Calcium, Chloride, Phosphorous and Sulfur.
  • Calcium is an essential component of bones and is especially necessary for the proper growth and development of newly hatched chicks and newborn animals.
  • compositions of the present invention comprises of synergistic components that not only serve as an excellent source of growth promoters to poultry and livestock, but also possess effective anti-pathogenic microbial properties.
  • the components of the present - methylsulfonylrnethane and probiotics - are surprisingly compatible with each other despite the anti-microbial effects of methylsulfonylmethane (which one would expect to effect the viability of the probiotics in the feed formulation).
  • another unique aspect of this formulation is that when the supplement is added to water, since with the saccharide present as a diluent, the probiotics count increases very rapidly — it can double over a period of 90 minutes - thus greatly increasing the potency of the probiotic component of the supplement.
  • the probiotics are also in an active growth phase to readily colonize the gut.
  • the supplements described in the present invention thus acts as an excellent alternative to antibiotics in poultry livestock feeds.
  • Vitamin C 1.0 g
  • Vitamin K3 1.104 g
  • Vitamin B2 2.864 g
  • Vitamin A 4.0O g
  • Vitamin C 5.0 g
  • Vitamin A 2.0O g
  • Vitamin D3 5.00 g
  • Vitamin A 1.00 g
  • Vitamin D3 3.00 g
  • Lactobacillus acidophilus 5 x 10 9 cells Carrier (sucrose) q.s
  • Vitamin C 2.0 g
  • Vitamin K3 3.00 g
  • Vitamin B2 5.00 g
  • Vitamin D3, Vitamin E and Marigold Oleoresin were charged in a blender with an open air valve and inlet air pressure at 5 kg/cm 2 or more. Vitamin A was dissolved in about
  • Vitamin D3 and Vitamin E in about 10 ml and 200 ml respectively of warm polyethylene glycol 600 and Marigold Oleoresin in about 400 ml of
  • Tween 80 Dissolved Vitamin A, D3, E and Marigold Oleoresin were then added to the blender and blended for about 10 minutes. The material in the blender was then sieved with a 40 mesh sieve. The sieved material was then packed into liner bags and heat sealed.
  • Example 7 A pure culture of Lactobacillus acidophilus was grown in thioglycollate broth for 16 hours. 10 8 cells were then inoculated in 10 mm diameter wells on nutrient agar plates that were spread with Escherichia coli, Salmonella typhi and Staphylococcus aureus, and incubated at 37 0 C overnight. Zones of inhibition were observed around the Lactobacillus acidophilus spots. The data are presented in the table below.
  • compositions of the present invention have greatly enhanced beneficial effects in birds supplemented with the same. Not only is the mortality levels in the "Treated Groups" much lesser then that of the "Control Group", both the average body weight, as well as the total body mass of the "Treated Group” are higher then that of the control group.

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Abstract

L'invention concerne de nouveaux compléments destinés aux volailles et au bétail, remplaçant efficacement les antibiotiques dans l'alimentation des volailles et du bétail, les nouveaux compléments contenant des probiotiques et du méthylsulfonylméthane. Lesdits compléments contiennent également des saccharides, des vitamines, des caroténoïdes, des xanthophylles, des minéraux et des électrolytes. Les composants des compléments fonctionnent de façon synergique en tant que sources de nutriments favorisant la croissance et la productivité des volailles et du bétail, et en tant que facteurs anti-microbiens inhibant efficacement des micro-organismes pathogènes, ou les éliminant complètement.
PCT/IB2006/001285 2005-05-31 2006-05-17 Nouveaux complements destines aux volailles et au betail Ceased WO2006129149A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06744714A EP1906754A4 (fr) 2005-05-31 2006-05-17 Nouveaux complements destines aux volailles et au betail

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN646/MUM/2005 2005-05-31
IN646MU2005 2005-05-31

Publications (2)

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WO2006129149A2 true WO2006129149A2 (fr) 2006-12-07
WO2006129149A3 WO2006129149A3 (fr) 2007-03-08

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Cited By (4)

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WO2011053854A1 (fr) * 2009-10-30 2011-05-05 Biogenic Innovations, Llc Utilisation de méthysulfonylméthane (msm) à des fins de modulation de l'activité microbienne
US8546373B2 (en) 2009-10-30 2013-10-01 Biogenic Innovations, Llc Methods of sensitizing drug resistant microorganisms using methylsulfonylmethane (MSM)
ITMI20131479A1 (it) * 2013-09-09 2015-03-10 Iros R C S R L Composizioni cosmetiche contenenti una combinazione di principi attivi naturali
CN107683975A (zh) * 2017-09-26 2018-02-13 陕西杨凌瑞祺生物科技有限公司 一种蛋鸡预产期专用5%复合预混料及制备方法和应用

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Cited By (14)

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US8841100B2 (en) 2009-10-30 2014-09-23 Biogenic Innovations, Llc Use of methylsulfonylmethane (MSM) to modulate microbial activity
US9839609B2 (en) 2009-10-30 2017-12-12 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) formulations to treat osteoarthritis
US8217085B2 (en) 2009-10-30 2012-07-10 Biogenic Innovations, Llc Methylsulfonylmethane (MSM) for treatment of drug resistant microorganisms
CN102834520A (zh) * 2009-10-30 2012-12-19 生物基因创新有限责任公司 甲基磺酰甲烷(msm)用于调制微生物活性的用途
EP2493464A4 (fr) * 2009-10-30 2013-04-24 Biogenic Innovations Llc Méthylsulfonylméthane (msm) pour le traitement de micro-organismes résistants aux médicaments
US8546373B2 (en) 2009-10-30 2013-10-01 Biogenic Innovations, Llc Methods of sensitizing drug resistant microorganisms using methylsulfonylmethane (MSM)
US10596109B2 (en) 2009-10-30 2020-03-24 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (DMSO) or DMSO and methylsulfonylmethane (MSM) formulations to treat infectious diseases
US9855212B2 (en) 2009-10-30 2018-01-02 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (DMSO) or DMSO and methylsulfonylmethane (MSM) formulations to treat infectious diseases
AU2010281739B2 (en) * 2009-10-30 2011-06-09 Biogenic Innovations, Llc Use of methylsulfonylmethane (MSM) to modulate microbial activity
US9487749B2 (en) 2009-10-30 2016-11-08 Biogenic Innovations, Llc Use of methylsulfonylmethane (MSM) to modulate microbial activity
WO2011053854A1 (fr) * 2009-10-30 2011-05-05 Biogenic Innovations, Llc Utilisation de méthysulfonylméthane (msm) à des fins de modulation de l'activité microbienne
ITMI20131479A1 (it) * 2013-09-09 2015-03-10 Iros R C S R L Composizioni cosmetiche contenenti una combinazione di principi attivi naturali
WO2015033316A1 (fr) * 2013-09-09 2015-03-12 Iros R.C. S.R.L. Compositions cosmétiques contenant une combinaison d'ingrédients actifs naturels
CN107683975A (zh) * 2017-09-26 2018-02-13 陕西杨凌瑞祺生物科技有限公司 一种蛋鸡预产期专用5%复合预混料及制备方法和应用

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