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WO2006129090A3 - Vaccines - Google Patents

Vaccines Download PDF

Info

Publication number
WO2006129090A3
WO2006129090A3 PCT/GB2006/001989 GB2006001989W WO2006129090A3 WO 2006129090 A3 WO2006129090 A3 WO 2006129090A3 GB 2006001989 W GB2006001989 W GB 2006001989W WO 2006129090 A3 WO2006129090 A3 WO 2006129090A3
Authority
WO
WIPO (PCT)
Prior art keywords
medicaments
gram
negative bacteria
vaccines
efflux pump
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2006/001989
Other languages
French (fr)
Other versions
WO2006129090A2 (en
Inventor
Laura Jane Violet Piddock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Birmingham
Original Assignee
University of Birmingham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Birmingham filed Critical University of Birmingham
Publication of WO2006129090A2 publication Critical patent/WO2006129090A2/en
Publication of WO2006129090A3 publication Critical patent/WO2006129090A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Medicaments comprising artificial proteins of the bacterial efflux pump AcrAB-TolC as well as medicaments comprising Gram-negative bacteria having defective efflux pump function. In particular vaccines comprising Gram-negative bacteria in which the function of the efflux pump component ToIC is defective.. Medicaments and vaccines of this sort are useful in the prevention and/or treatment of diseases such as Salmonellosis and Campylobacteriosis, and in the prevention and/or treatment of infection or colonisation of humans or poultry by Gram- negative bacteria.
PCT/GB2006/001989 2005-06-02 2006-06-02 Vaccines Ceased WO2006129090A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0511203.2A GB0511203D0 (en) 2005-06-02 2005-06-02 Vaccines
GB0511203.2 2005-06-02

Publications (2)

Publication Number Publication Date
WO2006129090A2 WO2006129090A2 (en) 2006-12-07
WO2006129090A3 true WO2006129090A3 (en) 2007-01-25

Family

ID=34834989

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001989 Ceased WO2006129090A2 (en) 2005-06-02 2006-06-02 Vaccines

Country Status (2)

Country Link
GB (1) GB0511203D0 (en)
WO (1) WO2006129090A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10842861B2 (en) * 2016-05-26 2020-11-24 Universiteit Gent Method of reducing egg contamination
CN110257312B (en) * 2019-05-06 2021-04-06 浙江工业大学 Recombinant gene engineering bacterium and application thereof in producing vanillin by fermentation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005326A1 (en) * 1992-09-04 1994-03-17 University Of Saskatchewan Novel bacterial vaccines using vaccine strains of pathogenic bacteria
WO2001027280A1 (en) * 1999-10-09 2001-04-19 Neutec Pharma Plc Antimicrobial compositions
US20020132814A1 (en) * 1999-07-22 2002-09-19 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
WO2003070987A1 (en) * 2002-02-20 2003-08-28 MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH Nucleotide sequence coding for a tolc containing a heterologous amino acid sequence

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005326A1 (en) * 1992-09-04 1994-03-17 University Of Saskatchewan Novel bacterial vaccines using vaccine strains of pathogenic bacteria
US20020132814A1 (en) * 1999-07-22 2002-09-19 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
WO2001027280A1 (en) * 1999-10-09 2001-04-19 Neutec Pharma Plc Antimicrobial compositions
WO2003070987A1 (en) * 2002-02-20 2003-08-28 MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH Nucleotide sequence coding for a tolc containing a heterologous amino acid sequence

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAUCHERON SYLVIE ET AL: "TolC but not AcrB is essential for multidrug-resistant Salmonella enterica serotype Typhimurium colonization of chicks", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 55, no. 5, May 2005 (2005-05-01), pages 707 - 712, XP002401859, ISSN: 0305-7453 *
BUCKLEY ANTHONY M ET AL: "The AcrAB-TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis.", CELLULAR MICROBIOLOGY. MAY 2006, vol. 8, no. 5, May 2006 (2006-05-01), pages 847 - 856, XP002401861, ISSN: 1462-5814 *
HIRAKATA YOICHI ET AL: "Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 196, no. 1, 1 July 2002 (2002-07-01), pages 109 - 118, XP002401862, ISSN: 0022-1007 *
J.A. JEDDELOH ET AL.: "Biodefense-driven murine model of pneumonic melioidosis", INFECTION AND IMMUNITY, vol. 71, no. 1, January 2003 (2003-01-01), pages 584 - 587, XP002401858 *
LIN JUN ET AL: "Critical role of multidrug efflux pump CmeABC in bile resistance and in vivo colonization of Campylobacter jejuni.", INFECTION AND IMMUNITY, vol. 71, no. 8, August 2003 (2003-08-01), pages 4250 - 4259, XP002401860, ISSN: 0019-9567 *
STONE BARBARA J ET AL: "Salmonella enteritidis has a homologue of tolC that is required for virulence in BALB/c mice", MOLECULAR MICROBIOLOGY, vol. 17, no. 4, 1995, pages 701 - 712, XP000978140, ISSN: 0950-382X *

Also Published As

Publication number Publication date
WO2006129090A2 (en) 2006-12-07
GB0511203D0 (en) 2005-07-06

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