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WO2006128915A1 - Seringue a plusieurs cylindres - Google Patents

Seringue a plusieurs cylindres Download PDF

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Publication number
WO2006128915A1
WO2006128915A1 PCT/EP2006/062892 EP2006062892W WO2006128915A1 WO 2006128915 A1 WO2006128915 A1 WO 2006128915A1 EP 2006062892 W EP2006062892 W EP 2006062892W WO 2006128915 A1 WO2006128915 A1 WO 2006128915A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe barrel
syringe
cylinder
piston
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/062892
Other languages
German (de)
English (en)
Inventor
Eckhard Schwöbel
Daniel Vuille
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP06763500A priority Critical patent/EP1890752A1/fr
Publication of WO2006128915A1 publication Critical patent/WO2006128915A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5013—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe
    • A61M5/502—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe for blocking the piston

Definitions

  • the invention relates to a multicylinder multi-cylinder syringe having at least one outer syringe barrel having a syringe outlet and an inner syringe barrel at least partially contained within the outer syringe barrel and slidable longitudinally from a proximal extended condition to a distal retracted condition is.
  • the invention further relates to a method for mixing two substances in such a multi-cylinder syringe.
  • multi-cylinder syringes substances to be injected as a substance mixture can be stored separately and mixed before injection.
  • Such substances may be, for example, freeze-dried medicaments which are to be mixed with a liquid prior to injection.
  • multi-cylinder syringes are designed as two-cylinder syringes, ie as syringes with two cylinders pushed one inside the other, each of the two cylinders containing one of the substances to be mixed.
  • the two substances can be both a powder and a liquid and two liquids.
  • EP 0 005 939 A1 to which the preambles of the two main claims refer, relates to a multi-chamber syringe having an outer housing in which a cylinder is slidably guided in the longitudinal direction. Between the cylinder and the outer housing a sealed with two plugs cavity is formed, in which a first substance is contained. The interior of the cylinder contains a second substance. In the cylinder, a piston ram is guided, wherein the piston ram has latching spring arms which hold in the extended state of the piston ram outward springs and the piston ram against a flange of the cylinder. When pulling out the cylinder from the outer housing creates a cavity with negative pressure.
  • the piston ram is prevented by the spring arms in the locked state from slipping due to the negative pressure in the cylinder.
  • actuation of the spring arms of the stamp can be moved back and forth within the cylinder, wherein the two substances are mixed by repeated actuation of the punch.
  • the punch is pulled out of the cylinder until the spring arms engage, whereby the mixture of the two substances is completely sucked into the interior of the cylinder.
  • the piston ram can be advanced to press the mixture of the two substances from the cylinder interior by a needle attached to a needle hub of the outer housing.
  • the invention has for its object to provide a multi-cylinder syringe, which simplifies the mixing and injecting several substances. Furthermore, lies the _ O -
  • Invention the task of providing a corresponding method for mixing a plurality of substances.
  • the multi-cylinder syringe according to the invention is defined by the features of claim 1.
  • the multi-cylinder syringe is characterized in that the inner syringe barrel has a front piston sealingly contacting the inner wall of the outer syringe barrel.
  • the front piston has a relief valve or check valve which connects the cavity of the inner syringe barrel to the cavity of the outer syringe barrel distal to the forward plunger, the substance of the outer syringe barrel being contained in the cavity distal to the forward plunger.
  • the locking element is arranged on the inner syringe cylinder and springs in the extended state of the inner syringe barrel to the outside and thereby blocks the inner syringe barrel against advancement in the outer cylinder.
  • the method according to the invention for mixing a plurality of substances in a multi-cylinder syringe is defined by the features of claim 9.
  • the method is characterized by the steps:
  • the latching element is to be pressed against the inner syringe barrel and, for example, by pushing the rear plunger in the distal direction, insert the inner syringe barrel into the outer syringe barrel, whereby the front plunger forces the substance mixture out of the syringe outlet.
  • the latching element may be formed of at least one elongate elastic spring arm which is arranged parallel to the inner syringe barrel, wherein the proximal end of the spring arm is connected to the inner syringe barrel and wherein the distal end protrudes from the inner syringe barrel in the relaxed state of the spring arm.
  • the distal end of the spring arm abuts in the extended state of the inner syringe barrel against a stop of the outer syringe barrel, whereby an insertion the inner syringe barrel is prevented in the outer syringe barrel.
  • the stop may be formed by a handle plate at the proximal end of the outer syringe barrel.
  • the outer syringe barrel may have an inner ring proximal to the forward piston that limits movement of the forward piston in the outer syringe barrel in the proximal direction, and the inner syringe barrel may have a projection cooperating with the inner ring proximal to the forward piston and distal to the inner ring , The inner syringe barrel can only be pulled out of the outer syringe barrel until the protrusion abuts against the inner ring.
  • the check valve allows, for example, a flow in the distal direction, d. H. from the inner syringe barrel into the outer syringe barrel, and prevents it from flowing in the reverse direction.
  • the pressure relief valve allows a flow in the distal and in the proximal direction only when a certain pressure is exceeded.
  • the pressure relief valve is preferably formed by a slot in an elastic membrane in the piston surface of the front piston, the membrane of the cavity of the inner syringe barrel from the cavity of the outer Syringe cylinder separates.
  • the pressure relief valve may be formed as a frangible membrane, which is destroyed when a certain pressure is exceeded to produce an opening between the cavity of the inner syringe barrel and the cavity of the outer syringe barrel.
  • the inner syringe barrel and the rear piston preferably have cooperating locking lugs, which engage in the inserted state of the rear piston and prevent displacement in the proximal direction.
  • a detent on the cavity inner wall of the inner syringe barrel and another detent on the outside of the rear piston is formed.
  • the rear piston is inserted into the inner syringe barrel until the locking lugs engage in one another and engage Prevent removal of the rear piston from the inner syringe barrel in the proximal direction.
  • the latching lugs allow in the locked state, a back and forth displacement of the rear piston together with the inner syringe barrel in the outer syringe barrel to better mix the mixture of substances in the cavity distal to the front piston.
  • the syringe outlet is preferably sealed with an airtight, multi-reusable closure, thereby allowing negative pressure to be established in the outer syringe barrel by withdrawing the inner syringe barrel from the outer syringe barrel. By subsequently removing the closure from the syringe outlet, the syringe outlet is released to allow the mixture of substances to be forced through the syringe outlet.
  • 1 is a longitudinal section of the multi-cylinder syringe with partially extended inner syringe barrel and partially extended rear piston
  • FIG. 2 shows the longitudinal section of Figure 1 with fully extended inner syringe barrel, 3 with the longitudinal section according to FIG. 2 with the rear piston fully inserted, FIG.
  • Fig. 5 is a plan view of the front piston.
  • the embodiment shown in the figures shows a multi-cylinder syringe 10 with an outer syringe barrel 12, an inner syringe barrel 14 and a rear piston 16.
  • the outer syringe barrel contains a cavity 18 for a first substance 20 and the inner syringe barrel 14 contains a cavity 22 for a second Substance 24.
  • the multi-cylinder syringe 10 is designed as a two-cylinder syringe with two cylinders 12, 14 and two cavities 18, 22 for two substances 20, 24.
  • the outer syringe barrel 12 has an elongated cylindrical shape with a forward distal 70 and a posterior proximal end 72.
  • a syringe outlet 26 in the form of a needle hub for securing a syringe needle and a sealing closure cap.
  • a handle plate 28 forms a stop 29 for the locking elements 38.
  • the inner syringe barrel 14 has an elongated and substantially cylindrical shape fitting into the cavity 18 of the outer syringe barrel 12 with a distal forward end 74 and a proximal rearward end 76.
  • the distal end 74 of the inner syringe barrel 14 is integral with a forward piston 30 formed.
  • Of the Front piston 30 has a sealing ring 31, which sealingly contacts the inner wall 32 of the cavity 18 of the outer syringe barrel 12, so that neither air nor the substances 20, 24 between the front piston 30, seal ring 31 and cavity inner wall 32 can escape.
  • the cavity 18 of the outer syringe barrel 12 is defined by the inner wall 32, the distal end 74 of the outer syringe barrel 12, and the forward piston 30.
  • the volume of the cavity 18 is variable depending on the position of the forward piston 30 within the outer syringe barrel 12
  • the inner syringe barrel 14 has, proximal of the forward piston 30, an annular projection 34 which cooperates with an inner ring 36 formed on the inner wall 32 of the outer syringe barrel 12 proximal of the forward piston 30 for limiting the movement of the inner syringe barrel 14 in the proximal direction.
  • the movement of the inner syringe barrel 14 is limited by the annular projection 34 abutting the inner ring 36.
  • the inner syringe barrel 14 has two latching elements 38 formed on its outer lateral surface 44, each in the form of an elongated elastic spring arm.
  • Each spring arm has a proximal end 40 and a distal end 42, wherein each proximal end 40 of the lateral surface 44 is integrally formed.
  • Each distal end 42 springs outward in the radial direction transversely to the longitudinal axis of the inner syringe barrel 14, d. H.
  • the distal end 42 protrudes from the lateral surface 44 and detents in the fully extended state shown in Figures 2 and 3 of the inner syringe barrel 14 against the handle plate 28 of the outer syringe barrel 12 and prevents insertion of the inner syringe barrel 14 in the outer syringe barrel 12th
  • FIG. 5 shows the front piston 30 with the valve 46 in plan view.
  • the pressure relief valve 46 is a double slot 52 in an elastic Membrane 50 formed in the piston surface 48. If the pressure in one of the two cavities 18, 22 exceeds a certain value with respect to the pressure in the other cavity, the double slot 52 in the valve 46 is opened by the overpressure, thereby opening the valve 46.
  • a detent 56 with a pointing in the distal direction of the attack surface 58 and with a pointing in the proximal direction inclined surface 60.
  • On the piston rod 68 of the rear piston 16 is on the outside one of the locking lug 56 corresponding locking lug 62nd attached.
  • the latching lug 62 has an engagement surface 64 facing in the proximal direction and an obliquely pointing inclined surface 66.
  • FIG. 1 shows the multicylinder syringe 10 in delivery condition.
  • the syringe outlet 26 is sealingly and firmly closed with a screwed on closure cap 82.
  • the first substance 20 is included in the cavity 18 of the outer syringe barrel 12.
  • the second substance 24 is included in the cavity 22 of the inner syringe barrel 14.
  • the first substance 20 is shown by dashed lines in FIGS. 1 to 4 and the second substance 24 by dots.
  • the inner syringe barrel 14 is half inserted into the outer syringe barrel 12 and the rear plunger 16 is half inserted into the inner syringe barrel 14.
  • the inner syringe barrel 14 is pulled out of the outer syringe barrel 12 in the proximal direction until the annular protrusion 34 abuts against the inner ring 36 and the inner syringe barrel 14 thereby prevented from further movement in the proximal direction.
  • the cavity 18 of the outer syringe barrel 12 is increased. Due to the sealing closure of the front piston 30 on the inner wall 32 and the closure cap 82 on the syringe outlet 26, a negative pressure is created in the cavity 18 of the outer syringe barrel 12.
  • the second substance 24 is then inserted by operating the rear piston 16 in the direction of the arrow C shown in Figure 3, whereby the second substance 24 is pressed through the slot 52 of the valve 46.
  • the second substance 24 mixes with the first substance 20 in the cavity 18 of the outer syringe barrel 12.
  • the locking elements 38 latched to the grip plate 28 prevent the inner syringe barrel 14 from being displaced in the distal direction when the posterior piston 16 is inserted in the distal direction ,
  • the latching lugs 56, 62 engage one another, so that the piston 16 is actuated by multiple actuation of the rear piston 16, as represented by the double arrow E in FIG proximal direction of the inner syringe barrel 14 and the front piston 30 in the direction of the double arrow E in Figure 3 in the distal and in the proximal direction back and be pushed to mix the substances 20, 24 better.
  • the cap 82 is removed from the syringe outlet 26 by unscrewing and instead a syringe needle 84 is screwed onto the syringe outlet 26.
  • Figure 4 shows the screwed syringe needle 84.
  • the locking elements 38 are first pressed in the direction of arrows D shown in Figure 3 and so the inner syringe barrel 14 released. Subsequently, by actuating the rear piston 16 in the distal direction, as shown in Figure 4 by the arrow F, operated and so the inner syringe barrel 14 is displaced in the distal direction.
  • the piston surface 48 of the front piston 30 presses the mixture of the two substances 20, 24 out of the cavity 18 through the syringe outlet 26 and the syringe needle 84.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne une seringue à plusieurs cylindres (10) pour plusieurs substances (20, 24), présentant au moins un cylindre de seringue extérieur (12), pourvu d'une sortie d'injection (26), et un cylindre de seringue intérieur (14), contenu au moins partiellement dans le cylindre de seringue extérieur (12) et pouvant coulisser dans le sens longitudinal d'un premier état proximal déployé à un état distal rétracté, un élément d'arrêt (38) faisant ressort étant prévu, lequel élément bute contre une butée (29) en position déployée de la seringue à plusieurs cylindres, évitant ainsi un coulissement de la seringue à plusieurs cylindres en position rétractée. L'objectif de cette invention est de faciliter le mélange et l'injection des substances (20, 24). A cet effet, le cylindre de seringue intérieur (14) présente un piston avant (30), entrant en contact étanche avec la paroi intérieure (32) du cylindre de seringue extérieur (12). Ce piston avant (30) présente un clapet de décharge (46) ou un clapet antiretour, reliant la cavité (22) du cylindre de seringue intérieur (14) à la cavité (18) du cylindre de seringue extérieur (12) distalement par rapport au piston avant (30), la substance (20) du cylindre de seringue extérieur (12) étant contenue dans la cavité (18) distalement par rapport au piston avant (30) et une substance (24), contenue dans le cylindre de seringue intérieur (14), pouvant être pressée dans la cavité (18) distalement par rapport au piston avant (30) par un coulissement du piston arrière (16) de l'état déployé à l'état rétracté. L'élément d'arrêt (38) est placé sur le cylindre de seringue intérieur (14) et fait ressort en position déployée du cylindre de seringue intérieur (14) vers l'extérieur, empêchant ainsi le cylindre de seringue intérieur (14) d'avancer. Cette invention concerne également un procédé correspondant pour mélanger plusieurs substances dans une seringue à plusieurs cylindres.
PCT/EP2006/062892 2005-06-02 2006-06-02 Seringue a plusieurs cylindres Ceased WO2006128915A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06763500A EP1890752A1 (fr) 2005-06-02 2006-06-02 Seringue a plusieurs cylindres

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00933/05 2005-06-02
CH9332005 2005-06-02

Publications (1)

Publication Number Publication Date
WO2006128915A1 true WO2006128915A1 (fr) 2006-12-07

Family

ID=36763122

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/062892 Ceased WO2006128915A1 (fr) 2005-06-02 2006-06-02 Seringue a plusieurs cylindres

Country Status (2)

Country Link
EP (1) EP1890752A1 (fr)
WO (1) WO2006128915A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008150208A1 (fr) * 2007-06-08 2008-12-11 Jan Svensson Dispositif pour la distribution d'une substance et instrument de remplissage pour un tel dispositif
US8597233B2 (en) 2009-05-29 2013-12-03 LTS Lohmann Therapie—Systeme AG Cylinder-piston unit suitable for storing injection solutions for a needle-free automatic or manual filling of the cylinder-piston unit, also under atmospheric pressure
CN105530975A (zh) * 2013-09-16 2016-04-27 硕腾服务有限责任公司 用于依序输送物质的总成以及相关方法
EP3710088B1 (fr) * 2017-11-17 2024-05-01 Sanofi Dispositif et procédé de mélange et/ou de reconstitution
WO2024099322A1 (fr) * 2022-11-10 2024-05-16 卡尤迪生物科技宜兴有限公司 Dispositif d'administration et méthode d'administration
WO2025159790A1 (fr) * 2024-01-24 2025-07-31 Nxtgen Biomedical Llc Seringue de séparation et procédés de traitement de séparation de fluides biologiques en fractions

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1130593A (en) * 1965-04-30 1968-10-16 Novo Terapeutisk Labor As Injection syringe with two coaxial cylindrical chambers
US3557787A (en) * 1968-05-28 1971-01-26 Milton J Cohen Disposable syringe
US3835835A (en) * 1972-11-07 1974-09-17 Richardson Merrell Inc Two compartment locking sampling syringe
US5181909A (en) * 1991-05-15 1993-01-26 Mcfarlane Richard H Ampule-container medical syringe and methods
US5429603A (en) * 1990-12-04 1995-07-04 Medinject A/S Two-compartment syringe assembly and a method of producing a two-compartment syringe assembly
EP1093826A1 (fr) * 1999-10-18 2001-04-25 Terumo Kabushiki Kaisha Seringue préchargée
US6228065B1 (en) * 1994-02-15 2001-05-08 Lawrence A. Lynn Displacement activated medical check valve
WO2001062319A2 (fr) * 2000-02-23 2001-08-30 Abbott Laboratories Seringues et dispositifs de seringues pour administrer de maniere selective des doses controlees d'une substance therapeutique

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1130593A (en) * 1965-04-30 1968-10-16 Novo Terapeutisk Labor As Injection syringe with two coaxial cylindrical chambers
US3557787A (en) * 1968-05-28 1971-01-26 Milton J Cohen Disposable syringe
US3835835A (en) * 1972-11-07 1974-09-17 Richardson Merrell Inc Two compartment locking sampling syringe
US5429603A (en) * 1990-12-04 1995-07-04 Medinject A/S Two-compartment syringe assembly and a method of producing a two-compartment syringe assembly
US5181909A (en) * 1991-05-15 1993-01-26 Mcfarlane Richard H Ampule-container medical syringe and methods
US6228065B1 (en) * 1994-02-15 2001-05-08 Lawrence A. Lynn Displacement activated medical check valve
EP1093826A1 (fr) * 1999-10-18 2001-04-25 Terumo Kabushiki Kaisha Seringue préchargée
WO2001062319A2 (fr) * 2000-02-23 2001-08-30 Abbott Laboratories Seringues et dispositifs de seringues pour administrer de maniere selective des doses controlees d'une substance therapeutique

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008150208A1 (fr) * 2007-06-08 2008-12-11 Jan Svensson Dispositif pour la distribution d'une substance et instrument de remplissage pour un tel dispositif
US8597233B2 (en) 2009-05-29 2013-12-03 LTS Lohmann Therapie—Systeme AG Cylinder-piston unit suitable for storing injection solutions for a needle-free automatic or manual filling of the cylinder-piston unit, also under atmospheric pressure
US9038675B2 (en) 2009-05-29 2015-05-26 Lts Lohmann Therapie-Systeme Ag Cylinder-piston unit suitable for storing injection solutions for a needle-free injector and method for the bubble-free automatic or manual filling of the cylinder-piston unit, also under atmospheric pressure
CN105530975A (zh) * 2013-09-16 2016-04-27 硕腾服务有限责任公司 用于依序输送物质的总成以及相关方法
EP3710088B1 (fr) * 2017-11-17 2024-05-01 Sanofi Dispositif et procédé de mélange et/ou de reconstitution
US12109395B2 (en) 2017-11-17 2024-10-08 Sanofi Device and mixing and/or reconstitution method
WO2024099322A1 (fr) * 2022-11-10 2024-05-16 卡尤迪生物科技宜兴有限公司 Dispositif d'administration et méthode d'administration
WO2025159790A1 (fr) * 2024-01-24 2025-07-31 Nxtgen Biomedical Llc Seringue de séparation et procédés de traitement de séparation de fluides biologiques en fractions

Also Published As

Publication number Publication date
EP1890752A1 (fr) 2008-02-27

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