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WO2006125978A3 - Assay particles - Google Patents

Assay particles Download PDF

Info

Publication number
WO2006125978A3
WO2006125978A3 PCT/GB2006/001896 GB2006001896W WO2006125978A3 WO 2006125978 A3 WO2006125978 A3 WO 2006125978A3 GB 2006001896 W GB2006001896 W GB 2006001896W WO 2006125978 A3 WO2006125978 A3 WO 2006125978A3
Authority
WO
WIPO (PCT)
Prior art keywords
microspheres
agent
magnetizable
assay particles
core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2006/001896
Other languages
French (fr)
Other versions
WO2006125978A2 (en
Inventor
Christopher Oldfield
Tom Johnston
David Nichols
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanosphere Ltd
Original Assignee
Nanosphere Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosphere Ltd filed Critical Nanosphere Ltd
Publication of WO2006125978A2 publication Critical patent/WO2006125978A2/en
Publication of WO2006125978A3 publication Critical patent/WO2006125978A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/04—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys
    • H01F1/06—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder
    • H01F1/063—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder with a non magnetic core

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Power Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to microspheres, more particularly magnetizable microspheres that may be used in separation procedures, or that may be used as the basis for constructing microspheres that may be used in separation procedures. The invention also relates to methods for making such microspheres. The microspheres comprise a core, an anchoring agent and a magnetizable agent, wherein the magnetizable agent is anchored to the core by binding to the anchoring agent.
PCT/GB2006/001896 2005-05-23 2006-05-23 Assay particles Ceased WO2006125978A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0510461.7 2005-05-23
GBGB0510461.7A GB0510461D0 (en) 2005-05-23 2005-05-23 Assay particles

Publications (2)

Publication Number Publication Date
WO2006125978A2 WO2006125978A2 (en) 2006-11-30
WO2006125978A3 true WO2006125978A3 (en) 2007-03-29

Family

ID=34834474

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001896 Ceased WO2006125978A2 (en) 2005-05-23 2006-05-23 Assay particles

Country Status (2)

Country Link
GB (2) GB0510461D0 (en)
WO (1) WO2006125978A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8632883B2 (en) * 2008-02-15 2014-01-21 Ge Healthcare Bio-Sciences Ab Separation media for biomolecules comprising porous hybrid particles containing inorganic metal oxide nanoparticles
JP6230997B2 (en) * 2011-08-05 2017-11-15 ジャンセン ダイアグノスティックス，エルエルシー A new method for molecular bonding to metal / metal oxide surfaces.
ES2439167B1 (en) * 2012-06-21 2014-11-17 Consejo Superior De Investigaciones Científicas (Csic) Compounds with magnetic functionality, implants or gels derived from them, and the use of both to determine the enzymatic activity of an enzyme
CN108267570B (en) * 2016-12-27 2023-09-12 北京达微生物科技有限公司 A multi-well plate for pre-storing reagent microbeads and preparation and use methods thereof
WO2025195935A1 (en) 2024-03-18 2025-09-25 Magnify Biotechnologies Gmbh Core-shell particles

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177253A (en) * 1976-07-30 1979-12-04 Imperial Chemical Industries Limited Magnetic particles for immunoassay
DE4308668A1 (en) * 1992-03-19 1993-10-21 Nippon Paint Co Ltd Contrast agent for ultrasound diagnoses - consists of aq. medium contg. gas filled particles coated with a layer of magnetic ferrite
WO2001078087A2 (en) * 2000-04-06 2001-10-18 Luminex Corporation Magnetically-responsive microspheres
US20020162798A1 (en) * 2001-05-02 2002-11-07 Johnson James R. Composite particles
WO2003062787A2 (en) * 2001-11-27 2003-07-31 The Regents Of The University Of California Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US6656587B2 (en) * 2001-05-02 2003-12-02 Phillips Plastics Corporation Composite particles

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177253A (en) * 1976-07-30 1979-12-04 Imperial Chemical Industries Limited Magnetic particles for immunoassay
DE4308668A1 (en) * 1992-03-19 1993-10-21 Nippon Paint Co Ltd Contrast agent for ultrasound diagnoses - consists of aq. medium contg. gas filled particles coated with a layer of magnetic ferrite
WO2001078087A2 (en) * 2000-04-06 2001-10-18 Luminex Corporation Magnetically-responsive microspheres
US20020162798A1 (en) * 2001-05-02 2002-11-07 Johnson James R. Composite particles
WO2003062787A2 (en) * 2001-11-27 2003-07-31 The Regents Of The University Of California Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GUPTA P K ET AL: "ULTRASTRUCTURAL DISPOSITION OF ADRIAMYCIN-ASSOCIATED MAGNETIC ALBUMIN MICROPHERES IN RATS", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 78, no. 4, 1 April 1989 (1989-04-01), pages 290 - 294, XP000104192, ISSN: 0022-3549 *
LALLA J K ET AL: "DRUG TARGETING USING NON-MAGNETIC AND MAGNETIC ALBUMIN-GLOBULIN MIX MICROSPHERES OF MEFENAMIC ACID", JOURNAL OF MICROENCAPSULATION, TAYLOR AND FRANCIS, BASINGSTOKE, GB, vol. 8, no. 1, January 1991 (1991-01-01), pages 37 - 52, XP000204967, ISSN: 0265-2048 *
ZHANG Q ET AL: "Electroless nickel plating on hollow glass microspheres", SURFACE AND COATINGS TECHNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 192, no. 2-3, 21 March 2005 (2005-03-21), pages 213 - 219, XP004697557, ISSN: 0257-8972 *

Also Published As

Publication number Publication date
WO2006125978A2 (en) 2006-11-30
GB0510461D0 (en) 2005-06-29
GB2426583A (en) 2006-11-29
GB0610209D0 (en) 2006-07-05

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