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WO2006125181A3 - Piperidine derivatives and their use as stearoyl-coa desaturase modulators - Google Patents

Piperidine derivatives and their use as stearoyl-coa desaturase modulators Download PDF

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Publication number
WO2006125181A3
WO2006125181A3 PCT/US2006/019566 US2006019566W WO2006125181A3 WO 2006125181 A3 WO2006125181 A3 WO 2006125181A3 US 2006019566 W US2006019566 W US 2006019566W WO 2006125181 A3 WO2006125181 A3 WO 2006125181A3
Authority
WO
WIPO (PCT)
Prior art keywords
stearoyl
piperidine derivatives
coa desaturase
desaturase modulators
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/019566
Other languages
French (fr)
Other versions
WO2006125181A2 (en
Inventor
Jianmin Fu
Vishnumurthy Kodumuru
Shifeng Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenon Pharmaceuticals Inc
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of WO2006125181A2 publication Critical patent/WO2006125181A2/en
Publication of WO2006125181A3 publication Critical patent/WO2006125181A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where p, G, J, L, M, W, R2, R3, R4 and R5 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
PCT/US2006/019566 2005-05-19 2006-05-19 Piperidine derivatives and their use as stearoyl-coa desaturase modulators Ceased WO2006125181A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68246505P 2005-05-19 2005-05-19
US60/682,465 2005-05-19

Publications (2)

Publication Number Publication Date
WO2006125181A2 WO2006125181A2 (en) 2006-11-23
WO2006125181A3 true WO2006125181A3 (en) 2007-03-29

Family

ID=37432189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/019566 Ceased WO2006125181A2 (en) 2005-05-19 2006-05-19 Piperidine derivatives and their use as stearoyl-coa desaturase modulators

Country Status (1)

Country Link
WO (1) WO2006125181A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582633B2 (en) 2007-01-26 2009-09-01 Merck Frosst Canada L.L.C. Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
US8063224B2 (en) 2006-12-01 2011-11-22 Merck Canada Inc. Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007050124A1 (en) * 2005-05-19 2007-05-03 Xenon Pharmaceuticals Inc. Fused piperidine derivatives and their uses as therapeutic agents
MX2009002019A (en) 2006-08-24 2009-03-09 Novartis Ag 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyraz0l-3-yl) -thiazole derivatives as well as related compounds as stearoyl-coa desaturase (scd) inhibitors for the treatment of metabolic, cardiovascular and other disorders.
US8575167B2 (en) 2007-02-06 2013-11-05 Takeda Pharmaceutical Company Limited Spiro compounds having stearoyl-CoA desaturase action
JP5597210B2 (en) 2009-02-17 2014-10-01 メルク カナダ インコーポレイテッド Novel spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
WO2011011872A1 (en) 2009-07-28 2011-02-03 Merck Frosst Canada Ltd. Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase
RU2014119426A (en) 2011-10-15 2015-11-20 Дженентек, Инк. WAYS OF APPLICATION OF SCD1 ANTAGONISTS
WO2013175474A2 (en) 2012-05-22 2013-11-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Selective inhibitors of undifferentiated cells
WO2018081167A1 (en) 2016-10-24 2018-05-03 Yumanity Therapeutics Compounds and uses thereof
IL304017A (en) 2017-01-06 2023-08-01 Yumanity Therapeutics Inc Methods for the treatment of neurological disorders
EP3700934A4 (en) 2017-10-24 2021-10-27 Yumanity Therapeutics, Inc. COMPOUNDS AND USES THEREOF
SG11202009280RA (en) 2018-03-23 2020-10-29 Yumanity Therapeutics Inc Compounds and uses thereof
SG11202108079RA (en) 2019-01-24 2021-08-30 Yumanity Therapeutics Inc Compounds and uses thereof
EA202192047A1 (en) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. COMPOUNDS AND THEIR APPLICATIONS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005011657A2 (en) * 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Piperazine derivatives and their use as therapeutic agents
WO2005042542A1 (en) * 2003-10-31 2005-05-12 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005011657A2 (en) * 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Piperazine derivatives and their use as therapeutic agents
WO2005042542A1 (en) * 2003-10-31 2005-05-12 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FRAHN, M.S. ET AL.: "Radiation-induced polymerization monitored in situ by time-resolved fluorescence of probe molecules in methyl methacrylate", NUCLEAR INSTRUMENTS AND METHODS IN PHYSICS RESEARCH B, vol. 208, 2003, pages 405 - 410, XP002411451 *
HUANG T L ET AL: "Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 6, no. 17, 1996, pages 2087 - 2090, XP002227683, ISSN: 0960-894X *
LAUTESLAGER, X.Y. ET AL.: "Conformational dynamics of charge-transfer states in donor-bridge-acceptor systems", EUR. J. ORG. CHEM., vol. 16, 2001, pages 3105, XP002411450 *
SCHERER T ET AL: "Synthesis and exploratory photophysical investigation of donor-bridge-acceptor systems derived from N-substituted 4-piperidones", RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS, ELSEVIER SCIENCE PUBLISHERS. AMSTERDAM, NL, vol. 112, no. 10, October 1993 (1993-10-01), pages 535 - 548, XP002087998, ISSN: 0165-0513 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8063224B2 (en) 2006-12-01 2011-11-22 Merck Canada Inc. Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
US7582633B2 (en) 2007-01-26 2009-09-01 Merck Frosst Canada L.L.C. Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase

Also Published As

Publication number Publication date
WO2006125181A2 (en) 2006-11-23

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