[go: up one dir, main page]

WO2006120472A3 - Novel beta-steroid compounds - Google Patents

Novel beta-steroid compounds Download PDF

Info

Publication number
WO2006120472A3
WO2006120472A3 PCT/GB2006/001767 GB2006001767W WO2006120472A3 WO 2006120472 A3 WO2006120472 A3 WO 2006120472A3 GB 2006001767 W GB2006001767 W GB 2006001767W WO 2006120472 A3 WO2006120472 A3 WO 2006120472A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
steroid compounds
novel beta
disease
pulmonary disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2006/001767
Other languages
French (fr)
Other versions
WO2006120472A2 (en
Inventor
Philip James Hilton Hilton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guys and St Thomas NHS Foundation Trust
Original Assignee
Guys and St Thomas NHS Foundation Trust
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guys and St Thomas NHS Foundation Trust filed Critical Guys and St Thomas NHS Foundation Trust
Publication of WO2006120472A2 publication Critical patent/WO2006120472A2/en
Publication of WO2006120472A3 publication Critical patent/WO2006120472A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a compound of formula (I). The invention provides the use of the compound in the inhibition of the sodium pump, use of the compound in medicine and particularly in the treatment of heart disease, hypertension, impaired renal function, renal disease, diabetes, metabolic disorders, neurological disorders, pulmonary disease, chronic obstructive pulmonary disease and cancer.
PCT/GB2006/001767 2005-05-13 2006-05-12 Novel beta-steroid compounds Ceased WO2006120472A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0509829.8A GB0509829D0 (en) 2005-05-13 2005-05-13 Compound
GB0509829.8 2005-05-13

Publications (2)

Publication Number Publication Date
WO2006120472A2 WO2006120472A2 (en) 2006-11-16
WO2006120472A3 true WO2006120472A3 (en) 2007-05-10

Family

ID=34708148

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001767 Ceased WO2006120472A2 (en) 2005-05-13 2006-05-12 Novel beta-steroid compounds

Country Status (2)

Country Link
GB (1) GB0509829D0 (en)
WO (1) WO2006120472A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858604B2 (en) 2005-07-12 2010-12-28 Scott & White Healthcare Method of treating human volume expansion mediated hypertension employing resibufogenin
GB0713463D0 (en) 2007-07-11 2007-08-22 Btg Int Ltd Modulators of hypoxia inducible factor-1 and related uses
MX2012012523A (en) 2010-04-27 2012-12-17 Pharma Mar Sa Anticancer steroidal lactones unsaturated in position 7 (8).
TWI466674B (en) * 2011-04-11 2015-01-01 高雄醫學大學 Taiwan Solo Wood Bioactive Composition
CN114395011B (en) * 2022-02-11 2023-04-25 上海中医药大学 Preparation method of natural bufogenin compound
CN114933624B (en) * 2022-05-24 2024-02-20 大连理工大学 An artificial synthesis method of natural product (+)-digoxigenin
CN117491535B (en) * 2023-12-22 2024-03-22 山东省食品药品检验研究院 Quality evaluation method of external gel bulk drug of lindera root

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071460A1 (en) * 1981-07-31 1983-02-09 Advance Biofactures Corporation Isobufalin and isoresibufogenin compounds and methods of preparing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071460A1 (en) * 1981-07-31 1983-02-09 Advance Biofactures Corporation Isobufalin and isoresibufogenin compounds and methods of preparing the same

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; RO, JAI SEUP ET AL: "Studies on sodium(+), potassium(+)-ATPase activity of the constituents of Adonis amurensis in Korea", XP002395129, retrieved from STN Database accession no. 1991:35425 *
DEL VALLE MONDRAGON, LEONARDO ET AL: "Relation between the electromolecular properties of digitalis compounds and their pharmacological properties", ARCHIVOS DE CARDIOLOGIA DE MEXICO , 73(1), 11-17 CODEN: ACMRCR; ISSN: 1405-9940, 2003, XP008067828 *
NAIDOO B K ET AL: "Cardiotonic steroids. I. Importance of 14 beta-hydroxy group in digitoxigenin.", JOURNAL OF PHARMACEUTICAL SCIENCES. SEP 1974, vol. 63, no. 9, September 1974 (1974-09-01), pages 1391 - 1394, XP002394977, ISSN: 0022-3549 *
PATI, UTTAM K. ET AL: "Synthesis of 5.beta.-androstan-17.beta.-(1'-oxocyclohex-2'-en-3'-yl)- 3.beta.,14.beta.-diol-3-.beta.-D-glucopyranoside, a potent cardiac glucoside with high safety margin", HETEROCYCLES , 29(7), 1275-82 CODEN: HTCYAM; ISSN: 0385-5414, 1989, XP008067860 *
SAENGYAK HAKHOECHI , 21(2), 130-6 CODEN: SYHJAM; ISSN: 0253-3073, 1990 *
SHIGEI T ET AL: "Structure-activity relationship of the cardenolide, with special reference to the substituents and configurations at C-14 and C-15.", EXPERIENTIA. 15 APR 1973, vol. 29, no. 4, 15 April 1973 (1973-04-15), pages 449 - 450, XP002394976, ISSN: 0014-4754 *
SHIMADA, KAZUTAKE ET AL: "Utility of cyclodextrin in mobile phase for high-performance liquid chromatographic separation of bufadienolides", JOURNAL OF LIQUID CHROMATOGRAPHY , 13(3), 493-504 CODEN: JLCHD8; ISSN: 0148-3919, 1990, XP008067844 *
STEYN, PIETER S. ET AL: "Bufadienolides of plant and animal origin", NATURAL PRODUCT REPORTS , 15(4), 397-413 CODEN: NPRRDF; ISSN: 0265-0568, 1998, XP002394978 *
TAKECHI M ET AL: "Structure-activity relationships of synthetic cardiac glycosides.", PHYTOCHEMISTRY. JAN 1996, vol. 41, no. 1, January 1996 (1996-01-01), pages 125 - 127, XP002394974, ISSN: 0031-9422 *

Also Published As

Publication number Publication date
GB0509829D0 (en) 2005-06-22
WO2006120472A2 (en) 2006-11-16

Similar Documents

Publication Publication Date Title
WO2007133653A3 (en) Methods for treating blood disorders
WO2005082863A3 (en) 1,4 diaryl-dihydropyrimidin-2 ones and their use as a human neutrophil elastase inhibitors
WO2007104789A3 (en) Amylin derivatives
EP1408038A3 (en) Imidazole deriviatives and their use as peripherally-selective inhibitors of dopamine-beta-hydroxylase
WO2009042922A3 (en) Peptide-peptidase inhibitor conjugates and methods of making and using same
WO2008001195A3 (en) Novel processes for the preparation of dpp iv inhibitors
WO2007102861A3 (en) Modulators of cdc2-like kinases (clks) and methods of use thereof
WO2007109354A3 (en) Peptide-peptidase inhibitor conjugates and methods of using same
TW200637849A (en) Kinase inhibitors
WO2005082871A3 (en) Guanidine compounds, and use thereof as binding partners for 5-ht5 receptors
WO2005044192A3 (en) Triazole compounds and uses related thereto
WO2008108958A8 (en) Benzimidazole derivatives and methods of use thereof
TN2010000292A1 (en) 6h-dibenzo[b,e] oxepine derived nonsteroidal mineralocorticoid receptor antagonists
WO2005097788A3 (en) Sulfonamides and uses thereof
WO2005072045A3 (en) The combined use of glp-1 agonists and gastrin for regulating blood glucose levels
IS8485A (en) Use of substituted 2-aminotetralins in the prevention of Parkinson's disease
WO2009121939A3 (en) C-aryl glycoside compounds for the treatment of diabetes and obesity
NO20054876L (en) Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as drug and drug containing such compounds
WO2007081630A3 (en) Substituted pyrimidinyl kinase inhibitors
WO2006120472A3 (en) Novel beta-steroid compounds
IL185410A0 (en) Use of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione in the treatment of parkinson's disease
WO2007019153A3 (en) Methods for treating hypertension
WO2006110882A3 (en) Hmgcoa reductase inhibitor codrugs and uses thereof
WO2008041134A3 (en) Use of chlorine guanabenz derivatives for treating prion-based diseases
WO2006051314A3 (en) Guanidine derivatives as inhibitors of ddah

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

NENP Non-entry into the national phase

Ref country code: RU

WWW Wipo information: withdrawn in national office

Country of ref document: RU

122 Ep: pct application non-entry in european phase

Ref document number: 06743895

Country of ref document: EP

Kind code of ref document: A2