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WO2006116678A3 - Tissue targeting of stem cells - Google Patents

Tissue targeting of stem cells Download PDF

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Publication number
WO2006116678A3
WO2006116678A3 PCT/US2006/016235 US2006016235W WO2006116678A3 WO 2006116678 A3 WO2006116678 A3 WO 2006116678A3 US 2006016235 W US2006016235 W US 2006016235W WO 2006116678 A3 WO2006116678 A3 WO 2006116678A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
tissue targeting
vivo
stem cell
unique
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/016235
Other languages
French (fr)
Other versions
WO2006116678A2 (en
Inventor
Maria Grant
Sean Sullivan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
University of Florida Research Foundation Inc
Original Assignee
University of Florida
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida, University of Florida Research Foundation Inc filed Critical University of Florida
Publication of WO2006116678A2 publication Critical patent/WO2006116678A2/en
Publication of WO2006116678A3 publication Critical patent/WO2006116678A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Stem cell compositions comprise a gene unique to the desired engrafted tissue which is introduced into the stem cell either ex vivo or in vivo. Expression of the unique gene results in the homing and differentiation of the stem cell into the desired cell type at a specific in vivo location.
PCT/US2006/016235 2005-04-28 2006-04-28 Tissue targeting of stem cells Ceased WO2006116678A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67576905P 2005-04-28 2005-04-28
US60/675,769 2005-04-28

Publications (2)

Publication Number Publication Date
WO2006116678A2 WO2006116678A2 (en) 2006-11-02
WO2006116678A3 true WO2006116678A3 (en) 2007-08-02

Family

ID=37215544

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/016235 Ceased WO2006116678A2 (en) 2005-04-28 2006-04-28 Tissue targeting of stem cells

Country Status (1)

Country Link
WO (1) WO2006116678A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7816140B2 (en) 2005-06-14 2010-10-19 The United States Of America As Represented By The Department Of Veterans Affairs Composition and methods for osteogenic gene therapy
DE102006005827B3 (en) * 2006-02-08 2007-07-26 Torzewski, Jan, Prof. Dr. med. mRNA transfection of adult progenitor cells for specific tissue regeneration
EP2404609A1 (en) * 2010-07-07 2012-01-11 Deutsches Krebsforschungszentrum Use of parvovirus for eliminating cancer stem cells (CSCs)
WO2012045086A1 (en) 2010-10-01 2012-04-05 The Trustees Of Columbia University In The City Of New York Pdgf induced cell homing

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153383A (en) * 1997-12-09 2000-11-28 Verdine; Gregory L. Synthetic transcriptional modulators and uses thereof
US20020086383A1 (en) * 2000-02-23 2002-07-04 Guy Sauvageau Hematopoietic stem cell expansion enhancing factor and method of use
US20020099196A1 (en) * 1996-08-27 2002-07-25 Kyowa Hakko Kogyo Co., Ltd. And Atsunobu Hiraoka Hematopoietic stem cell growth factor (scgf)
US20050063961A1 (en) * 2002-07-25 2005-03-24 The Scripps Research Institute Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020099196A1 (en) * 1996-08-27 2002-07-25 Kyowa Hakko Kogyo Co., Ltd. And Atsunobu Hiraoka Hematopoietic stem cell growth factor (scgf)
US6153383A (en) * 1997-12-09 2000-11-28 Verdine; Gregory L. Synthetic transcriptional modulators and uses thereof
US20020086383A1 (en) * 2000-02-23 2002-07-04 Guy Sauvageau Hematopoietic stem cell expansion enhancing factor and method of use
US20050063961A1 (en) * 2002-07-25 2005-03-24 The Scripps Research Institute Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith

Also Published As

Publication number Publication date
WO2006116678A2 (en) 2006-11-02

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