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WO2006110309A3 - Souris transgeniques exprimant une population unique de lymphocytes b et methodes d'utilisation - Google Patents

Souris transgeniques exprimant une population unique de lymphocytes b et methodes d'utilisation Download PDF

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Publication number
WO2006110309A3
WO2006110309A3 PCT/US2006/011105 US2006011105W WO2006110309A3 WO 2006110309 A3 WO2006110309 A3 WO 2006110309A3 US 2006011105 W US2006011105 W US 2006011105W WO 2006110309 A3 WO2006110309 A3 WO 2006110309A3
Authority
WO
WIPO (PCT)
Prior art keywords
transgenic mice
unique
methods
transgenic
cell population
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/011105
Other languages
English (en)
Other versions
WO2006110309A2 (fr
WO2006110309A9 (fr
Inventor
Patrick Swanson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Creighton University
Original Assignee
Creighton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creighton University filed Critical Creighton University
Publication of WO2006110309A2 publication Critical patent/WO2006110309A2/fr
Publication of WO2006110309A3 publication Critical patent/WO2006110309A3/fr
Publication of WO2006110309A9 publication Critical patent/WO2006110309A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention porte sur des animaux transgéniques, tels que des souris transgéniques, qui expriment une forme dominante-négative de RAG-I dans la phase de transition du développement des lymphocytes B, ce qui permet un réarrangement initial génétique du récepteur à l'antigène, mais bloque l'édition du récepteur et/ou la révision du récepteur qui se produit pendant les dernières phases du développement. Selon un aspect de cette invention, l'animal transgénique comprend dans son génome un polynucléotide exogène comprenant une séquence codante codant un polypeptide RAG-I catalytiquement défectueux ou un analogue de celui-ci. L'invention porte également sur des méthodes de fabrication et d'utilisation de ces animaux transgéniques.
PCT/US2006/011105 2005-03-26 2006-03-27 Souris transgeniques exprimant une population unique de lymphocytes b et methodes d'utilisation Ceased WO2006110309A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66540605P 2005-03-26 2005-03-26
US60/665,406 2005-03-26

Publications (3)

Publication Number Publication Date
WO2006110309A2 WO2006110309A2 (fr) 2006-10-19
WO2006110309A3 true WO2006110309A3 (fr) 2007-01-18
WO2006110309A9 WO2006110309A9 (fr) 2007-04-19

Family

ID=37087489

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/011105 Ceased WO2006110309A2 (fr) 2005-03-26 2006-03-27 Souris transgeniques exprimant une population unique de lymphocytes b et methodes d'utilisation

Country Status (1)

Country Link
WO (1) WO2006110309A2 (fr)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FURUSAWA T ET AL: "Catalytic RAG1 mutants obstruct V(D)J recombination in vitro and in vivo.", MOLECULAR IMMUNOLOGY, vol. 39, no. 14, May 2003 (2003-05-01), pages 871 - 878, XP002407203, ISSN: 0161-5890 *
KIM D R ET AL: "Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase", GENES AND DEVELOPMENT, vol. 13, no. 23, December 1999 (1999-12-01), pages 3070 - 3080, XP002407205, ISSN: 0890-9369 *
LANDREE M A ET AL: "Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination", GENES AND DEVELOPMENT, vol. 13, no. 23, December 1999 (1999-12-01), pages 3059 - 3069, XP002407204, ISSN: 0890-9369 *
PARKS K W ET AL: "Transgenic mice expressing catalytically inactive RAG-1 exhibit hypogammaglobulinemia and altered B cell development, but not autoreactivity", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 117, no. 2, Suppl. S, February 2006 (2006-02-01), & 62ND ANNUAL MEETING OF THE AMERICAN-ACADEMY-OF-ALLERGY-ASTHMA-AND-IMM UNOLOGY; MIAMI BEACH, FL, USA; MARCH 03 -07, 2006, pages S100, XP002407202, ISSN: 0091-6749 *

Also Published As

Publication number Publication date
WO2006110309A2 (fr) 2006-10-19
WO2006110309A9 (fr) 2007-04-19

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