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WO2006109073A3 - Inprovements in or relating to methods and apparatus for analyzing biological samples by mass spectrometry - Google Patents

Inprovements in or relating to methods and apparatus for analyzing biological samples by mass spectrometry Download PDF

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Publication number
WO2006109073A3
WO2006109073A3 PCT/GB2006/001356 GB2006001356W WO2006109073A3 WO 2006109073 A3 WO2006109073 A3 WO 2006109073A3 GB 2006001356 W GB2006001356 W GB 2006001356W WO 2006109073 A3 WO2006109073 A3 WO 2006109073A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass spectrometry
inprovements
relating
methods
biological samples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2006/001356
Other languages
French (fr)
Other versions
WO2006109073A2 (en
Inventor
Josephine Bunch
Alan G Cox
Cameron William Mcleod
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Sheffield
Original Assignee
University of Sheffield
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Sheffield filed Critical University of Sheffield
Publication of WO2006109073A2 publication Critical patent/WO2006109073A2/en
Publication of WO2006109073A3 publication Critical patent/WO2006109073A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A method and apparatus for mapping the biomoleoular and elemental content of tissue samples uses two complementary mass spectrometry techniques. In one embodiment the techniques comprise MALDI and LA - ICP - MS or LA-MS.
PCT/GB2006/001356 2005-04-13 2006-04-13 Inprovements in or relating to methods and apparatus for analyzing biological samples by mass spectrometry Ceased WO2006109073A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0507457.0 2005-04-13
GB0507457A GB2425178A (en) 2005-04-13 2005-04-13 Analysis of biological samples by mass spectrometry

Publications (2)

Publication Number Publication Date
WO2006109073A2 WO2006109073A2 (en) 2006-10-19
WO2006109073A3 true WO2006109073A3 (en) 2007-02-22

Family

ID=34611055

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001356 Ceased WO2006109073A2 (en) 2005-04-13 2006-04-13 Inprovements in or relating to methods and apparatus for analyzing biological samples by mass spectrometry

Country Status (2)

Country Link
GB (1) GB2425178A (en)
WO (1) WO2006109073A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2582169T3 (en) 2006-02-13 2016-09-09 Fluidigm Canada Inc.  Gene expression analysis with oligonucleotides labeled with elements
DE102006019530B4 (en) 2006-04-27 2008-01-31 Bruker Daltonik Gmbh Sample preparation for mass spectrometric thin-slice images
CA2658787C (en) 2006-08-15 2013-04-09 Alexei Antonov Apparatus and method for elemental analysis of particles by mass spectrometry
DE102006059695B3 (en) 2006-12-18 2008-07-10 Bruker Daltonik Gmbh Preparation of a matrix layer for mass spectrometry
US9576180B2 (en) * 2012-12-06 2017-02-21 Abbott Point Of Care, Inc. Method for imaging biologic fluid samples using a predetermined distribution
CN112964625B (en) 2015-03-06 2024-06-07 英国质谱公司 Cell population analysis
JP6783240B2 (en) 2015-03-06 2020-11-11 マイクロマス ユーケー リミテッド In vivo endoscopic tissue identification device
EP3265818B1 (en) 2015-03-06 2020-02-12 Micromass UK Limited Imaging guided ambient ionisation mass spectrometry
CN107533032A (en) 2015-03-06 2018-01-02 英国质谱公司 In situ ionization mass spectrometry imaging platform for direct mapping from bulk tissue
WO2016142685A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Collision surface for improved ionisation
WO2016142669A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Physically guided rapid evaporative ionisation mass spectrometry ("reims")
GB2553937B (en) 2015-03-06 2022-06-08 Micromass Ltd Improved ionisation of gaseous samples
GB2598259B (en) * 2015-03-06 2022-06-22 Micromass Ltd Cell Population Analysis
GB2554206B (en) 2015-03-06 2021-03-24 Micromass Ltd Spectrometric analysis of microbes
EP3741303A3 (en) 2015-03-06 2020-12-30 Micromass UK Limited Chemically guided ambient ionisation mass spectrometry
US10777397B2 (en) 2015-03-06 2020-09-15 Micromass Uk Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry (“REIMS”) device
WO2016142689A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
US10777398B2 (en) 2015-03-06 2020-09-15 Micromass Uk Limited Spectrometric analysis
JP6845148B2 (en) 2015-03-06 2021-03-17 マイクロマス ユーケー リミテッド Liquid trap or separator for electrosurgical applications
GB2552602B (en) 2015-03-06 2020-12-30 Micromass Ltd Desorption electrospray ionisation mass spectrometry ("DESI-MS") analysis of swabs
GB201517195D0 (en) 2015-09-29 2015-11-11 Micromass Ltd Capacitively coupled reims technique and optically transparent counter electrode
EP3443354B1 (en) 2016-04-14 2025-08-20 Micromass UK Limited Spectrometric analysis of plants

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030008327A1 (en) * 2001-06-26 2003-01-09 Olga Ornatskaia Methods and systems for identifying kinases, phosphatases, and substrates thereof
US20030073145A1 (en) * 2001-10-15 2003-04-17 Richard Caprioli Methods and apparatus for analyzing biological samples by mass spectrometry

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248592B1 (en) * 1995-03-27 2001-06-19 The Regents Of The University Of California Method for measuring lead concentrations in blood
US5808300A (en) * 1996-05-10 1998-09-15 Board Of Regents, The University Of Texas System Method and apparatus for imaging biological samples with MALDI MS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030008327A1 (en) * 2001-06-26 2003-01-09 Olga Ornatskaia Methods and systems for identifying kinases, phosphatases, and substrates thereof
US20030073145A1 (en) * 2001-10-15 2003-04-17 Richard Caprioli Methods and apparatus for analyzing biological samples by mass spectrometry

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BECKER J S ET AL: "Investigation of Cu-, Zn- and Fe-containing human brain proteins using isotopic-enriched tracers by LA-ICP-MS and MALDI-FT-ICR-MS", INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, ELSEVIER, AMSTERDAM, NL, vol. 242, no. 2-3, 1 April 2005 (2005-04-01), pages 135 - 144, XP004781147, ISSN: 1387-3806 *
CHAURAND PIERRE ET AL: "Integrating histology and imaging mass spectrometry.", ANALYTICAL CHEMISTRY. 15 FEB 2004, vol. 76, no. 4, 15 February 2004 (2004-02-15), pages 1145 - 1155, XP002398608, ISSN: 0003-2700 *
ENCINAR JORGE RUIZ ET AL: "Identification of water-soluble selenium-containing proteins in selenized yeast by size-exclusion-reversed-phase HPLC/ICPMS followed by MALDI-TOF and electrospray Q-TOF mass spectrometry.", ANALYTICAL CHEMISTRY. 1 AUG 2003, vol. 75, no. 15, 1 August 2003 (2003-08-01), pages 3765 - 3774, XP002398607, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
GB2425178A (en) 2006-10-18
GB0507457D0 (en) 2005-05-18
WO2006109073A2 (en) 2006-10-19

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