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WO2006108879A3 - Utilisation d'un compose de sulfonamide aux fins d'amelioration de la pharmacocinetique d'un medicament - Google Patents

Utilisation d'un compose de sulfonamide aux fins d'amelioration de la pharmacocinetique d'un medicament Download PDF

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Publication number
WO2006108879A3
WO2006108879A3 PCT/EP2006/061614 EP2006061614W WO2006108879A3 WO 2006108879 A3 WO2006108879 A3 WO 2006108879A3 EP 2006061614 W EP2006061614 W EP 2006061614W WO 2006108879 A3 WO2006108879 A3 WO 2006108879A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmacokinetics
improving
drug
sulfonamide compound
protease inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/061614
Other languages
English (en)
Other versions
WO2006108879A2 (fr
Inventor
T Klooster Gerben Albert E Van
Piet Tom Bert Paul Wigerinck
Meyer Sandra De
Lieven Elvire Colette Baert
Kock Herman Augustinus De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen R&D Ireland ULC
Original Assignee
Tibotec Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN2006800125424A priority Critical patent/CN101175491B/zh
Priority to EA200702242A priority patent/EA016340B1/ru
Priority to JP2008505907A priority patent/JP2008535896A/ja
Priority to AU2006234335A priority patent/AU2006234335B2/en
Priority to EP06754743A priority patent/EP1874307A2/fr
Priority to BRPI0608322-6A priority patent/BRPI0608322A2/pt
Application filed by Tibotec Pharmaceuticals Ltd filed Critical Tibotec Pharmaceuticals Ltd
Priority to US11/911,465 priority patent/US8557854B2/en
Priority to CA2604799A priority patent/CA2604799C/fr
Publication of WO2006108879A2 publication Critical patent/WO2006108879A2/fr
Anticipated expiration legal-status Critical
Publication of WO2006108879A3 publication Critical patent/WO2006108879A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne un procédé permettant d'améliorer la pharmacocinétique de médicaments métabolisés par la cytochrome P450 monooxygénase. Plus précisément, l'invention concerne un procédé permettant d'améliorer la pharmacocinétique d'inhibiteurs des protéases rétrovirales et, plus précisément, permettant d'améliorer la pharmacocinétique d'inhibiteurs de la protéase du virus de l'immunodéficience humaine (VIH). L'invention concerne enfin une composition pharmaceutique et l'utilisation de celle-ci dans la fabrication d'un médicament destiné à l'inhibition ou au traitement d'une infection au VIH ou SIDA chez un être humain.
PCT/EP2006/061614 2005-04-15 2006-04-14 Utilisation d'un compose de sulfonamide aux fins d'amelioration de la pharmacocinetique d'un medicament Ceased WO2006108879A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EA200702242A EA016340B1 (ru) 2005-04-15 2006-04-14 Применение 5-тиазолилметил[(1s,2r)-3-[[(2-амино-6-бензоксазолил)сульфонил](2-метилпропил)амино]-2-гидрокси-1-(фенилметил)пропил]карбамата или его энантиомера для улучшения фармакокинетики ингибиторов протеазы
JP2008505907A JP2008535896A (ja) 2005-04-15 2006-04-14 薬物の薬物動態を改善するためのスルホンアミド化合物の使用
AU2006234335A AU2006234335B2 (en) 2005-04-15 2006-04-14 Use of a sulfonamide compound for improving the pharmacokinetics of a drug
EP06754743A EP1874307A2 (fr) 2005-04-15 2006-04-14 Utilisation d'un compose de sulfonamide aux fins d'amelioration de la pharmacocinetique d'un medicament
BRPI0608322-6A BRPI0608322A2 (pt) 2005-04-15 2006-04-14 uso de um composto de sulfonamida para aperfeiçoamento da farmacocinética de um fármaco
CN2006800125424A CN101175491B (zh) 2005-04-15 2006-04-14 磺酰胺化合物用于提高药物的药代动力学的用途
US11/911,465 US8557854B2 (en) 2005-04-15 2006-04-14 Use of a sulfonamide compound for improving the pharmacokinetics of a drug
CA2604799A CA2604799C (fr) 2005-04-15 2006-04-14 Utilisation d'un compose de sulfonamide aux fins d'amelioration de la pharmacocinetique d'un medicament

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05103035.1 2005-04-15
EP05103035 2005-04-15
US68428305P 2005-05-25 2005-05-25
US60/684,283 2005-05-25

Publications (2)

Publication Number Publication Date
WO2006108879A2 WO2006108879A2 (fr) 2006-10-19
WO2006108879A3 true WO2006108879A3 (fr) 2008-01-10

Family

ID=35589560

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/061614 Ceased WO2006108879A2 (fr) 2005-04-15 2006-04-14 Utilisation d'un compose de sulfonamide aux fins d'amelioration de la pharmacocinetique d'un medicament

Country Status (12)

Country Link
US (1) US8557854B2 (fr)
EP (1) EP1874307A2 (fr)
JP (1) JP2008535896A (fr)
CN (1) CN101175491B (fr)
AR (1) AR053845A1 (fr)
AU (1) AU2006234335B2 (fr)
BR (1) BRPI0608322A2 (fr)
CA (1) CA2604799C (fr)
EA (1) EA016340B1 (fr)
TW (1) TW200745100A (fr)
WO (1) WO2006108879A2 (fr)
ZA (1) ZA200708811B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10027887A1 (de) 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
DE102005057421A1 (de) * 2005-11-30 2007-05-31 Bayer Schering Pharma Ag Heteroaromatische Sulfonamid-Prodrugs
EP2134336B1 (fr) * 2007-03-16 2013-12-11 Sequoia Pharmaceuticals Inhibiteurs de la protéase du vih dérivés de benzofuranne
AR069539A1 (es) * 2007-07-25 2010-02-03 Tibotec Pharm Ltd Avances respecto de las formulaciones de comprimidos contra el vih
JP5745855B2 (ja) * 2007-11-28 2015-07-08 セコイア、ファーマシューティカルズ、インコーポレイテッドＳｅｑｕｏｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． シトクロムｐ４５０ ２ｄ６を阻害するための組成物および方法
UA103013C2 (uk) * 2007-12-06 2013-09-10 Тиботек Фармасьютикелз Амідні сполуки як активатори противірусних препаратів
WO2009088719A1 (fr) * 2008-01-04 2009-07-16 Gilead Sciences, Inc. Inhibiteurs du cytrochrome p450
WO2010033219A2 (fr) * 2008-09-17 2010-03-25 Nektar Therapeutics Inhibiteurs de protéases ayant des propriétés améliorées
KR101660812B1 (ko) * 2008-10-07 2016-09-28 얀센 사이언시즈 아일랜드 유씨 항바이러스제 부스터로서의 신규 아미드 화합물
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
US20110155359A1 (en) * 2009-12-16 2011-06-30 E. I. Du Pont De Nemours And Company Hollow structures and associated method for conveying refrigerant fluids
US8829208B2 (en) 2010-01-28 2014-09-09 Mapi Pharma Ltd. Process for the preparation of darunavir and darunavir intermediates
AR080374A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida
CN102080122B (zh) * 2010-11-26 2013-04-10 吉林大学 同时测定五种cyp450酶探针药代谢产物的检测方法
CN102175804B (zh) * 2010-12-30 2013-06-05 吉林大学 Cyp450酶亚型生物质谱绝对定量方法
CN104540813A (zh) * 2012-06-27 2015-04-22 默沙东公司 磺酰胺衍生物以及使用它们用于改善药物的药物动力学的方法
WO2014000178A1 (fr) * 2012-06-27 2014-01-03 Merck Sharp & Dohme Corp. Dérivés de sulfamide et leurs méthodes d'utilisation permettant d'améliorer la pharmacocinétique d'un médicament
WO2014194519A1 (fr) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Dérivés imidazole et leurs procédés d'utilisation pour l'amélioration des propriétés pharmacocinétiques d'un médicament
WO2015070367A1 (fr) 2013-11-12 2015-05-21 Merck Sharp & Dohme Corp. Dérivés d'imidazole et de triazole liés à la pipéridine ou la pipérazine et leurs procédés d'utilisation pour améliorer la pharmacocinétique d'un médicament
WO2015070366A1 (fr) 2013-11-12 2015-05-21 Merck Sharp & Dohme Corp. Dérivés d'imidazole et de triazole liés à aryle et leurs procédés d'utilisation pour améliorer la pharmacocinétique d'un médicament
CN111202723A (zh) * 2020-02-15 2020-05-29 江苏艾立康药业股份有限公司 一种达芦那韦吸入干粉药物组合物及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020039998A1 (en) * 1995-06-29 2002-04-04 Norbeck Daniel W. Method for improving pharmacokinetics
WO2002092595A1 (fr) * 2001-05-11 2002-11-21 Tibotec Pharmaceuticals Ltd. Inhibiteurs des proteases du vih a large spectre sous forme de 2-amino-benzoxazole sulfonamides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999033795A1 (fr) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Promedicaments de la classe des inhibiteurs d'aspartyle protease
AU2010299A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
JP4530612B2 (ja) 2001-02-14 2010-08-25 テイボテク・フアーマシユーチカルズ・リミテツド 広域スペクトルの２−（置換−アミノ）−ベンゾチアゾールスルホンアミドｈｉｖプロテアーゼインヒビター
EP1304404A1 (fr) 2001-10-17 2003-04-23 Milliken Europe N.V. Textiles de renfort avec au moins deux directions de renfort
TWI286476B (en) * 2001-12-12 2007-09-11 Tibotec Pharm Ltd Combination of cytochrome P450 dependent protease inhibitors
EP1509537B9 (fr) 2002-04-26 2007-11-14 Gilead Sciences, Inc. Accumulation cellulaire d' analogues de phosphonate de composes inhibiteurs de la protease du vih
IN2012DN02301A (fr) * 2003-09-30 2015-08-14 Janssen R & D Ireland

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020039998A1 (en) * 1995-06-29 2002-04-04 Norbeck Daniel W. Method for improving pharmacokinetics
WO2002092595A1 (fr) * 2001-05-11 2002-11-21 Tibotec Pharmaceuticals Ltd. Inhibiteurs des proteases du vih a large spectre sous forme de 2-amino-benzoxazole sulfonamides

Also Published As

Publication number Publication date
EA200702242A1 (ru) 2008-02-28
WO2006108879A2 (fr) 2006-10-19
JP2008535896A (ja) 2008-09-04
AR053845A1 (es) 2007-05-23
CA2604799A1 (fr) 2006-10-19
AU2006234335B2 (en) 2011-09-29
CN101175491A (zh) 2008-05-07
CN101175491B (zh) 2011-07-27
US20080287488A1 (en) 2008-11-20
BRPI0608322A2 (pt) 2009-12-29
EP1874307A2 (fr) 2008-01-09
CA2604799C (fr) 2015-06-09
AU2006234335A1 (en) 2006-10-19
EA016340B1 (ru) 2012-04-30
US8557854B2 (en) 2013-10-15
TW200745100A (en) 2007-12-16
ZA200708811B (en) 2009-01-28

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