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WO2006100060A3 - Kolloidale nanokomposite aus lbl-partikeln, lipiden und biologischen komponenten sowie verfahren zur herstllung derselben - Google Patents

Kolloidale nanokomposite aus lbl-partikeln, lipiden und biologischen komponenten sowie verfahren zur herstllung derselben Download PDF

Info

Publication number
WO2006100060A3
WO2006100060A3 PCT/EP2006/002636 EP2006002636W WO2006100060A3 WO 2006100060 A3 WO2006100060 A3 WO 2006100060A3 EP 2006002636 W EP2006002636 W EP 2006002636W WO 2006100060 A3 WO2006100060 A3 WO 2006100060A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
lbl
lipids
production
biological components
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/002636
Other languages
English (en)
French (fr)
Other versions
WO2006100060A2 (de
Inventor
Martin Fischlechner
Edwin Donath
Lars Toellner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Leipzig
Capsulution Nanoscience AG
Original Assignee
Universitaet Leipzig
Capsulution Nanoscience AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaet Leipzig, Capsulution Nanoscience AG filed Critical Universitaet Leipzig
Publication of WO2006100060A2 publication Critical patent/WO2006100060A2/de
Publication of WO2006100060A3 publication Critical patent/WO2006100060A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

Es werden Mikropartikel vorgeschlagen, die einen Kern von kolloidaler Größe, eine den Kern umgebende Hüllschicht, die mehrere Schichten alternierend geladener Polyelektrolyte und/oder alternierend geladener Nanopartikel aufweist, eine die Hüllschicht umgebende bi- oder multilamellare Lipidschicht, und Viren, Virosomen oder virenähnliche Partikel, welche in die Lipidschicht integriert oder mit dieser verschmolzen sind, aufweisen.
PCT/EP2006/002636 2005-03-22 2006-03-22 Kolloidale nanokomposite aus lbl-partikeln, lipiden und biologischen komponenten sowie verfahren zur herstllung derselben Ceased WO2006100060A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005014083.1 2005-03-22
DE102005014083A DE102005014083A1 (de) 2005-03-22 2005-03-22 Kolloidale Nanokomposite aus LbL-Partikeln, Lipiden und biologischen Komponenten angewandt in Medizin, Molekularbiologie und Diagnostik

Publications (2)

Publication Number Publication Date
WO2006100060A2 WO2006100060A2 (de) 2006-09-28
WO2006100060A3 true WO2006100060A3 (de) 2006-11-30

Family

ID=36581924

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/002636 Ceased WO2006100060A2 (de) 2005-03-22 2006-03-22 Kolloidale nanokomposite aus lbl-partikeln, lipiden und biologischen komponenten sowie verfahren zur herstllung derselben

Country Status (2)

Country Link
DE (1) DE102005014083A1 (de)
WO (1) WO2006100060A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2883201A1 (en) * 2012-09-17 2014-03-20 Eastman Chemical Company Methods, materials and apparatus for improving control and efficiency of layer-by-layer processes
US9817166B2 (en) 2014-12-15 2017-11-14 Eastman Chemical Company Electromagnetic energy-absorbing optical product and method for making
US9891357B2 (en) 2014-12-15 2018-02-13 Eastman Chemical Company Electromagnetic energy-absorbing optical product and method for making
US9891347B2 (en) 2014-12-15 2018-02-13 Eastman Chemical Company Electromagnetic energy-absorbing optical product and method for making
US10338287B2 (en) 2017-08-29 2019-07-02 Southwall Technologies Inc. Infrared-rejecting optical products having pigmented coatings
US11747532B2 (en) 2017-09-15 2023-09-05 Southwall Technologies Inc. Laminated optical products and methods of making them
US10613261B2 (en) 2018-04-09 2020-04-07 Southwall Technologies Inc. Selective light-blocking optical products having a neutral reflection
US10627555B2 (en) 2018-04-09 2020-04-21 Southwall Technologies Inc. Selective light-blocking optical products having a neutral reflection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000003797A1 (de) * 1998-07-15 2000-01-27 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Polyelektrolythüllen auf biologischen templaten
WO2004047977A1 (de) * 2002-11-22 2004-06-10 Capsulution Nanoscience Ag Verfahen zum modifizieren von mikropartikeln sowie vorrichtung zum modifizieren von mikropartikeln

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000003797A1 (de) * 1998-07-15 2000-01-27 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Polyelektrolythüllen auf biologischen templaten
WO2004047977A1 (de) * 2002-11-22 2004-06-10 Capsulution Nanoscience Ag Verfahen zum modifizieren von mikropartikeln sowie vorrichtung zum modifizieren von mikropartikeln

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DONATH EDWIN ET AL: "Hollow polymer shells from biological templates: fabrication and potential applications", CHEMISTRY - A EUROPEAN JOURNAL, VCH PUBLISHERS, US, vol. 8, no. 23, 2 December 2002 (2002-12-02), pages 5481 - 5485, XP002364905, ISSN: 0947-6539 *
FISCHLECHNER ET AL: "Engineering Virus Functionalities on Colloidal Polyelectrolyte Lipid Composites", ANGEW. CHEM. INT. ED, vol. 44, 13 April 2005 (2005-04-13), Wiley-VCH Verlag, Weinheim, pages 2892 - 2895, XP002386619 *
FISCHLECHNER ET AL: "Virus-Engineered Colloidal Particles-A Surface Display System", ANGEW. CHEM. INT. ED, vol. 45, 1 January 2006 (2006-01-01), Wiley-VCH Verlag, Weinheim, pages 784 - 789, XP002386620 *
MOYA S E ET AL: "COMPOSITE LIPID POLYELECTROLYTE CAPSULES TEMPLATED ON RED BLOOD CELLS: FABRICATION AND STRUCTURAL CHARACTERISATION", MEDICAL AND BIOLOGICAL ENGINEERING AND COMPUTING, PETER PEREGRINUS LTD. / IFMBE, HERTS, GB, vol. 41, no. 4, July 2003 (2003-07-01), pages 504 - 508, XP001047280, ISSN: 0140-0118 *
MOYA S ET AL: "Microencapsulation of organic solvents in polyelectrolyte multilayer micrometer-sized shells", JOURNAL OF COLLOID AND INTERFACE SCIENCE 15 AUG 1999 UNITED STATES, vol. 216, no. 2, 15 August 1999 (1999-08-15), pages 297 - 302, XP002386618, ISSN: 0021-9797 *

Also Published As

Publication number Publication date
DE102005014083A1 (de) 2006-09-28
WO2006100060A2 (de) 2006-09-28

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