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WO2006039399A3 - Decroissance de l'arnm mediee par staufen 1 (stau1) - Google Patents

Decroissance de l'arnm mediee par staufen 1 (stau1) Download PDF

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Publication number
WO2006039399A3
WO2006039399A3 PCT/US2005/035011 US2005035011W WO2006039399A3 WO 2006039399 A3 WO2006039399 A3 WO 2006039399A3 US 2005035011 W US2005035011 W US 2005035011W WO 2006039399 A3 WO2006039399 A3 WO 2006039399A3
Authority
WO
WIPO (PCT)
Prior art keywords
mrna decay
staufen
mediated mrna
stau1
staul
Prior art date
Application number
PCT/US2005/035011
Other languages
English (en)
Other versions
WO2006039399A2 (fr
Inventor
Lynne E Maquat
Yoon Ki Kim
Original Assignee
Univ Rochester
Lynne E Maquat
Yoon Ki Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rochester, Lynne E Maquat, Yoon Ki Kim filed Critical Univ Rochester
Publication of WO2006039399A2 publication Critical patent/WO2006039399A2/fr
Publication of WO2006039399A3 publication Critical patent/WO2006039399A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des compositions et des méthodes de traitement de patients présentant des états résultant d'une décroissance de l'ARNm médiée par Stau1, de criblage et de production de ces agents thérapeutiques. L'invention concerne de nouveaux mécanismes de décroissance de l'ARNm faisant intervenir Staufen mammifère (Stau)1, le facteur Upf1 de décroissance d'ARNm à médiation nonsens (NMD), ainsi qu'un codon de terminaison. Il est montré que Stau1 se fixe directement au Upf1 et peut mettre en lumière une décroissance de l'ARNm lorsqu'il est attaché en aval d'un codon de terminaison. L'invention concerne également la nouvelle voie constituant un moyen permettant aux cellules de réguler négativement l'expression des ARNm liant Stau1.
PCT/US2005/035011 2004-09-29 2005-09-29 Decroissance de l'arnm mediee par staufen 1 (stau1) WO2006039399A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61407104P 2004-09-29 2004-09-29
US60/614,071 2004-09-29
US64684405P 2005-01-25 2005-01-25
US60/646,844 2005-01-25

Publications (2)

Publication Number Publication Date
WO2006039399A2 WO2006039399A2 (fr) 2006-04-13
WO2006039399A3 true WO2006039399A3 (fr) 2007-04-19

Family

ID=36143051

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/035011 WO2006039399A2 (fr) 2004-09-29 2005-09-29 Decroissance de l'arnm mediee par staufen 1 (stau1)

Country Status (1)

Country Link
WO (1) WO2006039399A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2626437A3 (fr) 2008-05-14 2013-12-11 Dermtech International Diagnostic de mélanome et de lentigo solaire par l'analyse d'acides nucléiques
US9206479B2 (en) 2011-02-09 2015-12-08 University Of Rochester Methods and compositions related to Staufen 1 binding sites formed by duplexing Alu elements
WO2016179043A1 (fr) 2015-05-01 2016-11-10 Dermtech, Inc. Système non invasif de prélèvement de peau
EP3551641A4 (fr) * 2016-12-08 2021-01-13 University of Utah Research Foundation Agents de la staufen1 et procédés associés
US11976332B2 (en) 2018-02-14 2024-05-07 Dermtech, Inc. Gene classifiers and uses thereof in non-melanoma skin cancers
JP2021527649A (ja) 2018-06-14 2021-10-14 ユニバーシティー オブ ユタ リサーチ ファウンデーションＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｕｔａｈ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Ｓｔａｕｆｅｎ１調節剤および関連する方法
JP2022524641A (ja) 2019-03-26 2022-05-09 ダームテック，インク． 皮膚癌における新規な遺伝子分類子とその使用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US20040241845A1 (en) * 1998-05-22 2004-12-02 Luc Desgroseillers Mammalian staufen and use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US20040241845A1 (en) * 1998-05-22 2004-12-02 Luc Desgroseillers Mammalian staufen and use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FERRAIUOLO ET AL: "A role for the elF4E-binding protein 4E-T in P-body formation and mRNA decay", THE JOURNAL OF CELL BIOLOGY, vol. 170, 12 September 2005 (2005-09-12), pages 913 - 924, XP003010912 *
KIM ET AL: "Mammalian Staufen1 recruits Upfl to specific mRNA 3'UTR so as to elicit mRNA decay", CELL, vol. 120, 28 January 2005 (2005-01-28), pages 195 - 208, XP003010913 *
MEYER E.L. ET AL: "Staufen does double duty", NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 12, 4 April 2005 (2005-04-04), pages 291 - 292, XP003010911 *

Also Published As

Publication number Publication date
WO2006039399A2 (fr) 2006-04-13

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