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WO2006032070A1 - Dispositif pour le prelevement et la distribution doses de liquide - Google Patents

Dispositif pour le prelevement et la distribution doses de liquide Download PDF

Info

Publication number
WO2006032070A1
WO2006032070A1 PCT/AT2005/000379 AT2005000379W WO2006032070A1 WO 2006032070 A1 WO2006032070 A1 WO 2006032070A1 AT 2005000379 W AT2005000379 W AT 2005000379W WO 2006032070 A1 WO2006032070 A1 WO 2006032070A1
Authority
WO
WIPO (PCT)
Prior art keywords
cylinder
liquid
piston
container
infusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AT2005/000379
Other languages
German (de)
English (en)
Inventor
Bernhard GALLNBÖCK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PRO-MED MEDIZINISCHE PRODUKTIONS- und HANDELS-AG
Original Assignee
PRO-MED MEDIZINISCHE PRODUKTIONS- und HANDELS-AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PRO-MED MEDIZINISCHE PRODUKTIONS- und HANDELS-AG filed Critical PRO-MED MEDIZINISCHE PRODUKTIONS- und HANDELS-AG
Publication of WO2006032070A1 publication Critical patent/WO2006032070A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
    • F04B53/14—Pistons, piston-rods or piston-rod connections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407—Infusion of two or more substances
    • A61M5/1409—Infusion of two or more substances in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B9/00—Piston machines or pumps characterised by the driving or driven means to or from their working members
    • F04B9/14—Pumps characterised by muscle-power operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/223—Multiway valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14216—Reciprocating piston type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/1424—Manually operated pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16809—Flow controllers by repeated filling and emptying of an intermediate volume

Definitions

  • the invention relates to a device for the metered intake and delivery of liquid, in particular infusion liquid, comprising a cylinder which pressurizes a liquid chamber and a piston guided along the cylinder axis in the cylinder and at least one line for introducing and discharging liquid from the liquid chamber.
  • Drugs for infusion are usually sold as concentrates or lyophilisates. This allows a more stable storage of the medically effective substance and an individual adjustment of the dose and the total amount of infusion to a patient.
  • the dosage of infusion solution from a Infusi ⁇ onsgebinde in a drug vial for reconstitution and dilution of the drug, and for returning this drug solution in the infusion container or the dosage of a drug from a drug into an infusion container to be transferred drug solution is usually carried out by syringes and needles.
  • the disadvantage of this procedure lies in the relatively high manipulation effort and in the danger of contaminating the environment or the operator with a potentially highly effective medicament on the one hand (for example a cytotoxic agent) Substance) and the microbial contamination of the drug or the drug ready for infusion diluted drug on the other hand.
  • a potentially highly effective medicament for example a cytotoxic agent
  • the possibility of puncture wounds when handling nails and cannulas has received ever increasing attention in recent times, so that the use of such agents should be avoided as far as possible or, if at all, should only be ensured.
  • the invention is therefore an object of the invention to provide a device for metered recording and dispensing of liquid of the type described above, which avoids the simplest possible handling contamination risks for the infusion solution, and as possible no risk of injury by needles.
  • the invention solves this problem in that the piston in the cylinder for the purpose of displacement of a defined cylinder volume against spring force from a stop-limited rest position in a stop-limited end position is displaced.
  • the device according to the invention allows a transfer of a precisely defined amount of liquid, for example an infusion carrier solution such as sodium chloride or the like, into a drug container and optionally a return of the dissolved or diluted drug to a solvent container, e.g. B. an infusion bag or an infusion bottle.
  • a solvent container e.g. B. an infusion bag or an infusion bottle.
  • the transferred amount of liquid is dependent on the liquid chamber volume, wherein a transfer of a certain amount of a liquid can be done for example by repeated actuation of the device.
  • a defined cylinder volume is displaced, with a liquid optionally being sucked into the cylinder or conveyed out of the cylinder.
  • the cylinder has two ports which are alternately flow-connected to the fluid chamber.
  • liquid can be sucked in via a first connection and the liquid can be conveyed out of the device via the second connection when relocating the piston into the first position without having to handle needles ( and vice versa).
  • each of the connections includes a check valve to which the two check valves are arranged in the sense of a flow of the liquid through the cylinder from one connection to the other in the cylinder.
  • a complex handling with the connections of the cylinder for the purpose of conveying direction reversal or for connecting the cylinder to a Zwi ⁇ rule container for mixing liquids can be essentially avoided if the cylinder is rotatably mounted around the cylinder axis in a Zylin ⁇ dergehotuse, wherein where appropriate, the two connections of the cylinder are alternately connected alternately to at least two connections formed by the cylinder housing.
  • the rotational position of the cylinder can also be adjusted so that all three ports are closed.
  • more than two connections can be provided in the cylinder housing, wherein it can be provided by rotating the cylinder in the cylinder housing simple way is possible to connect different ports of the cylinder housing via the cylinder with each other.
  • a particularly compact and easy-to-use device for the metered recording and dispensing of liquid which avoids contamination risks for the infusion solution with simple handling and low risk of injury by needling, is created when the cylinder housing part of an infusion pump with a Liquid container and preferably a gas pressure generator for expelling liquid from the container, wherein the container is flow-connected to a terminal of the infusion pump via lines and the cylinder and the liquid chamber.
  • drugs can be applied via the connection in the container and ready-mixed infusion solution from the container.
  • medicaments for reconstitution and dilution of the medicament are first conveyed into a first mixing container, transferred therefrom after rotation of the cylinder into an infusion container and can be dispensed from the container after further rotation of the cylinder, it is recommended that the cylinder housing Part of an infusion pump with at least two liquid containers and preferably a gas pressure generator for expelling liquid from at least one container, wherein either the two containers with each other or one of the two containers with a connection of the infusion pump via lines and the cylinder and its liquid chamber flow-connected are.
  • the distance between stop-limited rest position and stop-limited end position with respect to the cylinder axis is adjustable by means of an adjustment.
  • the piston stroke in the cylinder is thus optionally increased or reduced, whereby of course the volume of the liquid chamber also changes in the same sense.
  • the adjusting device is a stop for the piston forming, screwed onto the cylinder coaxial with the cylinder axis union nut, which preferably has a Betä ⁇ opening for the piston.
  • the distance between the two end positions can thus be adjusted by screwing or unscrewing the nut on the cylinder to the desired extent.
  • the piston can be displaced through the actuating opening in the union nut in the direction of its end position. If the cylinder additionally has subdivisions for subdivision, it is possible to simply set the liquid chamber volume precisely by turning the union nut. An unintentional twisting of the union nut can be prevented if, on the other hand, a latching device is provided between the union nut on the one hand and the housing, which allows the union nut to snap against the housing or piston during adjustment of the liquid chamber volume of, for example, 5 ml.
  • Fig. 1 shows a device according to the invention in a partially sectioned side view
  • FIG. 2 shows the device from FIG. 1 in a front view
  • FIG. 3 shows a construction variant of a device according to the invention in a partially sectioned side view
  • Fig. 4 shows the device of Fig. 3 in section along the line IV-IV and Fig. 5 to 7 infusion pump with a device according to the invention of Fig. 3 and 4 on a reduced scale.
  • a device 1 for the metered admission and delivery of infusion fluid comprises a cylinder 3 forming a pressurizable fluid chamber 2 and two lines 4, 5 for input and output Dispensing of liquid from the liquid chamber 2.
  • a piston 7 along the cylinder axis 8 is adjustably guided, which in order to Verdrän ⁇ tion of a defined cylinder volume against the force of at least one spring 9 from a stop-rest position R in a stop-limited end position E is displaced.
  • the position of the abutment-limited rest position R can be adjusted with respect to the end position E on the cylinder axis 8 by means of a stop 10 for the piston 7, which is screwed onto the cylinder 3 coaxially with the cylinder axis 8 and can be adjusted (FIG. 1).
  • the distance between the rest position R and the end position E and thus the defined liquid chamber volume, which is displaced in a stroke of the piston 7, can be adjusted in a simple manner by turning the union nut 11 over the cylinder 3.
  • the piston 7 carries an actuating projection 12, which projects through an actuating opening 13 of the union nut 11 in order to ensure a simple actuation of the piston 7 can.
  • the cylinder 3 has bull partitions 14. Between union nut 11 and piston 7, a latching device 15 is provided, which avoids unintentional adjustment of the fürsch ⁇ nut 11 and thus the liquid chamber volume.
  • the piston 7 is rotatably held in the cylinder 6 in this case via the springs 9.
  • the cylinder 3 has two ports 16, 17 which are alternately flow-connected to the fluid chamber 2.
  • a hinted dargestell ⁇ th pharmaceutical vial 18 via a check valve 19 for example, a ball or a diaphragm valve
  • the line 4 are sucked into the liquid chamber 2, when the piston moves from its end position E in its rest position R. becomes. If the piston is displaced from the rest position R into its end position E, liquid is discharged from the liquid chamber 2 via the line 5 and the check valve 20 out of the device.
  • a check valve 19 for example, a ball or a diaphragm valve
  • the cylinder 3 is mounted rotatably about the cylinder axis 8 in a cylinder housing 6, the two connections 16, 17 of the cylinder being alternately formed simultaneously on two out of three from the cylinder housing 6 Ports 21, 22, 23 are connected or in a middle position both ports are blocked.
  • an actuating handle 24 for the piston 7 and the cylinder 3 for example via a Keilverzah ⁇ voltage rotatably connected to each other, but the actuating handle 24 and piston 7 together in the cylinder 3 along the cylinder axis 8 slidably guided.
  • the cylinder housing 6 is part of an infusion pump 25 having two fluid reservoirs 26, 27 and a gas pressure generator 28 for expelling fluid from the reservoir 27.
  • a gas pressure generator of interest is disclosed, for example, in WO 95/23 641 A1 .
  • the two containers 26, 27 can either be interconnected with one another or one of the two containers 26, 27 can be connected to a connection 29 of the infusion pump 25 via lines and the cylinder 3 and its liquid chamber 2.
  • drugs for reconstitution and dilution of the drug for example, may first be delivered to the first container 26 via port 29 ( Figure 7), then transferred to the second container 27 after rotation of the cylinder 3 ( Figure 6) and another Turning the cylinder are discharged from the container 27 (Fig. 5).
  • the container 27 is associated with a coupling 30 for dispensing infusion liquid.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un dispositif (1) servant au prélèvement et à la distribution dosés de liquide, notamment de liquide de perfusion. Le dispositif selon l'invention comprend un cylindre (3) formant une chambre de liquide (2) pouvant être mise sous pression, un piston (7) guidé dans le cylindre (3) le long de l'axe (8) du cylindre, ainsi qu'au moins une conduite (4, 5) servant à introduire le liquide dans la chambre de liquide (2) et à l'en évacuer. L'invention vise à garantir une manipulation simple de ce dispositif et à éviter, le plus largement possible, les risques de contamination de la solution pour perfusion. A cet effet, le piston (7) peut être déplacé dans le cylindre (3), à l'encontre d'une force de ressort, d'une position de repos (R) délimitée par une butée dans une position de fin de course (E) délimitée par une butée afin de refouler un volume de cylindre défini.
PCT/AT2005/000379 2004-09-22 2005-09-21 Dispositif pour le prelevement et la distribution doses de liquide Ceased WO2006032070A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA1589/2004 2004-09-22
AT15892004A AT501250B1 (de) 2004-09-22 2004-09-22 Vorrichtung zur dosierten aufnahme und abgabe von flüssigkeit

Publications (1)

Publication Number Publication Date
WO2006032070A1 true WO2006032070A1 (fr) 2006-03-30

Family

ID=35276230

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT2005/000379 Ceased WO2006032070A1 (fr) 2004-09-22 2005-09-21 Dispositif pour le prelevement et la distribution doses de liquide

Country Status (2)

Country Link
AT (1) AT501250B1 (fr)
WO (1) WO2006032070A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2168616A1 (fr) * 2008-09-30 2010-03-31 Animas Corporation Pompe mécanique de dispositif médical
EP2303362A4 (fr) * 2008-07-18 2012-06-13 Becton Dickinson Co Ensemble pompe à engrenages et double compartiment pour système d'administration sous haute pression
WO2012130903A1 (fr) 2011-03-31 2012-10-04 Sanofi-Aventis Deutschland Gmbh Mécanisme d'administration
WO2014066249A1 (fr) * 2012-10-22 2014-05-01 Creaturo Michael A Appareil et procédé pour mélanger un médicament et l'ajouter à un fluide intraveineux
WO2014072689A1 (fr) * 2012-11-07 2014-05-15 Surgical Innovations Limited Instrument chirurgical destiné à distribuer un fluide
EP2105153A3 (fr) * 2008-03-27 2014-11-26 LifeScan, Inc. Pompe mécanique de dispositif médical

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3344785A (en) * 1965-02-01 1967-10-03 Pharmaseal Lab Valve for exchange transfusion system
US3831602A (en) * 1972-02-11 1974-08-27 Union Plastics Corp Adjustable syringe assemblies
US3905521A (en) * 1974-05-21 1975-09-16 Thyroid Diagnostics Inc Reagent dispenser
EP0178023A2 (fr) * 1984-10-08 1986-04-16 Echangex S.A. Dispositif pour l'administration de substances liquides ou solides
US5061243A (en) * 1985-08-06 1991-10-29 Baxter International Inc. System and apparatus for the patient-controlled delivery of a beneficial agent, and set therefor
EP0523456A1 (fr) * 1991-07-10 1993-01-20 Nissho Corporation Appareil et système pour se délivrer une dose d'un médicament sous forme liquide
US6001089A (en) * 1995-03-07 1999-12-14 Eli Lilly And Company Multiple dose medication dispensing method
US20020169416A1 (en) * 2000-11-30 2002-11-14 Gonnelli Robert R. Fluid delivery and measurement systems and methods
FR2850015A1 (fr) * 2003-01-22 2004-07-23 Rvp Finance Dispositif pour le transfert d'un liquide entre deux recipients

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3048171A (en) * 1958-11-03 1962-08-07 Bio Physical Res Inc Intravenous injection device
FR2588757B1 (fr) * 1985-10-21 1989-12-08 Perouse Sa Laboratoires Dispositif place sous la peau pour delivrer une substance medicamenteuse

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3344785A (en) * 1965-02-01 1967-10-03 Pharmaseal Lab Valve for exchange transfusion system
US3831602A (en) * 1972-02-11 1974-08-27 Union Plastics Corp Adjustable syringe assemblies
US3905521A (en) * 1974-05-21 1975-09-16 Thyroid Diagnostics Inc Reagent dispenser
EP0178023A2 (fr) * 1984-10-08 1986-04-16 Echangex S.A. Dispositif pour l'administration de substances liquides ou solides
US5061243A (en) * 1985-08-06 1991-10-29 Baxter International Inc. System and apparatus for the patient-controlled delivery of a beneficial agent, and set therefor
EP0523456A1 (fr) * 1991-07-10 1993-01-20 Nissho Corporation Appareil et système pour se délivrer une dose d'un médicament sous forme liquide
US6001089A (en) * 1995-03-07 1999-12-14 Eli Lilly And Company Multiple dose medication dispensing method
US20020169416A1 (en) * 2000-11-30 2002-11-14 Gonnelli Robert R. Fluid delivery and measurement systems and methods
FR2850015A1 (fr) * 2003-01-22 2004-07-23 Rvp Finance Dispositif pour le transfert d'un liquide entre deux recipients

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2105153A3 (fr) * 2008-03-27 2014-11-26 LifeScan, Inc. Pompe mécanique de dispositif médical
EP2303362A4 (fr) * 2008-07-18 2012-06-13 Becton Dickinson Co Ensemble pompe à engrenages et double compartiment pour système d'administration sous haute pression
US11383025B2 (en) 2008-07-18 2022-07-12 Becton, Dickinson And Company Dual chamber and gear pump assembly for a high pressure delivery system
US10314967B2 (en) 2008-07-18 2019-06-11 Becton, Dickinson And Company Dual chamber and gear pump assembly for a high pressure delivery system
US8905970B2 (en) 2008-07-18 2014-12-09 Becton, Dickinson And Company Dual chamber and gear pump assembly for a high pressure delivery system
EP2168616A1 (fr) * 2008-09-30 2010-03-31 Animas Corporation Pompe mécanique de dispositif médical
CN103501838A (zh) * 2011-03-31 2014-01-08 赛诺菲-安万特德国有限公司 定量机构
US9649435B2 (en) 2011-03-31 2017-05-16 Sanofi-Aventis Deutschland Gmbh Dosing mechanism
WO2012130903A1 (fr) 2011-03-31 2012-10-04 Sanofi-Aventis Deutschland Gmbh Mécanisme d'administration
US9433726B2 (en) 2012-10-22 2016-09-06 Parenteral Technologies, Llc Methods and apparatuses for delivering medicaments to intravenous fluid
WO2014066249A1 (fr) * 2012-10-22 2014-05-01 Creaturo Michael A Appareil et procédé pour mélanger un médicament et l'ajouter à un fluide intraveineux
WO2014072689A1 (fr) * 2012-11-07 2014-05-15 Surgical Innovations Limited Instrument chirurgical destiné à distribuer un fluide
US10004485B2 (en) 2012-11-07 2018-06-26 Surgical Innovations Limited Surgical instrument for dispensing a fluid

Also Published As

Publication number Publication date
AT501250A1 (de) 2006-07-15
AT501250B1 (de) 2007-03-15

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