[go: up one dir, main page]

WO2006031764A3 - Processes for prepating n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates - Google Patents

Processes for prepating n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates Download PDF

Info

Publication number
WO2006031764A3
WO2006031764A3 PCT/US2005/032473 US2005032473W WO2006031764A3 WO 2006031764 A3 WO2006031764 A3 WO 2006031764A3 US 2005032473 W US2005032473 W US 2005032473W WO 2006031764 A3 WO2006031764 A3 WO 2006031764A3
Authority
WO
WIPO (PCT)
Prior art keywords
piperidines
processes
prepating
intermediates
substituted arylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/032473
Other languages
French (fr)
Other versions
WO2006031764A2 (en
Inventor
Jaidev Goudar
David S Rosen
Guozhi Wang
Qun Zhang
Russell Patera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FMC Corp
Original Assignee
FMC Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FMC Corp filed Critical FMC Corp
Priority to JP2007531438A priority Critical patent/JP2008512495A/en
Priority to BRPI0515275-5A priority patent/BRPI0515275A/en
Priority to EP05798202A priority patent/EP1794144A2/en
Publication of WO2006031764A2 publication Critical patent/WO2006031764A2/en
Publication of WO2006031764A3 publication Critical patent/WO2006031764A3/en
Priority to IL181102A priority patent/IL181102A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Improved processes are described for preparing compounds of formulae: (B, C, F, H) wherein R1, R2, B and Z are defined herein. These compounds are useful in the preparation of N-(substituted arylmethyl)-4­(disubstituted methyl)piperidines.
PCT/US2005/032473 2004-09-13 2005-09-12 Processes for prepating n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates Ceased WO2006031764A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2007531438A JP2008512495A (en) 2004-09-13 2005-09-12 Process for preparing N- (substituted arylmethyl) -4- (disubstituted methyl) piperidines and intermediates
BRPI0515275-5A BRPI0515275A (en) 2004-09-13 2005-09-12 processes for the preparation of n- (substituted arylmethyl) -4- (methyl disubstituted) piperidines and intermediates
EP05798202A EP1794144A2 (en) 2004-09-13 2005-09-12 Processes for prepating n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates
IL181102A IL181102A0 (en) 2004-09-13 2007-02-01 Processes for preparing n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60953904P 2004-09-13 2004-09-13
US60/609,539 2004-09-13

Publications (2)

Publication Number Publication Date
WO2006031764A2 WO2006031764A2 (en) 2006-03-23
WO2006031764A3 true WO2006031764A3 (en) 2006-07-13

Family

ID=36060625

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/032473 Ceased WO2006031764A2 (en) 2004-09-13 2005-09-12 Processes for prepating n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates

Country Status (9)

Country Link
EP (1) EP1794144A2 (en)
JP (1) JP2008512495A (en)
KR (1) KR20070052319A (en)
CN (1) CN101018776A (en)
AR (1) AR052977A1 (en)
BR (1) BRPI0515275A (en)
IL (1) IL181102A0 (en)
TW (1) TW200621747A (en)
WO (1) WO2006031764A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1314955A (en) * 1970-11-27 1973-04-26 Richardson Merrell Inc 4-4-alpha-hydroxybenzyl piperidino 4-fluorobutyrophenone derivative
WO2004060371A1 (en) * 2002-12-18 2004-07-22 Fmc Corporation N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1314955A (en) * 1970-11-27 1973-04-26 Richardson Merrell Inc 4-4-alpha-hydroxybenzyl piperidino 4-fluorobutyrophenone derivative
WO2004060371A1 (en) * 2002-12-18 2004-07-22 Fmc Corporation N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHANKLIN J.R. ET AL.: "Synthesis, Calcium-Channel-Blocking Activity, and Antihypertensive Activity of 4-(Diarylmethyl)-1-[3-(aryloxy)propyl]piperidines and Structurally Related Compounds", J. MED. CHEM., vol. 34, May 1991 (1991-05-01), pages 3011 - 3022, XP002241320 *

Also Published As

Publication number Publication date
WO2006031764A2 (en) 2006-03-23
IL181102A0 (en) 2007-07-04
AR052977A1 (en) 2007-04-18
TW200621747A (en) 2006-07-01
KR20070052319A (en) 2007-05-21
CN101018776A (en) 2007-08-15
BRPI0515275A (en) 2008-07-15
JP2008512495A (en) 2008-04-24
EP1794144A2 (en) 2007-06-13

Similar Documents

Publication Publication Date Title
WO2005108358A3 (en) Pyrrolidine derivatives useful as bace inhibitors
GEP20094785B (en) Pyrrolopyrazoles, potent kinase inhibitors
WO2003093269A3 (en) Substituted pyrazolo-pyrimidine-4-ones
WO2005030751A3 (en) Dipeptidyl peptidase inhibitors
WO2007033780A3 (en) Thiazoles used as fungicides
AP2006003558A0 (en) Polymorphic forms of 3-(4-amino-1oxo-1,3 dilhydro-isoindol-2-yl)-piperidine-2,6-dione.
WO2006034093A3 (en) 3- (2-acylamino-1-hydroxyethyl)- morpholine derivatives and their use as bace inhibitors
TW200500339A (en) Pyrrolidine derivatives, and process for the preparation
WO2004099197A3 (en) Substituted oxyarenes, and use thereof for controlling pests
WO2005087700A3 (en) Bisphenyl compounds useful as vitamin d3 receptor agonists
WO2006103277A3 (en) 2 , 4 , 5-substituted piperidines as renin inhibitors
WO2005065018A3 (en) Crystalline forms of (6r) -l-erythro-tetrahydrobiopterin dihydrochloride
WO2006039250A3 (en) Chemokine-binding heterocyclic compound salts, and methods of use thereof
WO2007062308A3 (en) Homo- and heterocyclic compounds suitable as cetp inhibitors
NO20070550L (en) Process for Preparation of Pyrrolotriazine Compounds
WO2007053819A3 (en) Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase iv and methods
TW200619205A (en) A method for preparing irbesartan and intermediates thereof
WO2006050458A3 (en) Tadalafil crystal forms and processes for preparing them
TW200637806A (en) 2-alkylcycloalk(en)ylcarboxamides
IL177662A0 (en) Novel pyrrolidine-3,4-dicarboxamide derivatives
WO2005004606A3 (en) Pyridinylanilides
WO2006031764A3 (en) Processes for prepating n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates
ZA200706248B (en) Novel heterocyclic oxime derivatives, method for preparing same and use thereof as hypoglycaemic or hypolipidemic agents
IL182445A0 (en) Process for the preparation of n-(3,5-dichloropyrid-4-yl)-4difluoromethoxy-8-methanesulfona mido-dibenzo[b,d]furan-1-caboxamide
IL173582A0 (en) A process for the preparation of phenyltetrazole derivatives

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2005798202

Country of ref document: EP

Ref document number: 181102

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: MX/a/2007/002910

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2007531438

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 200580030754.0

Country of ref document: CN

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 1020077006338

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2005798202

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0515275

Country of ref document: BR