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WO2006031537A3 - Procede et systeme d'analyse de microplaque - Google Patents

Procede et systeme d'analyse de microplaque Download PDF

Info

Publication number
WO2006031537A3
WO2006031537A3 PCT/US2005/031772 US2005031772W WO2006031537A3 WO 2006031537 A3 WO2006031537 A3 WO 2006031537A3 US 2005031772 W US2005031772 W US 2005031772W WO 2006031537 A3 WO2006031537 A3 WO 2006031537A3
Authority
WO
WIPO (PCT)
Prior art keywords
light
wells
plate
analysis system
illumination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/031772
Other languages
English (en)
Other versions
WO2006031537A2 (fr
Inventor
David M Heffelfinger
Robert M Watson Jr
Charles S Smith Iii
Siavash Ghazvini
Christopherm F Bragg
John M Ii Collier
Gibson T Lam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alpha Innotech Corp
Original Assignee
Alpha Innotech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpha Innotech Corp filed Critical Alpha Innotech Corp
Publication of WO2006031537A2 publication Critical patent/WO2006031537A2/fr
Publication of WO2006031537A3 publication Critical patent/WO2006031537A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/02—Details
    • G01J1/04—Optical or mechanical part supplementary adjustable parts
    • G01J1/0488—Optical or mechanical part supplementary adjustable parts with spectral filtering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J2003/1213—Filters in general, e.g. dichroic, band
    • G01J2003/1217—Indexed discrete filters or choppers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)

Abstract

L'invention concerne un procédé et un dispositif destinés à éclairer une plaque multipuits, à collecter la lumière à partir d'une zone cible avec les puits de la plaque multipuits, à transmettre cette lumière à un vidéo-détecteur réseau, à détecter les cibles discrètes dans les puits de la plaque et à rattacher ente elles des images de la plaque multipuits. Ce dispositif et ce procédé peuvent comprendre la détection d'un microréseau et des cellules non ordonnées dans les puits. Ils peuvent également comprendre des éléments destinés à l'homogénéisation de la lumière, à la formation de la lumière d'éclairage afin d'éclairer une zone sélectionnée du réseau, à l'éclairage hors axe ainsi qu'à la modulation spatiale de la lumière d'éclairage.
PCT/US2005/031772 2004-09-09 2005-09-08 Procede et systeme d'analyse de microplaque Ceased WO2006031537A2 (fr)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US60844204P 2004-09-09 2004-09-09
US60843004P 2004-09-09 2004-09-09
US60840704P 2004-09-09 2004-09-09
US60846104P 2004-09-09 2004-09-09
US60847004P 2004-09-09 2004-09-09
US60845004P 2004-09-09 2004-09-09
US60833004P 2004-09-09 2004-09-09
US60/608,442 2004-09-09
US60/608,470 2004-09-09
US60/608,450 2004-09-09
US60/608,461 2004-09-09
US60/608,430 2004-09-09
US60/608,407 2004-09-09
US60/608,330 2004-09-09

Publications (2)

Publication Number Publication Date
WO2006031537A2 WO2006031537A2 (fr) 2006-03-23
WO2006031537A3 true WO2006031537A3 (fr) 2006-08-17

Family

ID=36060532

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/031772 Ceased WO2006031537A2 (fr) 2004-09-09 2005-09-08 Procede et systeme d'analyse de microplaque

Country Status (1)

Country Link
WO (1) WO2006031537A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20060495A0 (fi) 2006-05-19 2006-05-19 Wallac Oy Järjestely ja menetelmä kohteen valaisemiseksi
US8244021B2 (en) 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
US9557217B2 (en) 2007-02-13 2017-01-31 Bti Holdings, Inc. Universal multidetection system for microplates
EP2225548B1 (fr) 2007-12-19 2019-06-26 Koninklijke Philips N.V. Système et procédé de détection
DE102010016382B4 (de) * 2010-04-09 2022-06-02 Leica Microsystems Cms Gmbh Fluoreszenzmikroskop und Verfahren zur Durchführung von Multipositionierungen in einer Screening-Applikation
CH706326A2 (de) 2012-03-14 2013-09-30 Tecan Trading Ag Verfahren und Mikroplatten-Reader zum Untersuchung von biologischen Zellen oder Zellkulturen.
EP3301431B1 (fr) 2016-09-29 2019-08-28 Roche Diagniostics GmbH Dispositif d'analyse multi-chambres et procédé d'analyse
GB2597502A (en) 2020-07-24 2022-02-02 Ffei Ltd A whole slide imaging method for a microscope
WO2022217243A1 (fr) * 2021-04-07 2022-10-13 Illumina, Inc. Motif d'éclairage adaptable pour analyse d'échantillon
CN114121334B (zh) * 2021-11-16 2025-04-22 湖州霍里思特智能科技有限公司 一种射线准直调整装置
CN118647859A (zh) * 2021-12-24 2024-09-13 分子装置有限公司 微孔板读取器

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271042B1 (en) * 1998-08-26 2001-08-07 Alpha Innotech Corporation Biochip detection system
US20010055764A1 (en) * 1999-05-07 2001-12-27 Empedocles Stephen A. Microarray methods utilizing semiconductor nanocrystals
US20020158211A1 (en) * 2001-04-16 2002-10-31 Dakota Technologies, Inc. Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271042B1 (en) * 1998-08-26 2001-08-07 Alpha Innotech Corporation Biochip detection system
US20010055764A1 (en) * 1999-05-07 2001-12-27 Empedocles Stephen A. Microarray methods utilizing semiconductor nanocrystals
US20020158211A1 (en) * 2001-04-16 2002-10-31 Dakota Technologies, Inc. Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures

Also Published As

Publication number Publication date
WO2006031537A2 (fr) 2006-03-23

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