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WO2006031358A3 - Polymeres dendritiques, gels reticules, et leurs utilisations comme agents de scellement et lentilles ophtalmiques - Google Patents

Polymeres dendritiques, gels reticules, et leurs utilisations comme agents de scellement et lentilles ophtalmiques Download PDF

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Publication number
WO2006031358A3
WO2006031358A3 PCT/US2005/029097 US2005029097W WO2006031358A3 WO 2006031358 A3 WO2006031358 A3 WO 2006031358A3 US 2005029097 W US2005029097 W US 2005029097W WO 2006031358 A3 WO2006031358 A3 WO 2006031358A3
Authority
WO
WIPO (PCT)
Prior art keywords
lens
methods
compound
dendritic
isocysteine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/029097
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English (en)
Other versions
WO2006031358A2 (fr
Inventor
Mark W Grinstaff
Michael A Carnahan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hyperbranch Medical Technology Inc
Original Assignee
Hyperbranch Medical Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyperbranch Medical Technology Inc filed Critical Hyperbranch Medical Technology Inc
Publication of WO2006031358A2 publication Critical patent/WO2006031358A2/fr
Publication of WO2006031358A3 publication Critical patent/WO2006031358A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J189/00—Adhesives based on proteins; Adhesives based on derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J201/00—Adhesives based on unspecified macromolecular compounds
    • C09J201/005—Dendritic macromolecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Eyeglasses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention a trait à des compositions et des procédés pour le scellement d'une plaie et la préparation d'une lentille. Les procédés de l'invention utilisent des macromolécules dendritiques formées par le traitement d'un composé dendritique avec de la lumière ou un composé de liaison. Dans certains modes de réalisation, les composés dendritiques ont un résidu de lysine, de cystéine, d'isocystéine ou autre groupe nucléophile lié à la périphérie du dendrimère. L'addition d'un composé contenant au moins deux groupes électrophiles tels que des aldéhydes, des esters activés, ou des acrylates aux dendrimères coiffés de lysine, de cystèine, ou d'isocystéine produit un composé polymérique qui peut former un scellement ou une lentille. Un autre mode de réalisation de l'invention a trait à un procédé de traitement de maladies mettant en oeuvre les compositions pharmaceutiques de l'invention. D'autres modes de réalisation de l'invention on trait à des trousses pour le scellement d'une plaie ou la préparation d'une lentille, de dispositifs d'administration, et à des procédés pour contrôler la polymérisation d'un système hydrogel.
PCT/US2005/029097 2004-08-13 2005-08-15 Polymeres dendritiques, gels reticules, et leurs utilisations comme agents de scellement et lentilles ophtalmiques Ceased WO2006031358A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60169104P 2004-08-13 2004-08-13
US60/601691 2004-08-13

Publications (2)

Publication Number Publication Date
WO2006031358A2 WO2006031358A2 (fr) 2006-03-23
WO2006031358A3 true WO2006031358A3 (fr) 2006-11-16

Family

ID=36060486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029097 Ceased WO2006031358A2 (fr) 2004-08-13 2005-08-15 Polymeres dendritiques, gels reticules, et leurs utilisations comme agents de scellement et lentilles ophtalmiques

Country Status (1)

Country Link
WO (1) WO2006031358A2 (fr)

Cited By (14)

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US8512729B2 (en) 1996-08-27 2013-08-20 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8852646B2 (en) 2009-12-15 2014-10-07 Incept, Llc Particulate implants and biodegradable fiducial markers
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8951989B2 (en) 2009-04-09 2015-02-10 Actamax Surgical Materials, Llc Hydrogel tissue adhesive having reduced degradation time
US8962025B2 (en) 2006-08-02 2015-02-24 Baxter International Inc. Rapidly acting dry sealant and methods for use and manufacture
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing

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US7927626B2 (en) 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
EP1796746B1 (fr) 2004-10-07 2011-05-04 E.I. Du Pont De Nemours And Company Adhesif tissulaire polymere a base de polysaccharide destine a un usage medical
DE102005051334A1 (de) * 2005-10-25 2007-06-21 Degussa Gmbh Präparate umfassend hyperverzweigte Polymere
CA2627459C (fr) 2005-10-25 2011-08-09 Evonik Degussa Gmbh Preparation comprenant des polymeres hyperramifies
CA2635374C (fr) 2006-01-11 2015-12-08 Hyperbranch Medical Technology, Inc. Gels reticules comprenant des polyalkylene-imines et utilisation de ceux-ci en tant que dispositifs medicaux
EP2023941B1 (fr) 2006-04-24 2016-12-21 Incept, LLC Agents de réticulation de protéine, méthodes de réticulation et leurs applications
US8282959B2 (en) 2006-11-27 2012-10-09 Actamax Surgical Materials, Llc Branched end reactants and polymeric hydrogel tissue adhesives therefrom
AU2008207828B2 (en) 2007-01-25 2013-09-19 Hyperbranch Medical Technology, Inc. Applicators for multiple component formulations and the like, and methods of use thereof
WO2009064963A2 (fr) 2007-11-14 2009-05-22 E. I. Du Pont De Nemours And Company Adhésif tissulaire polymère à base de polysaccharide cationique oxydé, à usage médical
US7862538B2 (en) 2008-02-04 2011-01-04 Incept Llc Surgical delivery system for medical sealant
US8551136B2 (en) 2008-07-17 2013-10-08 Actamax Surgical Materials, Llc High swell, long-lived hydrogel sealant
EP2349357B1 (fr) 2008-11-19 2012-10-03 Actamax Surgical Materials LLC Adhésif de type hydrogel pour tissus formés à partir de polysaccharide aminé et de polyéther à plusieurs bras fonctionnalisé par aldéhyde
US8466327B2 (en) 2008-11-19 2013-06-18 Actamax Surgical Materials, Llc Aldehyde-functionalized polyethers and method of making same
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
WO2011002956A1 (fr) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Polysaccharides fonctionnalisés par aldéhyde
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
MX2012007056A (es) 2009-12-16 2012-09-28 Baxter Healthcare Sa Esponja hemostatica.
WO2013022801A1 (fr) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Administration de petites molécules à l'aide d'un dispositif thérapeutique implantable
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
US8211450B2 (en) 2010-05-05 2012-07-03 Senju Usa, Inc. Ophthalmic composition
KR101967085B1 (ko) 2010-06-01 2019-04-08 백스터 인터내셔널 인코포레이티드 건조 및 안정한 지혈 조성물의 제조 방법
AU2011285548B2 (en) 2010-08-05 2014-02-06 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
AU2011329656B2 (en) 2010-11-19 2017-01-05 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
EP2726016B1 (fr) 2011-06-28 2023-07-19 ForSight Vision4, Inc. Un appareil pour collecter un échantillon de fluide à partir d'une chambre réservoir d'un dispositif thérapeutique pour l'oeil
SI2755600T1 (sl) 2011-09-16 2021-08-31 Forsight Vision4, Inc. Naprava za izmenjavo tekočine
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
JP6195568B2 (ja) 2011-10-11 2017-09-13 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 止血組成物
MX356185B (es) 2011-10-11 2018-05-17 Baxter Int Composiciones hemostaticas.
TWI548417B (zh) 2011-10-27 2016-09-11 巴克斯特國際公司 止血組成物
AU2012347926B2 (en) 2011-12-05 2018-03-15 Incept, Llc Medical organogel processes and compositions
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
CA2865349C (fr) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Recipient mis sous pression contenant de la pate hemostatique
DE102012006946A1 (de) * 2012-04-10 2013-10-10 Stratley Ag Verfahren zur Herstellung von Caprolactam
AU2014236455B2 (en) 2013-03-14 2018-07-12 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
BR112015030612B1 (pt) 2013-06-21 2020-07-21 Ferrosan Medical Devices A/S método para preparar uma composição seca
US20160184474A1 (en) 2013-07-29 2016-06-30 Actamax Surgical Materials, Llc Low swell tissue adhesive and sealant formulations
CA2928963C (fr) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Composition seche comprenant un ameliorateur d'extrusion
MY182497A (en) 2014-07-15 2021-01-25 Forsight Vision4 Inc Ocular implant delivery device and method
WO2016058612A1 (fr) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Composition sèche destinée à être utilisée en hémostase et cicatrisation de plaie
WO2016065245A1 (fr) 2014-10-24 2016-04-28 Incept, Llc Échafaudage extraluminal
AU2015346450B2 (en) 2014-11-10 2020-01-30 Forsight Vision4, Inc. Expandable drug delivery devices and method of use
JP7092502B2 (ja) 2014-12-10 2022-06-28 インセプト・リミテッド・ライアビリティ・カンパニー ハイドロゲル薬物送達インプラント
CA2970710A1 (fr) 2014-12-24 2016-06-30 Ferrosan Medical Devices A/S Seringue pour retenir et melanger des premiere et seconde substances
CA2985656A1 (fr) 2015-05-12 2016-11-17 Incept, Llc Administration de medicament a partir d'hydrogels
EP3316930B1 (fr) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Seringue destinée à mélanger deux composants et à maintenir un vide dans une condition de stockage
WO2017087902A1 (fr) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Structures poreuses pour dispositifs d'administration de médicament à libération prolongée
CA3006303C (fr) 2015-11-25 2023-11-14 Incept, Llc Dispositifs d'administration de medicaments a changement de forme et procedes
ES2837524T3 (es) 2016-04-05 2021-06-30 Forsight Vision4 Inc Dispositivos de administración de fármacos oculares implantables
ES2725716T3 (es) * 2016-09-13 2019-09-26 Henkel Ag & Co Kgaa Silanos y composiciones curables que comprenden dichos silanos
WO2018058048A1 (fr) 2016-09-23 2018-03-29 Incept, Llc Dépôts pour l'administration de médicament en intracaméral
CN111655206B (zh) 2017-11-21 2022-10-14 弗赛特影像4股份有限公司 用于可扩展端口递送系统的流体交换装置及使用方法
EP3790600B1 (fr) 2018-05-09 2023-12-27 Ferrosan Medical Devices A/S Procédé de préparation d'une composition hémostatique
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device
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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512729B2 (en) 1996-08-27 2013-08-20 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US8962025B2 (en) 2006-08-02 2015-02-24 Baxter International Inc. Rapidly acting dry sealant and methods for use and manufacture
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8951989B2 (en) 2009-04-09 2015-02-10 Actamax Surgical Materials, Llc Hydrogel tissue adhesive having reduced degradation time
US8852646B2 (en) 2009-12-15 2014-10-07 Incept, Llc Particulate implants and biodegradable fiducial markers
US9308283B2 (en) 2009-12-15 2016-04-12 Incept, Llc Implants and biodegradable fiducial markers
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9033911B2 (en) 2010-08-05 2015-05-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof

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