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WO2006028524A3 - Compositions and treatments for inhibiting kinase and/or hmg-coa reductase - Google Patents

Compositions and treatments for inhibiting kinase and/or hmg-coa reductase Download PDF

Info

Publication number
WO2006028524A3
WO2006028524A3 PCT/US2005/014843 US2005014843W WO2006028524A3 WO 2006028524 A3 WO2006028524 A3 WO 2006028524A3 US 2005014843 W US2005014843 W US 2005014843W WO 2006028524 A3 WO2006028524 A3 WO 2006028524A3
Authority
WO
WIPO (PCT)
Prior art keywords
hmg
coa reductase
compositions
treatments
map kinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/014843
Other languages
French (fr)
Other versions
WO2006028524A2 (en
Inventor
John Griffin
William J Mydlowec
Guido Lanza
Jessen Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmix Corp
Original Assignee
Pharmix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmix Corp filed Critical Pharmix Corp
Priority to JP2007511020A priority Critical patent/JP2007535558A/en
Priority to EP05818178A priority patent/EP1755607A2/en
Publication of WO2006028524A2 publication Critical patent/WO2006028524A2/en
Anticipated expiration legal-status Critical
Publication of WO2006028524A3 publication Critical patent/WO2006028524A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38a MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.
PCT/US2005/014843 2004-04-29 2005-04-29 Compositions and treatments for inhibiting kinase and/or hmg-coa reductase Ceased WO2006028524A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2007511020A JP2007535558A (en) 2004-04-29 2005-04-29 Compositions and treatments for inhibiting kinases and / or HMG-COA reductase
EP05818178A EP1755607A2 (en) 2004-04-29 2005-04-29 Compositions and treatments for inhibiting kinase and/or hmg-coa reductase

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US56711804P 2004-04-29 2004-04-29
US60/567,118 2004-04-29
US63068404P 2004-11-23 2004-11-23
US63068304P 2004-11-23 2004-11-23
US60/630,684 2004-11-23
US60/630,683 2004-11-23

Publications (2)

Publication Number Publication Date
WO2006028524A2 WO2006028524A2 (en) 2006-03-16
WO2006028524A3 true WO2006028524A3 (en) 2009-04-23

Family

ID=35451387

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2005/014833 Ceased WO2005115397A2 (en) 2004-04-29 2005-04-29 Compositions and treatments for modulating kinase and/or hmg-coa reductase
PCT/US2005/014843 Ceased WO2006028524A2 (en) 2004-04-29 2005-04-29 Compositions and treatments for inhibiting kinase and/or hmg-coa reductase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2005/014833 Ceased WO2005115397A2 (en) 2004-04-29 2005-04-29 Compositions and treatments for modulating kinase and/or hmg-coa reductase

Country Status (3)

Country Link
EP (1) EP1755607A2 (en)
JP (1) JP2007535558A (en)
WO (2) WO2005115397A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9242960B2 (en) 2009-04-03 2016-01-26 Respivert, Ltd. P38MAP kinase inhibitors

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8329703B2 (en) 2005-02-15 2012-12-11 Xtl Biopharmaceuticals Ltd. Pyrazole compounds
EP1948168A4 (en) * 2005-10-28 2010-10-06 Numerate Inc Compositions and treatments for inhibiting kinase and/or hmg-coa reductase
JP2010506843A (en) 2006-10-13 2010-03-04 エックスティーエル バイオファーマシューティカルズ リミテッド Compounds and methods for treating HCV
GB0818033D0 (en) 2008-10-02 2008-11-05 Respivert Ltd Novel compound
EP2350049B1 (en) 2008-10-02 2014-02-26 Respivert Limited P38 map kinase inhibitors
NZ593104A (en) 2008-12-11 2012-11-30 Respivert Ltd P38 map kinase inhibitors
EP2308866A1 (en) * 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazoles and their use as fungicides
HUE059041T2 (en) * 2013-10-17 2022-10-28 Blueprint Medicines Corp Process for the preparation of compositions suitable for the treatment of KIT-related disorders
WO2018183712A1 (en) 2017-03-31 2018-10-04 Blueprint Medicines Corporation Pyrrolo[1,2-b]pyridazine compounds and compositions useful for treating disorders related to kit and pdgfr
CA3136802A1 (en) 2019-04-12 2020-10-15 Blueprint Medicines Corporation Pyrrolotriazine derivatives for treating kit- and pdgfra-mediated diseases
SMT202300447T1 (en) 2019-04-12 2024-01-10 Blueprint Medicines Corp Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120848A (en) * 1988-10-03 1992-06-09 Glaxo Group Limited Imidazole derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177121B1 (en) * 1997-09-29 2001-01-23 Purdue Research Foundation Composition and method for producing low cholesterol eggs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120848A (en) * 1988-10-03 1992-06-09 Glaxo Group Limited Imidazole derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHAN, C.: "Inhibitors of Cholesterol Biosynthesis. 1. 3,5-dihydroxy-7-(N-imidazolyl)-6- heptenoates and heptanoates, a novel series of HMG-CoA reductase inhibitors.", J. MED. CHEM., vol. 36, 1993, pages 3646 - 3657, XP002922110 *
SLISKOVIC, D.R.: "Inhibitors of Cholesterol Biosynthesis. 6. trans-6-[2-(2-N-hetroaryl-3,5- disubstituted-pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones.", J. MED. CHEM., vol. 35, 1992, pages 2095 - 2103, XP008122636 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9242960B2 (en) 2009-04-03 2016-01-26 Respivert, Ltd. P38MAP kinase inhibitors

Also Published As

Publication number Publication date
JP2007535558A (en) 2007-12-06
WO2006028524A2 (en) 2006-03-16
WO2005115397A3 (en) 2006-07-13
EP1755607A2 (en) 2007-02-28
WO2005115397A2 (en) 2005-12-08

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