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WO2006021924A1 - Therapeutic oil from plant origine - Google Patents

Therapeutic oil from plant origine Download PDF

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Publication number
WO2006021924A1
WO2006021924A1 PCT/IB2005/052752 IB2005052752W WO2006021924A1 WO 2006021924 A1 WO2006021924 A1 WO 2006021924A1 IB 2005052752 W IB2005052752 W IB 2005052752W WO 2006021924 A1 WO2006021924 A1 WO 2006021924A1
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WO
WIPO (PCT)
Prior art keywords
oil
chlorophyll
ozone
bleaching earth
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/052752
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French (fr)
Inventor
Pieter Josua Le Roux
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2006021924A1 publication Critical patent/WO2006021924A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00Refining fats or fatty oils
    • C11B3/008Refining fats or fatty oils by filtration, e.g. including ultra filtration, dialysis
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00Refining fats or fatty oils
    • C11B3/02Refining fats or fatty oils by chemical reaction
    • C11B3/08Refining fats or fatty oils by chemical reaction with oxidising agents
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00Refining fats or fatty oils
    • C11B3/10Refining fats or fatty oils by adsorption

Definitions

  • This invention relates to a therapeutic oil and to a method of producing such a therapeutic oil.
  • a known therapeutic oil consists of olive oil that has been ozonated by subjecting the oil to ozone. This oil has become very popular in the cosmetic industry as well as for the treatment of wounds.
  • the olive oil is ozonated by bubbling concentrated ozone gas through pure olive oil.
  • the consistency of the ozonated olive oil depends on the extent to which the olive oil is subjected to the ozone.
  • the known ozonated olive oil suffers from a number of disadvantages. For example, owing to the chlorophyll content of the olive oil and the relatively high concentration of short-chain fatty acids relative to long-chain fatty acids, the ozonated olive oil is highly unstable. The oil therefore has to be used shortly after preparation otherwise it becomes stale.
  • a method of producing a therapeutic oil including the steps of: providing an organic oil of a plant source having a relatively higher concentration of long-chain fatty acids relative to short- chain fatty acids; and - ozonating the oil by subjecting the same to a sufficient amount of ozone.
  • the organic oil may be of the type containing chlorophyll in its natural state and the method may include the further step of removing at least a major portion of the said chlorophyll.
  • the organic oil is avocado oil.
  • the step of removing the chlorophyll from the organic oil may include the steps of heating the oil to a temperature of between 40 0 C and 80 0 C, preferably to 60 0 C; adding a sufficient amount of a bleaching earth to the oil; allowing the bleaching earth to react with the chlorophyll to form a bleaching earth- chlorophyll complex; and removing the said complex from the oil.
  • the step of adding the bleaching earth to the oil may include the further step of adding between 3% and 12%, preferably 7% bleaching earth to the oil on a mass per mass basis.
  • the step of allowing the bleaching earth to react with the chlorophyll to form a bleaching earth-chlorophyll complex may include the further steps of agitating the mixture of oil and bleaching earth and allowing the oil and bleaching earth mixture to react for 10 to 60 minutes, preferably 30 minutes.
  • the step of removing the said complex from the oil may include the even further step of filtering the oil.
  • the step of subjecting the oil to ozone may include the step of bubbling the ozone in gas-form through the oil.
  • the step of bubbling the ozone in gas-form through the oil may include the steps of disposing the oil in a plurality of containers, each having an inlet and an outlet and passing the ozone gas emanating from the outlet of one container to the inlet of an adjacent container.
  • a therapeutic oil comprising an organic oil of a plant source having a relatively higher concentration of long-chain fatty acids relative to short-chain fatty acids, which has been ozonated by subjecting the oil to a sufficient amount of ozone.
  • the organic oil is of the type containing chlorophyll in its natural state and of which a major portion of the chlorophyll has been removed.
  • the organic oil is avocado oil.
  • figure 1 is an apparatus used to aid the production of a therapeutic oil, according to the invention.
  • an organic therapeutic oil of a plant source having a relatively higher concentration of long-chain fatty acids relative to short-chain fatty acids in the form of avocado oil.
  • avocado oil contains chlorophyll in its natural state, in preparing the therapeutic oil, the chlorophyll is firstly removed. Thereafter the oil is ozonated by being subjected to a sufficient amount of ozone with the aid of the apparatus 10 illustrated in figure 1.
  • a first container 12 provided with a first inlet 12.1 and a first outlet 12.2 and having a volume of approximately 3 litres; a second container 14 provided with a second inlet 14.1 and a second outlet 14.2 and having a volume of approximately 2 litres; and a third container 16 provided with a third inlet 16.1 and a third outlet 16.2 and also having a volume of approximately 2 litres.
  • the first outlet 12.2 is connected to the second inlet 14.1
  • the second outlet 14.2 is connected to the third inlet 16.1.
  • the first inlet 12.1 is connected to a source of ozone gas, such as an ozone generator (not shown).
  • the third outlet 16.2 is open to allow excess gas to escape from the third container 16.
  • the temperature of the oil 18 in the three containers 12, 14 and 16 is kept below 23 0 C at all times while the ozone is bubbled through the oil 18.
  • the first container 12 and the second container 14 are both filled completely with the oil 18, whereas the third container 16 is filled only halfway with oil 18.
  • the ozone generator is connected to the first inlet 12.1 and activated to generate ozone gas, which is bubbled through the oil.
  • the ozone gas flows from the first container 12 to the second container 14 and is similarly bubbled through the oil 18 in the second container 14. From the second container 14 the gas passes to the third container 16, also being bubbled though the oil 18, while excess gas escapes via the third outlet 16.2.
  • the duration for which the ozone gas is bubbled through the oil determines the consistency of the oil. For a relatively more viscose consistency and hence a relatively higher percentage of ozone, the oil is subjected to the ozone for a relatively longer period of time. Whereas, when the oil is subjected to the ozone for a shorter period of time, the resulting oil would be relatively less viscose containing a lower percentage of ozone.
  • the percentage of ozone in the oil determines its potency and is therefore determined by the type of treatment the oil is to be used for. It is foreseen that the therapeutic oil product is useful as a massage oil; in the cosmetics industry for facial and skin treatments; and in the treatment of wounds.
  • the therapeutic oil has an advantage over known therapeutic oils, since avocado oil penetrates the skin more deeply than other plant oils and it is therefore an ideal base for transdermal treatments and a natural carrier for ozone to reach the deepest targeted areas.
  • avocado oil has the highest rate of skin penetration and the ability to transport active substances through the outer epidermis of the skin and into the dermis for increased effectiveness.
  • avocado oil further has healing, anti-bacterial and anti-wrinkle properties.
  • the ozone which penetrates into the skin assists cell healing and regeneration. Since the avocado oil has a high concentration of fatty acids, the therapeutic oil aids in skin moisturising and restructuring of cells.
  • the oil also contains a high concentration of anti-oxidants, which are known to combat aging of living cells.
  • the therapeutic oil can be used for treatment of a large variety of skin ailments for human beings, as well as for animals.
  • any bacterial, viral and fungal infections skin cuts; abrasions; burn wounds; bed sores; herpes infections; eczema; fistulae; leg ulcers; gingivitis; haemorrhoids; vulvovaginitis; bee stings; insect bites; acne, and other skin related problems; secondary infections caused by aids; fistulae; decubitus; and mycosis.
  • variations in detail are possible with

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention provides an organic therapeutic oil of a plant source having a relatively higher concentration of long-chain fatty acids relative to short-chain fatty acids, in the form of avocado oil. In preparing the therapeutic oil, the chlorophyll is firstly removed from the oil and thereafter the oil is ozonated by being subjected to a sufficient amount of ozone with the aid of the apparatus (10). The apparatus (10) includes three containers (12), (14) and (16), each containing oil (18). An ozone generator is connected to the first inlet (12.1) and activated to generate ozone gas, which is bubbled through the oil.

Description

THERAPEUTIC OIL
INTRODUCTION AND BACKGROUND TO THE INVENTION
This invention relates to a therapeutic oil and to a method of producing such a therapeutic oil.
A known therapeutic oil consists of olive oil that has been ozonated by subjecting the oil to ozone. This oil has become very popular in the cosmetic industry as well as for the treatment of wounds. The olive oil is ozonated by bubbling concentrated ozone gas through pure olive oil. The consistency of the ozonated olive oil depends on the extent to which the olive oil is subjected to the ozone.
The known ozonated olive oil suffers from a number of disadvantages. For example, owing to the chlorophyll content of the olive oil and the relatively high concentration of short-chain fatty acids relative to long-chain fatty acids, the ozonated olive oil is highly unstable. The oil therefore has to be used shortly after preparation otherwise it becomes stale.
OBJECT OF THE INVENTION
It is an object of the present invention to provide a therapeutic oil and a method of producing such a therapeutic oil, which is a useful alternative to known therapeutic oils and with which the aforesaid disadvantages can be overcome or at least minimised.
SUMMARY OF THE INVENTION According to a first aspect of the invention there is provided a method of producing a therapeutic oil including the steps of: providing an organic oil of a plant source having a relatively higher concentration of long-chain fatty acids relative to short- chain fatty acids; and - ozonating the oil by subjecting the same to a sufficient amount of ozone.
The organic oil may be of the type containing chlorophyll in its natural state and the method may include the further step of removing at least a major portion of the said chlorophyll.
Further according to the invention the organic oil is avocado oil.
The step of removing the chlorophyll from the organic oil may include the steps of heating the oil to a temperature of between 400C and 800C, preferably to 60 0C; adding a sufficient amount of a bleaching earth to the oil; allowing the bleaching earth to react with the chlorophyll to form a bleaching earth- chlorophyll complex; and removing the said complex from the oil. The step of adding the bleaching earth to the oil may include the further step of adding between 3% and 12%, preferably 7% bleaching earth to the oil on a mass per mass basis.
The step of allowing the bleaching earth to react with the chlorophyll to form a bleaching earth-chlorophyll complex may include the further steps of agitating the mixture of oil and bleaching earth and allowing the oil and bleaching earth mixture to react for 10 to 60 minutes, preferably 30 minutes.
The step of removing the said complex from the oil may include the even further step of filtering the oil.
The step of subjecting the oil to ozone may include the step of bubbling the ozone in gas-form through the oil.
The step of bubbling the ozone in gas-form through the oil may include the steps of disposing the oil in a plurality of containers, each having an inlet and an outlet and passing the ozone gas emanating from the outlet of one container to the inlet of an adjacent container.
According to a second aspect of the invention there is provided a therapeutic oil comprising an organic oil of a plant source having a relatively higher concentration of long-chain fatty acids relative to short-chain fatty acids, which has been ozonated by subjecting the oil to a sufficient amount of ozone.
Further according to the invention the organic oil is of the type containing chlorophyll in its natural state and of which a major portion of the chlorophyll has been removed.
Preferably, the organic oil is avocado oil.
According to a third aspect of the invention there is provided a composition for use in the treatment of any one or more conditions selected from the group consisting of bacterial, viral and fungal infections; skin cuts; abrasions; burn wounds; bed sores; herpes infections; eczema; fistulae; leg ulcers; gingivitis; haemorrhoids; vulvovaginitis; bee stings; insect bites; acne, and other skin related problems; secondary infections caused by aids; fistulae; decubitus; and mycosis, the composition comprising a therapeutic oil including an organic oil of a plant source having a relatively higher concentration of long-chain fatty acids relative to short-chain fatty acids, which has been ozonated by subjecting the oil to a sufficient amount of ozone.
According to a fourth aspect of the invention there is provided a method of treating of any one or more conditions selected from the group consisting of bacterial, viral and fungal infections; skin cuts; abrasions; burn wounds; bed sores; herpes infections; eczema; fistulae; leg ulcers; gingivitis; haemorrhoids; vulvovaginitis; bee stings; insect bites; acne, and other skin related problems; secondary infections caused by aids; fistulae; decubitus; and mycosis, the method including the step of applying a composition according to the third aspect of the invention to the affected area of a person.
BRIEF DESCRIPTION OF THE DRAWING
The invention will now be described further by way of a non-limiting example with reference to figure 1 , which is an apparatus used to aid the production of a therapeutic oil, according to the invention.
DESCRIPTION OF A PREFERRED EMBODIMENT OF THE INVENTION
According to a preferred embodiment of the invention there is provided an organic therapeutic oil of a plant source having a relatively higher concentration of long-chain fatty acids relative to short-chain fatty acids, in the form of avocado oil. As avocado oil contains chlorophyll in its natural state, in preparing the therapeutic oil, the chlorophyll is firstly removed. Thereafter the oil is ozonated by being subjected to a sufficient amount of ozone with the aid of the apparatus 10 illustrated in figure 1.
In removing the chlorophyll from the avocado oil, the following steps are followed: 1. the oil is heated to a temperature of approximately 60 0C;
2. 7% bleaching earth is added to the oil on a mass per mass basis;
3. the mixture of oil and bleaching earth is agitated to allow the bleaching oil to react with the chlorophyll for approximately 30 minutes to form a bleaching earth-chlorophyll complex; and
4. the complex is removed from the oil through filtration.
Once the chlorophyll has been removed from the avocado oil, ozone gas is bubbled through the oil.
Referring to figure 1 , in bubbling the ozone gas through the oil, three containers 12, 14 and 16, each containing oil 18, is used. A first container 12 provided with a first inlet 12.1 and a first outlet 12.2 and having a volume of approximately 3 litres; a second container 14 provided with a second inlet 14.1 and a second outlet 14.2 and having a volume of approximately 2 litres; and a third container 16 provided with a third inlet 16.1 and a third outlet 16.2 and also having a volume of approximately 2 litres. The first outlet 12.2 is connected to the second inlet 14.1 , and the second outlet 14.2 is connected to the third inlet 16.1. The first inlet 12.1 is connected to a source of ozone gas, such as an ozone generator (not shown). The third outlet 16.2 is open to allow excess gas to escape from the third container 16. The temperature of the oil 18 in the three containers 12, 14 and 16 is kept below 23 0C at all times while the ozone is bubbled through the oil 18. The first container 12 and the second container 14 are both filled completely with the oil 18, whereas the third container 16 is filled only halfway with oil 18.
In use, the ozone generator is connected to the first inlet 12.1 and activated to generate ozone gas, which is bubbled through the oil. The ozone gas flows from the first container 12 to the second container 14 and is similarly bubbled through the oil 18 in the second container 14. From the second container 14 the gas passes to the third container 16, also being bubbled though the oil 18, while excess gas escapes via the third outlet 16.2.
The duration for which the ozone gas is bubbled through the oil, determines the consistency of the oil. For a relatively more viscose consistency and hence a relatively higher percentage of ozone, the oil is subjected to the ozone for a relatively longer period of time. Whereas, when the oil is subjected to the ozone for a shorter period of time, the resulting oil would be relatively less viscose containing a lower percentage of ozone.
The percentage of ozone in the oil determines its potency and is therefore determined by the type of treatment the oil is to be used for. It is foreseen that the therapeutic oil product is useful as a massage oil; in the cosmetics industry for facial and skin treatments; and in the treatment of wounds.
The therapeutic oil has an advantage over known therapeutic oils, since avocado oil penetrates the skin more deeply than other plant oils and it is therefore an ideal base for transdermal treatments and a natural carrier for ozone to reach the deepest targeted areas. Avocado oil has the highest rate of skin penetration and the ability to transport active substances through the outer epidermis of the skin and into the dermis for increased effectiveness. Avocado oil further has healing, anti-bacterial and anti-wrinkle properties. The ozone, which penetrates into the skin assists cell healing and regeneration. Since the avocado oil has a high concentration of fatty acids, the therapeutic oil aids in skin moisturising and restructuring of cells. The oil also contains a high concentration of anti-oxidants, which are known to combat aging of living cells.
It is further foreseen that the therapeutic oil can be used for treatment of a large variety of skin ailments for human beings, as well as for animals. For example, in the treatment of any bacterial, viral and fungal infections; skin cuts; abrasions; burn wounds; bed sores; herpes infections; eczema; fistulae; leg ulcers; gingivitis; haemorrhoids; vulvovaginitis; bee stings; insect bites; acne, and other skin related problems; secondary infections caused by aids; fistulae; decubitus; and mycosis. It will be appreciated that variations in detail are possible with a therapeutic oil and to a method of producing such a therapeutic oil according to the invention without departing from the scope of the appended claims.

Claims

1. A method of producing a therapeutic oil including the steps of: providing an organic oil of a plant source having a relatively higher concentration of long-chain fatty acids relative to short- chain fatty acids; and ozonating the oil by subjecting the same to a sufficient amount of ozone.
2. A method according to claim 1 wherein the organic oil is of the type containing chlorophyll in its natural state and the method includes the further step of removing at least a major portion of the said chlorophyll.
3. A method according to claim 2 wherein the organic oil is avocado oil.
4. A method according to claim 2 or claim 3 wherein the step of removing the chlorophyll from the organic oil includes the steps of heating the oil to a temperature of between 40 0C and 80 0C, adding a sufficient amount of a bleaching earth to the oil; allowing the bleaching earth to react with the chlorophyll to form a bleaching earth-chlorophyll complex; and removing the said complex from the oil.
5. A method according to claim 4 wherein the organic oil is heated to a temperature of 60 0C.
6. A method according to claim 4 or claim 5 wherein the step of adding the bleaching earth to the oil includes the further step of adding between 3% and 12% bleaching earth to the oil on a mass per mass basis.
7. A method according to claim 6 wherein 7% bleaching earth is added to the oil on a mass per mass basis.
8. A method according to any one of claims 4 to 7 wherein the step of allowing the bleaching earth to react with the chlorophyll to form a bleaching earth-chlorophyll complex includes the further steps of agitating the mixture of oil and bleaching earth and allowing the oil and bleaching earth mixture to react for 10 to 60 minutes.
9. A method according to claim 8 wherein the oil and bleaching earth mixture is allowed to react for 30 minutes.
10. A method according to any one of claims 4 to 9 wherein the step of removing the complex from the oil includes the even further step of filtering the oil.
11. A method according to any one of the preceding claims wherein the step of subjecting the oil to ozone includes the step of bubbling the ozone in gas-form through the oil.
12. A method according to claim 11 wherein the step of bubbling the ozone in gas-form through the oil includes the steps of disposing the oil in a plurality of containers, each having an inlet and an outlet and passing the ozone gas emanating from the outlet of one container to the inlet of an adjacent container.
13. A therapeutic oil comprising an organic oil of a plant source having a relatively higher concentration of long-chain fatty acids relative to short- chain fatty acids, which has been ozonated by subjecting the oil to a sufficient amount of ozone.
14. A therapeutic oil according to claim 13 wherein the organic oil is of the type containing chlorophyll in its natural state and of which a major portion of the chlorophyll has been removed.
15. A therapeutic oil according to claim 14 wherein the organic oil is avocado oil.
16. A composition for use in the treatment of any one or more conditions selected from the group consisting of bacterial, viral and fungal infections; skin cuts; abrasions; bum wounds; bed sores; herpes infections; eczema; fistulae; leg ulcers; gingivitis; haemorrhoids; vulvovaginitis; bee stings; insect bites; acne; secondary infections caused by aids; fistulae; decubitus; and mycosis, the composition comprising a therapeutic oil including an organic oil of a plant source having a relatively higher concentration of long-chain fatty acids relative to short-chain fatty acids, which has been ozonated by subjecting the oil to a sufficient amount of ozone.
17. A method of treating of any one or more conditions selected from the group consisting of bacterial, viral and fungal infections; skin cuts; abrasions; burn wounds; bed sores; herpes infections; eczema; fistulae; leg ulcers; gingivitis; haemorrhoids; vulvovaginitis; bee stings; insect bites; acne; secondary infections caused by aids; fistulae; decubitus; and mycosis, the method including the step of applying a composition according to the third aspect of the invention to the affected area of a person.
18. A method of producing a therapeutic oil substantially as herein described and exemplified and/or described with reference to the accompanying figure.
19. A therapeutic oil substantially as herein described and exemplified and/or described with reference to the accompanying figure.
20. A composition substantially as herein described and exemplified and/or described with reference to the accompanying figure.
21. A method of treatment substantially as herein described and exemplified and/or described with reference to the accompanying figure.
PCT/IB2005/052752 2004-08-26 2005-08-22 Therapeutic oil from plant origine Ceased WO2006021924A1 (en)

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ZA2004/6784 2004-08-26

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Cited By (9)

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Publication number Priority date Publication date Assignee Title
GB2431581A (en) * 2005-10-27 2007-05-02 Steven Karim Ozonated oil formulations
WO2007137881A1 (en) * 2006-06-01 2007-12-06 Sano Medical Bvba Wound care treatment product
WO2008050157A3 (en) * 2006-10-24 2008-09-25 Steven Karim Ozonated oil formulations
WO2010077694A1 (en) * 2008-12-08 2010-07-08 Sapphire Energy, Inc. Removal of nitrogen from a chlorophyll or pheophytin containing biomass
WO2012120454A1 (en) 2011-03-07 2012-09-13 Neovalis S.R.L. Composition for topical use based on ozonized oil
ITMI20111045A1 (en) * 2011-06-10 2012-12-11 Uni Del Salento PROCEDURE FOR THE OZONIZATION OF A VEGETABLE OIL.
CN110559189A (en) * 2019-08-20 2019-12-13 安徽氧趣生物科技有限公司 Preparation method of dimer and polymer ozone ointment
CN112867540A (en) * 2018-10-19 2021-05-28 R·索尔达蒂 Ozonized phytotherapeutic compositions for tissue and bone regeneration
US12453753B2 (en) 2019-05-23 2025-10-28 David Pauwels Oxygenated cannabis skin therapy compositions and methods for producing the compositions

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EP0235528A1 (en) * 1986-03-01 1987-09-09 Dr. J. Hänsler GmbH Process for preparing stable ozonized oils from unsaturated vegetable oils
WO1995018203A1 (en) * 1992-07-01 1995-07-06 The Procter & Gamble Company Process for removing chlorophyll color impurities from vegetable oils
WO2003047630A2 (en) * 2001-12-04 2003-06-12 Bertha Andras Method for oxygen treatment of unsaturated carbon compounds, novel epoxy-structured material obtained by the method, apparatus for carrying out the method and a therapeutic composition using the material
KR100414639B1 (en) * 2003-04-10 2004-01-07 Agitech Co Ltd Method and apparatus for manufacturing ozonizer using olive oil as base material

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EP0235528A1 (en) * 1986-03-01 1987-09-09 Dr. J. Hänsler GmbH Process for preparing stable ozonized oils from unsaturated vegetable oils
WO1995018203A1 (en) * 1992-07-01 1995-07-06 The Procter & Gamble Company Process for removing chlorophyll color impurities from vegetable oils
WO2003047630A2 (en) * 2001-12-04 2003-06-12 Bertha Andras Method for oxygen treatment of unsaturated carbon compounds, novel epoxy-structured material obtained by the method, apparatus for carrying out the method and a therapeutic composition using the material
KR100414639B1 (en) * 2003-04-10 2004-01-07 Agitech Co Ltd Method and apparatus for manufacturing ozonizer using olive oil as base material

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SOARES S E ET AL: "PHYSICAL AND CHEMICAL CHARACTERIZATION AND STABILITY EVALUATION OF AVOCADO OIL PERSEA-AMERICANA MILL. IN DIFFERENT STEPS OF THE REFINING PROCESS", REVISTA DE FARMACIA E BIOQUIMICA DA UNIVERSIDADE DE SAO PAULO, vol. 27, no. 1, 1991, pages 70 - 82, XP008058570, ISSN: 0370-4726 *

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