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WO2006018842A3 - Inhibitors of p38-alpha kinase - Google Patents

Inhibitors of p38-alpha kinase Download PDF

Info

Publication number
WO2006018842A3
WO2006018842A3 PCT/IL2005/000888 IL2005000888W WO2006018842A3 WO 2006018842 A3 WO2006018842 A3 WO 2006018842A3 IL 2005000888 W IL2005000888 W IL 2005000888W WO 2006018842 A3 WO2006018842 A3 WO 2006018842A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
alpha kinase
kinase
compounds
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2005/000888
Other languages
French (fr)
Other versions
WO2006018842A2 (en
Inventor
Yael Friedmann
Anat Shriki
David Engelberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jexys Pharmaceuticals Ltd
Original Assignee
Jexys Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jexys Pharmaceuticals Ltd filed Critical Jexys Pharmaceuticals Ltd
Publication of WO2006018842A2 publication Critical patent/WO2006018842A2/en
Anticipated expiration legal-status Critical
Publication of WO2006018842A3 publication Critical patent/WO2006018842A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to compounds capable of inhibiting p38a-Kinase, to pharmaceutical compositions comprising these compounds, and to methods of using the compounds for the treatment or prevention of diseases or disorders that are mediated by p38-a Kinase, particularly for the treatment or prevention of inflammatory diseases and disorders and heart conditions.
PCT/IL2005/000888 2004-08-17 2005-08-16 Inhibitors of p38-alpha kinase Ceased WO2006018842A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60197804P 2004-08-17 2004-08-17
US60/601,978 2004-08-17
US60325604P 2004-08-23 2004-08-23
US60/603,256 2004-08-23

Publications (2)

Publication Number Publication Date
WO2006018842A2 WO2006018842A2 (en) 2006-02-23
WO2006018842A3 true WO2006018842A3 (en) 2007-05-18

Family

ID=35907798

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2005/000888 Ceased WO2006018842A2 (en) 2004-08-17 2005-08-16 Inhibitors of p38-alpha kinase

Country Status (1)

Country Link
WO (1) WO2006018842A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410540B1 (en) * 1998-08-28 2002-06-25 Scios, Inc. Inhibitors of p38-αkinase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410540B1 (en) * 1998-08-28 2002-06-25 Scios, Inc. Inhibitors of p38-αkinase

Also Published As

Publication number Publication date
WO2006018842A2 (en) 2006-02-23

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