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WO2006015369A3 - Assays for identification of topoisomerase inhibitors - Google Patents

Assays for identification of topoisomerase inhibitors Download PDF

Info

Publication number
WO2006015369A3
WO2006015369A3 PCT/US2005/027605 US2005027605W WO2006015369A3 WO 2006015369 A3 WO2006015369 A3 WO 2006015369A3 US 2005027605 W US2005027605 W US 2005027605W WO 2006015369 A3 WO2006015369 A3 WO 2006015369A3
Authority
WO
WIPO (PCT)
Prior art keywords
assays
identification
topoisomerase inhibitors
topoisomerase
provides
Prior art date
Application number
PCT/US2005/027605
Other languages
French (fr)
Other versions
WO2006015369A2 (en
WO2006015369A9 (en
Inventor
James T Stivers
Keehwan Kwon
Original Assignee
Univ Johns Hopkins
James T Stivers
Keehwan Kwon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, James T Stivers, Keehwan Kwon filed Critical Univ Johns Hopkins
Publication of WO2006015369A2 publication Critical patent/WO2006015369A2/en
Publication of WO2006015369A9 publication Critical patent/WO2006015369A9/en
Priority to US11/701,981 priority Critical patent/US20080020973A1/en
Publication of WO2006015369A3 publication Critical patent/WO2006015369A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/533—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isomerase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The instant invention provides a continuous spectroscopic assay for DNA topoisomerase activity. The invention further provides topoisomerase inhibitors and pharmaceutical compositions for the treatment of topoisomerase associated diseases and disorders.
PCT/US2005/027605 2004-08-03 2005-08-03 Assays for identification of topoisomerase inhibitors WO2006015369A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/701,981 US20080020973A1 (en) 2004-08-03 2007-02-01 Assays for identification of topoisomerase inhibitors

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US59839504P 2004-08-03 2004-08-03
US60/598,395 2004-08-03
US59839804P 2004-08-08 2004-08-08
US60/598,398 2004-08-08
US69325205P 2005-06-23 2005-06-23
US60/693,252 2005-06-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/701,981 Continuation US20080020973A1 (en) 2004-08-03 2007-02-01 Assays for identification of topoisomerase inhibitors

Publications (3)

Publication Number Publication Date
WO2006015369A2 WO2006015369A2 (en) 2006-02-09
WO2006015369A9 WO2006015369A9 (en) 2006-03-30
WO2006015369A3 true WO2006015369A3 (en) 2009-04-16

Family

ID=35787925

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/027605 WO2006015369A2 (en) 2004-08-03 2005-08-03 Assays for identification of topoisomerase inhibitors

Country Status (1)

Country Link
WO (1) WO2006015369A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007146375A2 (en) * 2006-06-14 2007-12-21 Government Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services Highly soluble pyrimido-dione-quinoline compounds and their use in the treatment of cancer
WO2008124145A1 (en) * 2007-04-05 2008-10-16 Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Steroid compounds, compositions, and methods of treatment
WO2012036573A2 (en) * 2010-09-14 2012-03-22 Instytut Biochemii I Biofizyki Pan Compounds as modulators of a mutant cftr protein and their use for treating diseases associated with cftr protein malfunction
US10016402B2 (en) 2011-02-08 2018-07-10 Children's Medical Center Corporation Methods for treatment of melanoma
WO2020248075A1 (en) * 2019-06-12 2020-12-17 The Governors Of The University Of Alberta Targeting dna repair in tumor cells via inhibition of ercc1-xpf

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620588B1 (en) * 2000-05-31 2003-09-16 Salk Institute For Biological Studies Method of identifying inhibitors of topoisomerase DNA religation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620588B1 (en) * 2000-05-31 2003-09-16 Salk Institute For Biological Studies Method of identifying inhibitors of topoisomerase DNA religation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WILLIAMSON ET AL.: "The plastid DNA of the malaria parasite Plasmodium falciparum is replicated by two mechanisms", MOLECULAR MICROBIOLOGY, vol. 45, no. 2, 2002, pages 533 - 542 *

Also Published As

Publication number Publication date
WO2006015369A2 (en) 2006-02-09
WO2006015369A9 (en) 2006-03-30

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